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ONTOLOGY REPORT - ANNOTATIONS


Term:DNA catabolic process
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Accession:GO:0006308 term browser browse the term
Definition:The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one.
Synonyms:exact_synonym: DNA breakdown;   DNA catabolism;   DNA degradation


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DNA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffb DNA fragmentation factor subunit beta ISO (PMID:19944011) CAFA PMID:19944011 NCBI chrNW_004936737:79,789...96,140 JBrowse link
G Dnase1l2 deoxyribonuclease 1 like 2 ISO (MGI:5308183|PMID:21307874) MGI PMID:21307874 MGI:5308183 NCBI chrNW_004936694:1,808,184...1,810,735 JBrowse link
G Trex1 three prime repair exonuclease 1 ISO (MGI:5637600|PMID:25848017)
(MGI:3834787|PMID:18724932), (MGI:4414715|PMID:19923437), (MGI:5562498|PMID:23993650)
(MGI:4848004|PMID:20871604)
MGI PMID:18724932, PMID:19923437, PMID:20871604, PMID:23993650, PMID:25848017 MGI:3834787, MGI:4414715, MGI:4848004, MGI:5562498, MGI:5637600 NCBI chrNW_004936529:264,535...266,451 JBrowse link
apoptotic DNA fragmentation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffb DNA fragmentation factor subunit beta ISO (PMID:15572351), (PMID:22253444) MGI
RGD
PMID:11425895, PMID:15572351, PMID:22253444 RGD:628524 NCBI chrNW_004936737:79,789...96,140 JBrowse link
G Dnase1l3 deoxyribonuclease 1 like 3 ISO (PMID:23229555)
(MGI:2385551|PMID:12050166)
UniProtKB
MGI
PMID:12050166, PMID:23229555 MGI:2385551 NCBI chrNW_004936473:8,430,235...8,495,170 JBrowse link
G Endog endonuclease G ISO (MGI:3029597|PMID:14663139) MGI PMID:14663139 MGI:3029597 NCBI chrNW_004936487:16,282,115...16,285,486 JBrowse link
G Foxl2 forkhead box L2 ISO (PMID:16153597) UniProtKB PMID:16153597 NCBI chrNW_004936540:1,136,403...1,137,984 JBrowse link
DNA catabolic process, endonucleolytic term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dnase1 deoxyribonuclease 1 ISO (MGI:6094744|PMID:29191910) UniProt PMID:29191910 MGI:6094744 NCBI chrNW_004936694:704,948...715,846 JBrowse link
G Dnase1l3 deoxyribonuclease 1 like 3 ISO (MGI:6094744|PMID:29191910) UniProt PMID:29191910 MGI:6094744 NCBI chrNW_004936473:8,430,235...8,495,170 JBrowse link
G Fbh1 F-box DNA helicase 1 ISO (PMID:23361013) MGI PMID:23361013 NCBI chrNW_004936484:8,635,752...8,689,949 JBrowse link
G LOC101962206 histone-lysine N-methyltransferase SETMAR ISO (PMID:24573677)
(PMID:20521842), (PMID:21491884)
UniProtKB PMID:20521842, PMID:21491884, PMID:24573677 NCBI chrNW_004936577:3,761,078...3,771,864 JBrowse link
G Mus81 MUS81 structure-specific endonuclease subunit ISO (PMID:23361013) MGI PMID:23361013 NCBI chrNW_004936599:3,670,759...3,677,375 JBrowse link
G Rexo4 REX4 homolog, 3'-5' exonuclease ISO (PMID:21602889) ARUK-UCL PMID:21602889 NCBI chrNW_004936669:3,479,778...3,504,938 JBrowse link
DNA catabolic process, exonucleolytic term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Isg20 interferon stimulated exonuclease gene 20 ISO (PMID:11401564) UniProtKB PMID:11401564 NCBI chrNW_004936483:14,616,796...14,635,290 JBrowse link
G Rexo4 REX4 homolog, 3'-5' exonuclease ISO (PMID:21602889) ARUK-UCL PMID:21602889 NCBI chrNW_004936669:3,479,778...3,504,938 JBrowse link
G Xrn2 5'-3' exoribonuclease 2 ISO (PMID:15565158) UniProtKB PMID:15565158 NCBI chrNW_004936620:4,069,956...4,145,212 JBrowse link
negative regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dffa DNA fragmentation factor subunit alpha ISO (PMID:15572351)
(MGI:2182584|PMID:10601318), (MGI:3029597|PMID:14663139)
MGI PMID:10601318, PMID:14663139, PMID:15572351 MGI:2182584, MGI:3029597 NCBI chrNW_004936623:4,296,995...4,307,069 JBrowse link
G Nmnat1 nicotinamide nucleotide adenylyltransferase 1 ISO RGD PMID:27184051 RGD:13781945 NCBI chrNW_004936623:3,862,234...3,891,849 JBrowse link
G Pam16 presequence translocase associated motor 16 ISO RGD PMID:24069394 RGD:13462066 NCBI chrNW_004936694:153,958...161,635 JBrowse link
negative regulation of DNA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rgn regucalcin ISO RGD PMID:2001740 RGD:9590215 NCBI chrNW_004936502:12,872,938...12,891,270 JBrowse link
positive regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator ISO (PMID:11350920) BHF-UCL PMID:11350920 NCBI chrNW_004936664:2,968,103...2,973,652 JBrowse link
G Endog endonuclease G ISO RGD PMID:16407272 RGD:9685355 NCBI chrNW_004936487:16,282,115...16,285,486 JBrowse link
G Hsf1 heat shock transcription factor 1 ISO RGD PMID:21192280 RGD:10403035 NCBI chrNW_004936470:7,927,734...7,950,805 JBrowse link
G Igfbp3 insulin like growth factor binding protein 3 ISO RGD PMID:15125883 RGD:10402776 NCBI chrNW_004936478:20,511,490...20,518,251 JBrowse link
positive regulation of DNA catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase ISO RGD PMID:27895165 RGD:12879393 NCBI chrNW_004936551:359,134...534,672 JBrowse link
regulation of apoptotic DNA fragmentation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Aifm1 apoptosis inducing factor mitochondria associated 1 ISO (MGI:3577148|PMID:15703386) MGI PMID:15703386 MGI:3577148 NCBI chrNW_004936479:1,441,508...1,477,133 JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 ISO (MGI:3577148|PMID:15703386) MGI PMID:15703386 MGI:3577148 NCBI chrNW_004936492:14,818,561...14,902,231 JBrowse link
G Cidea cell death inducing DFFA like effector a ISO (MGI:1203887|PMID:9564035) BHF-UCL PMID:9564035 MGI:1203887 NCBI chrNW_004936626:230,372...246,893 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12003
    metabolic process 7586
      cellular metabolic process 6968
        cellular macromolecule metabolic process 5391
          DNA metabolic process 661
            DNA catabolic process 24
              DNA catabolic process, endonucleolytic + 18
              DNA catabolic process, exonucleolytic 3
              mitochondrial DNA catabolic process 0
              negative regulation of DNA catabolic process + 4
              positive regulation of DNA catabolic process + 5
              regulation of DNA catabolic process + 12
Path 2
Term Annotations click to browse term
  biological_process 12003
    cellular process 11179
      cellular metabolic process 6968
        cellular aromatic compound metabolic process 3734
          nucleobase-containing compound metabolic process 3573
            nucleic acid metabolic process 3285
              DNA metabolic process 661
                DNA catabolic process 24
                  DNA catabolic process, endonucleolytic + 18
                  DNA catabolic process, exonucleolytic 3
                  mitochondrial DNA catabolic process 0
                  negative regulation of DNA catabolic process + 4
                  positive regulation of DNA catabolic process + 5
                  regulation of DNA catabolic process + 12
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.