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ONTOLOGY REPORT - ANNOTATIONS


Term:glutathione metabolic process
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Accession:GO:0006749 term browser browse the term
Definition:The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
Synonyms:exact_synonym: glutathione metabolism
 narrow_synonym: oxidized glutathione reduction


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glutathione metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ARL6IP5 ADP ribosylation factor like GTPase 6 interacting protein 5 ISO (MGI:MGI:3822097|PMID:18799673)
(MGI:MGI:5315235|PMID:22210510)
MGI PMID:18799673, PMID:22210510 MGI:MGI:3822097, MGI:MGI:5315235 NCBI chr13:50,509,777...50,538,004
Ensembl chr13:50,509,519...50,538,967
JBrowse link
G CTH cystathionine gamma-lyase ISO RGD PMID:15683713 RGD:1600763 NCBI chr 6:142,454,922...142,486,352
Ensembl chr 6:142,435,690...142,486,367
JBrowse link
G CTNS cystinosin, lysosomal cystine transporter IEA Ensembl GO_REF:0000107 NCBI chr12:49,730,741...49,754,362
Ensembl chr12:49,730,955...49,753,208
JBrowse link
G ETHE1 ETHE1 persulfide dioxygenase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 6:50,375,836...50,395,769
Ensembl chr 6:50,375,841...50,396,237
JBrowse link
G G6PD glucose-6-phosphate dehydrogenase IEA Ensembl GO_REF:0000107 NCBI chr  X:125,029,147...125,041,040
Ensembl chr  X:125,025,257...125,041,033
JBrowse link
G GCLC glutamate-cysteine ligase catalytic subunit ISO (MGI:MGI:1928560|PMID:11118286) MGI PMID:11118286 MGI:MGI:1928560 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit ISO (MGI:MGI:2447526|PMID:12384496) MGI PMID:12384496 MGI:MGI:2447526 NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,135
JBrowse link
G GLO1 glyoxalase I ISO RGD PMID:8719777, PMID:8903102 RGD:1641958, RGD:1641959 NCBI chr 7:34,156,194...34,183,560 JBrowse link
G GPX1 glutathione peroxidase 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr13:31,916,269...31,917,337
Ensembl chr13:31,914,932...31,917,335
JBrowse link
G GPX3 glutathione peroxidase 3 ISO RGD PMID:16140890 RGD:1624364 NCBI chr16:71,980,467...71,989,011
Ensembl chr16:71,980,475...71,989,026
JBrowse link
G GPX4 glutathione peroxidase 4 ISO RGD PMID:16140890 RGD:1624364 NCBI chr 2:77,321,568...77,323,931
Ensembl chr 2:77,320,464...77,323,886
JBrowse link
G GSR glutathione-disulfide reductase IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr15:54,382,564...54,433,989
Ensembl chr15:54,382,567...54,433,989
JBrowse link
G GSTA1 glutathione S-transferase alpha 1 ISS
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000024 NCBI chr 7:46,538,743...46,550,781
Ensembl chr 7:46,538,032...46,567,728
JBrowse link
G GSTA4 glutathione S-transferase alpha 4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:46,635,903...46,656,491
Ensembl chr 7:46,610,467...46,656,451
JBrowse link
G GSTK1 glutathione S-transferase kappa 1 IBA
IEA
(PMID:21873635) GO_Central
Ensembl
PMID:21873635 GO_REF:0000107 NCBI chr18:6,992,623...6,999,068
Ensembl chr18:6,992,647...6,999,068
JBrowse link
G GSTM3 glutathione S-transferase mu 3 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:110,330,027...110,332,957
Ensembl chr 4:110,330,028...110,332,962
JBrowse link
G GSTZ1 glutathione S-transferase zeta 1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:100,392,217...100,404,025
Ensembl chr 7:100,392,271...100,408,423
JBrowse link
G HAGH hydroxyacylglutathione hydrolase ISO RGD PMID:8719777, PMID:8903102 RGD:1641958, RGD:1641959 NCBI chr 3:40,139,099...40,162,921 JBrowse link
G HMGN5 high mobility group nucleosome binding domain 5 ISO (MGI:MGI:5578301|PMID:24392144) MGI PMID:24392144 MGI:MGI:5578301 NCBI chr  X:64,541,310...64,617,345 JBrowse link
G HPGDS hematopoietic prostaglandin D synthase IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 8:125,375,906...125,406,066
Ensembl chr 8:125,382,952...125,405,955
JBrowse link
G IDH1 isocitrate dehydrogenase (NADP(+)) 1 IEA Ensembl GO_REF:0000107 NCBI chr15:111,341,153...111,362,330
Ensembl chr15:111,341,152...111,362,280
JBrowse link
G LOC100151901 glutathione S-transferase theta-4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:49,812,009...49,819,028
Ensembl chr14:49,812,019...49,819,060
JBrowse link
G LOC100153094 glutathione S-transferase theta-1 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr14:49,801,444...49,807,668 JBrowse link
G LOC100510917 glutathione S-transferase A4 IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 7:46,610,466...46,631,202 JBrowse link
G LOC100739163 glutathione S-transferase P-like IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:4,978,761...4,982,233 JBrowse link
G LOC100739508 glutathione S-transferase P-like IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 2:5,005,498...5,009,247 JBrowse link
G MGST1 microsomal glutathione S-transferase 1 ISO (MGI:MGI:1855828|PMID:10767383) MGI PMID:10767383 MGI:MGI:1855828 NCBI chr 5:56,259,566...56,283,823
Ensembl chr 5:56,259,568...56,282,277
JBrowse link
G MMACHC metabolism of cobalamin associated C IEA Ensembl GO_REF:0000107 NCBI chr 6:165,860,888...165,865,674
Ensembl chr 6:165,860,785...165,865,654
JBrowse link
G NAT8 N-acetyltransferase 8 (putative) ISO (PMID:20392701) UniProtKB PMID:20392701 NCBI chr 3:69,250,326...69,254,079 JBrowse link
G NFE2L1 nuclear factor, erythroid 2 like 1 IEA Ensembl GO_REF:0000107 NCBI chr12:24,303,381...24,316,765
Ensembl chr12:24,303,399...24,316,763
JBrowse link
G OPLAH 5-oxoprolinase, ATP-hydrolysing IBA (PMID:21873635) GO_Central PMID:21873635 NCBI chr 4:629,901...639,420
Ensembl chr 4:629,870...639,406
JBrowse link
G SLC1A1 solute carrier family 1 member 1 ISO (MGI:MGI:3822097|PMID:18799673)
(MGI:MGI:5465271|PMID:22732503)
MGI PMID:18799673, PMID:22732503 MGI:MGI:3822097, MGI:MGI:5465271 NCBI chr 1:217,366,493...217,441,643
Ensembl chr 1:217,366,499...217,441,674
JBrowse link
G SLC7A11 solute carrier family 7 member 11 IEA Ensembl GO_REF:0000107 NCBI chr 8:88,608,083...88,690,589
Ensembl chr 8:88,607,884...88,940,100
JBrowse link
G SOD1 superoxide dismutase 1 IEA Ensembl GO_REF:0000107 NCBI chr13:195,326,573...195,335,273
Ensembl chr13:195,326,649...195,337,749
JBrowse link
G SOD2 superoxide dismutase 2 ISO (MGI:MGI:1332377|PMID:10049502) MGI PMID:10049502 MGI:MGI:1332377 NCBI chr 1:7,679,352...7,689,564
Ensembl chr 1:7,651,280...7,691,723
JBrowse link
G TXNRD3 thioredoxin reductase 3 ISO (MGI:MGI:2386187|PMID:11259642) MGI PMID:11259642 MGI:MGI:2386187 NCBI chr13:73,276,249...73,336,782
Ensembl chr13:73,275,911...73,340,428
JBrowse link
glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G GCLC glutamate-cysteine ligase catalytic subunit IEA UniProt GO_REF:0000041 NCBI chr 7:27,209,565...27,253,535
Ensembl chr 7:27,209,564...27,253,535
JBrowse link
G GCLM glutamate-cysteine ligase modifier subunit IBA
IEA
(PMID:21873635) GO_Central
UniProt
PMID:21873635 GO_REF:0000041 NCBI chr 4:123,371,198...123,390,130
Ensembl chr 4:123,371,193...123,390,135
JBrowse link
G GGT1 gamma-glutamyltransferase 1 IEA Ensembl
UniProt
GO_REF:0000043, GO_REF:0000107 NCBI chr14:49,618,737...49,638,054 JBrowse link
G GSS glutathione synthetase IEA UniProt
InterPro
GO_REF:0000002, GO_REF:0000041 NCBI chr17:38,316,199...38,342,253
Ensembl chr17:38,312,720...38,342,304
JBrowse link
G HAGH hydroxyacylglutathione hydrolase ISO (PMID:8550579) UniProtKB PMID:8550579 NCBI chr 3:40,139,099...40,162,921 JBrowse link
G MGST2 microsomal glutathione S-transferase 2 IEA Ensembl GO_REF:0000107 NCBI chr 8:87,318,180...87,394,563
Ensembl chr 8:87,319,533...87,390,520
JBrowse link
glutathione catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000104 NCBI chr 1:130,360,510...130,363,332
Ensembl chr 1:130,360,513...130,363,308
JBrowse link
G CHAC2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 IEA
IBA
(PMID:21873635) UniProt
GO_Central
PMID:21873635 GO_REF:0000104 NCBI chr 3:87,405,937...87,417,268
Ensembl chr 3:87,405,974...87,416,260
JBrowse link
G DPEP1 dipeptidase 1 IEA
ISS
Ensembl
UniProt
GO_REF:0000024, GO_REF:0000107 NCBI chr 6:361,187...385,757
Ensembl chr 6:361,196...376,616
JBrowse link
G GGT1 gamma-glutamyltransferase 1 ISS
IEA
IBA
(PMID:21873635) UniProt
InterPro
GO_Central
PMID:21873635 GO_REF:0000002, GO_REF:0000024 NCBI chr14:49,618,737...49,638,054 JBrowse link
G GGT5 gamma-glutamyltransferase 5 IEA
IBA
(PMID:21873635) InterPro
GO_Central
PMID:21873635 GO_REF:0000002 NCBI chr14:49,638,184...49,663,007
Ensembl chr14:49,640,422...49,666,575
JBrowse link
G GGT7 gamma-glutamyltransferase 7 IBA
IEA
(PMID:21873635) GO_Central
InterPro
PMID:21873635 GO_REF:0000002 NCBI chr17:38,231,083...38,255,915
Ensembl chr17:38,231,076...38,255,880
JBrowse link
glutathione deglycation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PARK7 Parkinsonism associated deglycase IEA Ensembl GO_REF:0000107 NCBI chr 6:68,629,327...68,645,147
Ensembl chr 6:68,629,214...68,645,520
JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:MGI:5616326 NCBI chr 3:57,423,894...57,506,247
Ensembl chr 3:57,423,875...57,506,247
JBrowse link
G NFE2L2 nuclear factor, erythroid 2 like 2 IEA Ensembl GO_REF:0000107 NCBI chr15:82,967,485...83,146,185
Ensembl chr15:82,973,648...83,146,183
JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G SLC7A11 solute carrier family 7 member 11 IEA Ensembl GO_REF:0000107 NCBI chr 8:88,608,083...88,690,589
Ensembl chr 8:88,607,884...88,940,100
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 16545
    metabolic process 10584
      cellular metabolic process 9578
        cellular modified amino acid metabolic process 165
          glutathione metabolic process 47
            ascorbate glutathione cycle 0
            glutathione biosynthetic process + 9
            glutathione catabolic process 6
            glutathione deglycation 1
Path 2
Term Annotations click to browse term
  biological_process 16545
    cellular process 15777
      cellular metabolic process 9578
        cellular nitrogen compound metabolic process 5636
          cellular amide metabolic process 1015
            peptide metabolic process 763
              glutathione metabolic process 47
                ascorbate glutathione cycle 0
                glutathione biosynthetic process + 9
                glutathione catabolic process 6
                glutathione deglycation 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.