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ONTOLOGY REPORT - ANNOTATIONS


Term:xenobiotic metabolic process
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Accession:GO:0006805 term browser browse the term
Definition:The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide.
Synonyms:exact_synonym: xenobiotic metabolism
 xref: Wikipedia:Xenobiotic_metabolism


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xenobiotic metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ahr aryl hydrocarbon receptor JBrowse link 6 54,963,990 55,001,806 RGD:1600115
G Ahrr aryl-hydrocarbon receptor repressor JBrowse link 1 31,603,297 31,698,329 RGD:1600115
G Aip aryl-hydrocarbon receptor-interacting protein JBrowse link 1 219,361,859 219,373,924 RGD:1624291
G Aox1 aldehyde oxidase 1 JBrowse link 9 64,929,682 65,007,872 RGD:730052
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:727649
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:1600115
RGD:1624291
G Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 JBrowse link 1 256,382,861 256,386,729 RGD:1624291
G Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 JBrowse link 4 116,261,796 116,278,615 RGD:1624291
RGD:1600115
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 JBrowse link 1 83,711,223 83,725,222 RGD:13792537
G Cyp2a2 cytochrome P450, family 2, subfamily a, polypeptide 2 JBrowse link 1 83,744,229 83,766,490 RGD:13792537
G Cyp2a3 cytochrome P450, family 2, subfamily a, polypeptide 3 JBrowse link 1 83,653,248 83,662,118 RGD:13792537
G Cyp2ab1 cytochrome P450, family 2, subfamily ab, polypeptide 1 JBrowse link 11 84,506,074 84,514,164 RGD:13792537
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 JBrowse link 7 99,142,431 99,183,540 RGD:13792537
G Cyp2b12 cytochrome P450, family 2, subfamily b, polypeptide 12 JBrowse link 1 83,511,167 83,522,965 RGD:13792537
G Cyp2b15 cytochrome P450, family 2, subfamily b, polypeptide 15 JBrowse link 1 251,325,923 251,338,404 RGD:13792537
G Cyp2b2 cytochrome P450, family 2, subfamily b, polypeptide 2 JBrowse link 1 83,103,925 83,119,578 RGD:13792537
G Cyp2b21 cytochrome P450, family 2, subfamily b, polypeptide 21 JBrowse link 1 83,389,783 83,418,613 RGD:1299648
RGD:13792537
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 JBrowse link 1 83,163,103 83,236,615 RGD:1624291
RGD:13792537
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 JBrowse link 1 257,676,172 258,004,428 RGD:1298853
RGD:13792537
G Cyp2c12 cytochrome P450, family 2, subfamily c, polypeptide 12 JBrowse link 1 258,709,726 258,766,873 RGD:13792537
G Cyp2c13 cytochrome P450, family 2, subfamily c, polypeptide 13 JBrowse link 1 258,796,624 258,877,023 RGD:13792537
G Cyp2c22 cytochrome P450, family 2, subfamily c, polypeptide 22 JBrowse link 1 259,257,658 259,297,270 RGD:13792537
G Cyp2c23 cytochrome P450, family 2, subfamily c, polypeptide 23 JBrowse link 1 263,778,510 263,803,166 RGD:13792537
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 JBrowse link 1 258,074,797 258,139,176 RGD:13792537
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 JBrowse link 1 147,713,879 147,814,410 RGD:13792537
G Cyp2c7 cytochrome P450, family 2, subfamily c, polypeptide 7 JBrowse link 1 147,422,999 148,119,979 RGD:13792537
G Cyp2c80 cytochrome P450, family 2, subfamily c, polypeptide 80 RGD:13792537
G Cyp2d1 cytochrome P450, family 2, subfamily d, polypeptide 1 JBrowse link 7 123,625,641 123,630,045 RGD:1624291
RGD:13792537
G Cyp2d2 cytochrome P450, family 2, subfamily d, polypeptide 2 JBrowse link 7 123,651,827 123,655,896 RGD:13792537
G Cyp2d3 cytochrome P450, family 2, subfamily d, polypeptide 3 JBrowse link 7 123,634,400 123,638,757 RGD:13792537
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:13792537
G Cyp2d5 cytochrome P450, family 2, subfamily d, polypeptide 5 JBrowse link 7 123,616,596 123,621,102 RGD:13792537
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:625597
RGD:13792537
RGD:4892233
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 JBrowse link 1 83,933,974 83,947,804 RGD:13792537
G Cyp2g1 cytochrome P450, family 2, subfamily g, polypeptide 1 JBrowse link 1 83,626,639 83,638,154 RGD:13792537
G Cyp2j10 cytochrome P450, family 2, subfamily j, polypeptide 10 JBrowse link 5 115,067,847 115,101,961 RGD:13792537
G Cyp2j16 cytochrome P450, family 2, subfamily j, polypeptide 16 JBrowse link 5 119,454,997 119,505,533 RGD:13792537
G Cyp2j3 cytochrome P450, family 2, subfamily j, polypeptide 3 JBrowse link 5 115,196,982 115,222,084 RGD:13792537
G Cyp2j4 cytochrome P450, family 2, subfamily j, polypeptide 4 JBrowse link 5 119,546,458 119,564,843 RGD:13792537
G Cyp2r1 cytochrome P450, family 2, subfamily r, polypeptide 1 JBrowse link 1 184,060,521 184,106,604 RGD:13792537
G Cyp2s1 cytochrome P450, family 2, subfamily s, polypeptide 1 JBrowse link 1 82,595,211 82,610,350 RGD:13792537
G Cyp2t1 cytochrome P450, family 2, subfamily t, polypeptide 1 JBrowse link 1 83,965,370 83,969,466 RGD:13792537
G Cyp2u1 cytochrome P450, family 2, subfamily u, polypeptide 1 JBrowse link 2 236,414,131 236,431,650 RGD:13792537
G Cyp2w1 cytochrome P450, family 2, subfamily w, polypeptide 1 JBrowse link 12 17,382,749 17,387,909 RGD:1624291
RGD:13792537
G Cyp46a1 cytochrome P450, family 46, subfamily a, polypeptide 1 JBrowse link 6 132,242,328 132,273,788 RGD:1624291
G Fmo2 flavin containing dimethylaniline monoxygenase 2 JBrowse link 13 80,752,526 80,775,264 RGD:1624291
RGD:1600115
G Gsta1 glutathione S-transferase alpha 1 JBrowse link 9 27,366,404 27,381,004 RGD:13792537
G Gsta2 glutathione S-transferase alpha 2 JBrowse link 8 85,640,081 85,645,621 RGD:13792537
G Gsta3 glutathione S-transferase alpha 3 JBrowse link 9 27,357,490 27,417,023 RGD:13792537
G Gsta4 glutathione S-transferase alpha 4 JBrowse link 8 85,497,557 85,514,732 RGD:1641942
RGD:13792537
RGD:1624291
G Gsta5 glutathione S-transferase alpha 5 JBrowse link 8 85,553,659 85,564,914 RGD:13792537
G Gsta6 glutathione S-transferase alpha 6 JBrowse link 9 27,475,273 27,533,939 RGD:13792537
G Gstm2 glutathione S-transferase mu 2 JBrowse link 2 210,778,041 210,782,807 RGD:730286
G Gsto2 glutathione S-transferase omega 2 JBrowse link 1 267,617,517 267,640,455 RGD:1624291
RGD:1600115
G Gstp1 glutathione S-transferase pi 1 JBrowse link 1 219,291,679 219,294,147 RGD:728729
RGD:1624291
RGD:1641942
G Guk1 guanylate kinase 1 JBrowse link 10 45,535,617 45,552,455 RGD:1624291
G Hnf4a hepatocyte nuclear factor 4, alpha JBrowse link 3 159,902,441 159,965,003 RGD:1624291
RGD:1600115
G LOC100361492 cytochrome P450, family 2, subfamily c, polypeptide 55-like JBrowse link 1 258,210,311 258,252,829 RGD:13792537
G LOC100361547 Cytochrome P450, family 2, subfamily c, polypeptide 7-like JBrowse link 1 148,232,438 148,287,458 RGD:13792537
G LOC100910127 cytochrome P450 2B15-like JBrowse link 1 251,351,807 251,365,431 RGD:13792537
G LOC103690044 glutathione S-transferase omega-2 JBrowse link 1 271,228,018 271,243,517 RGD:1600115
G LOC103691072 cytochrome P450 2B15-like JBrowse link 1 83,571,210 83,584,833 RGD:13792537
G LOC103691092 cytochrome P450 2B9-like JBrowse link 1 83,296,869 83,315,317 RGD:13792537
G LOC108348061 glutathione S-transferase alpha-3 JBrowse link 9 27,436,255 27,452,897 RGD:13792537
G Nceh1 neutral cholesterol ester hydrolase 1 JBrowse link 2 112,868,834 112,932,622 RGD:1624291
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 JBrowse link 11 65,022,100 65,058,546 RGD:1624291
RGD:1600115
G RGD1562107 similar to class-alpha glutathione S-transferase JBrowse link 9 27,311,229 27,324,452 RGD:13792537
G Rora RAR-related orphan receptor A JBrowse link 8 75,515,886 75,616,477 RGD:1624291
G Rorc RAR-related orphan receptor C JBrowse link 2 195,612,471 195,636,797 RGD:1624291
G Slco1a6 solute carrier organic anion transporter family, member 1a6 JBrowse link 4 176,345,671 176,390,729 RGD:1600115
G Sult1a1 sulfotransferase family 1A member 1 JBrowse link 1 198,100,586 198,104,106 RGD:2301063
RGD:1624291
G Sult1b1 sulfotransferase family 1B member 1 JBrowse link 14 22,142,412 22,155,246 RGD:1624291
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:1624291
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:1624291
4-chlorobiphenyl metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:1600442
arsonoacetate metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G As3mt arsenite methyltransferase JBrowse link 1 266,482,787 266,514,570 RGD:625365
RGD:13792537
RGD:1624291
RGD:1600115
G N6amt1 N-6 adenine-specific DNA methyltransferase 1 JBrowse link 11 27,004,335 27,016,690 RGD:1624291
biphenyl catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:1600442
G Ugt2b17 UDP glucuronosyltransferase family 2 member B17 JBrowse link 14 22,724,399 22,736,148 RGD:1600442
dibenzo-p-dioxin catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:2306662
RGD:2306673
dibenzo-p-dioxin metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:4889921
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:4778755
G Cyp11b1 cytochrome P450, family 11, subfamily b, polypeptide 1 RGD:4889135
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 JBrowse link 1 266,422,127 266,429,947 RGD:2324640
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 JBrowse link 8 58,744,849 58,772,408 RGD:2324640
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:727674
RGD:1624291
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 JBrowse link 8 62,451,360 62,458,244 RGD:1624291
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 JBrowse link 6 2,308,179 2,316,739 RGD:1624291
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4778755
G Prkcb protein kinase C, beta JBrowse link 1 192,233,569 192,575,339 RGD:5131886
G Srd5a2 steroid 5 alpha-reductase 2 JBrowse link 6 25,279,635 25,315,501 RGD:4892000
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:4778755
insecticide metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 JBrowse link 8 62,472,087 62,478,122 RGD:2306660
G Hsd17b3 hydroxysteroid (17-beta) dehydrogenase 3 JBrowse link 17 1,579,319 1,610,745 RGD:4890969
G Hsd3b1 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1 RGD:4890969
G Star steroidogenic acute regulatory protein JBrowse link 16 71,036,204 71,040,847 RGD:4890969
L-cysteine catabolic process to taurine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Csad cysteine sulfinic acid decarboxylase JBrowse link 7 143,781,520 143,810,880 RGD:13800536
phenylacetate catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acaa1a acetyl-CoA acyltransferase 1A JBrowse link 8 128,027,880 128,036,471 RGD:13792537
G Acaa1b acetyl-Coenzyme A acyltransferase 1B JBrowse link 8 127,836,235 127,845,296 RGD:13792537
G Pon3 paraoxonase 3 JBrowse link 4 30,311,981 30,338,679 RGD:1303961
propylene metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 3 2,507,745 2,534,664 RGD:1624291
RGD:1600115
taurine biosynthetic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cdo1 cysteine dioxygenase type 1 JBrowse link 18 40,702,027 40,716,901 RGD:1600115
G Csad cysteine sulfinic acid decarboxylase JBrowse link 7 143,781,520 143,810,880 RGD:632596
RGD:1624291
RGD:1600115
taurine metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Baat bile acid CoA:amino acid N-acyltransferase JBrowse link 5 64,768,397 64,777,368 RGD:1624291
G Ghr growth hormone receptor JBrowse link 2 53,149,225 53,413,954 RGD:1624291
G Phgdh phosphoglycerate dehydrogenase JBrowse link 2 200,484,245 200,513,564 RGD:1624291
G Stat5a signal transducer and activator of transcription 5A JBrowse link 10 88,764,732 88,789,060 RGD:1624291
G Stat5b signal transducer and activator of transcription 5B JBrowse link 10 88,686,207 88,712,313 RGD:1624291
RGD:1600115
thiocyanate metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Lpo lactoperoxidase JBrowse link 10 75,100,385 75,120,247 RGD:1600115
trichloroethylene metabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cyp2f4 cytochrome P450, family 2, subfamily f, polypeptide 4 JBrowse link 1 83,933,974 83,947,804 RGD:2301693
xenobiotic catabolic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc2 ATP binding cassette subfamily C member 2 JBrowse link 1 263,554,426 263,612,556 RGD:14700808
G Acsl1 acyl-CoA synthetase long-chain family member 1 JBrowse link 16 48,937,456 49,003,898 RGD:2312871
G Cryz crystallin zeta JBrowse link 2 260,884,315 260,911,827 RGD:1624291
RGD:1600115
G Gsta1 glutathione S-transferase alpha 1 JBrowse link 9 27,366,404 27,381,004 RGD:1641938
RGD:12793043
G Gsta2 glutathione S-transferase alpha 2 JBrowse link 8 85,640,081 85,645,621 RGD:1641938
RGD:12793043
G Gsta5 glutathione S-transferase alpha 5 JBrowse link 8 85,553,659 85,564,914 RGD:12793043
G Gstm1 glutathione S-transferase mu 1 JBrowse link 2 210,803,869 210,809,461 RGD:1624291
RGD:12793043
G Gstm2 glutathione S-transferase mu 2 JBrowse link 2 210,778,041 210,782,807 RGD:12793043
RGD:1600115
RGD:1624291
G Gstm3 glutathione S-transferase mu 3 JBrowse link 2 210,685,204 210,688,273 RGD:1624291
G Gstm4 glutathione S-transferase mu 4 JBrowse link 2 210,834,013 210,839,242 RGD:1624291
G Gstm5 glutathione S-transferase, mu 5 JBrowse link 2 210,685,338 210,688,133 RGD:1624291
G Gstm7 glutathione S-transferase, mu 7 JBrowse link 2 210,720,719 210,726,179 RGD:1600115
G Gsto1 glutathione S-transferase omega 1 JBrowse link 1 267,607,437 267,617,387 RGD:1600115
RGD:1624291
G LOC108348061 glutathione S-transferase alpha-3 JBrowse link 9 27,436,255 27,452,897 RGD:12793043
xenobiotic glucuronidation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RGD1559459 similar to Expressed sequence AI788959 JBrowse link 14 22,932,454 22,955,663 RGD:1624291
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 JBrowse link 9 95,295,701 95,302,822 RGD:1624291
RGD:13792537
RGD:10769352
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 JBrowse link 9 95,285,592 95,302,822 RGD:1624291
G Ugt1a6 UDP glucuronosyltransferase family 1 member A6 JBrowse link 9 95,241,609 95,302,822 RGD:13792537
G Ugt1a7c UDP glucuronosyltransferase 1 family, polypeptide A7C JBrowse link 9 95,233,957 95,302,822 RGD:13792537
G Ugt1a8 UDP glucuronosyltransferase family 1 member A8 JBrowse link 9 95,221,474 95,302,822 RGD:1624291
RGD:13792537
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 JBrowse link 9 95,161,157 95,302,822 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19334
    metabolic process 11555
      cellular metabolic process 10567
        xenobiotic metabolic process 114
          1,3-dichloro-2-propanol metabolic process + 0
          2,4,5-trichlorophenoxyacetic acid metabolic process + 0
          2,4-dichlorophenoxyacetic acid metabolic process + 0
          2-chloro-N-isopropylacetanilide metabolic process + 0
          2-nitropropane metabolic process + 0
          3-methylquinoline metabolic process + 0
          acetylene metabolic process + 0
          acrylonitrile metabolic process + 0
          adamantanone metabolic process + 0
          arsonoacetate metabolic process + 2
          bromoxynil metabolic process 0
          caprolactam metabolic process + 0
          cocaine metabolic process + 0
          codeine metabolic process + 0
          cyanamide metabolic process 0
          cyclohexanol metabolic process + 0
          cyclohexylsulfamate metabolic process 0
          dibenzo-p-dioxin metabolic process + 12
          dibenzofuran metabolic process + 0
          dimethyl ether metabolic process 0
          dodecyl sulfate metabolic process 0
          erythromycin metabolic process + 0
          halogenated hydrocarbon metabolic process + 2
          insecticide metabolic process + 4
          methanesulfonic acid metabolic process 0
          methyl ethyl ketone metabolic process + 0
          methyl tert-butyl ether metabolic process 0
          morphine metabolic process + 0
          n-octane metabolic process + 0
          nitrilotriacetate metabolic process + 0
          nitroglycerin metabolic process 0
          nylon metabolic process + 0
          organosilicon metabolic process + 0
          pentaerythritol tetranitrate metabolic process 0
          phenanthrene metabolic process + 0
          propylene metabolic process + 1
          s-triazine compound metabolic process + 0
          taurine metabolic process + 7
          tetrahydrofuran metabolic process 0
          thiocyanate metabolic process + 1
          triethanolamine metabolic process + 0
          xenobiotic catabolic process + 20
          xenobiotic glucuronidation 7
Path 2
Term Annotations click to browse term
  biological_process 19334
    response to stimulus 10393
      response to chemical 6331
        response to xenobiotic stimulus 408
          cellular response to xenobiotic stimulus 213
            xenobiotic metabolic process 114
              1,3-dichloro-2-propanol metabolic process + 0
              2,4,5-trichlorophenoxyacetic acid metabolic process + 0
              2,4-dichlorophenoxyacetic acid metabolic process + 0
              2-chloro-N-isopropylacetanilide metabolic process + 0
              2-nitropropane metabolic process + 0
              3-methylquinoline metabolic process + 0
              acetylene metabolic process + 0
              acrylonitrile metabolic process + 0
              adamantanone metabolic process + 0
              arsonoacetate metabolic process + 2
              bromoxynil metabolic process 0
              caprolactam metabolic process + 0
              cocaine metabolic process + 0
              codeine metabolic process + 0
              cyanamide metabolic process 0
              cyclohexanol metabolic process + 0
              cyclohexylsulfamate metabolic process 0
              dibenzo-p-dioxin metabolic process + 12
              dibenzofuran metabolic process + 0
              dimethyl ether metabolic process 0
              dodecyl sulfate metabolic process 0
              erythromycin metabolic process + 0
              halogenated hydrocarbon metabolic process + 2
              insecticide metabolic process + 4
              methanesulfonic acid metabolic process 0
              methyl ethyl ketone metabolic process + 0
              methyl tert-butyl ether metabolic process 0
              morphine metabolic process + 0
              n-octane metabolic process + 0
              nitrilotriacetate metabolic process + 0
              nitroglycerin metabolic process 0
              nylon metabolic process + 0
              organosilicon metabolic process + 0
              pentaerythritol tetranitrate metabolic process 0
              phenanthrene metabolic process + 0
              propylene metabolic process + 1
              s-triazine compound metabolic process + 0
              taurine metabolic process + 7
              tetrahydrofuran metabolic process 0
              thiocyanate metabolic process + 1
              triethanolamine metabolic process + 0
              xenobiotic catabolic process + 20
              xenobiotic glucuronidation 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.