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ONTOLOGY REPORT - ANNOTATIONS


Term:purine nucleobase metabolic process
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Accession:GO:0006144 term browser browse the term
Definition:The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine.
Synonyms:exact_synonym: purine base metabolic process;   purine base metabolism
 narrow_synonym: purine metabolic process;   purine metabolism


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purine nucleobase metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 ISO (MGI:MGI:3849266|PMID:18940592) UniProtKB PMID:18940592 MGI:MGI:3849266 NCBI chrNW_004936529:5,661,772...5,723,108 JBrowse link
G Prps1 phosphoribosyl pyrophosphate synthetase 1 ISO (PMID:8253776) UniProtKB PMID:8253776 NCBI chrNW_004936499:7,114,838...7,136,468 JBrowse link
adenine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aprt adenine phosphoribosyltransferase ISO (MGI:MGI:83266|PMID:8894695)
(MGI:MGI:80735|PMID:8643571), (MGI:MGI:83266|PMID:8894695)
MGI PMID:8643571, PMID:8894695 MGI:MGI:80735, MGI:MGI:83266 NCBI chrNW_004936641:913,674...916,312 JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 ISO (MGI:MGI:83266|PMID:8894695) MGI PMID:8894695 MGI:MGI:83266 NCBI chrNW_004936691:650,753...694,362 JBrowse link
adenine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aprt adenine phosphoribosyltransferase ISO (MGI:MGI:85816|PMID:8864750) MGI PMID:8864750 MGI:MGI:85816 NCBI chrNW_004936641:913,674...916,312 JBrowse link
G Hprt1 hypoxanthine phosphoribosyltransferase 1 ISO (MGI:MGI:1331314|PMID:10037486) MGI PMID:10037486 MGI:MGI:1331314 NCBI chrNW_004936691:650,753...694,362 JBrowse link
guanine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kdm1a lysine demethylase 1A ISO RGD PMID:20418916 RGD:9588315 NCBI chrNW_004936474:8,262,913...8,319,089 JBrowse link
guanine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hprt1 hypoxanthine phosphoribosyltransferase 1 ISO (PMID:19527031)
(MGI:MGI:1331314|PMID:10037486)
UniProtKB
MGI
PMID:10037486, PMID:19527031 MGI:MGI:1331314 NCBI chrNW_004936691:650,753...694,362 JBrowse link
G Prtfdc1 phosphoribosyl transferase domain containing 1 NOT ISO (PMID:21054786) UniProtKB PMID:21054786 NCBI chrNW_004936484:568,056...650,820 JBrowse link
hypoxanthine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Prps1 phosphoribosyl pyrophosphate synthetase 1 ISO (PMID:17701896) UniProtKB PMID:17701896 NCBI chrNW_004936499:7,114,838...7,136,468 JBrowse link
hypoxanthine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hprt1 hypoxanthine phosphoribosyltransferase 1 ISO (PMID:9824441)
(MGI:MGI:63605|PMID:3029599)
(MGI:MGI:1331314|PMID:10037486)
UniProtKB
MGI
RGD
PMID:3029599, PMID:6206848, PMID:9824441, PMID:10037486 MGI:MGI:1331314, MGI:MGI:63605, RGD:1580844 NCBI chrNW_004936691:650,753...694,362 JBrowse link
hypoxanthine oxidation term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Xdh xanthine dehydrogenase ISO RGD PMID:232638 RGD:13210503 NCBI chrNW_004936493:1,762,814...1,824,501 JBrowse link
hypoxanthine salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Hprt1 hypoxanthine phosphoribosyltransferase 1 ISO (PMID:19527031) UniProtKB PMID:19527031 NCBI chrNW_004936691:650,753...694,362 JBrowse link
purine nucleobase biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Shmt1 serine hydroxymethyltransferase 1 ISO (PMID:11516159) UniProtKB PMID:11516159 NCBI chrNW_004936741:1,849,239...1,877,724 JBrowse link
purine nucleobase catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpyd dihydropyrimidine dehydrogenase ISO (PMID:11988088) UniProtKB PMID:11988088 NCBI chrNW_004936537:1,660,461...2,439,305 JBrowse link
xanthine catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Xdh xanthine dehydrogenase ISO PMID:15878860
(PMID:17301077), (PMID:8670112)
UniProt
UniProtKB
PMID:8670112, PMID:15878860, PMID:17301077 RGD:8553512 NCBI chrNW_004936493:1,762,814...1,824,501 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11968
    metabolic process 7653
      nitrogen compound metabolic process 6445
        organonitrogen compound metabolic process 4476
          nucleobase metabolic process 19
            purine nucleobase metabolic process 9
              adenine metabolic process + 2
              guanine metabolic process + 3
              hypoxanthine metabolic process + 3
              negative regulation of purine nucleobase metabolic process 0
              positive regulation of purine nucleobase metabolic process 0
              purine nucleobase biosynthetic process + 5
              purine nucleobase catabolic process + 2
              regulation of purine nucleobase metabolic process + 0
              xanthine metabolic process + 1
Path 2
Term Annotations click to browse term
  biological_process 11968
    metabolic process 7653
      nitrogen compound metabolic process 6445
        cellular nitrogen compound metabolic process 4076
          nucleobase-containing compound metabolic process 3574
            nucleobase-containing small molecule metabolic process 357
              nucleobase metabolic process 19
                purine nucleobase metabolic process 9
                  adenine metabolic process + 2
                  guanine metabolic process + 3
                  hypoxanthine metabolic process + 3
                  negative regulation of purine nucleobase metabolic process 0
                  positive regulation of purine nucleobase metabolic process 0
                  purine nucleobase biosynthetic process + 5
                  purine nucleobase catabolic process + 2
                  regulation of purine nucleobase metabolic process + 0
                  xanthine metabolic process + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.