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ONTOLOGY REPORT - ANNOTATIONS


Term:phagocytosis, engulfment
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Accession:GO:0006911 term browser browse the term
Definition:The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
Synonyms:related_synonym: phagosome biosynthesis;   phagosome formation


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phagocytosis, engulfment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07034739.1 Ig lambda-2 chain C region RGD:13792537
G AABR07065640.1 RGD:13792537
G AABR07065643.1 RGD:13792537
G AABR07065645.1 RGD:13792537
G AABR07065645.2 RGD:13792537
G AABR07065651.2 RGD:13792537
G AABR07065651.3 RGD:13792537
G AABR07065651.4 RGD:13792537
G AABR07065651.5 RGD:13792537
G AABR07065651.6 RGD:13792537
G AABR07065651.7 RGD:13792537
G AABR07065651.8 RGD:13792537
G AABR07065656.1 RGD:13792537
G AABR07065656.10 RGD:13792537
G AABR07065656.2 RGD:13792537
G AABR07065656.3 RGD:13792537
G AABR07065656.4 RGD:13792537
G AABR07065656.5 RGD:13792537
G AABR07065656.6 RGD:13792537
G AABR07065656.7 RGD:13792537
G AABR07065656.9 RGD:13792537
G AABR07065673.1 RGD:13792537
G AABR07065676.1 RGD:13792537
G AABR07065680.1 RGD:13792537
G AABR07065688.1 RGD:13792537
G AABR07065693.1 RGD:13792537
G AABR07065693.2 RGD:13792537
G AABR07065693.3 RGD:13792537
G AABR07065699.2 RGD:13792537
G AABR07065699.3 RGD:13792537
G AABR07065699.4 RGD:13792537
G AABR07065699.5 RGD:13792537
G AABR07065705.4 RGD:13792537
G AABR07065705.5 RGD:13792537
G AABR07065705.6 RGD:13792537
G AABR07065714.1 RGD:13792537
G AABR07065737.1 RGD:13792537
G AABR07065740.1 RGD:13792537
G AABR07065750.1 RGD:13792537
G AABR07065750.2 RGD:13792537
G AABR07065753.1 RGD:13792537
G AABR07065768.1 RGD:13792537
G AABR07065768.2 RGD:13792537
G AABR07065768.3 RGD:13792537
G AABR07065772.1 RGD:13792537
G AABR07065772.2 RGD:13792537
G AABR07065772.4 RGD:13792537
G AABR07065773.1 RGD:13792537
G AABR07065774.1 RGD:13792537
G AABR07065776.2 RGD:13792537
G AABR07065778.1 RGD:13792537
G AABR07065778.2 RGD:13792537
G AABR07065778.3 RGD:13792537
G AABR07065782.1 RGD:13792537
G AABR07065789.1 RGD:13792537
G AABR07065789.2 RGD:13792537
G AABR07065789.3 RGD:13792537
G AABR07065790.1 RGD:13792537
G AABR07065792.1 RGD:13792537
G AABR07065792.2 RGD:13792537
G AABR07065798.1 RGD:13792537
G AABR07065802.1 RGD:13792537
G AABR07065804.1 RGD:13792537
G AABR07065808.1 RGD:13792537
G AABR07065811.1 RGD:13792537
G AABR07065812.1 RGD:13792537
G AABR07065812.2 RGD:13792537
G AABR07065813.1 RGD:13792537
G AABR07065814.1 RGD:13792537
G AABR07065814.2 RGD:13792537
G AABR07065814.3 RGD:13792537
G AABR07065814.4 RGD:13792537
G AABR07065814.5 RGD:13792537
G AABR07065814.7 RGD:13792537
G AABR07065815.1 RGD:13792537
G AABR07065815.2 RGD:13792537
G AABR07065821.1 RGD:13792537
G AABR07065823.2 RGD:13792537
G AABR07065823.3 RGD:13792537
G AABR07065827.1 RGD:13792537
G AABR07065834.1 RGD:13792537
G AABR07065837.1 RGD:13792537
G AABR07065839.1 RGD:13792537
G AABR07065844.1 RGD:13792537
G AABR07065883.1 RGD:13792537
G AABR07065886.1 RGD:13792537
G AABR07065889.1 RGD:13792537
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link 5 69,857,717 69,983,042 RGD:1624291
G AC109737.1 RGD:13792537
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link 7 115,766,484 115,828,514 RGD:1624291
G Aif1 allograft inflammatory factor 1 JBrowse link 20 5,161,350 5,167,176 RGD:1624291
RGD:1600115
G Arhgap12 Rho GTPase activating protein 12 JBrowse link 17 54,280,815 54,394,716 RGD:1624291
G Arhgap25 Rho GTPase activating protein 25 JBrowse link 4 119,249,682 119,327,822 RGD:1624291
RGD:13792537
G Bin2 bridging integrator 2 JBrowse link 7 142,273,832 142,304,731 RGD:1624291
RGD:13792537
G Cdc42 cell division cycle 42 JBrowse link 5 155,690,267 155,728,385 RGD:1624291
RGD:1600115
G Clcn3 chloride voltage-gated channel 3 JBrowse link 16 32,448,821 32,520,649 RGD:1624291
G Dppa1 developmental pluripotency associated 1 JBrowse link 10 31,693,219 31,712,924 RGD:13792537
G Elmo1 engulfment and cell motility 1 JBrowse link 17 46,352,102 46,888,788 RGD:1624291
G Fcer1g Fc fragment of IgE receptor Ig JBrowse link 13 89,601,894 89,606,326 RGD:1624291
G Fcgr1a Fc fragment of IgG receptor Ia JBrowse link 2 198,430,536 198,439,453 RGD:1624291
G Fcgr2a Fc fragment of IgG receptor IIa JBrowse link 13 91,146,878 91,163,691 RGD:1624291
G Fcgr2b Fc fragment of IgG receptor IIb JBrowse link 13 89,329,298 89,343,916 RGD:1624291
G Gsn gelsolin JBrowse link 3 14,456,106 14,508,922 RGD:1624291
G Gulp1 GULP PTB domain containing engulfment adaptor 1 JBrowse link 9 51,263,484 51,538,066 RGD:1624291
G Havcr1 hepatitis A virus cellular receptor 1 JBrowse link 10 31,813,819 31,860,934 RGD:2316597
RGD:13792537
G IgG-2a gamma-2a immunoglobulin heavy chain RGD:13792537
G Igh-6 immunoglobulin heavy chain 6 RGD:13792537
G Ighe immunoglobulin heavy constant epsilon JBrowse link 6 138,066,728 138,068,606 RGD:13792537
G Ighg1 immunoglobulin heavy constant gamma 1 JBrowse link 6 139,140,572 139,784,388 RGD:1624291
RGD:13792537
G Ighm immunoglobulin heavy constant mu RGD:13792537
G Igkc immunoglobulin kappa constant RGD:13792537
G Igll1 immunoglobulin lambda-like polypeptide 1 JBrowse link 11 88,388,378 88,391,524 RGD:13792537
G Itgam integrin subunit alpha M JBrowse link 1 199,495,312 199,545,738 RGD:1624291
G Itgb2 integrin subunit beta 2 JBrowse link 20 11,777,773 11,815,647 RGD:1624291
G LOC100359777 mCG12681-like JBrowse link 10 31,603,613 31,620,449 RGD:13792537
G LOC100361706 lambda-chain C1-region-like JBrowse link 11 86,094,822 86,096,399 RGD:13792537
G LOC362795 immunoglobulin G heavy chain JBrowse link 6 138,192,156 138,201,560 RGD:13792537
G LOC689968 similar to kidney injury molecule 1 JBrowse link 10 31,647,519 31,661,204 RGD:13792537
G Marco macrophage receptor with collagenous structure JBrowse link 16 85,115,199 85,147,683 RGD:13432286
G Mfge8 milk fat globule EGF and factor V/VIII domain containing JBrowse link 1 140,845,478 140,860,882 RGD:1624291
RGD:1600115
G Msr1 macrophage scavenger receptor 1 JBrowse link 16 56,817,714 56,900,025 RGD:1624291
G Myh9 myosin, heavy chain 9 JBrowse link 7 118,740,005 118,792,507 RGD:1624291
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:1624291
G RGD1564318 similar to immunoglobulin light chain variable region RGD:13792537
G Sh3bp1 SH3-domain binding protein 1 JBrowse link 7 120,125,747 120,138,148 RGD:1624291
RGD:1600115
G Sirpa signal-regulatory protein alpha JBrowse link 3 122,113,735 122,152,478 RGD:1624291
RGD:1600115
G Timd2 T-cell immunoglobulin and mucin domain containing 2 JBrowse link 10 31,755,473 31,796,423 RGD:13792537
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:1624291
G Treml4 triggering receptor expressed on myeloid cells-like 4 JBrowse link 9 14,668,691 14,707,122 RGD:1624291
G Vamp7 vesicle-associated membrane protein 7 JBrowse link 12 18,996,566 19,033,714 RGD:4892614
engulfment of apoptotic cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link 7 115,766,484 115,828,514 RGD:1624291
RGD:13792537
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:1624291
G Megf10 multiple EGF-like domains 10 JBrowse link 18 52,215,652 52,366,212 RGD:1624291
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:1624291
RGD:13792537
G Rac2 Rac family small GTPase 2 JBrowse link 7 119,769,708 119,797,111 RGD:13792537
G Rhobtb3 Rho-related BTB domain containing 3 JBrowse link 2 2,627,655 2,683,305 RGD:13792537
G Rhog ras homolog family member G JBrowse link 1 167,336,147 167,347,720 RGD:13792537
G Thbs1 thrombospondin 1 JBrowse link 3 109,862,120 109,873,466 RGD:1624291
G Xkr4 XK related 4 JBrowse link 5 15,746,012 16,141,059 RGD:13792537
G Xkr5 XK related 5 JBrowse link 16 75,744,786 75,762,694 RGD:13792537
G Xkr6 XK related 6 JBrowse link 15 46,784,963 47,173,352 RGD:13792537
G Xkr7 XK related 7 JBrowse link 3 148,508,622 148,537,904 RGD:13792537
G Xkr8 XK related 8 JBrowse link 5 150,918,600 150,925,727 RGD:1624291
RGD:13792537
G Xkr9 XK related 9 JBrowse link 5 4,946,332 4,975,436 RGD:13792537
negative regulation of phagocytosis, engulfment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd300a Cd300a molecule JBrowse link 10 103,437,978 103,451,170 RGD:1624291
G Siglec8 sialic acid binding Ig-like lectin 8 JBrowse link 1 99,576,946 99,587,441 RGD:1624291
positive regulation of engulfment of apoptotic cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca7 ATP binding cassette subfamily A member 7 JBrowse link 7 12,742,433 12,762,423 RGD:1624291
RGD:1600115
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:1624291
positive regulation of phagocytosis, engulfment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:8696010
G Ano6 anoctamin 6 JBrowse link 7 137,142,063 137,335,208 RGD:1624291
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 JBrowse link 7 26,256,179 26,306,128 RGD:1624291
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:1600115
RGD:1624291
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:1624291
G F2rl1 F2R like trypsin receptor 1 JBrowse link 2 25,222,324 25,235,275 RGD:1624291
G Fcgr1a Fc fragment of IgG receptor Ia JBrowse link 2 198,430,536 198,439,453 RGD:9685698
G Gata2 GATA binding protein 2 JBrowse link 4 120,129,028 120,142,490 RGD:632788
G Itga2 integrin subunit alpha 2 JBrowse link 2 46,996,904 47,097,011 RGD:2307413
G Lbp lipopolysaccharide binding protein JBrowse link 3 154,786,232 154,812,910 RGD:9685187
G Nckap1l NCK associated protein 1 like JBrowse link 7 145,068,239 145,113,507 RGD:1624291
RGD:1600115
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:8553017
G Rab31 RAB31, member RAS oncogene family JBrowse link 9 113,370,072 113,504,606 RGD:1600115
RGD:1624291
G Stap1 signal transducing adaptor family member 1 JBrowse link 14 23,575,400 23,604,984 RGD:1624291
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link 9 14,611,541 14,618,076 RGD:1624291
regulation of engulfment of apoptotic cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox15 arachidonate 15-lipoxygenase JBrowse link 10 56,953,692 56,962,145 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19578
    cellular process 18362
      vesicle-mediated transport 1596
        phagocytosis 314
          phagocytosis, engulfment 159
            cytoskeletal rearrangement involved in phagocytosis, engulfment 0
            engulfment of apoptotic cell + 17
            membrane reorganization involved in phagocytosis, engulfment 0
            negative regulation of phagocytosis, engulfment + 2
            positive regulation of phagocytosis, engulfment + 16
            regulation of phagocytosis, engulfment + 19
Path 2
Term Annotations click to browse term
  biological_process 19578
    cellular process 18362
      cellular component organization or biogenesis 6481
        cellular component organization 6258
          membrane organization 821
            membrane invagination 176
              plasma membrane invagination 168
                phagocytosis, engulfment 159
                  cytoskeletal rearrangement involved in phagocytosis, engulfment 0
                  engulfment of apoptotic cell + 17
                  membrane reorganization involved in phagocytosis, engulfment 0
                  negative regulation of phagocytosis, engulfment + 2
                  positive regulation of phagocytosis, engulfment + 16
                  regulation of phagocytosis, engulfment + 19
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.