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ONTOLOGY REPORT - ANNOTATIONS


Term:glutathione metabolic process
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Accession:GO:0006749 term browser browse the term
Definition:The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
Synonyms:exact_synonym: glutathione metabolism
 narrow_synonym: oxidized glutathione reduction


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glutathione metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARL6IP5 ADP ribosylation factor like GTPase 6 interacting protein 5 ISO (MGI:MGI:3822097|PMID:18799673)
(MGI:MGI:5315235|PMID:22210510)
MGI PMID:18799673, PMID:22210510 MGI:MGI:3822097, MGI:MGI:5315235 NCBI chr20:22,632,613...22,653,894
Ensembl chr20:22,633,808...22,653,870
JBrowse link
G CTH cystathionine gamma-lyase ISO RGD PMID:15683713 RGD:1600763 NCBI chr 6:75,324,328...75,348,476
Ensembl chr 6:75,324,787...75,349,451
JBrowse link
G CTNS cystinosin, lysosomal cystine transporter IEA Ensembl GO_REF:0000107 NCBI chr 9:47,474,488...47,490,951
Ensembl chr 9:47,473,901...47,490,252
JBrowse link
G ETHE1 ETHE1 persulfide dioxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 1:111,583,690...111,607,420
Ensembl chr 1:111,471,522...111,607,386
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase IEA Ensembl GO_REF:0000107 NCBI chr  X:122,217,317...122,231,862
Ensembl chr  X:122,205,683...122,231,678
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit ISO (MGI:MGI:1928560|PMID:11118286) MGI PMID:11118286 MGI:MGI:1928560 NCBI chr12:20,999,815...21,047,779
Ensembl chr12:21,000,792...21,047,779
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit ISO (MGI:MGI:2447526|PMID:12384496) MGI PMID:12384496 MGI:MGI:2447526 NCBI chr 6:55,204,602...55,244,217 JBrowse link
G GLO1 glyoxalase I ISO RGD PMID:8719777, PMID:8903102 RGD:1641958, RGD:1641959 NCBI chr12:7,584,141...7,609,615
Ensembl chr12:7,585,531...7,609,550
JBrowse link
G GPX1 glutathione peroxidase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr20:39,889,165...39,890,253
Ensembl chr20:39,889,174...39,890,260
JBrowse link
G GPX3 glutathione peroxidase 3 ISO RGD PMID:16140890 RGD:1624364 NCBI chr 4:58,200,671...58,209,010
Ensembl chr 4:58,200,672...58,209,010
JBrowse link
G GSR glutathione-disulfide reductase IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr16:33,633,949...33,680,411
Ensembl chr16:33,633,968...33,679,752
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:20,426,724...20,443,200
Ensembl chr12:20,426,726...20,443,200
JBrowse link
G GSTK1 glutathione S-transferase kappa 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr16:6,411,678...6,416,135 JBrowse link
G GSTP1 glutathione S-transferase pi 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:49,905,161...49,908,182
Ensembl chr18:49,905,161...49,908,182
JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:50,133,496...50,143,487
Ensembl chr 8:50,133,714...50,143,439
JBrowse link
G HAGH hydroxyacylglutathione hydrolase ISO RGD PMID:8719777, PMID:8903102 RGD:1641958, RGD:1641959 NCBI chr 6:39,076,364...39,105,646
Ensembl chr 6:39,084,513...39,105,592
JBrowse link
G HPGDS hematopoietic prostaglandin D synthase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr32:17,172,372...17,196,851
Ensembl chr32:17,121,968...17,196,851
JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 IEA Ensembl GO_REF:0000107 NCBI chr37:16,512,027...16,531,269
Ensembl chr37:16,512,770...16,531,219
JBrowse link
G LOC100686488 glutathione S-transferase theta-2B-like IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr26:28,573,435...28,580,846 JBrowse link
G LOC100856518 glutathione S-transferase theta-3-like IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr26:28,526,152...28,532,656 JBrowse link
G LOC474938 glutathione S-transferase A2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:20,349,133...20,365,023 JBrowse link
G LOC476006 glutathione S-transferase P-like IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr18:49,950,873...49,953,856 JBrowse link
G LOC477556 glutathione S-transferase theta-1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr26:28,534,860...28,545,679 JBrowse link
G LOC479911 glutathione S-transferase Mu 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:42,187,869...42,191,274 JBrowse link
G LOC479912 glutathione S-transferase Mu 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:42,201,697...42,207,886 JBrowse link
G LOC480657 glutathione S-transferase pi 1 pseudogene IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 9:47,024,976...47,025,721 JBrowse link
G LOC481841 glutathione S-transferase-like IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:20,319,222...20,338,681 JBrowse link
G LOC609402 hemoglobin subunit beta-like ISO RGD PMID:19963409 RGD:2325281 NCBI chr21:28,187,535...28,188,991 JBrowse link
G LOC610304 glutathione S-transferase A4-like IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr12:20,404,178...20,423,639 JBrowse link
G MGST1 microsomal glutathione S-transferase 1 ISO (MGI:MGI:1855828|PMID:10767383) MGI PMID:10767383 MGI:MGI:1855828 NCBI chr27:30,370,588...30,391,898
Ensembl chr27:30,370,594...30,391,778
JBrowse link
G MMACHC metabolism of cobalamin associated C IEA Ensembl GO_REF:0000107 NCBI chr15:14,857,236...14,863,211
Ensembl chr15:14,857,231...14,863,113
JBrowse link
G NAT8 N-acetyltransferase 8 (putative) ISO (PMID:20392701) UniProtKB PMID:20392701 NCBI chr17:49,285,915...49,288,362 JBrowse link
G NFE2L1 nuclear factor, erythroid 2 like 1 IEA Ensembl GO_REF:0000107 NCBI chr 9:24,344,697...24,356,918
Ensembl chr 9:24,346,585...24,362,646
JBrowse link
G SLC1A1 solute carrier family 1 member 1 ISO (MGI:MGI:3822097|PMID:18799673)
(MGI:MGI:5465271|PMID:22732503)
MGI PMID:18799673, PMID:22732503 MGI:MGI:3822097, MGI:MGI:5465271 NCBI chr 1:92,898,274...92,978,260
Ensembl chr 1:92,898,274...92,978,260
JBrowse link
G SLC7A11 solute carrier family 7 member 11 IEA Ensembl GO_REF:0000107 NCBI chr19:4,289,792...4,379,060
Ensembl chr19:4,289,850...4,389,048
JBrowse link
G SOD1 superoxide dismutase 1 IEA Ensembl GO_REF:0000107 NCBI chr31:26,540,291...26,544,212
Ensembl chr31:26,486,274...26,662,815
JBrowse link
G SOD2 superoxide dismutase 2 ISO (MGI:MGI:1332377|PMID:10049502) MGI PMID:10049502 MGI:MGI:1332377 NCBI chr 1:48,943,472...48,955,158
Ensembl chr 1:48,836,262...48,955,706
JBrowse link
G TXNRD3 thioredoxin reductase 3 ISO (MGI:MGI:2386187|PMID:11259642) MGI PMID:11259642 MGI:MGI:2386187 NCBI chr20:782,653...844,159
Ensembl chr20:782,653...831,351
JBrowse link
glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCLC glutamate-cysteine ligase catalytic subunit IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000041 NCBI chr12:20,999,815...21,047,779
Ensembl chr12:21,000,792...21,047,779
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit ISO (PMID:12081989)
(PMID:10395918), (PMID:9675072)
(MGI:MGI:3607629|PMID:16081425)
UniProtKB
UniProt
MGI
RGD
PMID:9675072, PMID:10395918, PMID:12081989, PMID:16081425, PMID:16183645 MGI:MGI:3607629, RGD:1582661 NCBI chr 6:55,204,602...55,244,217 JBrowse link
G GGT1 gamma-glutamyltransferase 1 IEA Ensembl GO_REF:0000107 NCBI chr26:28,301,455...28,315,029 JBrowse link
G GGT7 gamma-glutamyltransferase 7 IEA UniProt GO_REF:0000041 NCBI chr24:23,900,842...23,924,555
Ensembl chr24:23,901,045...23,997,286
JBrowse link
G GSS glutathione synthetase IEA UniProtKB GO_REF:0000041 NCBI chr24:23,973,807...24,000,281
Ensembl chr24:23,901,045...23,997,286
JBrowse link
G HAGH hydroxyacylglutathione hydrolase ISO (PMID:8550579) UniProtKB PMID:8550579 NCBI chr 6:39,076,364...39,105,646
Ensembl chr 6:39,084,513...39,105,592
JBrowse link
G MGST2 microsomal glutathione S-transferase 2 ISO (PMID:8703034) UniProtKB PMID:8703034 NCBI chr19:3,067,062...3,070,579 JBrowse link
glutathione catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000104 Ensembl chr30:8,078,168...8,080,089 JBrowse link
G CHAC2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr10:54,790,670...54,799,823
Ensembl chr10:54,790,942...54,798,955
JBrowse link
G DPEP1 dipeptidase 1 IEA Ensembl GO_REF:0000107 NCBI chr 5:63,909,034...63,923,309
Ensembl chr 5:63,909,042...63,923,492
JBrowse link
G GGT1 gamma-glutamyltransferase 1 IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr26:28,301,455...28,315,029 JBrowse link
G GGT5 gamma-glutamyltransferase 5 IEA Ensembl GO_REF:0000107 NCBI chr26:28,316,022...28,343,928
Ensembl chr26:28,317,989...28,343,611
JBrowse link
G GGT7 gamma-glutamyltransferase 7 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr24:23,900,842...23,924,555
Ensembl chr24:23,901,045...23,997,286
JBrowse link
glutathione deglycation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase ISO (PMID:25416785) ParkinsonsUK-UCL PMID:25416785 NCBI chr 5:61,576,219...61,592,325
Ensembl chr 5:61,576,069...61,592,303
JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:MGI:5616326 NCBI chr17:37,886,397...37,950,671
Ensembl chr17:37,886,601...37,949,812
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 IEA Ensembl GO_REF:0000107 NCBI chr36:20,989,205...21,087,044
Ensembl chr36:20,989,360...21,012,524
JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC7A11 solute carrier family 7 member 11 IEA Ensembl GO_REF:0000107 NCBI chr19:4,289,792...4,379,060
Ensembl chr19:4,289,850...4,389,048
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16187
    metabolic process 10658
      cellular metabolic process 9650
        cellular modified amino acid metabolic process 167
          glutathione metabolic process 49
            ascorbate glutathione cycle 0
            glutathione biosynthetic process + 10
            glutathione catabolic process 6
            glutathione deglycation 1
Path 2
Term Annotations click to browse term
  biological_process 16187
    cellular process 15465
      cellular metabolic process 9650
        cellular nitrogen compound metabolic process 5712
          cellular amide metabolic process 1072
            peptide metabolic process 823
              glutathione metabolic process 49
                ascorbate glutathione cycle 0
                glutathione biosynthetic process + 10
                glutathione catabolic process 6
                glutathione deglycation 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.