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ONTOLOGY REPORT - ANNOTATIONS


Term:creatine biosynthetic process
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Accession:GO:0006601 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle.
Synonyms:exact_synonym: creatine anabolism;   creatine biosynthesis;   creatine formation;   creatine synthesis


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creatine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gamt guanidinoacetate N-methyltransferase JBrowse link 7 12,314,848 12,317,998 RGD:1359081
RGD:13792537
RGD:1624291
RGD:1600115
RGD:632754
G Gatm glycine amidinotransferase JBrowse link 3 114,711,570 114,728,155 RGD:70746
RGD:1624291
RGD:1600115
RGD:13792537

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  biological_process 19576
    cellular process 18361
      cellular metabolic process 10737
        drug metabolic process 591
          creatine metabolic process 2
            creatine biosynthetic process 2
Path 2
Term Annotations click to browse term
  biological_process 19576
    metabolic process 11899
      small molecule metabolic process 1824
        organic acid metabolic process 1053
          oxoacid metabolic process 1026
            carboxylic acid metabolic process 979
              monocarboxylic acid metabolic process 642
                monocarboxylic acid biosynthetic process 195
                  creatine biosynthetic process 2
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.