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ONTOLOGY REPORT - ANNOTATIONS


Term:phagocytosis, engulfment
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Accession:GO:0006911 term browser browse the term
Definition:The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
Synonyms:related_synonym: phagosome biosynthesis;   phagosome formation


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phagocytosis, engulfment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca1 ATP binding cassette subfamily A member 1 JBrowse link NW_004955419 21,553,863 21,681,626 RGD:9068941
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link NW_004955454 1,250,261 1,313,547 RGD:9068941
G Aif1 allograft inflammatory factor 1 JBrowse link NW_004955437 157,509 158,919 RGD:9068941
G Arhgap12 Rho GTPase activating protein 12 JBrowse link NW_004955429 23,452,880 23,560,948 RGD:9068941
G Arhgap25 Rho GTPase activating protein 25 JBrowse link NW_004955424 16,166,285 16,241,481 RGD:9068941
G Bin2 bridging integrator 2 JBrowse link NW_004955547 1,774,330 1,798,031 RGD:9068941
G Cdc42 cell division cycle 42 JBrowse link NW_004955452 2,255,940 2,299,042 RGD:9068941
G Clcn3 chloride voltage-gated channel 3 JBrowse link NW_004955403 36,625,871 36,710,201 RGD:9068941
G Elmo1 engulfment and cell motility 1 JBrowse link NW_004955460 6,044,827 6,580,770 RGD:9068941
G Fcer1g Fc fragment of IgE receptor Ig JBrowse link NW_004955468 12,971,931 12,975,206 RGD:9068941
G Fcgr2b Fc fragment of IgG receptor IIb JBrowse link NW_004955462 14,639,396 14,653,801 RGD:9068941
G Gsn gelsolin JBrowse link NW_004955419 6,682,202 6,733,361 RGD:9068941
G Gulp1 GULP PTB domain containing engulfment adaptor 1 JBrowse link NW_004955403 10,079,781 10,328,168 RGD:9068941
G Havcr1 hepatitis A virus cellular receptor 1 JBrowse link NW_004955408 11,047,679 11,070,492 RGD:9068941
G Itgam integrin subunit alpha M JBrowse link NW_004955493 8,116,886 8,160,806 RGD:9068941
G Itgb2 integrin subunit beta 2 JBrowse link NW_004955407 41,779,849 41,805,637 RGD:9068941
G Marco macrophage receptor with collagenous structure JBrowse link NW_004955459 10,700,645 10,739,222 RGD:9068941
G Mfge8 milk fat globule EGF and factor V/VIII domain containing JBrowse link NW_004955416 16,092,263 16,103,097 RGD:9068941
G Msr1 macrophage scavenger receptor 1 JBrowse link NW_004955463 1,197,086 1,263,943 RGD:9068941
G Myh9 myosin heavy chain 9 JBrowse link NW_004955413 22,881,759 22,972,182 RGD:9068941
G Rac1 Rac family small GTPase 1 JBrowse link NW_004955460 13,270,159 13,295,562 RGD:9068941
G Sh3bp1 SH3 domain binding protein 1 JBrowse link NW_004955413 24,042,875 24,054,826 RGD:9068941
G Sirpa signal regulatory protein alpha JBrowse link NW_004955415 13,030,752 13,072,735 RGD:9068941
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link NW_004955437 7,780,886 7,785,597 RGD:9068941
G Treml4 triggering receptor expressed on myeloid cells like 4 JBrowse link NW_004955437 7,827,329 7,846,406 RGD:9068941
G Vamp7 vesicle associated membrane protein 7 JBrowse link NW_004955594 20,496 72,648 RGD:9068941
engulfment of apoptotic cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Adgrb1 adhesion G protein-coupled receptor B1 JBrowse link NW_004955454 1,250,261 1,313,547 RGD:9068941
G Becn1 beclin 1 JBrowse link NW_004955451 16,616,595 16,625,731 RGD:9068941
G Megf10 multiple EGF like domains 10 JBrowse link NW_004955415 393,642 513,157 RGD:9068941
G Rac1 Rac family small GTPase 1 JBrowse link NW_004955460 13,270,159 13,295,562 RGD:9068941
G Thbs1 thrombospondin 1 JBrowse link NW_004955416 6,490,034 6,506,419 RGD:9068941
G Xkr8 XK related 8 JBrowse link NW_004955452 7,141,088 7,148,571 RGD:9068941
negative regulation of phagocytosis, engulfment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd300a CD300a molecule JBrowse link NW_004955553 1,335,854 1,356,001 RGD:9068941
positive regulation of engulfment of apoptotic cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abca7 ATP binding cassette subfamily A member 7 JBrowse link NW_004955495 6,818,002 6,838,177 RGD:9068941
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link NW_004955437 7,780,886 7,785,597 RGD:9068941
positive regulation of phagocytosis, engulfment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ager advanced glycosylation end-product specific receptor JBrowse link NW_004955437 645,482 648,607 RGD:9068941
G Ano6 anoctamin 6 JBrowse link NW_004955500 4,462,314 4,652,634 RGD:9068941
G Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 JBrowse link NW_004955405 39,503,020 39,540,069 RGD:9068941
G C3 complement C3 JBrowse link NW_004955495 2,796,601 2,824,233 RGD:9068941
G Cd36 CD36 molecule JBrowse link NW_004955410 5,003,720 5,120,903 RGD:9068941
G F2rl1 F2R like trypsin receptor 1 JBrowse link NW_004955425 24,050,901 24,054,039 RGD:9068941
G Gata2 GATA binding protein 2 JBrowse link NW_004955429 15,326,551 15,334,774 RGD:9068941
G Itga2 integrin subunit alpha 2 JBrowse link NW_004955446 14,309,516 14,421,991 RGD:9068941
G Nckap1l NCK associated protein 1 like JBrowse link NW_004955458 1,733,799 1,785,591 RGD:9068941
G Pparg peroxisome proliferator activated receptor gamma JBrowse link NW_004955429 14,814,690 14,936,869 RGD:9068941
G Rab31 RAB31, member RAS oncogene family JBrowse link NW_004955402 2,354,399 2,446,537 RGD:9068941
G Stap1 signal transducing adaptor family member 1 JBrowse link NW_004955447 5,292,708 5,345,214 RGD:9068941
G Trem2 triggering receptor expressed on myeloid cells 2 JBrowse link NW_004955437 7,780,886 7,785,597 RGD:9068941
regulation of engulfment of apoptotic cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Alox15 arachidonate 15-lipoxygenase JBrowse link NW_004955467 10,032,792 10,039,789 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 11825
    cellular process 11033
      vesicle-mediated transport 1106
        phagocytosis 174
          phagocytosis, engulfment 45
            cytoskeletal rearrangement involved in phagocytosis, engulfment 0
            engulfment of apoptotic cell + 9
            membrane reorganization involved in phagocytosis, engulfment 0
            negative regulation of phagocytosis, engulfment + 1
            positive regulation of phagocytosis, engulfment + 14
            regulation of phagocytosis, engulfment + 16
Path 2
Term Annotations click to browse term
  biological_process 11825
    cellular process 11033
      cellular component organization or biogenesis 4817
        cellular component organization 4737
          membrane organization 543
            membrane invagination 62
              plasma membrane invagination 54
                phagocytosis, engulfment 45
                  cytoskeletal rearrangement involved in phagocytosis, engulfment 0
                  engulfment of apoptotic cell + 9
                  membrane reorganization involved in phagocytosis, engulfment 0
                  negative regulation of phagocytosis, engulfment + 1
                  positive regulation of phagocytosis, engulfment + 14
                  regulation of phagocytosis, engulfment + 16
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.