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ONTOLOGY REPORT - ANNOTATIONS


Term:glutathione metabolic process
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Accession:GO:0006749 term browser browse the term
Definition:The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
Synonyms:exact_synonym: glutathione metabolism
 narrow_synonym: oxidized glutathione reduction


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glutathione metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARL6IP5 ADP ribosylation factor like GTPase 6 interacting protein 5 ISO (MGI:MGI:3822097|PMID:18799673)
(MGI:MGI:5315235|PMID:22210510)
MGI PMID:18799673, PMID:22210510 MGI:MGI:3822097, MGI:MGI:5315235 NCBI chr 3:69,084,937...69,106,092
Ensembl chr 3:69,084,937...69,106,092
JBrowse link
G CTH cystathionine gamma-lyase ISO RGD PMID:15683713 RGD:1600763 NCBI chr 1:70,411,268...70,441,949
Ensembl chr 1:70,411,218...70,439,851
JBrowse link
G CTNS cystinosin, lysosomal cystine transporter IMP (PMID:15956064) UniProtKB PMID:15956064 NCBI chr17:3,636,459...3,663,103
Ensembl chr17:3,636,459...3,661,542
Ensembl chr17:3,636,459...3,661,542
Ensembl chr17:3,636,459...3,661,542
JBrowse link
G DPEP1 dipeptidase 1 TAS (PMID:20031578) UniProtKB PMID:20031578 NCBI chr16:89,613,308...89,641,540
Ensembl chr16:89,613,308...89,638,456
JBrowse link
G ETHE1 ETHE1 persulfide dioxygenase IDA
IBA
(PMID:23144459)
(PMID:21873635)
UniProtKB
GO_Central
PMID:21873635, PMID:23144459 NCBI chr19:43,506,719...43,527,201
Ensembl chr19:43,506,719...43,527,230
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase IMP (PMID:17516514), (PMID:2420826) BHF-UCL PMID:2420826, PMID:17516514 NCBI chr  X:154,531,390...154,547,569
Ensembl chr  X:154,531,391...154,547,572
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit ISO (MGI:MGI:1928560|PMID:11118286) MGI PMID:11118286 MGI:MGI:1928560 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit ISO (MGI:MGI:2447526|PMID:12384496) MGI PMID:12384496 MGI:MGI:2447526 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GLO1 glyoxalase I IEA Ensembl GO_REF:0000107 NCBI chr 6:38,675,925...38,703,145
Ensembl chr 6:38,675,925...38,703,145
JBrowse link
G GLRX2 glutaredoxin 2 TAS (PMID:11397793) UniProtKB PMID:11397793 NCBI chr 1:193,096,465...193,106,114
Ensembl chr 1:193,090,866...193,106,114
JBrowse link
G GPX1 glutathione peroxidase 1 IDA
IBA
(PMID:12829378)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:12829378, PMID:21873635 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,176...49,358,358
JBrowse link
G GPX3 glutathione peroxidase 3 ISO RGD PMID:16140890 RGD:1624364 NCBI chr 5:151,020,591...151,028,988
Ensembl chr 5:151,020,438...151,028,992
JBrowse link
G GPX4 glutathione peroxidase 4 IEA Ensembl GO_REF:0000107 NCBI chr19:1,103,994...1,106,779
Ensembl chr19:1,103,926...1,106,791
JBrowse link
G GSR glutathione-disulfide reductase IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr 8:30,678,066...30,727,846
Ensembl chr 8:30,678,066...30,727,846
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 IDA
IBA
(PMID:11851347), (PMID:20606271)
(PMID:21873635)
MGI
GO_Central
PMID:11851347, PMID:20606271, PMID:21873635 NCBI chr 6:52,791,371...52,803,827
Ensembl chr 6:52,791,371...52,803,860
JBrowse link
G GSTA2 glutathione S-transferase alpha 2 ISS
IBA
(PMID:21873635) UniProtKB
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr 6:52,750,087...52,763,475
Ensembl chr 6:52,750,087...52,763,475
JBrowse link
G GSTA3 glutathione S-transferase alpha 3 ISS
IBA
(PMID:21873635) UniProtKB
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr 6:52,896,646...52,909,799
Ensembl chr 6:52,896,639...52,909,698
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 IDA
IBA
(PMID:10329152)
(PMID:21873635)
UniProtKB
GO_Central
PMID:10329152, PMID:21873635 NCBI chr 6:52,977,952...52,995,332
Ensembl chr 6:52,977,948...52,995,304
JBrowse link
G GSTA5 glutathione S-transferase alpha 5 ISS
IBA
(PMID:21873635) UniProtKB
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr 6:52,831,742...52,846,095
Ensembl chr 6:52,831,655...52,846,095
JBrowse link
G GSTK1 glutathione S-transferase kappa 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:143,263,441...143,269,115
Ensembl chr 7:143,244,093...143,270,854
JBrowse link
G GSTM1 glutathione S-transferase mu 1 IDA
IBA
(PMID:8373352)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:8373352, PMID:21873635 NCBI chr 1:109,687,817...109,693,745
Ensembl chr 1:109,687,814...109,709,039
JBrowse link
G GSTM2 glutathione S-transferase mu 2 IDA
IBA
(PMID:16549767), (PMID:2034681), (PMID:8373352)
(PMID:21873635)
UniProtKB
GO_Central
PMID:2034681, PMID:8373352, PMID:16549767, PMID:21873635 NCBI chr 1:109,668,057...109,683,997
Ensembl chr 1:109,668,022...109,709,551
JBrowse link
G GSTM3 glutathione S-transferase mu 3 IDA
IBA
(PMID:10587441), (PMID:8373352)
(PMID:21873635)
UniProtKB
GO_Central
PMID:8373352, PMID:10587441, PMID:21873635 NCBI chr 1:109,733,937...109,741,038
Ensembl chr 1:109,733,932...109,741,038
JBrowse link
G GSTM4 glutathione S-transferase mu 4 IDA
IBA
(PMID:8373352)
(PMID:21873635)
BHF-UCL
GO_Central
PMID:8373352, PMID:21873635 NCBI chr 1:109,656,076...109,665,497
Ensembl chr 1:109,656,099...109,674,836
JBrowse link
G GSTM5 glutathione S-transferase mu 5 IDA
IBA
(PMID:10587441)
(PMID:21873635)
UniProtKB
GO_Central
PMID:10587441, PMID:21873635 NCBI chr 1:109,711,751...109,718,268
Ensembl chr 1:109,711,780...109,775,428
JBrowse link
G GSTP1 glutathione S-transferase pi 1 IDA
IBA
(PMID:1540159)
(PMID:21873635)
UniProtKB
GO_Central
PMID:1540159, PMID:21873635 NCBI chr11:67,583,812...67,586,653
Ensembl chr11:67,583,742...67,586,656
Ensembl chr11:67,583,742...67,586,656
JBrowse link
G GSTT1 glutathione S-transferase theta 1 IDA
IBA
(PMID:20097269), (PMID:9307035), (PMID:9434735)
(PMID:21873635)
UniProtKB
GO_Central
PMID:9307035, PMID:9434735, PMID:20097269, PMID:21873635
G GSTT2 glutathione S-transferase theta 2 (gene/pseudogene) IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr22:23,980,134...23,983,915
Ensembl chr22:23,980,058...23,983,915
JBrowse link
G GSTT2B glutathione S-transferase theta 2B IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr22:23,957,414...23,961,206
Ensembl chr22:23,957,414...23,961,195
Ensembl chr22:23,957,414...23,961,195
JBrowse link
G GSTT4 glutathione S-transferase theta 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr22:23,988,481...24,005,474
Ensembl chr22:23,998,401...24,005,453
JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 IDA
IBA
(PMID:10739172)
(PMID:21873635)
UniProtKB
GO_Central
PMID:10739172, PMID:21873635 NCBI chr14:77,321,002...77,331,597
Ensembl chr14:77,320,996...77,331,597
JBrowse link
G HAGH hydroxyacylglutathione hydrolase ISO RGD PMID:8719777, PMID:8903102 RGD:1641958, RGD:1641959 NCBI chr16:1,807,629...1,827,194
Ensembl chr16:1,795,620...1,827,157
JBrowse link
G HBB hemoglobin subunit beta ISO RGD PMID:19963409 RGD:2325281 NCBI chr11:5,225,464...5,227,071
Ensembl chr11:5,225,464...5,229,395
JBrowse link
G HMGN5 high mobility group nucleosome binding domain 5 ISO (MGI:MGI:5578301|PMID:24392144) MGI PMID:24392144 MGI:MGI:5578301 NCBI chr  X:81,113,699...81,201,913
Ensembl chr  X:81,113,699...81,201,913
JBrowse link
G HPGDS hematopoietic prostaglandin D synthase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:94,298,535...94,342,876
Ensembl chr 4:94,298,535...94,342,876
JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 IEA Ensembl GO_REF:0000107 NCBI chr 2:208,236,227...208,255,071
Ensembl chr 2:208,236,229...208,266,074
Ensembl chr 2:208,236,229...208,266,074
JBrowse link
G MGST1 microsomal glutathione S-transferase 1 ISO (MGI:MGI:1855828|PMID:10767383) MGI PMID:10767383 MGI:MGI:1855828 NCBI chr12:16,347,115...16,377,192
Ensembl chr12:16,347,142...16,609,259
JBrowse link
G MMACHC metabolism of cobalamin associated C IDA (PMID:19801555), (PMID:22642810) UniProtKB PMID:19801555, PMID:22642810 NCBI chr 1:45,500,229...45,513,382
Ensembl chr 1:45,500,300...45,513,382
JBrowse link
G NAT8 N-acetyltransferase 8 (putative) IEA
IDA
(PMID:20392701) UniProtKB PMID:20392701 GO_REF:0000041 NCBI chr 2:73,640,723...73,642,422
Ensembl chr 2:73,640,723...73,642,422
JBrowse link
G NFE2L1 nuclear factor, erythroid 2 like 1 IEA Ensembl GO_REF:0000107 NCBI chr17:48,048,359...48,061,545
Ensembl chr17:48,048,329...48,061,545
JBrowse link
G OPLAH 5-oxoprolinase, ATP-hydrolysing IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:144,051,266...144,064,026
Ensembl chr 8:144,051,266...144,063,965
JBrowse link
G SLC1A1 solute carrier family 1 member 1 ISO (MGI:MGI:3822097|PMID:18799673)
(MGI:MGI:5465271|PMID:22732503)
MGI PMID:18799673, PMID:22732503 MGI:MGI:3822097, MGI:MGI:5465271 NCBI chr 9:4,490,466...4,587,469
Ensembl chr 9:4,490,468...4,587,469
JBrowse link
G SLC7A11 solute carrier family 7 member 11 IEA Ensembl GO_REF:0000107 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link
G SOD1 superoxide dismutase 1 ISS UniProtKB GO_REF:0000024 NCBI chr21:31,659,693...31,668,931
Ensembl chr21:31,659,622...31,668,931
Ensembl chr21:31,659,622...31,668,931
JBrowse link
G SOD2 superoxide dismutase 2 IEA Ensembl GO_REF:0000107 NCBI chr 6:159,669,069...159,762,281
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
Ensembl chr 6:159,669,069...159,762,529
JBrowse link
G TXNRD3 thioredoxin reductase 3 ISO (MGI:MGI:2386187|PMID:11259642) MGI PMID:11259642 MGI:MGI:2386187 NCBI chr 3:126,607,050...126,655,124
Ensembl chr 3:126,607,059...126,655,124
JBrowse link
glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 TAS Reactome Reactome:R-HSA-174403 NCBI chr15:40,942,137...40,956,518
Ensembl chr15:40,952,962...40,956,512
JBrowse link
G CHAC2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 TAS Reactome Reactome:R-HSA-174403 NCBI chr 2:53,767,783...53,775,196
Ensembl chr 2:53,767,804...53,775,196
JBrowse link
G CNDP2 carnosine dipeptidase 2 TAS Reactome Reactome:R-HSA-174403 NCBI chr18:74,496,363...74,523,454
Ensembl chr18:74,495,816...74,523,454
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit IEA
IDA
IBA
TAS
IMP
(PMID:10395918), (PMID:8104187), (PMID:9675072)
(PMID:21873635)
(PMID:12663448)
InterPro
UniProt
GO_Central
Reactome
UniProtKB
PMID:8104187, PMID:9675072, PMID:10395918, PMID:12663448, PMID:21873635 GO_REF:0000002, GO_REF:0000041, Reactome:R-HSA-174403 NCBI chr 6:53,497,341...53,545,101
Ensembl chr 6:53,497,341...53,616,970
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit IEA
IDA
TAS
IBA
IMP
(PMID:10395918), (PMID:9675072)
(PMID:21873635)
(PMID:12081989)
UniProtKB
UniProt
Reactome
GO_Central
PMID:9675072, PMID:10395918, PMID:12081989, PMID:21873635 GO_REF:0000041, Reactome:R-HSA-174403 NCBI chr 1:93,885,199...93,910,370
Ensembl chr 1:93,885,199...93,909,456
JBrowse link
G GGCT gamma-glutamylcyclotransferase TAS Reactome Reactome:R-HSA-174403 NCBI chr 7:30,496,621...30,504,829
Ensembl chr 7:30,496,621...30,504,841
JBrowse link
G GGT1 gamma-glutamyltransferase 1 TAS
ISS
Reactome
UniProtKB
GO_REF:0000024, Reactome:R-HSA-174403 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,556,007...24,628,987
Ensembl chr22:24,556,007...24,628,987
Ensembl chr22:24,556,007...24,628,987
JBrowse link
G GGT3P gamma-glutamyltransferase 3 pseudogene IEA UniProt GO_REF:0000043 NCBI chr22:18,773,689...18,791,961
Ensembl chr22:18,773,665...18,843,399
JBrowse link
G GGT5 gamma-glutamyltransferase 5 IEA UniProt GO_REF:0000043 NCBI chr22:24,219,654...24,245,142
Ensembl chr22:24,219,654...24,245,142
JBrowse link
G GGT6 gamma-glutamyltransferase 6 IEA UniProt GO_REF:0000043 NCBI chr17:4,556,927...4,560,920
Ensembl chr17:4,556,927...4,560,818
JBrowse link
G GGT7 gamma-glutamyltransferase 7 IEA UniProt GO_REF:0000043 NCBI chr20:34,844,720...34,872,857
Ensembl chr20:34,844,720...34,872,856
JBrowse link
G GSS glutathione synthetase TAS
IEA
Reactome
InterPro
GOC
UniProtKB
GO_REF:0000002, GO_REF:0000041, GO_REF:0000108, Reactome:R-HSA-174403 NCBI chr20:34,928,432...34,956,027
Ensembl chr20:34,928,432...34,956,027
JBrowse link
G HAGH hydroxyacylglutathione hydrolase IDA (PMID:8550579) UniProtKB PMID:8550579 NCBI chr16:1,807,629...1,827,194
Ensembl chr16:1,795,620...1,827,157
JBrowse link
G MGST2 microsomal glutathione S-transferase 2 IDA (PMID:8703034) UniProtKB PMID:8703034 NCBI chr 4:139,665,725...139,754,608
Ensembl chr 4:139,665,768...139,740,745
JBrowse link
G OPLAH 5-oxoprolinase, ATP-hydrolysing TAS Reactome Reactome:R-HSA-174403 NCBI chr 8:144,051,266...144,064,026
Ensembl chr 8:144,051,266...144,063,965
JBrowse link
glutathione catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr15:40,942,137...40,956,518
Ensembl chr15:40,952,962...40,956,512
JBrowse link
G CHAC2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:53,767,783...53,775,196
Ensembl chr 2:53,767,804...53,775,196
JBrowse link
G DPEP1 dipeptidase 1 ISS UniProt GO_REF:0000024 NCBI chr16:89,613,308...89,641,540
Ensembl chr16:89,613,308...89,638,456
JBrowse link
G GGT1 gamma-glutamyltransferase 1 IEA
IBA
IDA
(PMID:21873635)
(PMID:17924658), (PMID:21447318)
InterPro
GO_Central
UniProtKB
PMID:17924658, PMID:21447318, PMID:21873635 GO_REF:0000002 NCBI chr22:24,583,750...24,628,996
Ensembl chr22:24,556,007...24,628,987
Ensembl chr22:24,556,007...24,628,987
Ensembl chr22:24,556,007...24,628,987
JBrowse link
G GGT2 gamma-glutamyltransferase 2 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr22:21,207,972...21,283,023
Ensembl chr22:21,207,973...21,227,637
JBrowse link
G GGT3P gamma-glutamyltransferase 3 pseudogene IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr22:18,773,689...18,791,961
Ensembl chr22:18,773,665...18,843,399
JBrowse link
G GGT5 gamma-glutamyltransferase 5 IEA
IBA
IDA
(PMID:21873635)
(PMID:1676842), (PMID:21447318)
InterPro
GO_Central
BHF-UCL
PMID:1676842, PMID:21447318, PMID:21873635 GO_REF:0000002 NCBI chr22:24,219,654...24,245,142
Ensembl chr22:24,219,654...24,245,142
JBrowse link
G GGT7 gamma-glutamyltransferase 7 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr20:34,844,720...34,872,857
Ensembl chr20:34,844,720...34,872,856
JBrowse link
G GGTLC1 gamma-glutamyltransferase light chain 1 IEA InterPro GO_REF:0000002 NCBI chr20:23,985,053...23,989,134
Ensembl chr20:23,985,050...23,988,779
JBrowse link
G GGTLC2 gamma-glutamyltransferase light chain 2 IEA InterPro GO_REF:0000002 NCBI chr22:22,644,620...22,647,898
Ensembl chr22:22,644,475...22,647,903
JBrowse link
G GGTLC3 gamma-glutamyltransferase light chain family member 3 IEA InterPro GO_REF:0000002 NCBI chr22:18,516,335...18,518,165
Ensembl chr22:18,516,344...18,518,161
JBrowse link
glutathione deglycation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase IDA (PMID:25416785) ParkinsonsUK-UCL PMID:25416785 NCBI chr 1:7,961,711...7,985,505
Ensembl chr 1:7,954,291...7,985,505
JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:MGI:5616326 NCBI chr 2:88,556,741...88,627,464
Ensembl chr 2:88,556,741...88,627,464
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 IEA Ensembl GO_REF:0000107 NCBI chr 2:177,230,303...177,265,131
Ensembl chr 2:177,227,595...177,392,697
JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC7A11 solute carrier family 7 member 11 IEA Ensembl GO_REF:0000107 NCBI chr 4:138,164,097...138,242,349
Ensembl chr 4:138,164,097...138,242,349
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18670
    metabolic process 12301
      cellular metabolic process 11283
        cellular modified amino acid metabolic process 216
          glutathione metabolic process 64
            ascorbate glutathione cycle 0
            glutathione biosynthetic process + 18
            glutathione catabolic process 11
            glutathione deglycation 1
Path 2
Term Annotations click to browse term
  biological_process 18670
    cellular process 17687
      cellular metabolic process 11283
        cellular nitrogen compound metabolic process 6773
          cellular amide metabolic process 1206
            peptide metabolic process 899
              glutathione metabolic process 64
                ascorbate glutathione cycle 0
                glutathione biosynthetic process + 18
                glutathione catabolic process 11
                glutathione deglycation 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.