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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA topological change
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Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding


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DNA topological change term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit ISO (PMID:8663148) UniProtKB PMID:8663148 NCBI chr2B:32,983,492...33,020,492
Ensembl chr2B:127,922,483...127,959,372
JBrowse link
G HMGB2 high mobility group box 2 ISO (PMID:11275566) AgBase PMID:11275566 NCBI chr 4:165,559,848...165,562,625
Ensembl chr 4:177,797,457...177,800,952
JBrowse link
G TOP1 DNA topoisomerase I ISO (PMID:14654701), (PMID:8567649), (PMID:8631793), (PMID:8631794), (PMID:9611241)
(PMID:14594810)
(MGI:MGI:3612364|PMID:16261531), (MGI:MGI:70738|PMID:7842491)
CAFA
UniProtKB
MGI
RGD
PMID:1332866, PMID:7842491, PMID:8567649, PMID:8631793, PMID:8631794, PMID:9611241, PMID:14594810, PMID:14654701, PMID:16261531 MGI:MGI:3612364, MGI:MGI:70738, RGD:1580856 NCBI chr20:37,368,606...37,464,649
Ensembl chr20:38,468,452...38,562,652
JBrowse link
G TOP2A DNA topoisomerase II alpha ISO (PMID:12711669)
(MGI:MGI:51613|PMID:1331984), (MGI:MGI:895157|PMID:9224616)
(PMID:22323612)
RGD
UniProtKB
MGI
PMID:1331984, PMID:9224616, PMID:11334111, PMID:12711669, PMID:22323612 MGI:MGI:51613, MGI:MGI:895157, RGD:1580614 NCBI chr17:16,872,169...16,901,605
Ensembl chr17:17,097,778...17,126,207
JBrowse link
G TOP2B DNA topoisomerase II beta ISO (PMID:10684600) UniProtKB PMID:10684600 NCBI chr 3:25,499,239...25,566,029
Ensembl chr 3:25,828,879...25,896,912
JBrowse link
G TOP3A DNA topoisomerase III alpha ISO (PMID:20445207) UniProtKB PMID:20445207 NCBI chr17:32,814,448...32,858,076
Ensembl chr17:37,897,037...37,936,135
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12529
    metabolic process 7962
      cellular metabolic process 7310
        cellular macromolecule metabolic process 5682
          DNA metabolic process 671
            DNA topological change 6
Path 2
Term Annotations click to browse term
  biological_process 12529
    metabolic process 7962
      cellular metabolic process 7310
        cellular nitrogen compound metabolic process 4215
          nucleobase-containing compound metabolic process 3691
            nucleic acid metabolic process 3388
              DNA metabolic process 671
                DNA topological change 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.