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ONTOLOGY REPORT - ANNOTATIONS


Term:cholesterol biosynthetic process
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Accession:GO:0006695 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
Synonyms:exact_synonym: cholesterol anabolism;   cholesterol biosynthesis;   cholesterol formation;   cholesterol synthesis


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cholesterol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07060293.1 RGD:13792537
G Acat2 acetyl-CoA acetyltransferase 2 JBrowse link 1 47,972,399 47,992,654 RGD:2326086
G Apoa1 apolipoprotein A1 JBrowse link 8 50,525,091 50,526,875 RGD:1624291
RGD:13792537
G Apoa4 apolipoprotein A4 JBrowse link 8 50,536,983 50,539,371 RGD:13792537
G Apoa5 apolipoprotein A5 JBrowse link 8 50,559,079 50,561,720 RGD:13792537
G Ces1d carboxylesterase 1D JBrowse link 19 15,195,514 15,239,827 RGD:1624291
G Cftr CF transmembrane conductance regulator JBrowse link 4 42,693,263 42,860,679 RGD:1624291
RGD:1600115
G Cyb5r3 cytochrome b5 reductase 3 JBrowse link 7 124,024,003 124,041,564 RGD:1600115
G Dhcr24 24-dehydrocholesterol reductase JBrowse link 5 126,164,708 126,188,926 RGD:1624291
RGD:1600115
G Dhcr7 7-dehydrocholesterol reductase JBrowse link 1 217,018,916 217,034,890 RGD:625561
RGD:13792537
RGD:1624291
RGD:1600115
RGD:2316918
RGD:2316916
RGD:632010
G Ebp EBP, cholestenol delta-isomerase JBrowse link X 15,049,394 15,055,782 RGD:628445
RGD:13792537
RGD:1624291
RGD:1600115
G Fdft1 farnesyl diphosphate farnesyl transferase 1 JBrowse link 15 46,339,248 46,367,302 RGD:728402
RGD:13792537
RGD:1626611
G Fdps farnesyl diphosphate synthase JBrowse link 2 188,403,595 188,413,219 RGD:728501
G G6pd glucose-6-phosphate dehydrogenase JBrowse link X 156,274,800 156,293,935 RGD:1624291
G Hmgcr 3-hydroxy-3-methylglutaryl-CoA reductase JBrowse link 2 27,480,224 27,500,654 RGD:1300058
RGD:1624291
G Hmgcs1 3-hydroxy-3-methylglutaryl-CoA synthase 1 JBrowse link 2 52,427,351 52,445,082 RGD:1600115
G Hmgcs2 3-hydroxy-3-methylglutaryl-CoA synthase 2 JBrowse link 2 200,452,623 200,480,785 RGD:1600115
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 JBrowse link 13 88,288,116 88,308,019 RGD:1624291
RGD:1600115
RGD:13792537
G Idi1 isopentenyl-diphosphate delta isomerase 1 JBrowse link 17 57,976,266 57,984,036 RGD:729078
G Insig1 insulin induced gene 1 JBrowse link 4 342,302 350,515 RGD:1624291
RGD:13792537
G Insig2 insulin induced gene 2 JBrowse link 13 37,264,818 37,292,718 RGD:1624291
RGD:1600115
RGD:13792537
G Lbr lamin B receptor JBrowse link 13 100,431,390 100,450,209 RGD:1600115
RGD:1624291
G Lss lanosterol synthase JBrowse link 20 12,844,522 12,870,474 RGD:1626611
RGD:728996
RGD:13792537
RGD:1600115
RGD:1624291
RGD:2316919
G Msmo1 methylsterol monooxygenase 1 JBrowse link 16 26,859,441 26,875,880 RGD:1600115
G Mvd mevalonate diphosphate decarboxylase JBrowse link 19 55,258,910 55,268,933 RGD:729305
RGD:1600115
G Mvk mevalonate kinase JBrowse link 12 47,904,266 47,920,457 RGD:728935
RGD:1600115
RGD:13792537
RGD:1624291
G Npc1l1 NPC1 like intracellular cholesterol transporter 1 JBrowse link 14 86,345,946 86,560,694 RGD:1624291
G Nsdhl NAD(P) dependent steroid dehydrogenase-like JBrowse link X 152,933,118 152,964,399 RGD:1600115
G Pmvk phosphomevalonate kinase JBrowse link 2 188,784,329 188,793,890 RGD:8553625
RGD:13792537
RGD:1624291
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 JBrowse link 2 54,857,688 54,893,404 RGD:1600115
G Prkaa2 protein kinase AMP-activated catalytic subunit alpha 2 JBrowse link 5 124,568,845 124,642,569 RGD:1600115
G Tm7sf2 transmembrane 7 superfamily member 2 JBrowse link 1 221,426,017 221,430,340 RGD:13825441
RGD:1624291
cholesterol biosynthetic process via 24,25-dihydrolanosterol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp51 cytochrome P450, family 51 JBrowse link 4 27,175,564 27,194,018 RGD:2316902
cholesterol biosynthetic process via lathosterol term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sc5d sterol-C5-desaturase JBrowse link 8 46,525,406 46,537,014 RGD:2316911
RGD:13792537
negative regulation of cholesterol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:1624291
RGD:1600115
RGD:10059686
G Erlin1 ER lipid raft associated 1 JBrowse link 1 263,810,439 263,845,762 RGD:1624291
G Erlin2 ER lipid raft associated 2 JBrowse link 16 69,179,005 69,195,452 RGD:1624291
G Idi2 isopentenyl-diphosphate delta isomerase 2 JBrowse link 17 63,107,152 63,107,469 RGD:1624291
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:1624291
RGD:1600115
positive regulation of cholesterol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcg1 ATP binding cassette subfamily G member 1 JBrowse link 20 9,743,269 9,842,735 RGD:1624291
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 JBrowse link 5 19,358,734 19,368,431 RGD:13792517
G Fdps farnesyl diphosphate synthase JBrowse link 2 188,403,595 188,413,219 RGD:2316295
G Fgf1 fibroblast growth factor 1 JBrowse link 18 32,273,830 32,359,831 RGD:1624291
RGD:1600115
G Por cytochrome p450 oxidoreductase JBrowse link 12 23,998,411 24,017,063 RGD:2316785
G Scap SREBF chaperone JBrowse link 8 118,551,869 118,628,650 RGD:1624291
G Scp2 sterol carrier protein 2 JBrowse link 5 127,647,934 127,735,703 RGD:9850260
G Sec14l2 SEC14-like lipid binding 2 JBrowse link 14 84,335,594 84,360,354 RGD:727312
G Srebf1 sterol regulatory element binding transcription factor 1 JBrowse link 10 46,570,996 46,593,021 RGD:1624291
RGD:1600115
G Srebf2 sterol regulatory element binding transcription factor 2 JBrowse link 7 123,381,082 123,438,605 RGD:1624291
RGD:1600115
regulation of cholesterol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca2 ATP binding cassette subfamily A member 2 JBrowse link 3 2,648,787 2,668,770 RGD:1624291
G Apob apolipoprotein B JBrowse link 6 33,176,826 33,216,381 RGD:1624291
G Cyp51 cytochrome P450, family 51 JBrowse link 4 27,175,564 27,194,018 RGD:1298863
G Dhcr7 7-dehydrocholesterol reductase JBrowse link 1 217,018,916 217,034,890 RGD:632010
G Lpcat3 lysophosphatidylcholine acyltransferase 3 JBrowse link 4 157,181,722 157,222,997 RGD:1600115
RGD:1624291
G Mvk mevalonate kinase JBrowse link 12 47,904,266 47,920,457 RGD:728935
G Pex2 peroxisomal biogenesis factor 2 JBrowse link 2 98,251,756 98,269,185 RGD:1624291
G Scap SREBF chaperone JBrowse link 8 118,551,869 118,628,650 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19676
    metabolic process 11952
      small molecule metabolic process 1833
        alcohol metabolic process 350
          secondary alcohol metabolic process 141
            secondary alcohol biosynthetic process 52
              cholesterol biosynthetic process 52
                cholesterol biosynthetic process via 24,25-dihydrolanosterol 1
                cholesterol biosynthetic process via desmosterol 0
                cholesterol biosynthetic process via lathosterol 1
                negative regulation of cholesterol biosynthetic process 5
                positive regulation of cholesterol biosynthetic process 10
                regulation of cholesterol biosynthetic process + 22
Path 2
Term Annotations click to browse term
  biological_process 19676
    metabolic process 11952
      primary metabolic process 10613
        lipid metabolic process 1361
          steroid metabolic process 313
            sterol metabolic process 137
              cholesterol metabolic process 128
                cholesterol biosynthetic process 52
                  cholesterol biosynthetic process via 24,25-dihydrolanosterol 1
                  cholesterol biosynthetic process via desmosterol 0
                  cholesterol biosynthetic process via lathosterol 1
                  negative regulation of cholesterol biosynthetic process 5
                  positive regulation of cholesterol biosynthetic process 10
                  regulation of cholesterol biosynthetic process + 22
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.