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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA topological change
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Accession:GO:0006265 term browser browse the term
Definition:The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
Comment:Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo.
Synonyms:narrow_synonym: DNA underwinding


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DNA topological change term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ercc3 ERCC excision repair 3, TFIIH core complex helicase subunit ISO (PMID:8663148) UniProtKB PMID:8663148 NCBI chrNW_004936469:43,970,002...43,998,279 JBrowse link
G Hmgb2 high mobility group box 2 ISO (PMID:11275566) AgBase PMID:11275566 NCBI chrNW_004936516:4,536,664...4,539,331 JBrowse link
G Top1 DNA topoisomerase I ISO (MGI:MGI:3612364|PMID:16261531), (MGI:MGI:70738|PMID:7842491)
(PMID:14654701), (PMID:8567649), (PMID:8631793), (PMID:8631794), (PMID:9611241)
(PMID:14594810)
RGD
MGI
CAFA
UniProtKB
PMID:1332866, PMID:7842491, PMID:8567649, PMID:8631793, PMID:8631794, PMID:9611241, PMID:14594810, PMID:14654701, PMID:16261531 MGI:MGI:3612364, MGI:MGI:70738, RGD:1580856 NCBI chrNW_004936561:641,451...723,323 JBrowse link
G Top2a DNA topoisomerase II alpha ISO (PMID:12711669)
(MGI:MGI:51613|PMID:1331984), (MGI:MGI:895157|PMID:9224616)
(PMID:22323612)
UniProtKB
RGD
MGI
PMID:1331984, PMID:9224616, PMID:11334111, PMID:12711669, PMID:22323612 MGI:MGI:51613, MGI:MGI:895157, RGD:1580614 NCBI chrNW_004936490:15,441,463...15,465,692 JBrowse link
G Top2b DNA topoisomerase II beta ISO (PMID:10684600) UniProtKB PMID:10684600 NCBI chrNW_004936473:17,146,576...17,189,589 JBrowse link
G Top3a DNA topoisomerase III alpha ISO (PMID:20445207) UniProtKB PMID:20445207 NCBI chrNW_004936741:1,809,371...1,838,711 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11968
    metabolic process 7653
      cellular metabolic process 7051
        cellular macromolecule metabolic process 5508
          DNA metabolic process 655
            DNA topological change 6
Path 2
Term Annotations click to browse term
  biological_process 11968
    metabolic process 7653
      cellular metabolic process 7051
        cellular nitrogen compound metabolic process 4076
          nucleobase-containing compound metabolic process 3574
            nucleic acid metabolic process 3288
              DNA metabolic process 655
                DNA topological change 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.