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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA topological change
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Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding


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DNA topological change term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ERCC3 ERCC excision repair 3, TFIIH core complex helicase subunit IEA Ensembl GO_REF:0000107 NCBI chr15:25,189,644...25,224,381
Ensembl chr15:25,189,663...25,228,066
JBrowse link
G HMGB2 high mobility group box 2 IDA (PMID:11275566) AgBase PMID:11275566 NCBI chr14:16,709,966...16,712,288
Ensembl chr14:16,710,047...16,717,126
JBrowse link
G TOP1 DNA topoisomerase I IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr17:43,710,270...43,799,700
Ensembl chr17:43,710,290...43,799,700
JBrowse link
G TOP1MT DNA topoisomerase I mitochondrial IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000104 NCBI chr 4:1,134,179...1,188,149 JBrowse link
G TOP2A DNA topoisomerase II alpha ISS
IEA
UniProt
Ensembl
GO_REF:0000024, GO_REF:0000107 NCBI chr12:22,001,300...22,028,452
Ensembl chr12:22,001,336...22,028,454
JBrowse link
G TOP2B DNA topoisomerase II beta IEA Ensembl
InterPro
GO_REF:0000002, GO_REF:0000107 NCBI chr13:12,507,738...12,575,042
Ensembl chr13:12,507,138...12,575,583
JBrowse link
G TOP3A DNA topoisomerase III alpha IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr12:60,443,592...60,468,968
Ensembl chr12:60,443,731...60,469,040
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16524
    metabolic process 10565
      cellular metabolic process 9560
        cellular macromolecule metabolic process 7406
          DNA metabolic process 815
            DNA topological change 7
Path 2
Term Annotations click to browse term
  biological_process 16524
    metabolic process 10565
      cellular metabolic process 9560
        cellular nitrogen compound metabolic process 5620
          nucleobase-containing compound metabolic process 4902
            nucleic acid metabolic process 4482
              DNA metabolic process 815
                DNA topological change 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.