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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA replication initiation
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Accession:GO:0006270 term browser browse the term
Definition:The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
Synonyms:exact_synonym: DNA-dependent DNA replication initiation
 narrow_synonym: DNA endoreduplication initiation;   DNA re-replication initiation
 alt_id: GO:0042024


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DNA replication initiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccne1 cyclin E1 ISO
IEA
MGI:MGI:2675473 (MGI:MGI:2673102|PMID:12941272)
GO_REF:0000107
RGD
Ensembl
PMID:12941272 GO_REF:0000107, MGI:MGI:2673102 NCBI chr 1:94,485,830...94,495,112
Ensembl chr 1:94,485,832...94,494,980
JBrowse link
G Ccne2 cyclin E2 ISO MGI:MGI:2675474 (MGI:MGI:2673102|PMID:12941272) RGD PMID:12941272 MGI:MGI:2673102 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
JBrowse link
G Cdc45 cell division cycle 45 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:86,328,785...86,354,099
Ensembl chr11:86,329,012...86,358,453
JBrowse link
G Cdc6 cell division cycle 6 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr10:86,819,477...86,833,301
Ensembl chr10:86,819,472...86,833,402
JBrowse link
G Gmnc geminin coiled-coil domain containing IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr11:77,237,033...77,247,723
Ensembl chr11:77,239,098...77,246,315
JBrowse link
G Mcm10 minichromosome maintenance 10 replication initiation factor IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr17:77,224,218...77,245,486
Ensembl chr17:77,224,112...77,246,478
JBrowse link
G Mcm2 minichromosome maintenance complex component 2 ISO (PMID:16899510) RGD PMID:16899510 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm5 minichromosome maintenance complex component 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:14,523,482...14,561,281
Ensembl chr19:14,523,554...14,561,278
JBrowse link
G Mcm6 minichromosome maintenance complex component 6 IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr13:45,042,882...45,068,073
Ensembl chr13:45,042,882...45,068,077
JBrowse link
G Mcm7 minichromosome maintenance complex component 7 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr12:19,306,615...19,313,877
Ensembl chr12:19,306,607...19,314,016
JBrowse link
G Orc1 origin recognition complex, subunit 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:128,186,651...128,212,901
Ensembl chr 5:128,190,708...128,210,445
JBrowse link
G Orc3 origin recognition complex, subunit 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:50,019,159...50,075,533
Ensembl chr 5:50,020,815...50,075,454
JBrowse link
G Orc4 origin recognition complex, subunit 4 ISO
IBA
ISS
(PMID:9353276)
PMID:21873635
GO_REF:0000024
RGD
UniProt
PMID:9353276, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr 3:33,034,913...33,075,833
Ensembl chr 3:33,037,034...33,075,685
JBrowse link
G Orc5 origin recognition complex, subunit 5 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:9,160,050...9,223,998
Ensembl chr 4:9,160,067...9,223,997
JBrowse link
G Orc6 origin recognition complex, subunit 6 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr19:27,457,541...27,464,804
Ensembl chr19:27,457,474...27,464,805
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit ISO
ISS
(PMID:2175912)
GO_REF:0000024
RGD
UniProt
PMID:2175912 GO_REF:0000024 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
JBrowse link
G Pola2 DNA polymerase alpha 2, accessory subunit IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:221,297,417...221,321,601
Ensembl chr 1:221,273,538...221,321,570
JBrowse link
G Topbp1 DNA topoisomerase II binding protein 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 8:111,790,655...111,835,224
Ensembl chr 8:111,790,678...111,827,151
JBrowse link
mitotic DNA replication initiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mcm2 minichromosome maintenance complex component 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:120,825,699...120,840,221
Ensembl chr 4:120,825,699...120,840,111
JBrowse link
G Mcm3 minichromosome maintenance complex component 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 9:26,914,057...26,932,201
Ensembl chr 9:26,914,057...26,932,201
JBrowse link
G Mcm4 minichromosome maintenance complex component 4 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr11:89,511,191...89,524,892
Ensembl chr11:89,511,191...89,524,892
JBrowse link
G Mcmdc2 minichromosome maintenance domain containing 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:8,973,861...9,039,616
Ensembl chr 5:8,978,010...9,038,594
JBrowse link
G Pola1 DNA polymerase alpha 1, catalytic subunit IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr  X:62,382,604...62,698,830
Ensembl chr  X:62,382,608...62,698,830
JBrowse link
positive regulation of DNA-dependent DNA replication initiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdk2 cyclin dependent kinase 2 ISO
IEA
MGI:MGI:1920234 (MGI:MGI:4439421|PMID:20215406)
GO_REF:0000107
RGD
Ensembl
PMID:20215406 GO_REF:0000107, MGI:MGI:4439421 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
JBrowse link
G Ciz1 CDKN1A interacting zinc finger protein 1 ISO MGI:MGI:104772 (MGI:MGI:3513706|PMID:15585571), (MGI:MGI:4439421|PMID:20215406) RGD PMID:15585571, PMID:20215406 MGI:MGI:3513706, MGI:MGI:4439421 NCBI chr 3:11,392,046...11,409,218
Ensembl chr 3:11,392,791...11,410,180
JBrowse link
regulation of DNA-dependent DNA replication initiation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cdt1 chromatin licensing and DNA replication factor 1 ISO
IBA
(PMID:11125146)
PMID:21873635
(MGI:MGI:2388867|PMID:12192004)
RGD PMID:11125146, PMID:12192004, PMID:21873635 MGI:MGI:2388867, RGD:13792537 NCBI chr19:55,381,565...55,386,511
Ensembl chr19:55,381,565...55,386,511
JBrowse link
G Kat7 lysine acetyltransferase 7 ISO
ISS
IEA
(PMID:26620551)
GO_REF:0000024
GO_REF:0000107
RGD
UniProt
Ensembl
PMID:26620551 GO_REF:0000024, GO_REF:0000107 NCBI chr10:83,095,067...83,128,342
Ensembl chr10:83,095,068...83,128,297
JBrowse link
G Ticrr TOPBP1-interacting checkpoint and replication regulator ISO
IBA
(PMID:20116089)
PMID:21873635
RGD PMID:20116089, PMID:21873635 RGD:13792537 NCBI chr 1:141,391,738...141,433,615
Ensembl chr 1:141,391,262...141,433,109
JBrowse link
G Wdr18 WD repeat domain 18 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:12,561,318...12,569,120
Ensembl chr 7:12,561,324...12,569,143
JBrowse link
G Wrnip1 WRN helicase interacting protein 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:15670210)
Ensembl
UniProt
RGD
PMID:15670210 GO_REF:0000024, GO_REF:0000107 NCBI chr17:32,933,395...32,953,641
Ensembl chr17:32,933,396...32,953,641
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      cellular metabolic process 11065
        cellular macromolecule metabolic process 8535
          DNA metabolic process 919
            DNA replication initiation 28
              cell cycle DNA replication initiation + 5
              negative regulation of DNA-dependent DNA replication initiation + 0
              positive regulation of DNA-dependent DNA replication initiation + 2
              regulation of DNA-dependent DNA replication initiation + 7
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      organic substance metabolic process 11636
        organic substance biosynthetic process 6115
          macromolecule biosynthetic process 5161
            cellular macromolecule biosynthetic process 5074
              DNA replication 256
                DNA-dependent DNA replication 151
                  DNA replication initiation 28
                    cell cycle DNA replication initiation + 5
                    negative regulation of DNA-dependent DNA replication initiation + 0
                    positive regulation of DNA-dependent DNA replication initiation + 2
                    regulation of DNA-dependent DNA replication initiation + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.