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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA topological change
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Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding


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DNA topological change term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit IEA Ensembl GO_REF:0000107 NCBI chr19:23,310,911...23,344,083
Ensembl chr19:23,310,986...23,337,683
JBrowse link
G HMGB2 high mobility group box 2 ISS AgBase GO_REF:0000024 NCBI chr25:23,939,024...23,941,720
Ensembl chr25:23,939,027...23,941,606
JBrowse link
G TOP1 DNA topoisomerase I IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr24:29,075,267...29,166,733
Ensembl chr24:29,075,492...29,165,864
JBrowse link
G TOP2A DNA topoisomerase II alpha IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr 9:22,207,501...22,237,497
Ensembl chr 9:22,207,638...22,237,496
JBrowse link
G TOP2B DNA topoisomerase II beta IEA InterPro
Ensembl
GO_REF:0000002, GO_REF:0000107 NCBI chr23:18,159,521...18,206,413
Ensembl chr23:18,146,095...18,206,287
JBrowse link
G TOP3A DNA topoisomerase III alpha IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr 5:41,262,820...41,290,101
Ensembl chr 5:41,263,017...41,290,100
JBrowse link
G TOP3B DNA topoisomerase III beta IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr26:31,198,371...31,223,133
Ensembl chr26:31,198,382...31,215,134
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16162
    metabolic process 10639
      cellular metabolic process 9631
        cellular macromolecule metabolic process 7467
          DNA metabolic process 802
            DNA topological change 7
Path 2
Term Annotations click to browse term
  biological_process 16162
    metabolic process 10639
      cellular metabolic process 9631
        cellular nitrogen compound metabolic process 5695
          nucleobase-containing compound metabolic process 4907
            nucleic acid metabolic process 4459
              DNA metabolic process 802
                DNA topological change 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.