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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA topological change
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Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding


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DNA topological change term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit JBrowse link 18 25,037,668 25,068,380 RGD:1624291
G Hmgb2 high mobility group box 2 JBrowse link 16 36,077,615 36,080,191 RGD:1600115
RGD:1624291
G Hmgb2l1 high mobility group box 2-like 1 JBrowse link 11 49,708,038 49,709,128 RGD:1600115
G RGD1559962 similar to High mobility group protein 2 (HMG-2) JBrowse link 1 20,416,735 20,417,959 RGD:1600115
G Top1 DNA topoisomerase I JBrowse link 3 156,635,688 156,717,686 RGD:1580856
RGD:13792537
RGD:1600115
RGD:1624291
G Top1mt DNA topoisomerase I mitochondrial JBrowse link 7 116,688,801 116,714,421 RGD:1600115
RGD:13792537
G Top2a DNA topoisomerase II alpha JBrowse link 10 86,901,467 86,930,947 RGD:1580614
RGD:1624291
RGD:1600115
G Top2b DNA topoisomerase II beta JBrowse link 15 10,262,972 10,319,741 RGD:1624291
G Top3a DNA topoisomerase III alpha JBrowse link 10 46,980,646 47,018,728 RGD:1624291
RGD:13792537
G Top3b DNA topoisomerase III beta JBrowse link 11 88,346,305 88,374,896 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      cellular metabolic process 10918
        cellular macromolecule metabolic process 8393
          DNA metabolic process 911
            DNA topological change 10
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      cellular metabolic process 10918
        cellular nitrogen compound metabolic process 6542
          nucleobase-containing compound metabolic process 5344
            nucleic acid metabolic process 4850
              DNA metabolic process 911
                DNA topological change 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.