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Accession:GO:0006094 term browser browse the term
Definition:The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol.
Synonyms:exact_synonym: glucose biosynthesis;   glucose biosynthetic process
 xref: MetaCyc:GLUCONEO-PWY;   Wikipedia:Gluconeogenesis

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gluconeogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf3 activating transcription factor 3 ISO (MGI:MGI:2180255|PMID:11916968) MGI PMID:11916968 MGI:MGI:2180255 NCBI chrNW_004936557:909,302...922,619 JBrowse link
G Atf4 activating transcription factor 4 ISO (MGI:MGI:2180255|PMID:11916968) MGI PMID:11916968 MGI:MGI:2180255 NCBI chrNW_004936492:2,114,478...2,115,969 JBrowse link
G Crtc2 CREB regulated transcription coactivator 2 ISO (MGI:MGI:3606826|PMID:16148943) UniProtKB PMID:16148943 MGI:MGI:3606826 NCBI chrNW_004936580:3,693,429...3,704,104 JBrowse link
G Cry1 cryptochrome circadian regulator 1 ISO (MGI:MGI:5567906|PMID:20852621) UniProtKB PMID:20852621 MGI:MGI:5567906 NCBI chrNW_004936492:7,929,138...7,994,797 JBrowse link
G Eno2 enolase 2 ISO RGD PMID:15720133 RGD:2302795 NCBI chrNW_004936709:904,647...913,445 JBrowse link
G Fbp1 fructose-bisphosphatase 1 ISO (PMID:19259699), (PMID:20096900) RGD
PMID:4353083, PMID:11440903, PMID:19259699, PMID:20096900 RGD:2302851, RGD:2302970 NCBI chrNW_004936626:3,555,835...3,581,651 JBrowse link
G Fbp2 fructose-bisphosphatase 2 ISO RGD PMID:4353083, PMID:11440903 RGD:2302851, RGD:2302970 NCBI chrNW_004936626:3,521,953...3,548,206 JBrowse link
G G6pc glucose-6-phosphatase catalytic subunit ISO (PMID:8211187) UniProtKB
PMID:4303362, PMID:4353083, PMID:8211187, PMID:11440903 RGD:2302850, RGD:2302851, RGD:2302970 NCBI chrNW_004936490:17,605,865...17,614,754 JBrowse link
G G6pc3 glucose-6-phosphatase catalytic subunit 3 ISO RGD PMID:4303362, PMID:4353083, PMID:11440903 RGD:2302850, RGD:2302851, RGD:2302970 NCBI chrNW_004936541:556,413...561,336 JBrowse link
G Gapdh glyceraldehyde-3-phosphate dehydrogenase ISO RGD PMID:15720133, PMID:28258188 RGD:13792662, RGD:2302795 NCBI chrNW_004936709:1,243,149...1,247,782 JBrowse link
G Gpd1 glycerol-3-phosphate dehydrogenase 1 ISO (MGI:MGI:2386349|PMID:12093800) MGI PMID:12093800 MGI:MGI:2386349 NCBI chrNW_004936512:7,762,325...7,770,007 JBrowse link
G Gpd2 glycerol-3-phosphate dehydrogenase 2 ISO (MGI:MGI:2386349|PMID:12093800) MGI PMID:12093800 MGI:MGI:2386349 NCBI chrNW_004936469:21,705,421...21,833,143 JBrowse link
G Pc pyruvate carboxylase ISO RGD PMID:4353083, PMID:6049928 RGD:2302851, RGD:2302971 NCBI chrNW_004936599:2,677,770...2,793,033 JBrowse link
G Pck1 phosphoenolpyruvate carboxykinase 1 ISO (PMID:26971250)
PMID:4186849, PMID:4303362, PMID:4353083, PMID:6049928, PMID:11440903, PMID:11916968, PMID:26971250, PMID:29230018 MGI:MGI:2180255, MGI:MGI:6119963, RGD:2302850, RGD:2302851, RGD:2302970, RGD:2302971, RGD:8553288 NCBI chrNW_004936530:361,872...367,005 JBrowse link
G Pck2 phosphoenolpyruvate carboxykinase 2, mitochondrial ISO RGD PMID:4353083, PMID:6049928, PMID:11440903 RGD:2302851, RGD:2302970, RGD:2302971 NCBI chrNW_004936722:428,473...450,452 JBrowse link
G Per2 period circadian regulator 2 ISO (MGI:MGI:5319572|PMID:22504074) UniProtKB PMID:22504074 MGI:MGI:5319572 NCBI chrNW_004936525:221,601...263,284 JBrowse link
G Pgam2 phosphoglycerate mutase 2 ISO RGD PMID:15720133 RGD:2302795 NCBI chrNW_004936478:19,021,928...19,026,110 JBrowse link
G Pgk1 phosphoglycerate kinase 1 ISO RGD PMID:3091090, PMID:15720133 RGD:2302795, RGD:2302860 NCBI chrNW_004936547:286,267...310,062 JBrowse link
G Ppargc1a PPARG coactivator 1 alpha ISO RGD PMID:21212096 RGD:9585757 NCBI chrNW_004936477:4,881,230...5,488,208 JBrowse link
G Rbp4 retinol binding protein 4 ISO (PMID:18466349)
BHF-UCL PMID:16034410, PMID:18466349 MGI:MGI:3584329 NCBI chrNW_004936601:1,401,215...1,410,195 JBrowse link
G Slc39a14 solute carrier family 39 member 14 ISO (MGI:MGI:4950776|PMID:21445361) UniProt PMID:21445361 MGI:MGI:4950776 NCBI chrNW_004939045:1...7,491 JBrowse link
negative regulation of gluconeogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO (MGI:MGI:3055866|PMID:11479628) MGI PMID:11479628 MGI:MGI:3055866 NCBI chrNW_004936578:3,168,599...3,179,369 JBrowse link
G C1qtnf12 C1q and TNF related 12 ISO (MGI:MGI:5317500|PMID:22275362) MGI PMID:22275362 MGI:MGI:5317500 NCBI chrNW_004936737:1,877,428...1,881,345 JBrowse link
G C1qtnf3 C1q and TNF related 3 ISO (PMID:20952387)
MGI PMID:20952387 MGI:MGI:4868567 NCBI chrNW_004936518:7,039,590...7,060,463 JBrowse link
G Clk2 CDC like kinase 2 ISO (MGI:MGI:4429735|PMID:20074525) UniProtKB PMID:20074525 MGI:MGI:4429735 NCBI chrNW_004936580:4,746,276...4,758,236 JBrowse link
G Cry1 cryptochrome circadian regulator 1 ISO (MGI:MGI:5914352|PMID:28790135), (MGI:MGI:6208175|PMID:29937374) UniProt PMID:28790135, PMID:29937374 MGI:MGI:5914352, MGI:MGI:6208175 NCBI chrNW_004936492:7,929,138...7,994,797 JBrowse link
G Ep300 E1A binding protein p300 ISO (PMID:30193097) UniProt PMID:30193097 NCBI chrNW_004936492:696,982...778,132 JBrowse link
G Gck glucokinase ISO (PMID:8878425) UniProtKB PMID:8878425 NCBI chrNW_004936478:19,104,477...19,118,915 JBrowse link
G Ins insulin ISO (PMID:8069456) AgBase PMID:8069456 NCBI chrNW_004936816:1,002,137...1,003,357 JBrowse link
G Lepr leptin receptor ISO (MGI:MGI:5529403|PMID:24051374) MGI PMID:24051374 MGI:MGI:5529403 NCBI chrNW_004936591:5,771,371...5,846,177 JBrowse link
G Mst1 macrophage stimulating 1 ISO (PMID:19720831) UniProtKB PMID:19720831 NCBI chrNW_004936529:1,298,853...1,306,088 JBrowse link
G Pgp phosphoglycolate phosphatase ISO PMID:26755581
PMID:26755581 RGD:10679995 NCBI chrNW_004936694:1,834,016...1,836,359 JBrowse link
G Sik1 salt inducible kinase 1 ISO (MGI:MGI:3606826|PMID:16148943) UniProtKB PMID:16148943 MGI:MGI:3606826 NCBI chrNW_004936500:774,749...784,326 JBrowse link
G Soga1 suppressor of glucose, autophagy associated 1 ISO (MGI:MGI:4837302|PMID:20813965) UniProtKB PMID:20813965 MGI:MGI:4837302 NCBI chrNW_004936561:4,249,878...4,315,108 JBrowse link
positive regulation of gluconeogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arpp19 cAMP regulated phosphoprotein 19 ISO (PMID:9653196) UniProtKB PMID:9653196 NCBI chrNW_004936471:14,334,667...14,353,131 JBrowse link
G Ddb1 damage specific DNA binding protein 1 ISO (MGI:MGI:5914352|PMID:28790135) UniProt PMID:28790135 MGI:MGI:5914352 NCBI chrNW_004936581:1,710,382...1,742,598 JBrowse link
G Dgat2 diacylglycerol O-acyltransferase 2 ISO RGD PMID:17526931 RGD:10400884 NCBI chrNW_004936498:4,514,212...4,544,523 JBrowse link
G Foxo1 forkhead box O1 ISO (MGI:MGI:4454855|PMID:12783775) MGI PMID:12783775 MGI:MGI:4454855 NCBI chrNW_004936565:5,210,014...5,299,213 JBrowse link
G Gcg glucagon ISO (MGI:MGI:5529403|PMID:24051374) MGI PMID:24051374 MGI:MGI:5529403 NCBI chrNW_004936469:16,906,658...16,916,045 JBrowse link
G Gpt glutamic--pyruvic transaminase ISO RGD PMID:25865565 RGD:11342811 NCBI chrNW_004936470:7,765,810...7,770,837 JBrowse link
G Gpt2 glutamic--pyruvic transaminase 2 ISO RGD PMID:25865565 RGD:11342811 NCBI chrNW_004936475:262,558...299,766 JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha ISO RGD PMID:24177414 RGD:10445837 NCBI chrNW_004936495:5,770,988...5,816,157 JBrowse link
G Hnf4a hepatocyte nuclear factor 4 alpha ISO RGD PMID:16893891, PMID:24177414 RGD:10445837, RGD:1624992 NCBI chrNW_004936530:2,401,053...2,425,989 JBrowse link
G Kat2a lysine acetyltransferase 2A ISO (MGI:MGI:5529403|PMID:24051374) MGI PMID:24051374 MGI:MGI:5529403 NCBI chrNW_004936490:16,952,698...16,960,424 JBrowse link
G Kat2b lysine acetyltransferase 2B ISO (MGI:MGI:5529403|PMID:24051374) MGI PMID:24051374 MGI:MGI:5529403 NCBI chrNW_004936473:12,341,545...12,415,637 JBrowse link
G Ppara peroxisome proliferator activated receptor alpha ISO (MGI:MGI:3046612|PMID:15232616) MGI PMID:15232616 MGI:MGI:3046612 NCBI chrNW_004936629:3,672,445...3,725,645 JBrowse link
G Ppp4r3a protein phosphatase 4 regulatory subunit 3A ISO (MGI:MGI:4837269|PMID:20876121) MGI PMID:20876121 MGI:MGI:4837269 NCBI chrNW_004936488:18,423,353...18,467,363 JBrowse link
G Ppp4r3b protein phosphatase 4 regulatory subunit 3B ISO (MGI:MGI:4837269|PMID:20876121) MGI PMID:20876121 MGI:MGI:4837269 NCBI chrNW_004936491:1,917,559...1,981,954 JBrowse link
G Ptpn2 protein tyrosine phosphatase non-receptor type 2 ISO (MGI:MGI:4941441|PMID:20484139) UniProtKB PMID:20484139 MGI:MGI:4941441 NCBI chrNW_004936626:2,390,004...2,472,039 JBrowse link
G Sirt1 sirtuin 1 ISO (PMID:30193097) UniProt
PMID:21212096, PMID:30193097 RGD:9585757 NCBI chrNW_004936521:10,296,097...10,316,673 JBrowse link
G Stk11 serine/threonine kinase 11 ISO RGD PMID:17083919 RGD:2291956 NCBI chrNW_004936588:579,816...601,033 JBrowse link
G Supt20h SPT20 homolog, SAGA complex component ISO (MGI:MGI:5529403|PMID:24051374) MGI PMID:24051374 MGI:MGI:5529403 NCBI chrNW_004936472:31,119,671...31,129,939 JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO (MGI:MGI:5468191|PMID:23260145) MGI PMID:23260145 MGI:MGI:5468191 NCBI chrNW_004936486:3,473,877...3,660,565 JBrowse link
G Wdr5 WD repeat domain 5 ISO (MGI:MGI:5529403|PMID:24051374) MGI PMID:24051374 MGI:MGI:5529403 NCBI chrNW_004936669:2,943,759...2,959,788 JBrowse link
regulation of gluconeogenesis term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acadm acyl-CoA dehydrogenase medium chain ISO (MGI:MGI:4412440|PMID:18459129) BHF-UCL PMID:18459129 MGI:MGI:4412440 NCBI chrNW_004936571:2,761,254...2,797,045 JBrowse link
G Dgkq diacylglycerol kinase theta ISO (PMID:23767959) ParkinsonsUK-UCL PMID:23767959 NCBI chrNW_004936477:22,225,624...22,238,825 JBrowse link
G Fbp1 fructose-bisphosphatase 1 ISO (PMID:7558035) UniProtKB PMID:7558035 NCBI chrNW_004936626:3,555,835...3,581,651 JBrowse link
G Foxo1 forkhead box O1 ISO (MGI:MGI:3801555|PMID:18497885) MGI PMID:18497885 MGI:MGI:3801555 NCBI chrNW_004936565:5,210,014...5,299,213 JBrowse link
G Insr insulin receptor ISO RGD PMID:29896241 RGD:14700925 NCBI chrNW_004936588:4,345,306...4,453,380 JBrowse link
G Lep leptin ISO (MGI:MGI:3769319|PMID:16513828) MGI PMID:16513828 MGI:MGI:3769319 NCBI chrNW_004936479:15,394,966...15,411,334 JBrowse link
G LOC101964621 glycine N-methyltransferase ISO (MGI:MGI:3842675|PMID:17937387) MGI PMID:17937387 MGI:MGI:3842675 NCBI chrNW_004936476:16,961,734...16,965,487 JBrowse link
G LOC101974817 E3 SUMO-protein ligase RanBP2 ISO (MGI:MGI:3693040|PMID:17069463) MGI PMID:17069463 MGI:MGI:3693040 NCBI chrNW_004936829:261,017...333,910 JBrowse link
G Nln neurolysin ISO (MGI:MGI:5588077|PMID:24719317) MGI PMID:24719317 MGI:MGI:5588077 NCBI chrNW_004936480:3,383,514...3,480,991 JBrowse link
G Nr3c1 nuclear receptor subfamily 3 group C member 1 ISO (MGI:MGI:74913|PMID:7628695) MGI PMID:7628695 MGI:MGI:74913 NCBI chrNW_004936504:10,960,069...11,056,834 JBrowse link
G Ogt O-linked N-acetylglucosamine (GlcNAc) transferase ISO (MGI:MGI:5495336|PMID:23395176) UniProtKB PMID:23395176 MGI:MGI:5495336 NCBI chrNW_004936762:99,335...137,833 JBrowse link
G Pdk2 pyruvate dehydrogenase kinase 2 ISO (MGI:MGI:5428826|PMID:22360721) UniProtKB PMID:22360721 MGI:MGI:5428826 NCBI chrNW_004936490:11,534,412...11,549,128 JBrowse link
G Sesn2 sestrin 2 ISO (MGI:MGI:5444071|PMID:22958918) MGI PMID:22958918 MGI:MGI:5444071 NCBI chrNW_004936474:12,416,652...12,436,799 JBrowse link
G Sirt7 sirtuin 7 ISO (PMID:28655758) UniProt PMID:28655758 NCBI chrNW_004936594:5,418,331...5,425,050 JBrowse link
G Slc35b4 solute carrier family 35 member B4 ISO (MGI:MGI:5142157|PMID:21507882) MGI PMID:21507882 MGI:MGI:5142157 NCBI chrNW_004936579:1,454,951...1,474,035 JBrowse link
G Tcf7l2 transcription factor 7 like 2 ISO (MGI:MGI:5448876|PMID:23028378) MGI PMID:23028378 MGI:MGI:5448876 NCBI chrNW_004936486:3,473,877...3,660,565 JBrowse link
G Usp7 ubiquitin specific peptidase 7 ISO (PMID:28655758) UniProt PMID:28655758 NCBI chrNW_004936530:7,693,681...7,724,215 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11966
    metabolic process 7654
      biosynthetic process 3902
        small molecule biosynthetic process 456
          monosaccharide biosynthetic process 74
            hexose biosynthetic process 69
              gluconeogenesis 67
                negative regulation of gluconeogenesis 13
                positive regulation of gluconeogenesis 20
                regulation of gluconeogenesis + 48
Path 2
Term Annotations click to browse term
  biological_process 11966
    metabolic process 7654
      primary metabolic process 6775
        carbohydrate metabolic process 382
          monosaccharide metabolic process 205
            hexose metabolic process 192
              glucose metabolic process 176
                gluconeogenesis 67
                  negative regulation of gluconeogenesis 13
                  positive regulation of gluconeogenesis 20
                  regulation of gluconeogenesis + 48
paths to the root


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.