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ONTOLOGY REPORT - ANNOTATIONS


Term:glutathione biosynthetic process
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Accession:GO:0006750 term browser browse the term
Definition:The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins.
Synonyms:exact_synonym: glutathione anabolism;   glutathione biosynthesis;   glutathione formation;   glutathione synthesis
 xref: MetaCyc:GLUTATHIONESYN-PWY


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glutathione biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gclc glutamate-cysteine ligase, catalytic subunit JBrowse link 8 85,059,051 85,097,471 RGD:1582661
RGD:1624291
RGD:13792537
RGD:1600115
G Gclm glutamate cysteine ligase, modifier subunit JBrowse link 2 225,827,504 225,847,876 RGD:1582661
RGD:1624291
RGD:13792537
RGD:1600115
G Ggt1 gamma-glutamyltransferase 1 JBrowse link 20 14,019,723 14,045,781 RGD:1624291
G Ggt5 gamma-glutamyltransferase 5 JBrowse link 20 13,988,444 14,001,296 RGD:1600115
G Ggt6 gamma-glutamyl transferase 6 JBrowse link 10 58,995,253 58,998,431 RGD:1600115
G Ggt7 gamma-glutamyltransferase 7 JBrowse link 3 151,005,960 151,029,941 RGD:1600115
G Gss glutathione synthetase JBrowse link 3 151,076,254 151,106,557 RGD:1599340
RGD:1600115
G Hagh hydroxyacyl glutathione hydrolase JBrowse link 10 14,215,913 14,230,506 RGD:1600115
RGD:1624291
G Mgst2 microsomal glutathione S-transferase 2 JBrowse link 2 140,708,396 140,727,381 RGD:1624291
positive regulation of glutathione biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1624291
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:1624291
regulation of glutathione biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc7a11 solute carrier family 7 member 11 JBrowse link 2 139,453,774 139,528,479 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    cellular process 18618
      cellular metabolic process 10918
        cellular modified amino acid metabolic process 185
          glutathione metabolic process 66
            glutathione biosynthetic process 12
              negative regulation of glutathione biosynthetic process 0
              positive regulation of glutathione biosynthetic process 2
              regulation of glutathione biosynthetic process + 3
Path 2
Term Annotations click to browse term
  biological_process 19858
    metabolic process 12097
      cellular metabolic process 10918
        cellular biosynthetic process 5930
          cellular nitrogen compound biosynthetic process 4931
            amide biosynthetic process 1232
              peptide biosynthetic process 1109
                nonribosomal peptide biosynthetic process 14
                  glutathione biosynthetic process 12
                    negative regulation of glutathione biosynthetic process 0
                    positive regulation of glutathione biosynthetic process 2
                    regulation of glutathione biosynthetic process + 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.