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ONTOLOGY REPORT - ANNOTATIONS


Term:SRP-dependent cotranslational protein targeting to membrane, translocation
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Accession:GO:0006616 term browser browse the term
Definition:The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen.
Synonyms:exact_synonym: SRP-dependent cotranslational membrane targeting, translocation;   SRP-dependent cotranslational protein-membrane targeting, translocation;   translocation during SRP-dependent cotranslational protein targeting to membrane
 broad_synonym: ER translocation


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SRP-dependent cotranslational protein targeting to membrane, translocation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sec61a1 SEC61 translocon subunit alpha 1 JBrowse link 4 120,453,577 120,467,932 RGD:13792537
G Sec61a2 SEC61 translocon subunit alpha 2 JBrowse link 17 76,358,947 76,385,860 RGD:13792537
G Sec61b SEC61 translocon subunit beta JBrowse link 5 63,192,322 63,200,532 RGD:13792537
G Srp54a signal recognition particle 54A JBrowse link 6 75,996,629 76,035,768 RGD:1624291
RGD:13792537
G Tram1 translocation associated membrane protein 1 JBrowse link 5 5,215,196 5,297,337 RGD:1624291
RGD:1600115
G Tram1l1 translocation associated membrane protein 1-like 1 JBrowse link 2 228,544,418 228,546,599 RGD:1600115
G Tram2 translocation associated membrane protein 2 JBrowse link 9 27,117,861 27,192,166 RGD:1600115
G Zfand2b zinc finger AN1-type containing 2B JBrowse link 9 82,370,887 82,373,843 RGD:1624291
RGD:1600115

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Term Annotations click to browse term
  biological_process 19317
    localization 6317
      cellular localization 2662
        intracellular transport 1503
          intracellular protein transport 988
            intracellular protein transmembrane transport 57
              SRP-dependent cotranslational protein targeting to membrane, translocation 8
Path 2
Term Annotations click to browse term
  biological_process 19317
    localization 6317
      establishment of localization 4859
        transport 4720
          nitrogen compound transport 2241
            amide transport 1921
              peptide transport 1889
                protein transport 1831
                  intracellular protein transport 988
                    protein targeting 289
                      protein targeting to membrane 114
                        cotranslational protein targeting to membrane 17
                          SRP-dependent cotranslational protein targeting to membrane 16
                            SRP-dependent cotranslational protein targeting to membrane, translocation 8
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.