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ONTOLOGY REPORT - ANNOTATIONS


Term:glutathione metabolic process
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Accession:GO:0006749 term browser browse the term
Definition:The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
Synonyms:exact_synonym: glutathione metabolism
 narrow_synonym: oxidized glutathione reduction


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glutathione metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARL6IP5 ADP ribosylation factor like GTPase 6 interacting protein 5 ISO (MGI:MGI:3822097|PMID:18799673)
(MGI:MGI:5315235|PMID:22210510)
MGI PMID:18799673, PMID:22210510 MGI:MGI:3822097, MGI:MGI:5315235 NCBI chr 3:69,020,908...69,042,065
Ensembl chr 3:70,387,581...70,408,909
JBrowse link
G CTH cystathionine gamma-lyase ISO RGD PMID:15683713 RGD:1600763 NCBI chr 1:69,646,608...69,674,301
Ensembl chr 1:71,629,333...71,677,666
JBrowse link
G CTNS cystinosin, lysosomal cystine transporter ISO (PMID:15956064) UniProtKB PMID:15956064 NCBI chr17:3,686,903...3,711,857
Ensembl chr17:3,683,575...3,708,253
JBrowse link
G ETHE1 ETHE1 persulfide dioxygenase ISO (PMID:23144459) UniProtKB PMID:23144459 NCBI chr19:40,447,367...40,469,037 JBrowse link
G G6PD glucose-6-phosphate dehydrogenase ISO (PMID:17516514), (PMID:2420826)
(MGI:MGI:2449252|PMID:12521604)
BHF-UCL
MGI
PMID:2420826, PMID:12521604, PMID:17516514 MGI:MGI:2449252 NCBI chr  X:143,972,798...143,988,960
Ensembl chr  X:153,843,092...153,860,674
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit ISO (MGI:MGI:1928560|PMID:11118286) MGI PMID:11118286 MGI:MGI:1928560 NCBI chr 6:53,052,145...53,102,794
Ensembl chr 6:54,687,315...54,734,994
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit ISO (MGI:MGI:2447526|PMID:12384496) MGI PMID:12384496 MGI:MGI:2447526 NCBI chr 1:96,548,850...96,573,273
Ensembl chr 1:95,278,665...95,297,893
JBrowse link
G GLO1 glyoxalase I ISO RGD PMID:8719777, PMID:8903102 RGD:1641958, RGD:1641959 NCBI chr 6:38,247,881...38,275,098
Ensembl chr 6:39,434,746...39,461,971
JBrowse link
G GPX1 glutathione peroxidase 1 ISO (PMID:12829378) RGD
BHF-UCL
PMID:12829378, PMID:16140890 RGD:1624364 NCBI chr 3:49,280,038...49,281,455
Ensembl chr 3:50,360,947...50,361,826
JBrowse link
G GPX3 glutathione peroxidase 3 ISO RGD PMID:16140890 RGD:1624364 NCBI chr 5:146,447,939...146,456,476 JBrowse link
G GPX4 glutathione peroxidase 4 ISO RGD PMID:16140890 RGD:1624364 NCBI chr19:20,904...23,828 JBrowse link
G GSR glutathione-disulfide reductase ISO RGD PMID:237922 RGD:1625133 NCBI chr 8:29,990,543...30,040,157
Ensembl chr 8:27,180,300...27,229,557
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 ISO (PMID:10329152) UniProtKB PMID:10329152 NCBI chr 6:52,532,942...52,550,404
Ensembl chr 6:54,171,318...54,188,976
JBrowse link
G GSTK1 glutathione S-transferase kappa 1 ISO (MGI:MGI:2668784|PMID:12720545) MGI PMID:12720545 MGI:MGI:2668784 NCBI chr 7:135,258,184...135,267,254
Ensembl chr 7:147,749,461...147,755,158
JBrowse link
G GSTM1 glutathione S-transferase mu 1 ISO PMID:10229687
(PMID:8373352)
UniProt
BHF-UCL
RGD
PMID:8373352, PMID:10229687, PMID:12027896 RGD:2302181, RGD:70307 Ensembl chr 1:127,979,238...128,010,411 JBrowse link
G GSTM2 glutathione S-transferase mu 2 ISO (PMID:16549767), (PMID:2034681), (PMID:8373352) UniProtKB
RGD
PMID:2034681, PMID:8373352, PMID:12027896, PMID:16549767 RGD:2302181 NCBI chr 1:112,043,201...112,050,810 JBrowse link
G GSTM3 glutathione S-transferase mu 3 ISO (PMID:10587441), (PMID:8373352) UniProtKB PMID:8373352, PMID:10587441 NCBI chr 1:112,380,890...112,384,988
Ensembl chr 1:127,957,008...127,960,578
JBrowse link
G GSTM4 glutathione S-transferase mu 4 ISO (PMID:8373352) BHF-UCL PMID:8373352 NCBI chr 1:112,033,462...112,337,606
Ensembl chr 1:111,261,585...111,270,919
JBrowse link
G GSTM5 glutathione S-transferase mu 5 ISO (PMID:10587441) UniProtKB PMID:10587441 NCBI chr 1:112,356,184...112,361,731
Ensembl chr 1:127,979,238...128,010,411
JBrowse link
G GSTP1 glutathione S-transferase pi 1 ISO (PMID:1540159)
(MGI:MGI:69635|PMID:7982937)
UniProtKB
MGI
PMID:1540159, PMID:7982937 MGI:MGI:69635 NCBI chr11:62,942,756...62,945,701
Ensembl chr11:66,253,421...66,256,472
JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 ISO (PMID:10739172) UniProtKB PMID:10739172 NCBI chr14:57,874,184...57,901,397
Ensembl chr14:77,075,814...77,086,530
JBrowse link
G HAGH hydroxyacylglutathione hydrolase ISO RGD PMID:8719777, PMID:8903102 RGD:1641958, RGD:1641959 NCBI chr16:431,417...455,211 JBrowse link
G HMGN5 high mobility group nucleosome binding domain 5 ISO (MGI:MGI:5578301|PMID:24392144) MGI PMID:24392144 MGI:MGI:5578301 NCBI chr  X:70,180,585...70,268,545 JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 ISO (MGI:MGI:2389531|PMID:12031902) MGI PMID:12031902 MGI:MGI:2389531 NCBI chr2B:95,475,320...95,494,286
Ensembl chr2B:213,599,036...213,617,175
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 ISO (MGI:MGI:1855828|PMID:10767383) MGI PMID:10767383 MGI:MGI:1855828 NCBI chr12:16,347,737...16,383,776
Ensembl chr12:16,743,739...16,773,290
JBrowse link
G MMACHC metabolism of cobalamin associated C ISO (PMID:19801555), (PMID:22642810) UniProtKB PMID:19801555, PMID:22642810 NCBI chr 1:44,802,724...44,811,893
Ensembl chr 1:46,160,364...46,171,662
JBrowse link
G NAT8 N-acetyltransferase 8 (putative) ISO (PMID:20392701) UniProtKB PMID:20392701 NCBI chr2A:73,702,173...73,703,763
Ensembl chr2A:75,189,726...75,190,409
JBrowse link
G NFE2L1 nuclear factor, erythroid 2 like 1 ISO (MGI:MGI:5662039|PMID:25092871) MGI PMID:25092871 MGI:MGI:5662039 NCBI chr17:9,476,482...9,489,661
Ensembl chr17:9,657,847...9,671,040
JBrowse link
G SLC1A1 solute carrier family 1 member 1 ISO (MGI:MGI:3822097|PMID:18799673)
(MGI:MGI:5465271|PMID:22732503)
MGI PMID:18799673, PMID:22732503 MGI:MGI:3822097, MGI:MGI:5465271 NCBI chr 9:4,323,124...4,420,193
Ensembl chr 9:4,511,491...4,608,337
JBrowse link
G SLC7A11 solute carrier family 7 member 11 ISO (MGI:MGI:3710059|PMID:17200146), (MGI:MGI:5469541|PMID:23085521) MGI PMID:17200146, PMID:23085521 MGI:MGI:3710059, MGI:MGI:5469541 NCBI chr 4:130,529,677...130,601,396
Ensembl chr 4:141,849,343...141,959,849
JBrowse link
G SOD1 superoxide dismutase 1 ISO (MGI:MGI:3640408|PMID:16377630) MGI PMID:16377630 MGI:MGI:3640408 NCBI chr21:18,029,831...18,037,526 JBrowse link
G SOD2 superoxide dismutase 2 ISO (MGI:MGI:1332377|PMID:10049502) MGI PMID:10049502 MGI:MGI:1332377 NCBI chr 6:157,562,814...157,610,155
Ensembl chr 6:162,576,082...162,589,960
JBrowse link
G TXNRD3 thioredoxin reductase 3 ISO (MGI:MGI:2386187|PMID:11259642) MGI PMID:11259642 MGI:MGI:2386187 NCBI chr 3:123,644,679...123,697,563
Ensembl chr 3:130,967,026...131,013,667
JBrowse link
glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCLC glutamate-cysteine ligase catalytic subunit ISO (MGI:MGI:3607629|PMID:16081425)
(MGI:MGI:1858542|PMID:10805773)
(PMID:12663448)
(PMID:10395918), (PMID:8104187), (PMID:9675072)
MGI
RGD
UniProtKB
UniProt
PMID:8104187, PMID:9675072, PMID:10395918, PMID:10805773, PMID:12663448, PMID:16081425, PMID:16183645 MGI:MGI:1858542, MGI:MGI:3607629, RGD:1582661 NCBI chr 6:53,052,145...53,102,794
Ensembl chr 6:54,687,315...54,734,994
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit ISO (PMID:12081989)
(MGI:MGI:3607629|PMID:16081425)
(PMID:10395918), (PMID:9675072)
RGD
UniProtKB
MGI
UniProt
PMID:9675072, PMID:10395918, PMID:12081989, PMID:16081425, PMID:16183645 MGI:MGI:3607629, RGD:1582661 NCBI chr 1:96,548,850...96,573,273
Ensembl chr 1:95,278,665...95,297,893
JBrowse link
G GGT1 gamma-glutamyltransferase 1 ISO (MGI:MGI:5294309|PMID:12468440) UniProtKB PMID:12468440 MGI:MGI:5294309 NCBI chr22:5,424,334...5,469,705 JBrowse link
G GSS glutathione synthetase ISO RGD PMID:10964706 RGD:1599340 NCBI chr20:31,256,734...31,284,356
Ensembl chr20:32,381,745...32,409,297
JBrowse link
G HAGH hydroxyacylglutathione hydrolase ISO (PMID:8550579) UniProtKB PMID:8550579 NCBI chr16:431,417...455,211 JBrowse link
G MGST2 microsomal glutathione S-transferase 2 ISO (PMID:8703034) UniProtKB PMID:8703034 NCBI chr 4:132,031,087...132,106,864
Ensembl chr 4:143,338,016...143,412,966
JBrowse link
glutathione catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G DPEP1 dipeptidase 1 ISO (MGI:MGI:1203838|PMID:9560193) UniProt PMID:9560193 MGI:MGI:1203838 NCBI chr16:70,365,900...70,392,377
Ensembl chr16:89,975,105...89,997,978
JBrowse link
G GGT1 gamma-glutamyltransferase 1 ISO (PMID:17924658), (PMID:21447318) UniProtKB PMID:17924658, PMID:21447318 NCBI chr22:5,424,334...5,469,705 JBrowse link
G GGT5 gamma-glutamyltransferase 5 ISO (PMID:1676842), (PMID:21447318) BHF-UCL PMID:1676842, PMID:21447318 NCBI chr22:5,025,740...5,053,074
Ensembl chr22:23,110,780...23,125,632
JBrowse link
glutathione deglycation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase ISO (PMID:25416785) ParkinsonsUK-UCL PMID:25416785 NCBI chr 1:6,722,260...6,745,915
Ensembl chr 1:7,969,280...7,993,271
JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:MGI:5616326 NCBI chr2A:87,688,732...87,759,580
Ensembl chr2A:89,596,833...89,667,468
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 ISO (MGI:MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:MGI:5616326 NCBI chr2B:64,509,446...64,544,600
Ensembl chr2B:182,214,116...182,248,085
JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC7A11 solute carrier family 7 member 11 ISO (MGI:MGI:3588610|PMID:16037214) MGI PMID:16037214 MGI:MGI:3588610 NCBI chr 4:130,529,677...130,601,396
Ensembl chr 4:141,849,343...141,959,849
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12561
    metabolic process 7977
      cellular metabolic process 7333
        cellular modified amino acid metabolic process 139
          glutathione metabolic process 41
            ascorbate glutathione cycle 0
            glutathione biosynthetic process + 9
            glutathione catabolic process 3
            glutathione deglycation 1
Path 2
Term Annotations click to browse term
  biological_process 12561
    cellular process 11665
      cellular metabolic process 7333
        cellular nitrogen compound metabolic process 4233
          cellular amide metabolic process 696
            peptide metabolic process 490
              glutathione metabolic process 41
                ascorbate glutathione cycle 0
                glutathione biosynthetic process + 9
                glutathione catabolic process 3
                glutathione deglycation 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.