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ONTOLOGY REPORT - ANNOTATIONS


Term:SRP-dependent cotranslational protein targeting to membrane
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Accession:GO:0006614 term browser browse the term
Definition:The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane.
Synonyms:exact_synonym: SRP-dependent cotranslational membrane targeting;   SRP-dependent cotranslational protein-membrane targeting
 broad_synonym: ER translocation


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SRP-dependent cotranslational protein targeting to membrane term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G LOC108348180 signal recognition particle subunit SRP72-like JBrowse link 14 33,958,495 33,960,973 RGD:1600115
G Sec61a1 Sec61 translocon alpha 1 subunit JBrowse link 4 120,453,577 120,467,932 RGD:1624291
G Sec63 SEC63 homolog, protein translocation regulator JBrowse link 20 47,494,270 47,563,222 RGD:1624291
RGD:13792537
G Srp14 signal recognition particle 14 JBrowse link 3 110,245,936 110,249,627 RGD:1600115
G Srp68 signal recognition particle 68 JBrowse link 10 105,123,324 105,150,080 RGD:1600115
G Srp9 signal recognition particle 9 JBrowse link 13 100,551,307 100,559,447 RGD:1600115
G Srpra SRP receptor subunit alpha JBrowse link 8 36,410,683 36,416,766 RGD:1600115
G Ssr3 signal sequence receptor subunit 3 JBrowse link 2 156,010,997 156,023,853 RGD:1600115
SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Srp19 signal recognition particle 19 JBrowse link 18 27,114,822 27,121,062 RGD:13792537
G Srp54a signal recognition particle 54A JBrowse link 6 75,996,629 76,035,768 RGD:1624291
SRP-dependent cotranslational protein targeting to membrane, translocation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sec61a1 Sec61 translocon alpha 1 subunit JBrowse link 4 120,453,577 120,467,932 RGD:13792537
G Sec61a2 Sec61 translocon alpha 2 subunit JBrowse link 17 76,358,947 76,385,860 RGD:13792537
G Sec61b Sec61 translocon beta subunit JBrowse link 5 63,192,322 63,200,532 RGD:13792537
G Srp54a signal recognition particle 54A JBrowse link 6 75,996,629 76,035,768 RGD:1624291
RGD:13792537
G Tram1 translocation associated membrane protein 1 JBrowse link 5 5,215,196 5,297,337 RGD:1624291
RGD:1600115
G Tram1l1 translocation associated membrane protein 1-like 1 JBrowse link 2 228,544,418 228,546,599 RGD:1600115
G Tram2 translocation associated membrane protein 2 JBrowse link 9 27,117,861 27,192,166 RGD:1600115
G Zfand2b zinc finger AN1-type containing 2B JBrowse link 9 82,370,887 82,373,843 RGD:1624291
RGD:1600115

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Term Annotations click to browse term
  biological_process 19245
    localization 6273
      establishment of localization 4844
        establishment of protein localization 1929
          establishment of protein localization to organelle 435
            establishment of protein localization to endoplasmic reticulum 36
              protein targeting to ER 32
                SRP-dependent cotranslational protein targeting to membrane 16
                  SRP-dependent cotranslational protein targeting to membrane, docking 0
                  SRP-dependent cotranslational protein targeting to membrane, signal sequence processing 0
                  SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition 2
                  SRP-dependent cotranslational protein targeting to membrane, translocation 8
Path 2
Term Annotations click to browse term
  biological_process 19245
    localization 6273
      establishment of localization 4844
        transport 4705
          nitrogen compound transport 2235
            amide transport 1913
              peptide transport 1880
                protein transport 1822
                  intracellular protein transport 981
                    protein targeting 287
                      protein targeting to membrane 114
                        cotranslational protein targeting to membrane 17
                          SRP-dependent cotranslational protein targeting to membrane 16
                            SRP-dependent cotranslational protein targeting to membrane, docking 0
                            SRP-dependent cotranslational protein targeting to membrane, signal sequence processing 0
                            SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition 2
                            SRP-dependent cotranslational protein targeting to membrane, translocation 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.