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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA topological change
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Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding


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DNA topological change term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc3 excision repair cross-complementing rodent repair deficiency, complementation group 3 ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr18:32,240,304...32,270,151
Ensembl chr18:32,240,300...32,270,151
JBrowse link
G Hmgb2 high mobility group box 2 ISO (PMID:11275566) AgBase PMID:11275566 NCBI chr 8:57,511,843...57,515,999
Ensembl chr 8:57,511,907...57,515,999
JBrowse link
G Top1 topoisomerase (DNA) I ISO
IBA
IDA
(MGI:MGI:6201960|PMID:21873635)
(MGI:MGI:3612364|PMID:16261531), (MGI:MGI:70738|PMID:7842491)
RGD
GO_Central
MGI
PMID:7842491, PMID:16261531, PMID:21873635 GO_REF:0000096, MGI:MGI:3612364, MGI:MGI:4417868, MGI:MGI:4834177, MGI:MGI:6201960, MGI:MGI:70738 NCBI chr 2:160,645,897...160,722,764
Ensembl chr 2:160,645,888...160,722,764
JBrowse link
G Top1mt DNA topoisomerase 1, mitochondrial IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr15:75,657,033...75,678,800
Ensembl chr15:75,657,035...75,678,800
JBrowse link
G Top2a topoisomerase (DNA) II alpha ISO
IDA
(MGI:MGI:51613|PMID:1331984), (MGI:MGI:895157|PMID:9224616) MGI
RGD
PMID:1331984, PMID:9224616 GO_REF:0000096, MGI:MGI:4417868, MGI:MGI:4834177, MGI:MGI:51613, MGI:MGI:895157 NCBI chr11:98,992,947...99,024,199
Ensembl chr11:98,992,943...99,024,189
JBrowse link
G Top2b topoisomerase (DNA) II beta ISO MGI GO_REF:0000096, MGI:MGI:4834177 NCBI chr14:16,365,206...16,430,787
Ensembl chr14:16,365,179...16,435,462
JBrowse link
G Top3a topoisomerase (DNA) III alpha ISO
IBA
(MGI:MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:MGI:4834177, MGI:MGI:6201960 NCBI chr11:60,738,209...60,777,365
Ensembl chr11:60,740,058...60,777,365
JBrowse link
G Top3b topoisomerase (DNA) III beta IBA (MGI:MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:MGI:6201960 NCBI chr16:16,870,722...16,892,986
Ensembl chr16:16,870,736...16,892,990
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23360
    metabolic process 11269
      cellular metabolic process 10049
        cellular macromolecule metabolic process 7728
          DNA metabolic process 866
            DNA topological change 8
Path 2
Term Annotations click to browse term
  biological_process 23360
    metabolic process 11269
      cellular metabolic process 10049
        cellular nitrogen compound metabolic process 5964
          nucleobase-containing compound metabolic process 5182
            nucleic acid metabolic process 4744
              DNA metabolic process 866
                DNA topological change 8
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.