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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA topological change
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Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding


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DNA topological change term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit ISO (PMID:8663148) UniProtKB PMID:8663148 NCBI chrNW_004955459:3,210,936...3,238,401 JBrowse link
G Hmgb2 high mobility group box 2 ISO (PMID:11275566) AgBase PMID:11275566 NCBI chrNW_004955403:33,656,314...33,659,115 JBrowse link
G Top1 DNA topoisomerase I ISO (MGI:MGI:3612364|PMID:16261531), (MGI:MGI:70738|PMID:7842491)
(PMID:14594810)
(PMID:14654701), (PMID:8567649), (PMID:8631793), (PMID:8631794), (PMID:9611241)
MGI
RGD
UniProtKB
CAFA
PMID:1332866, PMID:7842491, PMID:8567649, PMID:8631793, PMID:8631794, PMID:9611241, PMID:14594810, PMID:14654701, PMID:16261531 MGI:MGI:3612364, MGI:MGI:70738, RGD:1580856 NCBI chrNW_004955445:15,834,017...15,922,785 JBrowse link
G Top2a DNA topoisomerase II alpha ISO (PMID:22323612)
(PMID:12711669)
(MGI:MGI:51613|PMID:1331984), (MGI:MGI:895157|PMID:9224616)
UniProtKB
RGD
MGI
PMID:1331984, PMID:9224616, PMID:11334111, PMID:12711669, PMID:22323612 MGI:MGI:51613, MGI:MGI:895157, RGD:1580614 NCBI chrNW_004955451:14,928,273...14,964,855 JBrowse link
G Top2b DNA topoisomerase II beta ISO (PMID:10684600) UniProtKB PMID:10684600 NCBI chrNW_004955430:17,457,603...17,523,115 JBrowse link
G Top3a DNA topoisomerase III alpha ISO (PMID:20445207) UniProtKB PMID:20445207 NCBI chrNW_004955478:11,015,378...11,045,717 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11862
    metabolic process 7593
      cellular metabolic process 7005
        cellular macromolecule metabolic process 5473
          DNA metabolic process 652
            DNA topological change 6
Path 2
Term Annotations click to browse term
  biological_process 11862
    metabolic process 7593
      cellular metabolic process 7005
        cellular nitrogen compound metabolic process 4049
          nucleobase-containing compound metabolic process 3554
            nucleic acid metabolic process 3267
              DNA metabolic process 652
                DNA topological change 6
paths to the root

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