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ONTOLOGY REPORT - ANNOTATIONS


Term:water-soluble vitamin metabolic process
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Accession:GO:0006767 term browser browse the term
Definition:The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water.
Synonyms:exact_synonym: water-soluble vitamin metabolism


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biotin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Btd biotinidase IBA
ISO
PMID:21873635
MGI:4888510 (MGI:4888153|PMID:21051254)
RGD PMID:21051254, PMID:21873635 MGI:4888153, RGD:13792537 NCBI chr16:7,758,192...7,791,301
Ensembl chr16:7,758,996...7,791,243
JBrowse link
cobalamin catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cubn cubilin IMP RGD PMID:14576052 RGD:8554807 NCBI chr17:80,584,921...80,807,181
Ensembl chr17:80,584,878...80,807,243
JBrowse link
cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcd4 ATP binding cassette subfamily D member 4 ISO (PMID:22922874) RGD PMID:22922874 NCBI chr 6:108,315,026...108,329,550
Ensembl chr 6:108,315,035...108,329,464
JBrowse link
G Atic 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase TAS RGD PMID:3994693 RGD:5135263 NCBI chr 9:78,862,013...78,882,061
Ensembl chr 9:78,862,013...78,882,060
JBrowse link
G Cblif cobalamin binding intrinsic factor IDA RGD PMID:14166172 RGD:1624368 NCBI chr 1:228,118,048...228,132,296
Ensembl chr 1:228,118,048...228,132,404
JBrowse link
G Gart phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase TAS RGD PMID:3994693 RGD:5135263 NCBI chr11:31,780,477...31,805,728
Ensembl chr11:31,780,487...31,805,728
JBrowse link
G Mmachc metabolism of cobalamin associated C ISO
IBA
(PMID:19700356), (PMID:22642810), (PMID:23825108)
PMID:21873635
RGD PMID:19700356, PMID:22642810, PMID:23825108, PMID:21873635 RGD:13792537 NCBI chr 5:135,555,587...135,561,723
Ensembl chr 5:135,555,565...135,561,914
JBrowse link
G Mmadhc metabolism of cobalamin associated D IEA
ISS
ISO
GO_REF:0000002
GO_REF:0000024
(PMID:24722857)
InterPro
UniProt
RGD
PMID:24722857 GO_REF:0000002, GO_REF:0000024 NCBI chr 3:35,783,511...35,801,474
Ensembl chr 3:35,783,623...35,801,614
JBrowse link
G Mtr 5-methyltetrahydrofolate-homocysteine methyltransferase ISO
IEA
(PMID:23825108)
GO_REF:0000107
RGD
Ensembl
PMID:23825108 GO_REF:0000107 NCBI chr17:66,210,444...66,295,014
Ensembl chr17:66,210,461...66,295,014
JBrowse link
folic acid catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Mthfs methenyltetrahydrofolate synthetase ISO (PMID:12764149) RGD PMID:12764149 NCBI chr 8:96,564,877...96,614,386
Ensembl chr 8:96,564,877...96,614,348
JBrowse link
G Pm20d2 peptidase M20 domain containing 2 NOT IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 5:48,416,005...48,437,054
Ensembl chr 5:48,420,302...48,436,531
JBrowse link
folic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Dhfr dihydrofolate reductase IDA
IBA
PMID:20424322
PMID:21873635
BHF-UCL
GO_Central
PMID:20424322, PMID:21873635 RGD:10054082, RGD:13792537 NCBI chr 2:21,931,887...21,958,927
Ensembl chr 2:21,931,493...21,962,453
JBrowse link
G Folr1 folate receptor alpha ISO MGI:2383986 (MGI:2669340|PMID:12854656) RGD PMID:12854656 MGI:2669340 NCBI chr 1:166,934,457...166,945,864
Ensembl chr 1:166,934,460...166,943,592
JBrowse link
G Gnmt glycine N-methyltransferase TAS RGD PMID:12054489 RGD:728472 NCBI chr 9:16,565,274...16,568,626
Ensembl chr 9:16,565,225...16,568,627
JBrowse link
G Mtrr 5-methyltetrahydrofolate-homocysteine methyltransferase reductase ISO
ISS
(PMID:11466310)
(MGI:5512657|PMID:24074862)
GO_REF:0000024
RGD
UniProt
PMID:11466310, PMID:24074862 GO_REF:0000024, MGI:5512657 NCBI chr 1:37,743,089...37,774,485
Ensembl chr 1:37,743,147...37,774,015
JBrowse link
G Shmt1 serine hydroxymethyltransferase 1 ISO
IBA
(PMID:11278996)
PMID:21873635
RGD PMID:11278996, PMID:21873635 RGD:13792537 NCBI chr10:47,030,813...47,059,216
Ensembl chr10:47,031,050...47,059,216
JBrowse link
G Shmt2 serine hydroxymethyltransferase 2 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 7:70,824,718...70,829,822
Ensembl chr 7:70,824,715...70,829,815
JBrowse link
L-ascorbic acid biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Akr1a1 aldo-keto reductase family 1 member A1 IMP
ISO
PMID:22820017
(MGI:3588122|PMID:15769935), (MGI:4834110|PMID:20410296)
RGD PMID:15769935, PMID:20410296, PMID:22820017 MGI:3588122, MGI:4834110, RGD:13825440 NCBI chr 5:135,482,068...135,498,693
Ensembl chr 5:135,482,068...135,498,822
JBrowse link
G Gsto1 glutathione S-transferase omega 1 IMP RGD PMID:9786866 RGD:70644 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
JBrowse link
G Gulo gulonolactone (L-) oxidase IEA
ISS
GO_REF:0000107
GO_REF:0000024
Ensembl
UniProt
GO_REF:0000024, GO_REF:0000107 NCBI chr15:42,671,206...42,693,711
Ensembl chr15:42,671,203...42,693,694
JBrowse link
G Rgn regucalcin ISS
ISO
IBA
GO_REF:0000024
(MGI:5486063|PMID:23349732)
PMID:21873635
UniProt
RGD
PMID:23349732, PMID:21873635 GO_REF:0000024, MGI:5486063, RGD:13792537 NCBI chr  X:1,833,484...1,848,904
Ensembl chr  X:1,833,492...1,848,904
JBrowse link
L-ascorbic acid metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gclc glutamate-cysteine ligase, catalytic subunit ISO MGI:2429419 (MGI:1928560|PMID:11118286) RGD PMID:11118286 MGI:1928560 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
JBrowse link
G Gsto1 glutathione S-transferase omega 1 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:11511179)
Ensembl
UniProt
RGD
PMID:11511179 GO_REF:0000024, GO_REF:0000107 NCBI chr 1:267,607,437...267,617,387
Ensembl chr 1:267,607,418...267,617,387
JBrowse link
G Gsto2 glutathione S-transferase omega 2 ISO
ISS
(PMID:15970797)
GO_REF:0000024
RGD
UniProt
PMID:15970797 GO_REF:0000024 NCBI chr 1:267,617,517...267,640,455
Ensembl chr 1:271,229,036...271,243,517
Ensembl chr 1:271,229,036...271,243,517
JBrowse link
G LOC103690044 glutathione S-transferase omega-2 ISS GO_REF:0000024 UniProt GO_REF:0000024 NCBI chr 1:271,228,018...271,243,517
Ensembl chr 1:271,229,036...271,243,517
JBrowse link
G Mir125a microRNA 125a IDA RGD PMID:27085842 RGD:26884454 NCBI chr 1:59,704,827...59,704,911
Ensembl chr 1:59,704,827...59,704,911
JBrowse link
G Slc23a2 solute carrier family 23 member 2 IMP
IBA
PMID:21873635 RGD
GO_Central
PMID:10331392, PMID:21873635 RGD:634186, RGD:13792537 NCBI chr 3:124,632,491...124,842,225
Ensembl chr 3:124,632,492...124,724,252
JBrowse link
pantothenate metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Vnn1 vanin 1 ISO
IBA
(PMID:11491533), (PMID:25478849)
PMID:21873635
RGD PMID:11491533, PMID:25478849, PMID:21873635 RGD:13792537 NCBI chr 1:22,614,832...22,625,134
Ensembl chr 1:22,614,783...22,625,204
JBrowse link
G Vnn3 vanin 3 IBA
ISO
PMID:21873635
(MGI:2149227|PMID:11491533)
RGD PMID:11491533, PMID:21873635 MGI:2149227, RGD:13792537 NCBI chr 1:22,649,114...22,661,376
Ensembl chr 1:22,649,081...22,661,377
JBrowse link
positive regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clybl citramalyl-CoA lyase ISO (MGI:5926841|PMID:29056341) RGD PMID:29056341 MGI:5926841 NCBI chr15:108,608,203...108,838,222
Ensembl chr15:108,608,204...108,838,235
JBrowse link
pyridoxal 5'-phosphate salvage term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxk pyridoxal kinase IEA
IBA
GO_REF:0000002
PMID:21873635
InterPro PMID:21873635 GO_REF:0000002, RGD:13792537 NCBI chr20:10,930,651...10,952,194
Ensembl chr20:10,930,518...10,952,391
JBrowse link
G RGD1566085 similar to pyridoxal (pyridoxine, vitamin B6) kinase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr20:10,883,952...10,912,870
Ensembl chr20:10,889,573...10,912,769
JBrowse link
pyridoxal phosphate biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxk pyridoxal kinase IDA RGD PMID:2988502 RGD:2303018 NCBI chr20:10,930,651...10,952,194
Ensembl chr20:10,930,518...10,952,391
JBrowse link
G Pnpo pyridoxamine 5'-phosphate oxidase ISO
IBA
(PMID:12824491)
PMID:21873635
RGD PMID:12824491, PMID:21873635 RGD:13792537 NCBI chr10:84,874,926...84,881,190
Ensembl chr10:84,874,927...84,881,190
JBrowse link
pyridoxal phosphate catabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pdxp pyridoxal phosphatase ISS
ISO
IEA
GO_REF:0000024
(MGI:5545857|PMID:24338473)
GO_REF:0000107
UniProt
RGD
Ensembl
PMID:24338473 GO_REF:0000024, GO_REF:0000107, MGI:5545857 NCBI chr 7:120,140,460...120,145,908
Ensembl chr 7:120,140,460...120,145,908
JBrowse link
pyridoxine biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pnpo pyridoxamine 5'-phosphate oxidase IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr10:84,874,926...84,881,190
Ensembl chr10:84,874,927...84,881,190
JBrowse link
regulation of cobalamin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Clybl citramalyl-CoA lyase ISO
ISS
IBA
(PMID:29056341)
(MGI:5926841|PMID:29056341)
GO_REF:0000024
PMID:21873635
RGD
UniProt
PMID:29056341, PMID:21873635 GO_REF:0000024, MGI:5926841, RGD:13792537 NCBI chr15:108,608,203...108,838,222
Ensembl chr15:108,608,204...108,838,235
JBrowse link
riboflavin biosynthetic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rfk riboflavin kinase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr 1:236,494,221...236,501,733
Ensembl chr 1:236,494,221...236,501,733
JBrowse link
riboflavin metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Rfk riboflavin kinase IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 NCBI chr 1:236,494,221...236,501,733
Ensembl chr 1:236,494,221...236,501,733
JBrowse link
thiamine metabolic process term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Acp3 acid phosphatase 3 IEA
ISO
GO_REF:0000107
(MGI:3849266|PMID:18940592)
Ensembl
RGD
PMID:18940592 GO_REF:0000107, MGI:3849266 NCBI chr 8:112,838,574...112,884,062
Ensembl chr 8:112,834,707...112,884,077
JBrowse link
G Thtpa thiamine triphosphatase IEA GO_REF:0000002 InterPro GO_REF:0000002 NCBI chr15:33,755,157...33,759,117
Ensembl chr15:33,755,478...33,759,115
JBrowse link
G Tpk1 thiamin pyrophosphokinase 1 ISO (MGI:1350425|PMID:10567383) RGD PMID:10567383 MGI:1350425 NCBI chr 4:72,792,252...73,174,179
Ensembl chr 4:72,792,252...73,174,179
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20020
    metabolic process 12263
      small molecule metabolic process 1798
        vitamin metabolic process 79
          water-soluble vitamin metabolic process 37
            L-ascorbic acid metabolic process + 9
            biotin metabolic process + 1
            cobalamin metabolic process + 9
            folic acid metabolic process + 8
            nicotinamide metabolic process + 0
            pantothenate metabolic process + 2
            riboflavin metabolic process + 1
            thiamine-containing compound metabolic process + 3
            vitamin B6 metabolic process + 4
            water-soluble vitamin biosynthetic process + 8
            water-soluble vitamin catabolic process + 4
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.