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ONTOLOGY REPORT - ANNOTATIONS


Term:purine nucleobase metabolic process
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Accession:GO:0006144 term browser browse the term
Definition:The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
Synonyms:exact_synonym: purine base metabolic process;   purine base metabolism
 narrow_synonym: purine metabolic process;   purine metabolism


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purine nucleobase metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP3 acid phosphatase 3 IEA Ensembl GO_REF:0000107 NCBI chr 3:132,317,403...132,368,765
Ensembl chr 3:132,317,369...132,368,298
JBrowse link
G GMPR guanosine monophosphate reductase IEA UniProt GO_REF:0000043 NCBI chr 6:16,238,587...16,295,549
Ensembl chr 6:16,238,587...16,295,549
JBrowse link
G GMPR2 guanosine monophosphate reductase 2 IEA UniProt GO_REF:0000043 NCBI chr14:24,232,622...24,239,242
Ensembl chr14:24,232,422...24,239,242
JBrowse link
G PRPS1 phosphoribosyl pyrophosphate synthetase 1 IMP (PMID:8253776) UniProtKB PMID:8253776 NCBI chr  X:107,628,510...107,651,026
Ensembl chr  X:107,628,428...107,651,993
Ensembl chr  X:107,628,428...107,651,993
JBrowse link
G TTR transthyretin IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:31,591,877...31,598,821
Ensembl chr18:31,557,009...31,598,833
Ensembl chr18:31,557,009...31,598,833
JBrowse link
G URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase IEA UniProt GO_REF:0000043 NCBI chr13:27,977,717...27,988,693
Ensembl chr13:27,977,717...27,988,693
JBrowse link
adenine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr21:33,503,931...33,542,892
Ensembl chr21:33,503,931...33,543,491
JBrowse link
adenine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APRT adenine phosphoribosyltransferase ISO (MGI:MGI:83266|PMID:8894695)
(MGI:MGI:80735|PMID:8643571), (MGI:MGI:83266|PMID:8894695)
MGI PMID:8643571, PMID:8894695 MGI:MGI:80735, MGI:MGI:83266 NCBI chr16:88,809,339...88,811,928
Ensembl chr16:88,809,339...88,811,937
JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISO (MGI:MGI:83266|PMID:8894695) MGI PMID:8894695 MGI:MGI:83266 NCBI chr  X:134,460,165...134,500,668
Ensembl chr  X:134,460,165...134,520,513
JBrowse link
adenine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APRT adenine phosphoribosyltransferase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:88,809,339...88,811,928
Ensembl chr16:88,809,339...88,811,937
JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr  X:134,460,165...134,500,668
Ensembl chr  X:134,460,165...134,520,513
JBrowse link
guanine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GDA guanine deaminase IEA InterPro
UniProtKB
GO_REF:0000002, GO_REF:0000041 NCBI chr 9:72,114,595...72,256,045
Ensembl chr 9:72,114,595...72,257,193
JBrowse link
guanine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GDA guanine deaminase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:72,114,595...72,256,045
Ensembl chr 9:72,114,595...72,257,193
JBrowse link
G KDM1A lysine demethylase 1A IEA Ensembl GO_REF:0000107 NCBI chr 1:23,019,443...23,083,691
Ensembl chr 1:23,019,443...23,083,689
JBrowse link
guanine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPRT1 hypoxanthine phosphoribosyltransferase 1 IDA
IBA
(PMID:19527031)
(PMID:21873635)
UniProtKB
GO_Central
PMID:19527031, PMID:21873635 NCBI chr  X:134,460,165...134,500,668
Ensembl chr  X:134,460,165...134,520,513
JBrowse link
G PRTFDC1 phosphoribosyl transferase domain containing 1 NOT IDA (PMID:21054786) UniProtKB PMID:21054786 NCBI chr10:24,848,614...24,952,606
Ensembl chr10:24,848,614...24,952,606
JBrowse link
hypoxanthine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase ISO (MGI:MGI:3640719|PMID:10720488) MGI PMID:10720488 MGI:MGI:3640719 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,619,522...44,652,233
JBrowse link
G PRPS1 phosphoribosyl pyrophosphate synthetase 1 IMP (PMID:17701896) UniProtKB PMID:17701896 NCBI chr  X:107,628,510...107,651,026
Ensembl chr  X:107,628,428...107,651,993
Ensembl chr  X:107,628,428...107,651,993
JBrowse link
hypoxanthine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPRT1 hypoxanthine phosphoribosyltransferase 1 IMP
IBA
(PMID:9824441)
(PMID:21873635)
UniProtKB
GO_Central
PMID:9824441, PMID:21873635 NCBI chr  X:134,460,165...134,500,668
Ensembl chr  X:134,460,165...134,520,513
JBrowse link
hypoxanthine oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G XDH xanthine dehydrogenase ISO RGD PMID:232638 RGD:13210503 NCBI chr 2:31,334,320...31,414,777
Ensembl chr 2:31,334,321...31,414,742
JBrowse link
hypoxanthine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,619,522...44,652,233
JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 IDA (PMID:19527031) UniProtKB PMID:19527031 NCBI chr  X:134,460,165...134,500,668
Ensembl chr  X:134,460,165...134,520,513
JBrowse link
purine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase IEA InterPro GO_REF:0000002 NCBI chr21:33,503,931...33,542,892
Ensembl chr21:33,503,931...33,543,491
JBrowse link
G GMPS guanine monophosphate synthase TAS (PMID:8089153) PINC PMID:8089153 NCBI chr 3:155,869,430...155,944,020
Ensembl chr 3:155,870,650...155,944,020
JBrowse link
G PAICS phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase TAS (PMID:2253271) PINC PMID:2253271 NCBI chr 4:56,435,752...56,464,578
Ensembl chr 4:56,435,741...56,464,578
Ensembl chr 4:56,435,741...56,464,578
JBrowse link
G PPAT phosphoribosyl pyrophosphate amidotransferase IEA InterPro GO_REF:0000002 NCBI chr 4:56,393,362...56,435,615
Ensembl chr 4:56,393,362...56,435,615
JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 IDA
IBA
(PMID:11516159)
(PMID:21873635)
UniProtKB
GO_Central
PMID:11516159, PMID:21873635 NCBI chr17:18,327,873...18,363,560
Ensembl chr17:18,327,860...18,363,563
JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:57,229,685...57,234,935
Ensembl chr12:57,229,573...57,234,935
JBrowse link
purine nucleobase catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase IMP (PMID:11988088) UniProtKB PMID:11988088 NCBI chr 1:97,077,743...97,921,059
Ensembl chr 1:97,077,743...97,995,000
JBrowse link
xanthine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase IEA Ensembl GO_REF:0000107 NCBI chr20:44,619,522...44,651,699
Ensembl chr20:44,619,522...44,652,233
JBrowse link
xanthine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AOX1 aldehyde oxidase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:200,585,952...200,677,064
Ensembl chr 2:200,586,014...200,677,064
JBrowse link
G XDH xanthine dehydrogenase IDA
IBA
(PMID:17301077), (PMID:8670112)
(PMID:21873635)
UniProtKB
GO_Central
PMID:8670112, PMID:17301077, PMID:21873635 NCBI chr 2:31,334,320...31,414,777
Ensembl chr 2:31,334,321...31,414,742
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18650
    metabolic process 12284
      nitrogen compound metabolic process 10478
        organonitrogen compound metabolic process 7147
          nucleobase metabolic process 43
            purine nucleobase metabolic process 21
              adenine metabolic process + 3
              guanine metabolic process + 4
              hypoxanthine metabolic process + 4
              negative regulation of purine nucleobase metabolic process 0
              positive regulation of purine nucleobase metabolic process 0
              purine nucleobase biosynthetic process + 11
              purine nucleobase catabolic process + 4
              regulation of purine nucleobase metabolic process + 0
              xanthine metabolic process + 3
Path 2
Term Annotations click to browse term
  biological_process 18650
    metabolic process 12284
      nitrogen compound metabolic process 10478
        cellular nitrogen compound metabolic process 6759
          nucleobase-containing compound metabolic process 5975
            nucleobase-containing small molecule metabolic process 669
              nucleobase metabolic process 43
                purine nucleobase metabolic process 21
                  adenine metabolic process + 3
                  guanine metabolic process + 4
                  hypoxanthine metabolic process + 4
                  negative regulation of purine nucleobase metabolic process 0
                  positive regulation of purine nucleobase metabolic process 0
                  purine nucleobase biosynthetic process + 11
                  purine nucleobase catabolic process + 4
                  regulation of purine nucleobase metabolic process + 0
                  xanthine metabolic process + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.