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ONTOLOGY REPORT - ANNOTATIONS


Term:methionine metabolic process
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Accession:GO:0006555 term browser browse the term
Definition:The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins.
Synonyms:exact_synonym: methionine metabolism
 broad_synonym: methionine and threonine metabolic process;   methionine and threonine metabolism
 xref: UM-BBD_pathwayID:met


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methionine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:47,940,211...47,947,173
Ensembl chr 6:47,940,183...47,947,230
JBrowse link
G Gnmt glycine N-methyltransferase ISO MGI:MGI:3842652 (MGI:MGI:3842675|PMID:17937387) RGD PMID:17937387 MGI:MGI:3842675 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO (MGI:MGI:5621260|PMID:23190757) RGD PMID:23190757 MGI:MGI:5621260 NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO UniProtKB:P53128 (PMID:10551815) RGD PMID:10551815 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IMP RGD PMID:21121936 RGD:7207080 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
L-methionine salvage term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhmt betaine-homocysteine S-methyltransferase ISO
IEA
(PMID:18230605)
GO_REF:0000107
RGD
Ensembl
PMID:18230605 GO_REF:0000107 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G Bhmt2 betaine-homocysteine S-methyltransferase 2 ISO
IEA
(PMID:18230605)
GO_REF:0000107
RGD
Ensembl
PMID:18230605 GO_REF:0000107 NCBI chr 2:23,272,320...23,289,266
Ensembl chr 2:23,272,328...23,289,266
JBrowse link
L-methionine salvage from methylthioadenosine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adi1 acireductone dioxygenase 1 IEA
ISS
ISO
GO_REF:0000041
GO_REF:0000024
(PMID:15938715)
UniProt
RGD
PMID:15938715 GO_REF:0000024, GO_REF:0000041 NCBI chr 6:47,940,211...47,947,173
Ensembl chr 6:47,940,183...47,947,230
JBrowse link
G Apip APAF1 interacting protein IEA
IBA
ISO
GO_REF:0000041
PMID:21873635
(PMID:22837397), (PMID:23285211)
UniProt
RGD
PMID:22837397, PMID:23285211, PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 3:92,969,128...92,998,104
Ensembl chr 3:92,969,141...92,995,483
JBrowse link
G Enoph1 enolase-phosphatase 1 IEA
IBA
ISS
ISO
GO_REF:0000041
PMID:21873635
GO_REF:0000024
(PMID:15843022)
UniProt
RGD
PMID:15843022, PMID:21873635 GO_REF:0000024, GO_REF:0000041, RGD:13792537 NCBI chr14:11,172,359...11,198,799
Ensembl chr14:11,172,362...11,198,194
JBrowse link
G Mri1 methylthioribose-1-phosphate isomerase 1 IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr19:25,360,299...25,366,283
Ensembl chr19:25,360,164...25,366,806
JBrowse link
G Mtap methylthioadenosine phosphorylase IEA
IBA
GO_REF:0000041
PMID:21873635
UniProt PMID:21873635 GO_REF:0000041, RGD:13792537 NCBI chr 5:107,711,077...107,777,530
Ensembl chr 5:107,711,077...107,777,530
JBrowse link
L-methionine salvage from S-adenosylmethionine term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apip APAF1 interacting protein IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr 3:92,969,128...92,998,104
Ensembl chr 3:92,969,141...92,995,483
JBrowse link
G Enoph1 enolase-phosphatase 1 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr14:11,172,359...11,198,799
Ensembl chr14:11,172,362...11,198,194
JBrowse link
G Mri1 methylthioribose-1-phosphate isomerase 1 IEA GO_REF:0000104 UniProt GO_REF:0000104 NCBI chr19:25,360,299...25,366,283
Ensembl chr19:25,360,164...25,366,806
JBrowse link
methionine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bhmt betaine-homocysteine S-methyltransferase IDA
ISO
(MGI:MGI:3510291|PMID:15217352) RGD PMID:15217352, PMID:15845641 MGI:MGI:3510291, RGD:1359026 NCBI chr 2:23,236,573...23,256,158
Ensembl chr 2:23,236,575...23,256,158
JBrowse link
G Mthfd1 methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 ISO (PMID:25633902) RGD PMID:25633902 NCBI chr 6:99,282,850...99,350,367
Ensembl chr 6:99,282,850...99,350,340
JBrowse link
G Mthfd2l methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr14:18,640,274...18,721,298
Ensembl chr14:18,640,277...18,720,357
JBrowse link
G Mthfr methylenetetrahydrofolate reductase ISO
IBA
MGI:MGI:2385823 (MGI:MGI:3510291|PMID:15217352)
PMID:21873635
RGD PMID:15217352, PMID:21873635 MGI:MGI:3510291, RGD:13792537 NCBI chr 5:164,844,642...164,864,360
Ensembl chr 5:164,845,925...164,860,910
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase IDA
IEA
ISO
GO_REF:0000107
(PMID:23825108)
MGI:MGI:2180496 (MGI:MGI:1930456|PMID:11158293)
Ensembl
RGD
PMID:11158293, PMID:23825108, PMID:15845641, PMID:11730351 GO_REF:0000107, MGI:MGI:1930456, RGD:1359026, RGD:1601423 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO
IBA
(PMID:11466310)
PMID:21873635
(MGI:MGI:3710265|PMID:17369066)
RGD PMID:11466310, PMID:17369066, PMID:21873635 MGI:MGI:3710265, RGD:13792537 NCBI chr 1:37,743,089...37,774,485
Ensembl chr 1:37,743,147...37,774,015
JBrowse link
methionine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mat1a methionine adenosyltransferase 1A IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:10677294)
Ensembl
UniProt
RGD
PMID:10677294 GO_REF:0000024, GO_REF:0000107 NCBI chr16:18,690,649...18,709,135
Ensembl chr16:18,690,246...18,709,133
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    cellular process 18788
      cellular metabolic process 11065
        sulfur compound metabolic process 307
          sulfur amino acid metabolic process 35
            methionine metabolic process 14
              methionine biosynthetic process + 12
              methionine catabolic process + 1
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      organic substance metabolic process 11636
        organic acid metabolic process 1090
          oxoacid metabolic process 1061
            carboxylic acid metabolic process 1005
              cellular amino acid metabolic process 274
                alpha-amino acid metabolic process 198
                  aspartate family amino acid metabolic process 41
                    methionine metabolic process 14
                      methionine biosynthetic process + 12
                      methionine catabolic process + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.