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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA catabolic process
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Accession:GO:0006308 term browser browse the term
Definition:The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
Synonyms:exact_synonym: DNA breakdown;   DNA catabolism;   DNA degradation


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DNA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffb DNA fragmentation factor, beta subunit ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 4:153,964,447...153,975,121
Ensembl chr 4:153,964,449...153,975,126
JBrowse link
G Dnase1 deoxyribonuclease I IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr16:4,036,958...4,040,024
Ensembl chr16:4,036,942...4,040,024
JBrowse link
G Dnase1l1 deoxyribonuclease 1-like 1 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr  X:74,273,217...74,282,333
Ensembl chr  X:74,273,217...74,282,337
JBrowse link
G Dnase1l2 deoxyribonuclease 1-like 2 IBA
IMP
(MGI:6201960|PMID:21873635)
(MGI:5308183|PMID:21307874)
GO_Central
MGI
PMID:21307874, PMID:21873635 MGI:5308183, MGI:6201960 NCBI chr17:24,440,087...24,443,763
Ensembl chr17:24,440,081...24,443,105
JBrowse link
G Dnase1l3 deoxyribonuclease 1-like 3 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr14:7,965,187...7,994,760
Ensembl chr14:7,964,533...7,994,573
JBrowse link
G Dnase2a deoxyribonuclease II alpha IMP (MGI:3521632|PMID:15568025) MGI PMID:15568025 MGI:3521632 NCBI chr 8:84,908,755...84,911,703
Ensembl chr 8:84,908,560...84,922,915
JBrowse link
G Endog endonuclease G TAS (MGI:5306292|PMID:18309324) UniProt PMID:18309324 MGI:5306292 NCBI chr 2:30,171,408...30,174,069
Ensembl chr 2:30,171,493...30,174,069
JBrowse link
G Trex1 three prime repair exonuclease 1 IMP
IDA
(MGI:3834787|PMID:18724932), (MGI:4414715|PMID:19923437), (MGI:5562498|PMID:23993650)
(MGI:4848004|PMID:20871604)
(MGI:5637600|PMID:25848017)
MGI PMID:18724932, PMID:19923437, PMID:20871604, PMID:23993650, PMID:25848017 MGI:3834787, MGI:4414715, MGI:4848004, MGI:5562498, MGI:5637600 NCBI chr 9:109,057,932...109,059,723
Ensembl chr 9:109,057,933...109,059,734
JBrowse link
apoptotic DNA fragmentation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffa DNA fragmentation factor, alpha subunit IEA UniProt GO_REF:0000002, MGI:2152098 NCBI chr 4:149,104,142...149,120,653
Ensembl chr 4:149,104,146...149,120,647
JBrowse link
G Dffb DNA fragmentation factor, beta subunit ISO
IBA
(MGI:3574013|PMID:15572351)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:15572351, PMID:21873635 GO_REF:0000096, MGI:3574013, MGI:4417868, MGI:4834177, MGI:6201960 NCBI chr 4:153,964,447...153,975,121
Ensembl chr 4:153,964,449...153,975,126
JBrowse link
G Dicer1 dicer 1, ribonuclease type III IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr12:104,687,740...104,751,968
Ensembl chr12:104,687,742...104,751,952
JBrowse link
G Dnase1l3 deoxyribonuclease 1-like 3 IDA
ISO
IBA
(MGI:2385551|PMID:12050166)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:12050166, PMID:21873635 GO_REF:0000096, MGI:2385551, MGI:4834177, MGI:6201960 NCBI chr14:7,965,187...7,994,760
Ensembl chr14:7,964,533...7,994,573
JBrowse link
G Dnase2a deoxyribonuclease II alpha IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 8:84,908,755...84,911,703
Ensembl chr 8:84,908,560...84,922,915
JBrowse link
G Dnase2b deoxyribonuclease II beta IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 3:146,569,733...146,617,060
Ensembl chr 3:146,580,985...146,615,596
JBrowse link
G Endog endonuclease G IMP
IBA
(MGI:3029597|PMID:14663139)
(MGI:6201960|PMID:21873635)
MGI
GO_Central
PMID:14663139, PMID:21873635 MGI:3029597, MGI:6201960 NCBI chr 2:30,171,408...30,174,069
Ensembl chr 2:30,171,493...30,174,069
JBrowse link
G Exog endo/exonuclease (5'-3'), endonuclease G-like IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 9:119,444,925...119,465,518
Ensembl chr 9:119,444,943...119,465,517
JBrowse link
G Foxl2 forkhead box L2 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 9:98,955,607...98,958,126
Ensembl chr 9:98,955,288...98,958,543
JBrowse link
DNA catabolic process, endonucleolytic term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnase1 deoxyribonuclease I IDA
IBA
(MGI:6094744|PMID:29191910)
(MGI:6201960|PMID:21873635)
UniProt
GO_Central
PMID:21873635, PMID:29191910 MGI:6094744, MGI:6201960 NCBI chr16:4,036,958...4,040,024
Ensembl chr16:4,036,942...4,040,024
JBrowse link
G Dnase1l1 deoxyribonuclease 1-like 1 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr  X:74,273,217...74,282,333
Ensembl chr  X:74,273,217...74,282,337
JBrowse link
G Dnase1l2 deoxyribonuclease 1-like 2 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr17:24,440,087...24,443,763
Ensembl chr17:24,440,081...24,443,105
JBrowse link
G Dnase1l3 deoxyribonuclease 1-like 3 IDA
IBA
(MGI:6094744|PMID:29191910)
(MGI:6201960|PMID:21873635)
UniProt
GO_Central
PMID:21873635, PMID:29191910 MGI:6094744, MGI:6201960 NCBI chr14:7,965,187...7,994,760
Ensembl chr14:7,964,533...7,994,573
JBrowse link
G Dnase2a deoxyribonuclease II alpha IMP (MGI:3818215|PMID:18991290) MGI PMID:18991290 MGI:3818215 NCBI chr 8:84,908,755...84,911,703
Ensembl chr 8:84,908,560...84,922,915
JBrowse link
G Fbh1 F-box DNA helicase 1 ISO MGI GO_REF:0000008, MGI:2154458 NCBI chr 2:11,742,573...11,777,585
Ensembl chr 2:11,742,573...11,777,582
JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit ISO MGI GO_REF:0000008, MGI:2154458 NCBI chr19:5,482,561...5,488,389
Ensembl chr19:5,482,345...5,488,402
JBrowse link
G Rexo4 REX4, 3'-5' exonuclease ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr 2:26,953,559...26,964,386
Ensembl chr 2:26,953,563...26,964,386
JBrowse link
G Setmar SET domain without mariner transposase fusion ISO (PMID:24573677)
(PMID:20521842), (PMID:21491884)
UniProtKB PMID:20521842, PMID:21491884, PMID:24573677 NCBI chr 6:108,065,045...108,077,127
Ensembl chr 6:108,065,045...108,077,122
JBrowse link
G Spo11 SPO11 initiator of meiotic double stranded breaks IEA UniProt GO_REF:0000002, MGI:2152098 NCBI chr 2:172,977,379...172,993,576
Ensembl chr 2:172,977,700...172,993,576
JBrowse link
DNA catabolic process, exonucleolytic term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eri1 exoribonuclease 1 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 8:35,465,265...35,495,533
Ensembl chr 8:35,465,253...35,496,196
JBrowse link
G Eri2 exoribonuclease 2 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 7:119,783,826...119,794,058
Ensembl chr 7:119,768,679...119,794,058
JBrowse link
G Eri3 exoribonuclease 3 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 4:117,550,241...117,674,297
Ensembl chr 4:117,550,365...117,674,297
JBrowse link
G Isg20 interferon-stimulated protein ISO
IBA
(MGI:6201960|PMID:21873635) MGI
GO_Central
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr 7:78,913,396...78,920,396
Ensembl chr 7:78,913,424...78,920,396
JBrowse link
G Rexo4 REX4, 3'-5' exonuclease IBA
ISO
(MGI:6201960|PMID:21873635) GO_Central
MGI
PMID:21873635 GO_REF:0000096, MGI:4834177, MGI:6201960 NCBI chr 2:26,953,559...26,964,386
Ensembl chr 2:26,953,563...26,964,386
JBrowse link
G Trex1 three prime repair exonuclease 1 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr 9:109,057,932...109,059,723
Ensembl chr 9:109,057,933...109,059,734
JBrowse link
G Trex2 three prime repair exonuclease 2 IBA (MGI:6201960|PMID:21873635) GO_Central PMID:21873635 MGI:6201960 NCBI chr  X:73,433,705...73,435,343
Ensembl chr  X:73,433,705...73,435,344
JBrowse link
G Xrn2 5'-3' exoribonuclease 2 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 2:147,012,755...147,078,000
Ensembl chr 2:147,012,996...147,078,000
JBrowse link
negative regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffa DNA fragmentation factor, alpha subunit ISO
IMP
(MGI:3574013|PMID:15572351)
(MGI:2182584|PMID:10601318), (MGI:3029597|PMID:14663139)
MGI PMID:10601318, PMID:14663139, PMID:15572351 MGI:2182584, MGI:3029597, MGI:3574013 NCBI chr 4:149,104,142...149,120,653
Ensembl chr 4:149,104,146...149,120,647
JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 4:149,467,569...149,485,210
Ensembl chr 4:149,467,572...149,485,202
JBrowse link
G Pam16 presequence translocase-asssociated motor 16 homolog (S. cerevisiae) ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr16:4,616,466...4,624,946
Ensembl chr16:4,616,464...4,624,988
JBrowse link
negative regulation of DNA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgn regucalcin ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr  X:20,549,766...20,562,089
Ensembl chr  X:20,549,787...20,562,089
JBrowse link
positive regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2-associated X protein ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 7:45,461,695...45,466,903
Ensembl chr 7:45,461,697...45,466,898
JBrowse link
G Endog endonuclease G ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 2:30,171,408...30,174,069
Ensembl chr 2:30,171,493...30,174,069
JBrowse link
G Hsf1 heat shock factor 1 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr15:76,477,362...76,501,155
Ensembl chr15:76,477,422...76,501,913
JBrowse link
G Igfbp3 insulin-like growth factor binding protein 3 ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr11:7,206,086...7,215,498
Ensembl chr11:7,206,086...7,213,923
JBrowse link
G Il6 interleukin 6 ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 5:30,013,114...30,019,975
Ensembl chr 5:30,013,114...30,019,981
JBrowse link
positive regulation of DNA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ataxia telangiectasia mutated ISO MGI GO_REF:0000096, MGI:4417868 NCBI chr 9:53,437,122...53,536,828
Ensembl chr 9:53,439,149...53,536,740
JBrowse link
regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis-inducing factor, mitochondrion-associated 1 IGI (MGI:3577148|PMID:15703386) MGI PMID:15703386 MGI:3577148 NCBI chr  X:48,474,944...48,513,563
Ensembl chr  X:48,474,944...48,513,563
JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 IGI (MGI:3577148|PMID:15703386) MGI PMID:15703386 MGI:3577148 NCBI chr10:90,989,311...91,082,743
Ensembl chr10:90,989,311...91,082,770
JBrowse link
G Cdkn2a cyclin dependent kinase inhibitor 2A ISO MGI GO_REF:0000096, MGI:4834177 NCBI chr 4:89,274,473...89,294,619
Ensembl chr 4:89,274,471...89,294,653
JBrowse link
G Cidea cell death-inducing DNA fragmentation factor, alpha subunit-like effector A IDA (MGI:1203887|PMID:9564035) BHF-UCL PMID:9564035 MGI:1203887 NCBI chr18:67,343,564...67,367,794
Ensembl chr18:67,343,604...67,367,785
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 23386
    metabolic process 11305
      cellular metabolic process 10088
        cellular macromolecule metabolic process 7760
          DNA metabolic process 875
            DNA catabolic process 36
              DNA catabolic process, endonucleolytic + 27
              DNA catabolic process, exonucleolytic 8
              mitochondrial DNA catabolic process 0
              negative regulation of DNA catabolic process + 4
              positive regulation of DNA catabolic process + 6
              regulation of DNA catabolic process + 14
Path 2
Term Annotations click to browse term
  biological_process 23386
    cellular process 17420
      cellular metabolic process 10088
        cellular aromatic compound metabolic process 5425
          nucleobase-containing compound metabolic process 5206
            nucleic acid metabolic process 4766
              DNA metabolic process 875
                DNA catabolic process 36
                  DNA catabolic process, endonucleolytic + 27
                  DNA catabolic process, exonucleolytic 8
                  mitochondrial DNA catabolic process 0
                  negative regulation of DNA catabolic process + 4
                  positive regulation of DNA catabolic process + 6
                  regulation of DNA catabolic process + 14
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.