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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA topological change
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Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding


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DNA topological change term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit IMP (PMID:8663148) UniProtKB PMID:8663148 NCBI chr 2:127,257,290...127,294,166
Ensembl chr 2:127,257,290...127,294,166
Ensembl chr 2:127,257,290...127,294,166
JBrowse link
G HMGB1 high mobility group box 1 ISS UniProtKB GO_REF:0000024 NCBI chr13:30,456,704...30,617,597
Ensembl chr13:30,456,704...30,617,597
JBrowse link
G HMGB2 high mobility group box 2 ISS AgBase
UniProtKB
GO_REF:0000024 NCBI chr 4:173,331,376...173,334,358
Ensembl chr 4:173,331,376...173,334,432
JBrowse link
G TOP1 DNA topoisomerase I IDA
IBA
IMP
(PMID:14594810)
(PMID:21873635)
(PMID:14654701), (PMID:8567649), (PMID:8631793), (PMID:8631794), (PMID:9611241)
UniProtKB
GO_Central
CAFA
PMID:8567649, PMID:8631793, PMID:8631794, PMID:9611241, PMID:14594810, PMID:14654701, PMID:21873635 NCBI chr20:41,028,822...41,124,487
Ensembl chr20:41,028,822...41,124,487
JBrowse link
G TOP1MT DNA topoisomerase I mitochondrial IEA
IBA
(PMID:21873635) UniProt
GO_Central
InterPro
PMID:21873635 GO_REF:0000002, GO_REF:0000104 NCBI chr 8:143,309,324...143,359,977
Ensembl chr 8:143,304,384...143,359,979
JBrowse link
G TOP2A DNA topoisomerase II alpha IMP
IDA
(PMID:12711669)
(PMID:22323612)
UniProtKB PMID:12711669, PMID:22323612 NCBI chr17:40,388,525...40,417,902
Ensembl chr17:40,388,525...40,417,896
JBrowse link
G TOP2B DNA topoisomerase II beta IDA
IEA
(PMID:10684600) UniProtKB
InterPro
PMID:10684600 GO_REF:0000002 NCBI chr 3:25,597,905...25,664,907
Ensembl chr 3:25,597,905...25,664,907
JBrowse link
G TOP3A DNA topoisomerase III alpha IEA
IBA
IDA
(PMID:21873635)
(PMID:20445207)
InterPro
GO_Central
UniProtKB
PMID:20445207, PMID:21873635 GO_REF:0000002 NCBI chr17:18,269,958...18,314,996
Ensembl chr17:18,271,428...18,315,007
JBrowse link
G TOP3B DNA topoisomerase III beta IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr22:21,957,025...21,982,787
Ensembl chr22:21,957,025...21,982,813
Ensembl chr22:21,957,025...21,982,813
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18650
    metabolic process 12284
      cellular metabolic process 11267
        cellular macromolecule metabolic process 8759
          DNA metabolic process 1019
            DNA topological change 9
Path 2
Term Annotations click to browse term
  biological_process 18650
    metabolic process 12284
      cellular metabolic process 11267
        cellular nitrogen compound metabolic process 6759
          nucleobase-containing compound metabolic process 5975
            nucleic acid metabolic process 5426
              DNA metabolic process 1019
                DNA topological change 9
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.