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ONTOLOGY REPORT - ANNOTATIONS


Term:glutathione metabolic process
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Accession:GO:0006749 term browser browse the term
Definition:The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle.
Synonyms:exact_synonym: glutathione metabolism
 narrow_synonym: oxidized glutathione reduction


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glutathione metabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Arl6ip5 ADP ribosylation factor like GTPase 6 interacting protein 5 ISO (MGI:MGI:3822097|PMID:18799673) MGI PMID:18799673 MGI:MGI:3822097 NCBI chrNW_004936603:1,524,959...1,549,923 JBrowse link
G Cth cystathionine gamma-lyase ISO RGD PMID:15683713 RGD:1600763 NCBI chrNW_004936591:1,619,446...1,643,667 JBrowse link
G Ctns cystinosin, lysosomal cystine transporter ISO (PMID:15956064) UniProtKB PMID:15956064 NCBI chrNW_004936677:342,964...360,890 JBrowse link
G Ethe1 ETHE1 persulfide dioxygenase ISO (PMID:23144459) UniProtKB PMID:23144459 NCBI chrNW_004936706:726,106...750,733 JBrowse link
G G6pd glucose-6-phosphate dehydrogenase ISO (PMID:17516514), (PMID:2420826)
(MGI:MGI:2449252|PMID:12521604)
BHF-UCL
MGI
PMID:2420826, PMID:12521604, PMID:17516514 MGI:MGI:2449252 NCBI chrNW_004936809:1,269,900...1,285,853 JBrowse link
G Gclc glutamate-cysteine ligase catalytic subunit ISO (MGI:MGI:1928560|PMID:11118286) MGI PMID:11118286 MGI:MGI:1928560 NCBI chrNW_004936476:7,371,270...7,418,756 JBrowse link
G Gclm glutamate-cysteine ligase modifier subunit ISO (MGI:MGI:2447526|PMID:12384496) MGI PMID:12384496 MGI:MGI:2447526 NCBI chrNW_004936537:5,356,914...5,378,998 JBrowse link
G Glo1 glyoxalase I ISO RGD PMID:8719777, PMID:8903102 RGD:1641958, RGD:1641959 NCBI chrNW_004936476:20,910,696...20,928,583 JBrowse link
G Gpx1 glutathione peroxidase 1 ISO (PMID:12829378) BHF-UCL
RGD
PMID:12829378, PMID:16140890 RGD:1624364 NCBI chrNW_004936529:997,943...999,123 JBrowse link
G Gpx3 glutathione peroxidase 3 ISO RGD PMID:16140890 RGD:1624364 NCBI chrNW_004936647:3,904,787...3,914,223 JBrowse link
G Gpx4 glutathione peroxidase 4 ISO RGD PMID:16140890 RGD:1624364 NCBI chrNW_004936588:506,101...508,469 JBrowse link
G Gsr glutathione-disulfide reductase ISO RGD PMID:237922 RGD:1625133 NCBI chrNW_004936792:531,076...579,083 JBrowse link
G Gsta4 glutathione S-transferase alpha 4 ISO (PMID:10329152) UniProtKB PMID:10329152 NCBI chrNW_004936476:7,873,218...7,888,301 JBrowse link
G Gstk1 glutathione S-transferase kappa 1 ISO (MGI:MGI:2668784|PMID:12720545) MGI PMID:12720545 MGI:MGI:2668784 NCBI chrNW_004936527:722,548...727,169 JBrowse link
G Gstm3 glutathione S-transferase mu 3 ISO (PMID:10587441), (PMID:8373352) UniProtKB PMID:8373352, PMID:10587441 NCBI chrNW_004936704:1,233,909...1,236,864 JBrowse link
G Gstm4 glutathione S-transferase mu 4 ISO (PMID:8373352) BHF-UCL PMID:8373352 NCBI chrNW_004936704:1,142,990...1,150,491 JBrowse link
G Gstp1 glutathione S-transferase pi 1 ISO (PMID:1540159)
(MGI:MGI:69635|PMID:7982937)
UniProtKB
MGI
PMID:1540159, PMID:7982937 MGI:MGI:69635 NCBI chrNW_004936599:2,197,681...2,200,642 JBrowse link
G Gstz1 glutathione S-transferase zeta 1 ISO (PMID:10739172) UniProtKB PMID:10739172 NCBI chrNW_004936488:6,141,913...6,153,591 JBrowse link
G Hagh hydroxyacylglutathione hydrolase ISO RGD PMID:8719777, PMID:8903102 RGD:1641958, RGD:1641959 NCBI chrNW_004936694:2,181,475...2,200,469 JBrowse link
G Hmgn5 high mobility group nucleosome binding domain 5 ISO (MGI:MGI:5578301|PMID:24392144) MGI PMID:24392144 MGI:MGI:5578301 NCBI chrNW_004936547:2,607,491...2,614,037 JBrowse link
G Idh1 isocitrate dehydrogenase (NADP(+)) 1 ISO (MGI:MGI:2389531|PMID:12031902) MGI PMID:12031902 MGI:MGI:2389531 NCBI chrNW_004936950:334,894...349,221 JBrowse link
G Mgst1 microsomal glutathione S-transferase 1 ISO (MGI:MGI:1855828|PMID:10767383) MGI PMID:10767383 MGI:MGI:1855828 NCBI chrNW_004936587:1,270,030...1,287,130 JBrowse link
G Mmachc metabolism of cobalamin associated C ISO (PMID:19801555), (PMID:22642810) UniProtKB PMID:19801555, PMID:22642810 NCBI chrNW_004936474:26,636,277...26,641,486 JBrowse link
G Nfe2l1 nuclear factor, erythroid 2 like 1 ISO (MGI:MGI:5662039|PMID:25092871) MGI PMID:25092871 MGI:MGI:5662039 NCBI chrNW_004936490:13,265,269...13,279,164 JBrowse link
G Slc1a1 solute carrier family 1 member 1 ISO (MGI:MGI:3822097|PMID:18799673) MGI PMID:18799673 MGI:MGI:3822097 NCBI chrNW_004936503:613,250...690,555 JBrowse link
G Slc7a11 solute carrier family 7 member 11 ISO (MGI:MGI:3710059|PMID:17200146), (MGI:MGI:5469541|PMID:23085521) MGI PMID:17200146, PMID:23085521 MGI:MGI:3710059, MGI:MGI:5469541 NCBI chrNW_004936535:9,177,305...9,242,743 JBrowse link
G Sod1 superoxide dismutase 1 ISO (MGI:MGI:3640408|PMID:16377630) MGI PMID:16377630 MGI:MGI:3640408 NCBI chrNW_004936500:10,345,154...10,352,873 JBrowse link
G Sod2 superoxide dismutase 2 ISO (MGI:MGI:1332377|PMID:10049502) MGI PMID:10049502 MGI:MGI:1332377 NCBI chrNW_004936489:11,178,338...11,191,601 JBrowse link
G Txnrd3 thioredoxin reductase 3 ISO (MGI:MGI:2386187|PMID:11259642) MGI PMID:11259642 MGI:MGI:2386187 NCBI chrNW_004936798:1,190,975...1,231,732 JBrowse link
glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase catalytic subunit ISO (MGI:MGI:3607629|PMID:16081425)
(MGI:MGI:1858542|PMID:10805773)
(PMID:12663448)
(PMID:10395918), (PMID:8104187), (PMID:9675072)
MGI
RGD
UniProtKB
UniProt
PMID:8104187, PMID:9675072, PMID:10395918, PMID:10805773, PMID:12663448, PMID:16081425, PMID:16183645 MGI:MGI:1858542, MGI:MGI:3607629, RGD:1582661 NCBI chrNW_004936476:7,371,270...7,418,756 JBrowse link
G Gclm glutamate-cysteine ligase modifier subunit ISO (MGI:MGI:3607629|PMID:16081425)
(PMID:12081989)
(PMID:10395918), (PMID:9675072)
RGD
MGI
UniProtKB
UniProt
PMID:9675072, PMID:10395918, PMID:12081989, PMID:16081425, PMID:16183645 MGI:MGI:3607629, RGD:1582661 NCBI chrNW_004936537:5,356,914...5,378,998 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO (MGI:MGI:5294309|PMID:12468440) UniProtKB PMID:12468440 MGI:MGI:5294309 NCBI chrNW_004936619:762,278...791,610 JBrowse link
G Gss glutathione synthetase ISO RGD PMID:10964706 RGD:1599340 NCBI chrNW_004936561:5,765,637...5,793,951 JBrowse link
G Hagh hydroxyacylglutathione hydrolase ISO (PMID:8550579) UniProtKB PMID:8550579 NCBI chrNW_004936694:2,181,475...2,200,469 JBrowse link
G Mgst2 microsomal glutathione S-transferase 2 ISO (PMID:8703034) UniProtKB PMID:8703034 NCBI chrNW_004936535:7,995,185...8,015,463 JBrowse link
glutathione catabolic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dpep1 dipeptidase 1 ISO (MGI:MGI:1203838|PMID:9560193) UniProt PMID:9560193 MGI:MGI:1203838 NCBI chrNW_004936641:379,112...384,711 JBrowse link
G Ggt1 gamma-glutamyltransferase 1 ISO (PMID:17924658), (PMID:21447318) UniProtKB PMID:17924658, PMID:21447318 NCBI chrNW_004936619:762,278...791,610 JBrowse link
G Ggt5 gamma-glutamyltransferase 5 ISO (PMID:1676842), (PMID:21447318) BHF-UCL PMID:1676842, PMID:21447318 NCBI chrNW_004936619:794,876...837,748 JBrowse link
glutathione deglycation term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Park7 Parkinsonism associated deglycase ISO (PMID:25416785) ParkinsonsUK-UCL PMID:25416785 NCBI chrNW_004936623:2,422,780...2,436,817 JBrowse link
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:MGI:5616326 NCBI chrNW_004936712:413,602...454,443 JBrowse link
G Nfe2l2 nuclear factor, erythroid 2 like 2 ISO (MGI:MGI:5616326|PMID:14978030) ParkinsonsUK-UCL PMID:14978030 MGI:MGI:5616326 NCBI chrNW_004936509:6,589,967...6,621,171 JBrowse link
regulation of glutathione biosynthetic process term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc7a11 solute carrier family 7 member 11 ISO (MGI:MGI:3588610|PMID:16037214) MGI PMID:16037214 MGI:MGI:3588610 NCBI chrNW_004936535:9,177,305...9,242,743 JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 12001
    metabolic process 7670
      cellular metabolic process 7071
        cellular modified amino acid metabolic process 132
          glutathione metabolic process 37
            ascorbate glutathione cycle 0
            glutathione biosynthetic process + 9
            glutathione catabolic process 3
            glutathione deglycation 1
Path 2
Term Annotations click to browse term
  biological_process 12001
    cellular process 11174
      cellular metabolic process 7071
        cellular nitrogen compound metabolic process 4095
          cellular amide metabolic process 668
            peptide metabolic process 470
              glutathione metabolic process 37
                ascorbate glutathione cycle 0
                glutathione biosynthetic process + 9
                glutathione catabolic process 3
                glutathione deglycation 1
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.