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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA replication initiation
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Accession:GO:0006270 term browser browse the term
Definition:The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
Synonyms:exact_synonym: DNA-dependent DNA replication initiation
 narrow_synonym: DNA endoreduplication initiation;   DNA re-replication initiation
 alt_id: GO:0042024


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DNA replication initiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccne1 cyclin E1 JBrowse link 1 94,485,830 94,495,112 RGD:1624291
RGD:1600115
G Ccne2 cyclin E2 JBrowse link 5 24,434,077 24,446,406 RGD:1624291
G Cdc45 cell division cycle 45 JBrowse link 11 86,328,785 86,354,099 RGD:13792537
G Cdc6 cell division cycle 6 JBrowse link 10 86,819,477 86,833,301 RGD:1600115
G Gmnc geminin coiled-coil domain containing JBrowse link 11 77,237,033 77,247,723 RGD:1600115
G Mcm10 minichromosome maintenance 10 replication initiation factor JBrowse link 17 77,224,218 77,245,486 RGD:13792537
G Mcm2 minichromosome maintenance complex component 2 JBrowse link 4 120,825,699 120,840,221 RGD:1624291
G Mcm5 minichromosome maintenance complex component 5 JBrowse link 19 14,523,482 14,561,281 RGD:13792537
G Mcm6 minichromosome maintenance complex component 6 JBrowse link 13 45,042,882 45,068,073 RGD:1600115
G Mcm7 minichromosome maintenance complex component 7 JBrowse link 12 19,306,615 19,313,877 RGD:13792537
G Orc1 origin recognition complex, subunit 1 JBrowse link 5 128,186,651 128,212,901 RGD:13792537
G Orc3 origin recognition complex, subunit 3 JBrowse link 5 50,019,159 50,075,533 RGD:13792537
G Orc4 origin recognition complex, subunit 4 JBrowse link 3 33,034,913 33,075,833 RGD:1624291
RGD:13792537
RGD:1600115
G Orc5 origin recognition complex, subunit 5 JBrowse link 4 9,160,050 9,223,998 RGD:13792537
G Orc6 origin recognition complex, subunit 6 JBrowse link 19 27,457,541 27,464,804 RGD:13792537
G Pola1 DNA polymerase alpha 1, catalytic subunit JBrowse link X 62,382,604 62,698,830 RGD:1624291
RGD:1600115
G Pola2 DNA polymerase alpha 2, accessory subunit JBrowse link 1 221,297,417 221,321,601 RGD:13792537
G Topbp1 DNA topoisomerase II binding protein 1 JBrowse link 8 111,790,655 111,835,224 RGD:13792537
mitotic DNA replication initiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mcm2 minichromosome maintenance complex component 2 JBrowse link 4 120,825,699 120,840,221 RGD:13792537
G Mcm3 minichromosome maintenance complex component 3 JBrowse link 9 26,914,057 26,932,201 RGD:13792537
G Mcm4 minichromosome maintenance complex component 4 JBrowse link 11 89,511,191 89,524,892 RGD:13792537
G Mcmdc2 minichromosome maintenance domain containing 2 JBrowse link 5 8,973,861 9,039,616 RGD:13792537
G Pola1 DNA polymerase alpha 1, catalytic subunit JBrowse link X 62,382,604 62,698,830 RGD:13792537
positive regulation of DNA-dependent DNA replication initiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdk2 cyclin dependent kinase 2 JBrowse link 7 3,124,953 3,132,533 RGD:1624291
RGD:1600115
G Ciz1 CDKN1A interacting zinc finger protein 1 JBrowse link 3 11,392,046 11,409,218 RGD:1624291
regulation of DNA-dependent DNA replication initiation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdt1 chromatin licensing and DNA replication factor 1 JBrowse link 19 55,381,565 55,386,511 RGD:1624291
RGD:13792537
G Kat7 lysine acetyltransferase 7 JBrowse link 10 83,095,067 83,128,342 RGD:1624291
RGD:1600115
G Ticrr TOPBP1-interacting checkpoint and replication regulator JBrowse link 1 141,391,738 141,433,615 RGD:1624291
RGD:13792537
G Wdr18 WD repeat domain 18 JBrowse link 7 12,561,318 12,569,120 RGD:13792537
G Wrnip1 WRN helicase interacting protein 1 JBrowse link 17 32,933,395 32,953,641 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      cellular metabolic process 10918
        cellular macromolecule metabolic process 8393
          DNA metabolic process 911
            DNA replication initiation 28
              cell cycle DNA replication initiation + 5
              negative regulation of DNA-dependent DNA replication initiation + 0
              positive regulation of DNA-dependent DNA replication initiation + 2
              regulation of DNA-dependent DNA replication initiation + 7
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      organic substance metabolic process 11495
        organic substance biosynthetic process 6000
          macromolecule biosynthetic process 5060
            cellular macromolecule biosynthetic process 4951
              DNA replication 251
                DNA-dependent DNA replication 148
                  DNA replication initiation 28
                    cell cycle DNA replication initiation + 5
                    negative regulation of DNA-dependent DNA replication initiation + 0
                    positive regulation of DNA-dependent DNA replication initiation + 2
                    regulation of DNA-dependent DNA replication initiation + 7
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.