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ONTOLOGY REPORT - ANNOTATIONS


Term:glutathione metabolic process
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Accession:GO:0006749 term browser browse the term
Definition:The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
Synonyms:exact_synonym: glutathione metabolism
 narrow_synonym: oxidized glutathione reduction


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glutathione metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arl6ip5 ADP ribosylation factor like GTPase 6 interacting protein 5 ISO (MGI:MGI:3822097|PMID:18799673)
(MGI:MGI:5315235|PMID:22210510)
MGI PMID:18799673, PMID:22210510 MGI:MGI:3822097, MGI:MGI:5315235 NCBI chrNW_004955421:18,747,729...18,766,559
Ensembl chrNW_004955421:18,747,729...18,766,408
JBrowse link
G Cth cystathionine gamma-lyase ISO RGD PMID:15683713 RGD:1600763 NCBI chrNW_004955423:21,542,587...21,567,935
Ensembl chrNW_004955423:21,542,179...21,567,786
JBrowse link
G Ctns cystinosin, lysosomal cystine transporter ISO (PMID:15956064) UniProtKB PMID:15956064 NCBI chrNW_004955467:13,151,663...13,169,005
Ensembl chrNW_004955467:13,151,957...13,168,696
JBrowse link
G Ethe1 ETHE1 persulfide dioxygenase ISO (PMID:23144459) UniProtKB PMID:23144459 NCBI chrNW_004955555:1,262,860...1,279,714
Ensembl chrNW_004955555:1,262,802...1,279,714
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase ISO (PMID:17516514), (PMID:2420826)
(MGI:MGI:2449252|PMID:12521604)
BHF-UCL
MGI
PMID:2420826, PMID:12521604, PMID:17516514 MGI:MGI:2449252 NCBI chrNW_004955580:1,045,294...1,058,129
Ensembl chrNW_004955580:1,045,294...1,057,083
JBrowse link
G Gclc glutamate-cysteine ligase catalytic subunit ISO (MGI:MGI:1928560|PMID:11118286) MGI PMID:11118286 MGI:MGI:1928560 NCBI chrNW_004955411:2,593,523...2,617,553
Ensembl chrNW_004955411:2,593,541...2,616,539
JBrowse link
G Gclm glutamate-cysteine ligase modifier subunit ISO (MGI:MGI:2447526|PMID:12384496) MGI PMID:12384496 MGI:MGI:2447526 NCBI chrNW_004955423:782,468...805,384
Ensembl chrNW_004955423:782,468...805,384
JBrowse link
G Glo1 glyoxalase I ISO RGD PMID:8719777, PMID:8903102 RGD:1641958, RGD:1641959 NCBI chrNW_004955437:4,728,709...4,749,834
Ensembl chrNW_004955437:4,728,709...4,749,834
JBrowse link
G Gpx1 glutathione peroxidase 1 ISO (PMID:12829378) BHF-UCL
RGD
PMID:12829378, PMID:16140890 RGD:1624364 NCBI chrNW_004955532:1,298,336...1,298,830 JBrowse link
G Gpx3 glutathione peroxidase 3 ISO RGD PMID:16140890 RGD:1624364 NCBI chrNW_004955408:2,622,162...2,629,088
Ensembl chrNW_004955408:2,622,741...2,629,032
JBrowse link
G Gpx4 glutathione peroxidase 4 ISO RGD PMID:16140890 RGD:1624364 NCBI chrNW_004955495:6,767,969...6,772,256
Ensembl chrNW_004955495:6,767,975...6,772,178
JBrowse link
G Gsr glutathione-disulfide reductase ISO RGD PMID:237922 RGD:1625133 NCBI chrNW_004955463:7,130,459...7,153,631
Ensembl chrNW_004955463:7,131,364...7,153,583
JBrowse link
G Gstk1 glutathione S-transferase kappa 1 ISO (MGI:MGI:2668784|PMID:12720545) MGI PMID:12720545 MGI:MGI:2668784 NCBI chrNW_004955494:383,107...387,483
Ensembl chrNW_004955494:383,341...387,630
JBrowse link
G Gstm3 glutathione S-transferase mu 3 ISO (PMID:10587441), (PMID:8373352) UniProtKB PMID:8373352, PMID:10587441 NCBI chrNW_004955435:13,253,947...13,256,965
Ensembl chrNW_004955435:13,253,947...13,256,965
JBrowse link
G Gstm4 glutathione S-transferase mu 4 ISO (PMID:8373352) BHF-UCL PMID:8373352 NCBI chrNW_004955435:13,064,691...13,069,734
Ensembl chrNW_004955435:13,063,966...13,210,264
JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO (PMID:1540159)
(MGI:MGI:69635|PMID:7982937)
UniProtKB
MGI
PMID:1540159, PMID:7982937 MGI:MGI:69635 NCBI chrNW_004955422:17,914,228...17,916,918
Ensembl chrNW_004955422:17,914,305...17,917,428
JBrowse link
G Gstz1 glutathione S-transferase zeta 1 ISO (PMID:10739172) UniProtKB PMID:10739172 NCBI chrNW_004955438:1,218,990...1,231,407
Ensembl chrNW_004955438:1,219,018...1,231,287
JBrowse link
G Hagh hydroxyacylglutathione hydrolase ISO RGD PMID:8719777, PMID:8903102 RGD:1641958, RGD:1641959 NCBI chrNW_004955442:15,451,910...15,465,211
Ensembl chrNW_004955442:15,451,910...15,465,211
JBrowse link
G Hbb hemoglobin subunit beta ISO RGD PMID:19963409 RGD:2325281 NCBI chrNW_004955414:21,188,012...21,189,363 JBrowse link
G Hmgn5 high mobility group nucleosome binding domain 5 ISO (MGI:MGI:5578301|PMID:24392144) MGI PMID:24392144 MGI:MGI:5578301 NCBI chrNW_004955529:1,118,706...1,125,596 JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 ISO (MGI:MGI:2389531|PMID:12031902) MGI PMID:12031902 MGI:MGI:2389531 NCBI chrNW_004955457:6,851,542...6,869,452
Ensembl chrNW_004955457:6,851,517...6,872,367
JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 ISO (MGI:MGI:1855828|PMID:10767383) MGI PMID:10767383 MGI:MGI:1855828 NCBI chrNW_004955413:12,989,935...13,005,203
Ensembl chrNW_004955413:12,989,935...13,007,761
JBrowse link
G Mmachc metabolism of cobalamin associated C ISO (PMID:19801555), (PMID:22642810) UniProtKB PMID:19801555, PMID:22642810 NCBI chrNW_004955464:12,774,018...12,780,612
Ensembl chrNW_004955464:12,772,420...12,780,612
JBrowse link
G Nfe2l1 nuclear factor, erythroid 2 like 1 ISO (MGI:MGI:5662039|PMID:25092871) MGI PMID:25092871 MGI:MGI:5662039 NCBI chrNW_004955451:13,088,680...13,099,839
Ensembl chrNW_004955451:13,088,906...13,099,839
JBrowse link
G Slc1a1 solute carrier family 1 member 1 ISO (MGI:MGI:3822097|PMID:18799673)
(MGI:MGI:5465271|PMID:22732503)
MGI PMID:18799673, PMID:22732503 MGI:MGI:3822097, MGI:MGI:5465271 NCBI chrNW_004955434:8,790,685...8,879,757
Ensembl chrNW_004955434:8,790,685...8,879,757
JBrowse link
G Slc7a11 solute carrier family 7 member 11 ISO (MGI:MGI:3710059|PMID:17200146), (MGI:MGI:5469541|PMID:23085521) MGI PMID:17200146, PMID:23085521 MGI:MGI:3710059, MGI:MGI:5469541 NCBI chrNW_004955428:5,238,460...5,309,085
Ensembl chrNW_004955428:5,237,865...5,309,085
JBrowse link
G Sod1 superoxide dismutase 1 ISO (MGI:MGI:3640408|PMID:16377630) MGI PMID:16377630 MGI:MGI:3640408 NCBI chrNW_004955407:31,261,451...31,267,657
Ensembl chrNW_004955407:31,263,863...31,267,727
JBrowse link
G Sod2 superoxide dismutase 2 ISO (MGI:MGI:1332377|PMID:10049502) MGI PMID:10049502 MGI:MGI:1332377 NCBI chrNW_004955439:21,209,101...21,223,538
Ensembl chrNW_004955439:21,209,101...21,224,163
JBrowse link
G Txnrd3 thioredoxin reductase 3 ISO (MGI:MGI:2386187|PMID:11259642) MGI PMID:11259642 MGI:MGI:2386187 NCBI chrNW_004955429:16,845,466...16,880,481
Ensembl chrNW_004955429:16,845,526...16,879,797
JBrowse link
glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase catalytic subunit ISO (PMID:12663448)
(MGI:MGI:1858542|PMID:10805773)
(MGI:MGI:3607629|PMID:16081425)
(PMID:10395918), (PMID:8104187), (PMID:9675072)
UniProtKB
MGI
RGD
UniProt
PMID:8104187, PMID:9675072, PMID:10395918, PMID:10805773, PMID:12663448, PMID:16081425, PMID:16183645 MGI:MGI:1858542, MGI:MGI:3607629, RGD:1582661 NCBI chrNW_004955411:2,593,523...2,617,553
Ensembl chrNW_004955411:2,593,541...2,616,539
JBrowse link
G Gclm glutamate-cysteine ligase modifier subunit ISO (MGI:MGI:3607629|PMID:16081425)
(PMID:12081989)
(PMID:10395918), (PMID:9675072)
RGD
MGI
UniProtKB
UniProt
PMID:9675072, PMID:10395918, PMID:12081989, PMID:16081425, PMID:16183645 MGI:MGI:3607629, RGD:1582661 NCBI chrNW_004955423:782,468...805,384
Ensembl chrNW_004955423:782,468...805,384
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO (MGI:MGI:5294309|PMID:12468440) UniProtKB PMID:12468440 MGI:MGI:5294309 NCBI chrNW_004955455:8,082,578...8,099,523 JBrowse link
G Gss glutathione synthetase ISO RGD PMID:10964706 RGD:1599340 NCBI chrNW_004955422:26,427,581...26,483,380
Ensembl chrNW_004955422:26,427,581...26,463,781
JBrowse link
G Hagh hydroxyacylglutathione hydrolase ISO (PMID:8550579) UniProtKB PMID:8550579 NCBI chrNW_004955442:15,451,910...15,465,211
Ensembl chrNW_004955442:15,451,910...15,465,211
JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 ISO (PMID:8703034) UniProtKB PMID:8703034 NCBI chrNW_004955428:4,006,054...4,049,497
Ensembl chrNW_004955428:4,014,810...4,037,901
JBrowse link
glutathione catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpep1 dipeptidase 1 ISO (MGI:MGI:1203838|PMID:9560193) UniProt PMID:9560193 MGI:MGI:1203838 NCBI chrNW_004955541:3,204,421...3,215,514
Ensembl chrNW_004955541:3,204,055...3,215,565
JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO (PMID:17924658), (PMID:21447318) UniProtKB PMID:17924658, PMID:21447318 NCBI chrNW_004955455:8,082,578...8,099,523 JBrowse link
G Ggt5 gamma-glutamyltransferase 5 ISO (PMID:1676842), (PMID:21447318) BHF-UCL PMID:1676842, PMID:21447318 NCBI chrNW_004955455:8,101,251...8,125,597
Ensembl chrNW_004955455:8,102,499...8,125,966
JBrowse link
glutathione deglycation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase ISO (PMID:25416785) ParkinsonsUK-UCL PMID:25416785 NCBI chrNW_004955486:4,974,130...4,985,927
Ensembl chrNW_004955486:4,969,497...4,985,885
JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:MGI:5616326 NCBI chrNW_004955424:210,867...279,267
Ensembl chrNW_004955424:226,038...280,593
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2 like 2 ISO (MGI:MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:MGI:5616326 NCBI chrNW_004955403:19,510,122...19,536,428
Ensembl chrNW_004955403:19,532,103...19,535,944
JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc7a11 solute carrier family 7 member 11 ISO (MGI:MGI:3588610|PMID:16037214) MGI PMID:16037214 MGI:MGI:3588610 NCBI chrNW_004955428:5,238,460...5,309,085
Ensembl chrNW_004955428:5,237,865...5,309,085
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11889
    metabolic process 7609
      cellular metabolic process 7027
        cellular modified amino acid metabolic process 127
          glutathione metabolic process 37
            ascorbate glutathione cycle 0
            glutathione biosynthetic process + 9
            glutathione catabolic process 3
            glutathione deglycation 1
Path 2
Term Annotations click to browse term
  biological_process 11889
    cellular process 11094
      cellular metabolic process 7027
        cellular nitrogen compound metabolic process 4064
          cellular amide metabolic process 668
            peptide metabolic process 474
              glutathione metabolic process 37
                ascorbate glutathione cycle 0
                glutathione biosynthetic process + 9
                glutathione catabolic process 3
                glutathione deglycation 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.