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ONTOLOGY REPORT - ANNOTATIONS


Term:glucocorticoid biosynthetic process
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Accession:GO:0006704 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol.
Synonyms:exact_synonym: glucocorticoid anabolism;   glucocorticoid biosynthesis;   glucocorticoid formation;   glucocorticoid synthesis


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glucocorticoid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:1624291
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:13792537
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:4891164
RGD:13792537
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:727991
RGD:13792537
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 JBrowse link 7 116,155,928 116,161,781 RGD:1624291
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:1624291
RGD:1600115
G Cyp21a1 cytochrome P450, family 21, subfamily a, polypeptide 1 JBrowse link 20 4,486,213 4,489,358 RGD:13792537
G Hsd11b1 hydroxysteroid 11-beta dehydrogenase 1 JBrowse link 13 111,946,626 111,996,536 RGD:1625060
cortisol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cacna1h calcium voltage-gated channel subunit alpha1 H JBrowse link 10 14,730,932 14,789,201 RGD:4891166
RGD:1600115
RGD:1624291
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:4891166
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:1624291
G Cyp11b3 cytochrome P450, family 11, subfamily b, polypeptide 3 JBrowse link 7 116,155,928 116,161,781 RGD:1624291
negative regulation of cortisol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bmp2 bone morphogenetic protein 2 JBrowse link 3 126,335,963 126,346,771 RGD:1624291
RGD:1600115
G Bmp5 bone morphogenetic protein 5 JBrowse link 8 82,669,466 82,950,273 RGD:1624291
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 JBrowse link 1 176,940,424 176,983,076 RGD:1624291
G Rest RE1-silencing transcription factor JBrowse link 14 33,131,985 33,152,019 RGD:4891166
RGD:1624291
RGD:1600115
negative regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 JBrowse link 2 204,003,742 204,032,023 RGD:1624291
positive regulation of cortisol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Wnt4 Wnt family member 4 JBrowse link 5 155,649,238 155,668,065 RGD:1600115
RGD:1624291
regulation of cortisol biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Dgkq diacylglycerol kinase, theta JBrowse link 14 2,069,409 2,083,370 RGD:1624291
G H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) JBrowse link 5 166,994,683 167,030,441 RGD:1624291
regulation of glucocorticoid biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nr3c1 nuclear receptor subfamily 3, group C, member 1 JBrowse link 18 31,728,373 32,704,022 RGD:1624291

Term paths to the root
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Term Annotations click to browse term
  biological_process 19578
    metabolic process 11901
      primary metabolic process 10563
        lipid metabolic process 1343
          steroid metabolic process 310
            steroid biosynthetic process 163
              glucocorticoid biosynthetic process 18
                cortisol biosynthetic process + 11
                negative regulation of glucocorticoid biosynthetic process + 5
                positive regulation of glucocorticoid biosynthetic process + 1
                regulation of glucocorticoid biosynthetic process + 9
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.