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ONTOLOGY REPORT - ANNOTATIONS


Term:endoplasmic reticulum to Golgi vesicle-mediated transport
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Accession:GO:0006888 term browser browse the term
Definition:The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi.
Synonyms:exact_synonym: ER to Golgi transport;   ER to Golgi vesicle-mediated transport;   anterograde transport, ER to Golgi;   anterograde transport, endoplasmic reticulum to Golgi;   anterograde vesicle-mediated transport, ER to Golgi;   anterograde vesicle-mediated transport, endoplasmic reticulum to Golgi;   endoplasmic reticulum to Golgi transport;   rough ER to cis-Golgi transport;   rough ER to cis-Golgi vesicle-mediated transport;   rough endoplasmic reticulum to cis-Golgi transport;   rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport
 alt_id: GO:0048221
 xref: MIPS_funcat:20.09.07.03


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endoplasmic reticulum to Golgi vesicle-mediated transport term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ank1 ankyrin 1 JBrowse link 16 73,681,422 73,912,605 RGD:1624291
RGD:1600115
G Arcn1 archain 1 JBrowse link 8 49,051,257 49,075,861 RGD:13792537
G Arfgap2 ADP-ribosylation factor GTPase activating protein 2 JBrowse link 3 80,081,541 80,093,659 RGD:13792537
G Arfgap3 ADP-ribosylation factor GTPase activating protein 3 JBrowse link 7 124,149,665 124,198,298 RGD:13792537
G Atl2 atlastin GTPase 2 JBrowse link 6 2,568,975 2,610,432 RGD:1624291
G Atl3 atlastin GTPase 3 JBrowse link 1 222,746,023 222,788,439 RGD:1624291
G Bcap29 B-cell receptor-associated protein 29 JBrowse link 6 50,883,758 50,923,743 RGD:1624291
RGD:13792537
G Bcap31 B-cell receptor-associated protein 31 JBrowse link X 157,094,365 157,126,397 RGD:1624291
RGD:13792537
G Bet1 Bet1 golgi vesicular membrane trafficking protein JBrowse link 4 29,082,368 29,092,638 RGD:4892613
RGD:13792537
RGD:8554056
G Cnih4 cornichon family AMPA receptor auxiliary protein 4 JBrowse link 13 99,469,382 99,490,693 RGD:1624291
RGD:1600115
G Cog3 component of oligomeric golgi complex 3 JBrowse link 15 57,753,814 57,805,627 RGD:1624291
RGD:1600115
G Copa coatomer protein complex subunit alpha JBrowse link 13 90,467,285 90,508,894 RGD:13792537
G Copb1 coatomer protein complex, subunit beta 1 JBrowse link 1 183,695,480 183,729,569 RGD:13792537
G Copb2 coatomer protein complex subunit beta 2 JBrowse link 8 106,582,339 106,603,763 RGD:13792537
G Cope coatomer protein complex, subunit epsilon JBrowse link 16 20,863,141 20,873,516 RGD:13792537
G Copg1 coatomer protein complex, subunit gamma 1 JBrowse link 4 119,815,041 119,840,997 RGD:13792537
G Copg2 coatomer protein complex, subunit gamma 2 JBrowse link 4 58,064,394 58,195,242 RGD:13792537
G Creb3l2 cAMP responsive element binding protein 3-like 2 JBrowse link 4 64,869,285 64,981,519 RGD:1624291
RGD:1600115
G Cul3 cullin 3 JBrowse link 9 86,044,485 86,129,066 RGD:1624291
RGD:1600115
G Ddhd2 DDHD domain containing 2 JBrowse link 16 71,090,096 71,120,713 RGD:13792537
G Ergic1 endoplasmic reticulum-golgi intermediate compartment 1 JBrowse link 10 16,821,393 16,912,050 RGD:1624291
RGD:13792537
G Ergic2 ERGIC and golgi 2 JBrowse link 4 182,569,086 182,600,258 RGD:13792537
G Ergic3 ERGIC and golgi 3 JBrowse link 3 151,553,567 151,563,318 RGD:13792537
G Golga2 golgin A2 JBrowse link 3 11,317,328 11,337,569 RGD:10400863
RGD:10400877
G Gosr1 golgi SNAP receptor complex member 1 JBrowse link 10 63,405,526 63,442,257 RGD:70749
RGD:13792537
RGD:8554056
G Gosr2 golgi SNAP receptor complex member 2 JBrowse link 10 91,735,772 91,756,123 RGD:1624291
RGD:13792537
G Hint1-ps1 histidine triad nucleotide binding protein 1, pseudogene 1 JBrowse link 4 93,405,665 93,406,239 RGD:724652
G Htt huntingtin JBrowse link 14 81,105,139 81,254,637 RGD:1624291
G Hyou1 hypoxia up-regulated 1 JBrowse link 8 48,699,796 48,711,912 RGD:1624291
RGD:1600115
G Kdelr1 KDEL endoplasmic reticulum protein retention receptor 1 JBrowse link 1 101,859,346 101,870,232 RGD:13792537
G Kdelr2 KDEL endoplasmic reticulum protein retention receptor 2 JBrowse link 12 13,192,452 13,210,758 RGD:13792537
G Kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 JBrowse link 7 120,749,680 120,760,163 RGD:13792537
G Klhl12 kelch-like family member 12 JBrowse link 13 51,280,933 51,314,753 RGD:1600115
RGD:1624291
G Lman1 lectin, mannose-binding, 1 JBrowse link 18 61,683,377 61,707,344 RGD:1549454
RGD:13792537
RGD:1600115
G Lman1l lectin, mannose-binding, 1 like JBrowse link 8 62,386,806 62,400,370 RGD:13792537
G Lman2 lectin, mannose-binding 2 JBrowse link 17 9,798,136 9,815,820 RGD:13792537
G Lmf1 lipase maturation factor 1 JBrowse link 10 14,945,185 15,031,855 RGD:1624291
RGD:1600115
G LOC100363782 RAB1B, member RAS oncogene family-like RGD:1600115
G LOC102555167 ras-related protein Rab-1B-like JBrowse link 1 220,480,828 220,491,456 RGD:1600115
G LOC103689986 protein YIF1B JBrowse link 1 87,180,590 87,190,783 RGD:1600115
G Mia2 MIA SH3 domain ER export factor 2 JBrowse link 6 80,188,721 80,286,918 RGD:1624291
RGD:13792537
G Mia3 MIA SH3 domain ER export factor 3 JBrowse link 13 101,727,434 101,770,127 RGD:1624291
G Mppe1 metallophosphoesterase 1 JBrowse link 18 62,946,952 62,966,174 RGD:1600115
G Nrbp1 nuclear receptor binding protein 1 JBrowse link 6 26,486,823 26,497,396 RGD:1624291
RGD:13792537
G Nrbp2 nuclear receptor binding protein 2 JBrowse link 7 117,145,106 117,151,694 RGD:13792537
G Pdcd6 programmed cell death 6 JBrowse link 1 31,576,183 31,591,852 RGD:1600115
RGD:1624291
G Pef1 penta-EF hand domain containing 1 JBrowse link 5 148,320,610 148,343,876 RGD:1624291
RGD:1600115
G Pgap1 post-GPI attachment to proteins 1 JBrowse link 9 61,066,170 61,134,963 RGD:13792537
G Pitpnm3 PITPNM family member 3 JBrowse link 10 58,618,679 58,722,679 RGD:13792537
G Preb prolactin regulatory element binding JBrowse link 6 26,784,088 26,787,875 RGD:11344947
G Rab12 RAB12, member RAS oncogene family JBrowse link 9 114,683,985 114,709,613 RGD:13792537
G Rab19 RAB19, member RAS oncogene family JBrowse link 4 67,166,412 67,176,141 RGD:13792537
G Rab1a RAB1A, member RAS oncogene family JBrowse link 14 104,475,082 104,500,176 RGD:8554056
RGD:13792537
RGD:1624291
G Rab1b RAB1B, member RAS oncogene family JBrowse link 1 220,483,529 220,491,469 RGD:1624291
RGD:1600115
G Rab29 RAB29, member RAS oncogene family JBrowse link 13 48,644,575 48,650,229 RGD:1624291
G Rab2a RAB2A, member RAS oncogene family JBrowse link 5 21,632,654 21,696,721 RGD:1624291
G Rab30 RAB30, member RAS oncogene family JBrowse link 1 157,573,344 157,667,973 RGD:13792537
G Rab33a RAB33A, member RAS oncogene family JBrowse link X 135,348,799 135,360,204 RGD:13792537
G Rab33b RAB33B, member RAS oncogene family JBrowse link 2 140,541,619 140,552,220 RGD:13792537
G Rab43 RAB43, member RAS oncogene family JBrowse link 4 119,695,012 119,714,490 RGD:13792537
G Rangrf RAN guanine nucleotide release factor JBrowse link 10 55,559,049 55,560,420 RGD:1624291
RGD:1600115
G Sar1b secretion associated, Ras related GTPase 1B JBrowse link 10 37,215,989 37,245,603 RGD:13792537
G Scfd1 sec1 family domain containing 1 JBrowse link 6 72,124,408 72,202,703 RGD:633773
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component JBrowse link 4 145,686,186 145,699,577 RGD:8554056
G Sec16a SEC16 homolog A, endoplasmic reticulum export factor JBrowse link 3 3,856,218 3,890,785 RGD:1624291
G Sec16b SEC16 homolog B, endoplasmic reticulum export factor JBrowse link 13 75,153,074 75,216,941 RGD:1600115
RGD:1624291
G Sec22a SEC22 homolog A, vesicle trafficking protein JBrowse link 11 68,633,080 68,686,553 RGD:69776
G Sec22b SEC22 homolog B, vesicle trafficking protein JBrowse link 2 200,076,079 200,096,861 RGD:13792537
G Sec23ip SEC23 interacting protein JBrowse link 1 200,167,075 200,210,362 RGD:13792537
G Sec24a SEC24 homolog A, COPII coat complex component JBrowse link 10 37,138,539 37,215,899 RGD:1624291
G Sec24b SEC24 homolog B, COPII coat complex component JBrowse link 2 230,286,886 230,356,887 RGD:1624291
G Sec24c SEC24 homolog C, COPII coat complex component JBrowse link 15 4,035,196 4,057,209 RGD:1624291
RGD:1600115
G Sec24d SEC24 homolog D, COPII coat complex component JBrowse link 2 227,455,704 227,562,801 RGD:1624291
G Sec31a SEC31 homolog A, COPII coat complex component JBrowse link 14 10,854,713 10,909,579 RGD:13792537
RGD:1600115
G Sec31b SEC31 homolog B, COPII coat complex component JBrowse link 1 264,266,279 264,294,687 RGD:13792537
G Spast spastin JBrowse link 6 22,230,067 22,282,166 RGD:1624291
RGD:1600115
G Stx17 syntaxin 17 JBrowse link 5 63,866,346 63,926,276 RGD:1624291
RGD:1600115
G Stx5 syntaxin 5 JBrowse link 1 224,939,497 224,955,658 RGD:4892613
RGD:13792537
G Tbc1d20 TBC1 domain family, member 20 JBrowse link 3 147,772,006 147,790,946 RGD:1624291
RGD:13792537
G Tex261 testis expressed 261 JBrowse link 4 115,446,830 115,454,035 RGD:13792537
G Tfg Trk-fused gene JBrowse link 11 46,180,189 46,206,723 RGD:1624291
G Ticam2 toll-like receptor adaptor molecule 2 JBrowse link 18 40,555,106 40,572,569 RGD:13792537
G Tmed1 transmembrane p24 trafficking protein 1 JBrowse link 8 22,540,422 22,544,369 RGD:13792537
G Tmed10 transmembrane p24 trafficking protein 10 JBrowse link 6 109,169,739 109,205,004 RGD:13792537
G Tmed11 transmembrane emp24 protein transport domain containing 11 JBrowse link 14 1,936,972 1,959,089 RGD:13792537
G Tmed2 transmembrane p24 trafficking protein 2 JBrowse link 12 37,471,259 37,480,344 RGD:13792537
G Tmed3 transmembrane p24 trafficking protein 3 JBrowse link 8 97,075,194 97,083,107 RGD:13792537
G Tmed4 transmembrane p24 trafficking protein 4 JBrowse link 14 86,390,327 86,395,151 RGD:13792537
G Tmed5 transmembrane p24 trafficking protein 5 JBrowse link 14 2,613,318 2,624,773 RGD:13792537
G Tmed6 transmembrane p24 trafficking protein 6 JBrowse link 19 39,261,841 39,267,928 RGD:13792537
G Tmed7 transmembrane p24 trafficking protein 7 JBrowse link 18 40,579,182 40,586,260 RGD:13792537
G Tmed9 transmembrane p24 trafficking protein 9 JBrowse link 17 9,560,735 9,565,249 RGD:13792537
G Trappc1 trafficking protein particle complex 1 JBrowse link 10 55,924,996 55,926,582 RGD:13792537
G Trappc11 trafficking protein particle complex 11 JBrowse link 16 47,874,993 47,920,822 RGD:1624291
RGD:1600115
G Trappc12 trafficking protein particle complex 12 JBrowse link 6 47,954,822 48,020,280 RGD:1624291
RGD:1600115
G Trappc2 trafficking protein particle complex 2 JBrowse link X 29,550,871 29,562,135 RGD:1600115
G Trappc2b trafficking protein particle complex 2B JBrowse link 10 35,036,176 35,040,918 RGD:1600115
G Trappc2l trafficking protein particle complex 2-like JBrowse link 19 55,423,350 55,428,551 RGD:1600115
G Trappc3 trafficking protein particle complex 3 JBrowse link 5 144,281,720 144,295,306 RGD:1624291
RGD:13792537
G Trappc3l trafficking protein particle complex 3-like JBrowse link 20 27,578,268 27,664,689 RGD:13792537
G Trappc4 trafficking protein particle complex 4 JBrowse link 8 48,723,755 48,727,182 RGD:13792537
G Trappc5 trafficking protein particle complex 5 JBrowse link 12 2,228,670 2,232,973 RGD:13792537
G Trappc6a trafficking protein particle complex 6A JBrowse link 1 80,417,514 80,424,429 RGD:13792537
G Trappc6b trafficking protein particle complex 6B JBrowse link 6 80,142,126 80,153,216 RGD:13792537
G Trappc8 trafficking protein particle complex 8 JBrowse link 18 15,298,673 15,375,034 RGD:13792537
G Uso1 USO1 vesicle transport factor JBrowse link 14 17,371,451 17,436,948 RGD:10400863
RGD:13792537
G Vamp4 vesicle-associated membrane protein 4 JBrowse link 13 80,460,699 80,483,597 RGD:1624291
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:4892613
RGD:4892615
G Vapa VAMP associated protein A JBrowse link 9 113,300,831 113,331,872 RGD:1624291
G Vapb VAMP associated protein B and C JBrowse link 3 171,832,558 171,871,042 RGD:1624291
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:730179
G Vti1a vesicle transport through interaction with t-SNAREs 1A JBrowse link 1 276,310,072 276,508,635 RGD:4892613
RGD:13792537
G Vti1b vesicle transport through interaction with t-SNAREs 1B JBrowse link 6 102,340,261 102,353,612 RGD:13792537
G Whamm WASP homolog associated with actin, golgi membranes and microtubules JBrowse link 1 143,401,986 143,430,356 RGD:1624291
RGD:13792537
G Yif1a Yip1 interacting factor homolog A, membrane trafficking protein JBrowse link 1 220,470,070 220,474,131 RGD:1600115
G Yif1b Yip1 interacting factor homolog B, membrane trafficking protein JBrowse link 1 88,182,379 88,192,568 RGD:1600115
G Ykt6 YKT6 v-SNARE homolog JBrowse link 14 86,196,018 86,207,057 RGD:1624291
RGD:8553660
G Zw10 zw10 kinetochore protein JBrowse link 8 53,365,881 53,390,742 RGD:1624291
RGD:13792537
RGD:1600115
COPII vesicle coating term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cul3 cullin 3 JBrowse link 9 86,044,485 86,129,066 RGD:1600115
RGD:1624291
G Klhl12 kelch-like family member 12 JBrowse link 13 51,280,933 51,314,753 RGD:1600115
RGD:13792537
RGD:1624291
G Pdcd6 programmed cell death 6 JBrowse link 1 31,576,183 31,591,852 RGD:1624291
RGD:1600115
G Pef1 penta-EF hand domain containing 1 JBrowse link 5 148,320,610 148,343,876 RGD:1624291
RGD:13792537
RGD:1600115
G Preb prolactin regulatory element binding JBrowse link 6 26,784,088 26,787,875 RGD:11344947
G Sec16a SEC16 homolog A, endoplasmic reticulum export factor JBrowse link 3 3,856,218 3,890,785 RGD:13792537
G Sec16b SEC16 homolog B, endoplasmic reticulum export factor JBrowse link 13 75,153,074 75,216,941 RGD:13792537
G Tfg Trk-fused gene JBrowse link 11 46,180,189 46,206,723 RGD:1600115
COPII-coated vesicle budding term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component JBrowse link 4 145,686,186 145,699,577 RGD:13792537
G Sec31a SEC31 homolog A, COPII coat complex component JBrowse link 14 10,854,713 10,909,579 RGD:13792537
G Sec31b SEC31 homolog B, COPII coat complex component JBrowse link 1 264,266,279 264,294,687 RGD:13792537
G Vapa VAMP associated protein A JBrowse link 9 113,300,831 113,331,872 RGD:1624291
RGD:1600115
G Vapb VAMP associated protein B and C JBrowse link 3 171,832,558 171,871,042 RGD:1624291
RGD:1600115
COPII-coated vesicle cargo loading term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mia3 MIA SH3 domain ER export factor 3 JBrowse link 13 101,727,434 101,770,127 RGD:1624291
G Rab1a RAB1A, member RAS oncogene family JBrowse link 14 104,475,082 104,500,176 RGD:1624291
G Sar1a secretion associated, Ras related GTPase 1A JBrowse link 20 31,298,269 31,310,676 RGD:1624291
G Sec13 SEC13 homolog, nuclear pore and COPII coat complex component JBrowse link 4 145,686,186 145,699,577 RGD:1624291
G Sec23a Sec23 homolog A, coat complex II component JBrowse link 6 80,059,742 80,107,340 RGD:1624291
RGD:13792537
G Sec23b Sec23 homolog B, coat complex II component JBrowse link 3 138,715,118 138,757,111 RGD:13792537
G Sec24a SEC24 homolog A, COPII coat complex component JBrowse link 10 37,138,539 37,215,899 RGD:1624291
RGD:1600115
G Sec24b SEC24 homolog B, COPII coat complex component JBrowse link 2 230,286,886 230,356,887 RGD:1624291
RGD:1600115
G Sec24c SEC24 homolog C, COPII coat complex component JBrowse link 15 4,035,196 4,057,209 RGD:1624291
G Sec24d SEC24 homolog D, COPII coat complex component JBrowse link 2 227,455,704 227,562,801 RGD:1624291
RGD:1600115
G Sec31a SEC31 homolog A, COPII coat complex component JBrowse link 14 10,854,713 10,909,579 RGD:1600115
RGD:13792537
RGD:1624291
G Sec31b SEC31 homolog B, COPII coat complex component JBrowse link 1 264,266,279 264,294,687 RGD:13792537
G Tbc1d20 TBC1 domain family, member 20 JBrowse link 3 147,772,006 147,790,946 RGD:1624291
RGD:1600115
negative regulation of cargo loading into COPII-coated vesicle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Insig1 insulin induced gene 1 JBrowse link 4 342,302 350,515 RGD:1624291
G Sar1a secretion associated, Ras related GTPase 1A JBrowse link 20 31,298,269 31,310,676 RGD:1624291
positive regulation of ER to Golgi vesicle-mediated transport term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arf1 ADP-ribosylation factor 1 JBrowse link 10 45,562,700 45,579,214 RGD:9684856
G Sorl1 sortilin related receptor 1 JBrowse link 8 46,228,077 46,287,171 RGD:1624291
G Stx18 syntaxin 18 JBrowse link 14 77,402,952 77,492,910 RGD:1624291
RGD:1600115
G Tbc1d20 TBC1 domain family, member 20 JBrowse link 3 147,772,006 147,790,946 RGD:1624291
RGD:1600115
regulation of cargo loading into COPII-coated vesicle term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Sar1a secretion associated, Ras related GTPase 1A JBrowse link 20 31,298,269 31,310,676 RGD:1624291
G Sec24b SEC24 homolog B, COPII coat complex component JBrowse link 2 230,286,886 230,356,887 RGD:1624291
RGD:1600115
regulation of COPII vesicle coating term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Mapk15 mitogen-activated protein kinase 15 JBrowse link 7 117,041,287 117,061,799 RGD:1600115
RGD:1624291
G Preb prolactin regulatory element binding JBrowse link 6 26,784,088 26,787,875 RGD:13792537
G Sar1b secretion associated, Ras related GTPase 1B JBrowse link 10 37,215,989 37,245,603 RGD:13792537
regulation of ER to Golgi vesicle-mediated transport term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Gas1 growth arrest-specific 1 JBrowse link 17 4,846,116 4,849,350 RGD:1624291
RGD:1600115
G Lrrk2 leucine-rich repeat kinase 2 JBrowse link 7 132,857,311 133,018,549 RGD:1600115
RGD:1624291
G Rint1 RAD50 interactor 1 JBrowse link 4 7,851,602 7,885,446 RGD:1624291
RGD:13792537
G Rnf139 ring finger protein 139 JBrowse link 7 98,770,840 98,782,025 RGD:1624291
RGD:1600115
G Scfd1 sec1 family domain containing 1 JBrowse link 6 72,124,408 72,202,703 RGD:2312425
G Use1 unconventional SNARE in the ER 1 JBrowse link 16 19,762,202 19,765,781 RGD:1624291
G Yipf5 Yip1 domain family, member 5 JBrowse link 18 33,401,103 33,436,885 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 17967
    localization 6025
      cellular localization 2681
        intracellular transport 1435
          endoplasmic reticulum to Golgi vesicle-mediated transport 132
            COPII vesicle uncoating + 0
            COPII-coated vesicle budding + 26
            endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with Golgi cis cisterna membrane 0
            endoplasmic reticulum-derived vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane 0
            positive regulation of ER to Golgi vesicle-mediated transport 4
            regulation of ER to Golgi vesicle-mediated transport + 17
            vesicle targeting, rough ER to cis-Golgi + 10
Path 2
Term Annotations click to browse term
  biological_process 17967
    localization 6025
      establishment of localization 4624
        transport 4483
          vesicle-mediated transport 1450
            Golgi vesicle transport 272
              endoplasmic reticulum to Golgi vesicle-mediated transport 132
                COPII vesicle uncoating + 0
                COPII-coated vesicle budding + 26
                endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with Golgi cis cisterna membrane 0
                endoplasmic reticulum-derived vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane 0
                positive regulation of ER to Golgi vesicle-mediated transport 4
                regulation of ER to Golgi vesicle-mediated transport + 17
                vesicle targeting, rough ER to cis-Golgi + 10
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.