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ONTOLOGY REPORT - ANNOTATIONS


Term:thyroid hormone generation
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Accession:GO:0006590 term browser browse the term
Definition:The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones.
Comment:Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis.


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thyroid hormone generation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cga glycoprotein hormones, alpha polypeptide JBrowse link 5 50,362,491 50,393,368 RGD:1624291
RGD:13792537
G Cpq carboxypeptidase Q JBrowse link 7 71,709,174 72,167,413 RGD:8554022
RGD:13792537
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:1600115
RGD:1624291
G Ctsk cathepsin K JBrowse link 2 196,655,469 196,666,447 RGD:1600115
RGD:1624291
G Ctsl cathepsin L JBrowse link 17 1,873,105 1,879,266 RGD:1624291
G Dio2 iodothyronine deiodinase 2 JBrowse link 6 114,475,156 114,489,443 RGD:1626436
G Duox1 dual oxidase 1 JBrowse link 3 114,251,794 114,286,827 RGD:1600115
G Duox2 dual oxidase 2 JBrowse link 3 114,218,187 114,237,808 RGD:632568
RGD:1600115
G Foxe1 forkhead box E1 JBrowse link 5 61,954,549 61,957,357 RGD:1624291
G Med1 mediator complex subunit 1 JBrowse link 10 86,101,560 86,145,271 RGD:1624291
G Slc16a10 solute carrier family 16 member 10 JBrowse link 20 45,138,433 45,260,155 RGD:1624291
RGD:1600115
G Slc16a2 solute carrier family 16 member 2 JBrowse link X 74,578,600 74,706,068 RGD:1624291
RGD:1600115
G Slc5a5 solute carrier family 5 member 5 JBrowse link 16 20,297,414 20,307,401 RGD:68854
RGD:1600115
G Tg thyroglobulin JBrowse link 7 107,467,260 107,652,897 RGD:728752
RGD:1624291
RGD:13792537
RGD:1600115
RGD:1600150
G Tpo thyroid peroxidase JBrowse link 6 49,020,918 49,089,855 RGD:1599649
RGD:1624291
RGD:1600115
positive regulation of thyroid hormone generation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gata3 GATA binding protein 3 JBrowse link 17 72,419,752 72,452,043 RGD:1600115
RGD:1624291
G Hpn hepsin JBrowse link 1 89,534,112 89,549,575 RGD:1624291
RGD:1600115
G Pax8 paired box 8 JBrowse link 3 1,527,316 1,586,019 RGD:1624291
RGD:1600115
G Slco1c1 solute carrier organic anion transporter family, member 1c1 JBrowse link 4 175,729,709 175,776,749 RGD:1624291
RGD:1600115
regulation of thyroid hormone generation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Duoxa1 dual oxidase maturation factor 1 JBrowse link 3 114,241,057 114,251,720 RGD:1624291
G Duoxa2 dual oxidase maturation factor 2 JBrowse link 3 114,236,718 114,240,086 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12096
      hormone metabolic process 213
        thyroid hormone metabolic process 32
          thyroid hormone generation 21
            negative regulation of thyroid hormone generation 0
            positive regulation of thyroid hormone generation 4
            regulation of thyroid hormone generation + 6
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12096
      cellular metabolic process 10917
        cellular aromatic compound metabolic process 5567
          phenol-containing compound metabolic process 122
            thyroid hormone metabolic process 32
              thyroid hormone generation 21
                negative regulation of thyroid hormone generation 0
                positive regulation of thyroid hormone generation 4
                regulation of thyroid hormone generation + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.