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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylcholine biosynthetic process
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Accession:GO:0006656 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline.
Synonyms:exact_synonym: phosphatidylcholine anabolism;   phosphatidylcholine biosynthesis;   phosphatidylcholine formation;   phosphatidylcholine synthesis


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phosphatidylcholine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Apoa1 apolipoprotein A1 ISO (PMID:4335615) RGD PMID:4335615 NCBI chr 8:50,525,091...50,526,875
Ensembl chr 8:50,525,091...50,526,875
JBrowse link
G Apoa2 apolipoprotein A2 ISO (PMID:14967812) RGD PMID:14967812 NCBI chr13:89,596,872...89,598,805
Ensembl chr13:89,597,138...89,598,802
JBrowse link
G Cept1 choline/ethanolamine phosphotransferase 1 ISO (MGI:MGI:4460850|PMID:20018880) RGD PMID:20018880 MGI:MGI:4460850 NCBI chr 2:209,118,140...209,162,071
Ensembl chr 2:209,118,922...209,160,653
JBrowse link
G Chka choline kinase alpha ISO
ISS
(MGI:MGI:3623691|PMID:16371353)
GO_REF:0000024
(PMID:19915674)
RGD
UniProt
PMID:16371353, PMID:19915674 GO_REF:0000024, MGI:MGI:3623691 NCBI chr 1:219,076,618...219,126,221
Ensembl chr 1:219,077,771...219,126,220
JBrowse link
G Chkb choline kinase beta ISO MGI:MGI:3578417 (MGI:MGI:3623691|PMID:16371353) RGD PMID:16371353 MGI:MGI:3623691 NCBI chr 7:130,404,818...130,408,813
Ensembl chr 7:130,404,832...130,408,187
JBrowse link
G Chpt1 choline phosphotransferase 1 ISO (MGI:MGI:4460850|PMID:20018880)
(PMID:10893425)
RGD PMID:10893425, PMID:20018880 MGI:MGI:4460850 NCBI chr 7:29,019,518...29,070,928
Ensembl chr 7:29,043,916...29,070,928
JBrowse link
G Dhrs7b dehydrogenase/reductase 7B ISO (MGI:MGI:6103958|PMID:28930673) RGD PMID:28930673 MGI:MGI:6103958 NCBI chr10:47,065,755...47,111,089
Ensembl chr10:47,065,850...47,111,101
JBrowse link
G Fabp5 fatty acid binding protein 5 ISO MGI:MGI:95476 (MGI:MGI:3045488|PMID:15164767) RGD PMID:15164767 MGI:MGI:3045488 NCBI chr 2:93,981,662...93,985,322
Ensembl chr 2:93,981,656...93,985,378
JBrowse link
G Fgf7 fibroblast growth factor 7 IMP surfactant disaturated phosphatidylcholine (DSPC) synthesis RGD PMID:11316745 RGD:68696 NCBI chr 3:118,315,859...118,368,464
Ensembl chr 3:118,317,761...118,366,872
JBrowse link
G Gpat4 glycerol-3-phosphate acyltransferase 4 ISO (PMID:18238778) RGD PMID:18238778 NCBI chr16:73,615,949...73,649,769
Ensembl chr16:73,615,949...73,649,767
JBrowse link
G Lcat lecithin cholesterol acyltransferase ISO (PMID:11966470), (PMID:12354767) RGD PMID:11966470, PMID:12354767 NCBI chr19:37,913,333...37,916,799
Ensembl chr19:37,913,336...37,916,813
JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 4:157,181,722...157,222,997
Ensembl chr 4:157,181,795...157,222,996
JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1, choline, alpha TAS
ISO
IDA
IMP
MGI:MGI:2176050|MGI:MGI:3027956 (MGI:MGI:2159547|PMID:11829742), (MGI:MGI:2667298|PMID:12842190), (MGI:MGI:3575987|PMID:15798219)
PMID:8185307
PMID:8381041
(PMID:10480912)
RGD PMID:10480912, PMID:11829742, PMID:12842190, PMID:15798219, PMID:2166941, PMID:8185307, PMID:8381041, PMID:12718547 MGI:MGI:2159547, MGI:MGI:2667298, MGI:MGI:3575987, RGD:70012, RGD:39458015, RGD:729578, RGD:729598 NCBI chr11:71,547,865...71,592,037
Ensembl chr11:71,548,222...71,591,502
JBrowse link
G Pcyt1b phosphate cytidylyltransferase 1, choline, beta ISO
ISS
(PMID:10480912)
(MGI:MGI:2667298|PMID:12842190)
GO_REF:0000024
RGD
UniProt
PMID:10480912, PMID:12842190 GO_REF:0000024, MGI:MGI:2667298 NCBI chr  X:62,727,691...62,821,199
Ensembl chr  X:62,727,755...62,818,522
JBrowse link
G Pemt phosphatidylethanolamine N-methyltransferase IDA
IBA
IEA
PMID:21873635
GO_REF:0000041
UniProt PMID:8344945, PMID:21873635 GO_REF:0000041, RGD:729486, RGD:13792537 NCBI chr10:46,339,821...46,404,640
Ensembl chr10:46,339,821...46,404,642
JBrowse link
G Phka1 phosphorylase kinase regulatory subunit alpha 1 TAS RGD PMID:12401806 RGD:724642 NCBI chr  X:72,377,020...72,515,385
Ensembl chr  X:72,377,021...72,515,366
JBrowse link
G Slc27a1 solute carrier family 27 member 1 IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:19523918)
Ensembl
RGD
PMID:19523918, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr16:19,997,823...20,016,193
Ensembl chr16:19,999,112...20,016,190
JBrowse link
CDP-choline pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cept1 choline/ethanolamine phosphotransferase 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 2:209,118,140...209,162,071
Ensembl chr 2:209,118,922...209,160,653
JBrowse link
G Chka choline kinase alpha IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 1:219,076,618...219,126,221
Ensembl chr 1:219,077,771...219,126,220
JBrowse link
G Chkb choline kinase beta IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:130,404,818...130,408,813
Ensembl chr 7:130,404,832...130,408,187
JBrowse link
G Chpt1 choline phosphotransferase 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr 7:29,019,518...29,070,928
Ensembl chr 7:29,043,916...29,070,928
JBrowse link
G Etnk2 ethanolamine kinase 2 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr13:50,481,178...50,498,991
Ensembl chr13:50,481,163...50,499,140
JBrowse link
G Pcyt1a phosphate cytidylyltransferase 1, choline, alpha IDA
ISO
PMID:19783652
(MGI:MGI:2667298|PMID:12842190)
PMID:8185307
PMID:8381041
(PMID:10480912)
RGD PMID:10480912, PMID:12842190, PMID:19783652, PMID:8185307, PMID:8381041 MGI:MGI:2667298, RGD:8553740, RGD:39458015, RGD:729578 NCBI chr11:71,547,865...71,592,037
Ensembl chr11:71,548,222...71,591,502
JBrowse link
G Pcyt1b phosphate cytidylyltransferase 1, choline, beta ISO
ISS
(PMID:10480912)
(MGI:MGI:2667298|PMID:12842190)
GO_REF:0000024
RGD
UniProt
PMID:10480912, PMID:12842190 GO_REF:0000024, MGI:MGI:2667298 NCBI chr  X:62,727,691...62,821,199
Ensembl chr  X:62,727,755...62,818,522
JBrowse link
G Phka1 phosphorylase kinase regulatory subunit alpha 1 IEA GO_REF:0000108 GOC GO_REF:0000108 NCBI chr  X:72,377,020...72,515,385
Ensembl chr  X:72,377,021...72,515,366
JBrowse link
negative regulation of phosphatidylcholine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpcat1 lysophosphatidylcholine acyltransferase 1 ISO (MGI:MGI:4460850|PMID:20018880) RGD PMID:20018880 MGI:MGI:4460850 NCBI chr 1:32,379,431...32,429,917
Ensembl chr 1:32,379,432...32,429,917
JBrowse link
positive regulation of phosphatidylcholine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acsl3 acyl-CoA synthetase long-chain family member 3 ISO (PMID:18003621) RGD PMID:18003621 NCBI chr 9:84,569,601...84,593,565
Ensembl chr 9:84,569,597...84,593,565
JBrowse link
G Capn2 calpain 2 IMP RGD PMID:9481489 RGD:13792658 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
JBrowse link
G Rab38 RAB38, member RAS oncogene family IDA RGD PMID:28438206 RGD:13524861 NCBI chr 1:152,072,716...152,153,449
Ensembl chr 1:152,072,665...152,153,449
JBrowse link
regulation of phosphatidylcholine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fabp3 fatty acid binding protein 3 ISO MGI:MGI:101790 (MGI:MGI:3045488|PMID:15164767) RGD PMID:15164767 MGI:MGI:3045488 NCBI chr 5:148,528,854...148,535,597
Ensembl chr 5:148,528,725...148,535,565
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      nitrogen compound metabolic process 10390
        organonitrogen compound metabolic process 7186
          phosphatidylcholine metabolic process 65
            phosphatidylcholine biosynthetic process 23
              CDP-choline pathway 8
              negative regulation of phosphatidylcholine biosynthetic process 1
              phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol 0
              phosphatidylcholine biosynthesis from phosphatidylethanolamine 0
              phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine 0
              phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine 0
              phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline 0
              phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine 0
              positive regulation of phosphatidylcholine biosynthetic process 3
              regulation of phosphatidylcholine biosynthetic process + 5
Path 2
Term Annotations click to browse term
  biological_process 20027
    metabolic process 12278
      cellular metabolic process 11085
        phosphorus metabolic process 3301
          phosphate-containing compound metabolic process 3280
            phospholipid metabolic process 381
              glycerophospholipid metabolic process 293
                phosphatidylcholine metabolic process 65
                  phosphatidylcholine biosynthetic process 23
                    CDP-choline pathway 8
                    negative regulation of phosphatidylcholine biosynthetic process 1
                    phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol 0
                    phosphatidylcholine biosynthesis from phosphatidylethanolamine 0
                    phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via CDP-N-methylethanolamine 0
                    phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-N-dimethylethanolamine 0
                    phosphatidylcholine biosynthesis from phosphoryl-ethanolamine via N-dimethylethanolamine phosphate and CDP-choline 0
                    phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine 0
                    positive regulation of phosphatidylcholine biosynthetic process 3
                    regulation of phosphatidylcholine biosynthetic process + 5
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.