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ONTOLOGY REPORT - ANNOTATIONS


Term:phosphatidylserine metabolic process
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Accession:GO:0006658 term browser browse the term
Definition:The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes.
Synonyms:exact_synonym: phosphatidylserine metabolism


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phosphatidylserine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lipc lipase C, hepatic type IDA RGD PMID:2223857 RGD:1600650 NCBI chr 8:77,272,582...77,398,485
Ensembl chr 8:77,272,570...77,398,248
JBrowse link
G Pla2g10 phospholipase A2, group X ISO
IEA
ISS
(PMID:12359733)
GO_REF:0000107
(MGI:MGI:2446974|PMID:12359733)
GO_REF:0000024
RGD
Ensembl
UniProt
PMID:12359733 GO_REF:0000024, GO_REF:0000107, MGI:MGI:2446974 NCBI chr10:1,509,732...1,520,970
Ensembl chr10:1,509,732...1,520,970
JBrowse link
G Pla2g3 phospholipase A2, group III ISO
IEA
(PMID:28947740)
GO_REF:0000107
RGD
Ensembl
PMID:28947740 GO_REF:0000107 NCBI chr14:83,724,828...83,730,614
Ensembl chr14:83,724,933...83,730,614
JBrowse link
G Serinc1 serine incorporator 1 IDA PMID:16120614 HGNC PMID:16120614 RGD:8553290 NCBI chr20:38,966,016...38,985,056
Ensembl chr20:38,967,238...38,985,036
JBrowse link
G Serinc2 serine incorporator 2 IDA PMID:16120614 HGNC PMID:16120614 RGD:8553290 NCBI chr 5:148,470,060...148,492,232
Ensembl chr 5:148,470,061...148,492,232
JBrowse link
G Serinc3 serine incorporator 3 ISS PMID:16120614 HGNC PMID:16120614 RGD:8553290 NCBI chr 3:160,018,643...160,038,078
Ensembl chr 3:160,018,646...160,038,078
JBrowse link
G Serinc5 serine incorporator 5 IDA
IEA
PMID:16120614
GO_REF:0000002
InterPro PMID:16120614 GO_REF:0000002, RGD:8553290 NCBI chr 2:22,195,507...22,310,289
Ensembl chr 2:22,195,600...22,310,312
JBrowse link
phosphatidylserine acyl-chain remodeling term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpcat3 lysophosphatidylcholine acyltransferase 3 ISO
ISS
(PMID:18195019), (PMID:18772128), (PMID:18782225)
GO_REF:0000024
RGD
UniProt
PMID:18195019, PMID:18772128, PMID:18782225 GO_REF:0000024 NCBI chr 4:157,181,722...157,222,997
Ensembl chr 4:157,181,795...157,222,996
JBrowse link
G Lpcat4 lysophosphatidylcholine acyltransferase 4 ISO
IEA
(PMID:18458083)
GO_REF:0000107
RGD
Ensembl
PMID:18458083 GO_REF:0000107 NCBI chr 3:103,725,762...103,733,888
Ensembl chr 3:103,726,238...103,733,354
JBrowse link
phosphatidylserine biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Plscr1 phospholipid scramblase 1 IEA
ISO
GO_REF:0000107
(MGI:MGI:5284813|PMID:12509439)
Ensembl
RGD
PMID:12509439 GO_REF:0000107, MGI:MGI:5284813 NCBI chr 8:99,625,523...99,645,882
Ensembl chr 8:99,625,545...99,725,217
JBrowse link
G Ptdss1 phosphatidylserine synthase 1 IEA
ISO
GO_REF:0000041
(PMID:19014349)
UniProt
RGD
PMID:19014349 GO_REF:0000041 NCBI chr 7:71,294,140...71,356,153
Ensembl chr 7:71,293,388...71,356,153
JBrowse link
G Ptdss2 phosphatidylserine synthase 2 IEA
ISO
GO_REF:0000041
(PMID:19014349)
MGI:MGI:2447151 (MGI:MGI:2446765|PMID:12361952)
UniProt
RGD
PMID:12361952, PMID:19014349 GO_REF:0000041, MGI:MGI:2446765 NCBI chr 1:214,122,981...214,148,011
Ensembl chr 1:214,123,044...214,149,729
JBrowse link
G Slc27a1 solute carrier family 27 member 1 IEA
IBA
ISO
GO_REF:0000107
PMID:21873635
(PMID:19523918)
Ensembl
RGD
PMID:19523918, PMID:21873635 GO_REF:0000107, RGD:13792537 NCBI chr16:19,997,823...20,016,193
Ensembl chr16:19,999,112...20,016,190
JBrowse link
phosphatidylserine catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abhd12 abhydrolase domain containing 12, lysophospholipase ISO
IBA
ISS
MGI:MGI:5487621 (MGI:MGI:5469248|PMID:23297193)
PMID:21873635
GO_REF:0000024
(PMID:30643283)
RGD
UniProt
PMID:23297193, PMID:30643283, PMID:21873635 GO_REF:0000024, MGI:MGI:5469248, RGD:13792537 NCBI chr 3:146,630,298...146,690,375
Ensembl chr 3:146,630,299...146,690,375
JBrowse link
G Abhd12b abhydrolase domain containing 12B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 6:92,568,975...92,596,327
Ensembl chr 6:92,568,975...92,596,327
JBrowse link
G Abhd16a abhydrolase domain containing 16A, phospholipase ISS
IBA
ISO
IEA
GO_REF:0000024
PMID:21873635
(MGI:MGI:5779796|PMID:25580854)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:25580854, PMID:21873635 GO_REF:0000024, GO_REF:0000107, MGI:MGI:5779796, RGD:13792537 NCBI chr20:5,080,070...5,094,935
Ensembl chr20:5,080,070...5,094,935
JBrowse link
G Abhd16b abhydrolase domain containing 16B IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 3:176,985,900...176,987,797
Ensembl chr 3:176,985,900...176,987,796
JBrowse link
regulation of phosphatidylserine metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mfsd2a major facilitator superfamily domain containing 2A ISO (MGI:MGI:6196220|PMID:30074985) RGD PMID:30074985 MGI:MGI:6196220 NCBI chr 5:140,642,865...140,657,759
Ensembl chr 5:140,642,885...140,657,745
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      cellular metabolic process 11065
        cellular modified amino acid metabolic process 187
          phosphatidylserine metabolic process 18
            negative regulation of phosphatidylserine metabolic process + 0
            phosphatidylserine acyl-chain remodeling 2
            phosphatidylserine biosynthetic process + 4
            phosphatidylserine catabolic process 4
            positive regulation of phosphatidylserine metabolic process + 0
            regulation of phosphatidylserine metabolic process + 1
Path 2
Term Annotations click to browse term
  biological_process 20014
    metabolic process 12256
      organic substance metabolic process 11636
        lipid metabolic process 1378
          cellular lipid metabolic process 1057
            glycerolipid metabolic process 393
              glycerophospholipid metabolic process 289
                phosphatidylserine metabolic process 18
                  negative regulation of phosphatidylserine metabolic process + 0
                  phosphatidylserine acyl-chain remodeling 2
                  phosphatidylserine biosynthetic process + 4
                  phosphatidylserine catabolic process 4
                  positive regulation of phosphatidylserine metabolic process + 0
                  regulation of phosphatidylserine metabolic process + 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.