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ONTOLOGY REPORT - ANNOTATIONS


Term:cholesterol catabolic process
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Accession:GO:0006707 term browser browse the term
Definition:The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.
Synonyms:exact_synonym: cholesterol breakdown;   cholesterol catabolism;   cholesterol degradation


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cholesterol catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1d1 aldo-keto reductase family 1, member D1 IEA
ISO
GO_REF:0000107
(PMID:7508385)
Ensembl
RGD
PMID:7508385 GO_REF:0000107 NCBI chr 4:65,110,706...65,143,930
Ensembl chr 4:65,110,746...65,143,941
JBrowse link
G Apoe apolipoprotein E IBA
ISO
PMID:21873635
(MGI:1314982|PMID:9826706)
RGD PMID:9826706, PMID:21873635 MGI:1314982, RGD:13792537 NCBI chr 1:80,612,894...80,616,820
Ensembl chr 1:80,612,895...80,617,057
JBrowse link
G Cel carboxyl ester lipase ISO (PMID:12031288) RGD PMID:12031288 NCBI chr 3:7,134,021...7,141,522
Ensembl chr 3:7,134,021...7,141,522
JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 ISS
IEA
ISO
GO_REF:0000024
GO_REF:0000041
(PMID:9660774)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:9660774 GO_REF:0000024, GO_REF:0000041, GO_REF:0000107 NCBI chr 9:81,968,285...81,998,213
Ensembl chr 9:81,968,332...81,998,169
JBrowse link
G Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 ISO (MGI:1859119|PMID:10748047) RGD PMID:10748047 MGI:1859119 NCBI chr 9:19,804,079...19,880,346
Ensembl chr 9:19,804,079...19,880,346
JBrowse link
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 IBA
ISO
PMID:21873635
(MGI:1339884|PMID:10377398), (MGI:6393037|PMID:20193040)
(PMID:14640697), (PMID:18621681), (PMID:25017465)
RGD PMID:10377398, PMID:14640697, PMID:18621681, PMID:20193040, PMID:25017465, PMID:21873635 MGI:1339884, MGI:6393037, RGD:13792537 NCBI chr 6:132,242,328...132,273,788
Ensembl chr 6:132,242,328...132,273,787
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 IDA
ISO
IEA
PMID:1694852
(MGI:1933035|PMID:11279518), (MGI:3603484|PMID:15845870)
GO_REF:0000041
RGD
UniProt
PMID:11279518, PMID:15845870, PMID:1694852 GO_REF:0000041, MGI:1933035, MGI:3603484, RGD:70534 NCBI chr 5:19,358,734...19,368,431
Ensembl chr 5:19,358,734...19,368,431
JBrowse link
G Hsd3b7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 IDA RGD PMID:16081591 RGD:1599972 NCBI chr 1:199,248,084...199,251,745
Ensembl chr 1:199,248,470...199,251,740
JBrowse link
G Mt3 metallothionein 3 ISS
ISO
GO_REF:0000024
(MGI:4881636|PMID:20544854)
UniProt
RGD
PMID:20544854 GO_REF:0000024, MGI:4881636 NCBI chr19:11,324,708...11,326,112
Ensembl chr19:11,324,698...11,326,139
JBrowse link
G Scarb1 scavenger receptor class B, member 1 ISO MGI:1928989 (MGI:1934548|PMID:11278646), (MGI:3690692|PMID:10559220) RGD PMID:10559220, PMID:11278646 MGI:1934548, MGI:3690692 NCBI chr12:36,694,952...36,761,445
Ensembl chr12:36,694,960...36,761,455
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      small molecule metabolic process 1798
        alcohol metabolic process 355
          alcohol catabolic process 57
            cholesterol catabolic process 10
Path 2
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      primary metabolic process 10900
        lipid metabolic process 1373
          steroid metabolic process 324
            sterol metabolic process 146
              cholesterol metabolic process 138
                cholesterol catabolic process 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.