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ONTOLOGY REPORT - ANNOTATIONS


Term:purine nucleobase metabolic process
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Accession:GO:0006144 term browser browse the term
Definition:The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
Synonyms:exact_synonym: purine base metabolic process;   purine base metabolism
 narrow_synonym: purine metabolic process;   purine metabolism


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purine nucleobase metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ACP3 acid phosphatase 3 IEA Ensembl GO_REF:0000107 NCBI chr13:73,471,837...73,530,778
Ensembl chr13:73,471,881...73,571,052
JBrowse link
G GMPR guanosine monophosphate reductase IEA UniProt GO_REF:0000043 NCBI chr 7:12,254,393...12,298,802 JBrowse link
G GMPR2 guanosine monophosphate reductase 2 IEA UniProt GO_REF:0000043 NCBI chr 7:75,060,680...75,070,079
Ensembl chr 7:75,060,676...75,069,772
JBrowse link
G PRPS1 phosphoribosyl pyrophosphate synthetase 1 ISO (PMID:8253776) UniProtKB PMID:8253776 NCBI chr  X:88,074,861...88,101,925
Ensembl chr  X:88,074,963...88,119,094
JBrowse link
G TTR transthyretin IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:115,496,338...115,503,974
Ensembl chr 6:115,496,193...115,503,977
JBrowse link
G UOX urate oxidase IEA UniProt GO_REF:0000043 NCBI chr 6:129,343,632...129,374,833
Ensembl chr 6:129,247,176...129,375,724
JBrowse link
G URAD ureidoimidazoline (2-oxo-4-hydroxy-4-carboxy-5-) decarboxylase IEA UniProt GO_REF:0000043 NCBI chr11:5,353,524...5,363,481 JBrowse link
adenine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GART phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:197,130,898...197,158,797
Ensembl chr13:197,130,904...197,161,891
JBrowse link
adenine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APRT adenine phosphoribosyltransferase ISO (MGI:MGI:83266|PMID:8894695)
(MGI:MGI:80735|PMID:8643571), (MGI:MGI:83266|PMID:8894695)
MGI PMID:8643571, PMID:8894695 MGI:MGI:80735, MGI:MGI:83266 NCBI chr 6:890,272...893,278
Ensembl chr 6:890,831...893,277
JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISO (MGI:MGI:83266|PMID:8894695) MGI PMID:8894695 MGI:MGI:83266 NCBI chr  X:110,321,144...110,357,902
Ensembl chr  X:110,321,208...110,357,899
JBrowse link
adenine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APRT adenine phosphoribosyltransferase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:890,272...893,278
Ensembl chr 6:890,831...893,277
JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr  X:110,321,144...110,357,902
Ensembl chr  X:110,321,208...110,357,899
JBrowse link
guanine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GDA guanine deaminase IEA UniProt GO_REF:0000041 NCBI chr 1:225,425,389...225,589,835
Ensembl chr 1:225,402,117...225,589,830
JBrowse link
guanine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GDA guanine deaminase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:225,425,389...225,589,835
Ensembl chr 1:225,402,117...225,589,830
JBrowse link
G KDM1A lysine demethylase 1A ISO RGD PMID:20418916 RGD:9588315 NCBI chr 6:80,903,407...80,971,875
Ensembl chr 6:80,903,496...80,971,595
JBrowse link
guanine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISS
IBA
IEA
(PMID:21873635) UniProt
GO_Central
Ensembl
PMID:21873635 GO_REF:0000024, GO_REF:0000107 NCBI chr  X:110,321,144...110,357,902
Ensembl chr  X:110,321,208...110,357,899
JBrowse link
G PRTFDC1 phosphoribosyl transferase domain containing 1 NOT ISO (PMID:21054786) UniProtKB PMID:21054786 NCBI chr10:50,365,654...50,458,487
Ensembl chr10:50,365,786...50,463,271
JBrowse link
hypoxanthine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase IEA Ensembl GO_REF:0000107 NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,495...47,072,245
JBrowse link
G PRPS1 phosphoribosyl pyrophosphate synthetase 1 IEA Ensembl GO_REF:0000107 NCBI chr  X:88,074,861...88,101,925
Ensembl chr  X:88,074,963...88,119,094
JBrowse link
hypoxanthine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISS
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr  X:110,321,144...110,357,902
Ensembl chr  X:110,321,208...110,357,899
JBrowse link
hypoxanthine oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G XDH xanthine dehydrogenase ISO RGD PMID:232638 RGD:13210503 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,986,528...108,080,151
JBrowse link
hypoxanthine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,495...47,072,245
JBrowse link
G HPRT1 hypoxanthine phosphoribosyltransferase 1 ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr  X:110,321,144...110,357,902
Ensembl chr  X:110,321,208...110,357,899
JBrowse link
purine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PPAT phosphoribosyl pyrophosphate amidotransferase IEA InterPro GO_REF:0000002 NCBI chr 8:55,652,194...55,701,077
Ensembl chr 8:55,652,201...55,701,077
JBrowse link
G SHMT1 serine hydroxymethyltransferase 1 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr12:60,414,421...60,435,451
Ensembl chr12:60,414,446...60,435,450
JBrowse link
G SHMT2 serine hydroxymethyltransferase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 5:22,535,780...22,540,322
Ensembl chr 5:22,532,894...22,540,321
JBrowse link
purine nucleobase catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPYD dihydropyrimidine dehydrogenase IEA Ensembl GO_REF:0000107 NCBI chr 4:119,931,471...120,712,461
Ensembl chr 4:119,931,458...120,712,462
JBrowse link
xanthine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ADA adenosine deaminase IEA Ensembl GO_REF:0000107 NCBI chr17:47,044,492...47,072,232
Ensembl chr17:47,044,495...47,072,245
JBrowse link
xanthine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AOX1 aldehyde oxidase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:104,157,748...104,234,533
Ensembl chr15:104,153,702...104,238,400
JBrowse link
G AOX2 aldehyde oxidase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:104,396,502...104,499,789 JBrowse link
G AOX4 aldehyde oxidase 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:104,329,873...104,393,436 JBrowse link
G XDH xanthine dehydrogenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 3:107,987,060...108,052,043
Ensembl chr 3:107,986,528...108,080,151
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16524
    metabolic process 10565
      nitrogen compound metabolic process 8897
        organonitrogen compound metabolic process 6072
          nucleobase metabolic process 42
            purine nucleobase metabolic process 22
              adenine metabolic process + 3
              guanine metabolic process + 4
              hypoxanthine metabolic process + 4
              negative regulation of purine nucleobase metabolic process 0
              positive regulation of purine nucleobase metabolic process 0
              purine nucleobase biosynthetic process + 9
              purine nucleobase catabolic process + 6
              regulation of purine nucleobase metabolic process + 0
              xanthine metabolic process + 5
Path 2
Term Annotations click to browse term
  biological_process 16524
    metabolic process 10565
      nitrogen compound metabolic process 8897
        cellular nitrogen compound metabolic process 5620
          nucleobase-containing compound metabolic process 4902
            nucleobase-containing small molecule metabolic process 505
              nucleobase metabolic process 42
                purine nucleobase metabolic process 22
                  adenine metabolic process + 3
                  guanine metabolic process + 4
                  hypoxanthine metabolic process + 4
                  negative regulation of purine nucleobase metabolic process 0
                  positive regulation of purine nucleobase metabolic process 0
                  purine nucleobase biosynthetic process + 9
                  purine nucleobase catabolic process + 6
                  regulation of purine nucleobase metabolic process + 0
                  xanthine metabolic process + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.