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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA topological change
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Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding


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DNA topological change term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit ISO (PMID:8663148) RGD PMID:8663148 NCBI chr18:25,037,668...25,068,380
Ensembl chr18:25,037,625...25,068,389
JBrowse link
G Hmgb2 high mobility group box 2 ISS
ISO
GO_REF:0000024
(PMID:11275566)
AgBase
RGD
PMID:11275566 GO_REF:0000024 NCBI chr16:36,077,615...36,080,191
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G Hmgb2l1 high mobility group box 2-like 1 ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr11:49,708,038...49,709,128
Ensembl chr16:36,077,617...36,080,191
Ensembl chr11:36,077,617...36,080,191
JBrowse link
G RGD1559962 similar to High mobility group protein 2 (HMG-2) ISS GO_REF:0000024 AgBase GO_REF:0000024 NCBI chr 1:20,416,735...20,417,959
Ensembl chr 1:20,417,008...20,417,637
JBrowse link
G Top1 DNA topoisomerase I IDA
IBA
IEA
ISO
PMID:21873635
GO_REF:0000104
(MGI:MGI:3612364|PMID:16261531), (MGI:MGI:70738|PMID:7842491)
(PMID:14594810), (PMID:14654701), (PMID:8567649), (PMID:8631793), (PMID:8631794), (PMID:9611241)
UniProt
RGD
PMID:7842491, PMID:8567649, PMID:8631793, PMID:8631794, PMID:9611241, PMID:14594810, PMID:14654701, PMID:16261531, PMID:1332866, PMID:21873635 GO_REF:0000104, MGI:MGI:3612364, MGI:MGI:70738, RGD:1580856, RGD:13792537 NCBI chr 3:156,635,688...156,717,686
Ensembl chr 3:156,642,464...156,717,686
JBrowse link
G Top1mt DNA topoisomerase I mitochondrial IEA
IBA
GO_REF:0000104
PMID:21873635
UniProt PMID:21873635 GO_REF:0000104, RGD:13792537 NCBI chr 7:116,688,801...116,714,421
Ensembl chr 7:116,688,701...116,712,387
JBrowse link
G Top2a DNA topoisomerase II alpha IDA
ISO
IEA
(MGI:MGI:51613|PMID:1331984), (MGI:MGI:895157|PMID:9224616)
(PMID:12711669), (PMID:22323612)
GO_REF:0000002
GO_REF:0000107
RGD
InterPro
Ensembl
PMID:1331984, PMID:9224616, PMID:12711669, PMID:22323612, PMID:11334111 GO_REF:0000002, GO_REF:0000107, MGI:MGI:51613, MGI:MGI:895157, RGD:1580614 NCBI chr10:86,901,467...86,930,947
Ensembl chr10:86,901,007...86,932,154
JBrowse link
G Top2b DNA topoisomerase II beta ISO (PMID:10684600) RGD PMID:10684600 NCBI chr15:10,262,972...10,319,741
Ensembl chr15:10,262,651...10,320,233
JBrowse link
G Top3a DNA topoisomerase III alpha ISO
IBA
(PMID:20445207)
PMID:21873635
RGD PMID:20445207, PMID:21873635 RGD:13792537 NCBI chr10:46,980,646...47,018,728
Ensembl chr10:46,981,958...47,018,537
JBrowse link
G Top3b DNA topoisomerase III beta IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:88,346,305...88,374,896
Ensembl chr11:88,346,313...88,374,679
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      cellular metabolic process 11065
        cellular macromolecule metabolic process 8535
          DNA metabolic process 919
            DNA topological change 10
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      cellular metabolic process 11065
        cellular nitrogen compound metabolic process 6683
          nucleobase-containing compound metabolic process 5483
            nucleic acid metabolic process 4980
              DNA metabolic process 919
                DNA topological change 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.