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ONTOLOGY REPORT - ANNOTATIONS


Term:phagocytosis, engulfment
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Accession:GO:0006911 term browser browse the term
Definition:The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis.
Synonyms:related_synonym: phagosome biosynthesis;   phagosome formation


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phagocytosis, engulfment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCA1 ATP binding cassette subfamily A member 1 JBrowse link 9 104,781,006 104,928,232 RGD:2290271
G AC135068.2 novel protein, identical to IGHV4-4 RGD:2290271
G ADGRB1 adhesion G protein-coupled receptor B1 JBrowse link 8 142,449,649 142,545,009 RGD:9068941
G AIF1 allograft inflammatory factor 1 JBrowse link 6 31,615,212 31,617,015 RGD:2290271
G ARHGAP12 Rho GTPase activating protein 12 JBrowse link 10 31,805,398 31,928,876 RGD:2290271
G ARHGAP25 Rho GTPase activating protein 25 JBrowse link 2 68,710,510 68,826,845 RGD:2290271
G BIN2 bridging integrator 2 JBrowse link 12 51,281,038 51,324,668 RGD:2290271
G CD36 CD36 molecule JBrowse link 7 80,602,207 80,679,277 RGD:2290271
G CDC42 cell division cycle 42 JBrowse link 1 22,052,709 22,101,360 RGD:2290271
G CLCN3 chloride voltage-gated channel 3 JBrowse link 4 169,620,578 169,723,673 RGD:9068941
G DOCK1 dedicator of cytokinesis 1 JBrowse link 10 126,905,428 127,452,517 RGD:2290271
G ELMO1 engulfment and cell motility 1 JBrowse link 7 36,852,906 37,449,326 RGD:2290271
G FCER1G Fc fragment of IgE receptor Ig JBrowse link 1 161,215,295 161,219,245 RGD:2290271
G FCGR1A Fc fragment of IgG receptor Ia JBrowse link 1 149,782,694 149,800,609 RGD:2290271
G FCGR2A Fc fragment of IgG receptor IIa JBrowse link 1 161,505,430 161,524,048 RGD:9068941
G FCGR2B Fc fragment of IgG receptor IIb JBrowse link 1 161,647,243 161,678,654 RGD:2290271
G GSN gelsolin JBrowse link 9 121,201,483 121,332,844 RGD:2290271
G GULP1 GULP PTB domain containing engulfment adaptor 1 JBrowse link 2 188,291,699 188,595,926 RGD:2290271
G HAVCR1 hepatitis A virus cellular receptor 1 JBrowse link 5 157,028,383 157,069,633 RGD:2290271
G IGHA1 immunoglobulin heavy constant alpha 1 JBrowse link 14 105,707,168 105,708,664 RGD:2290271
G IGHA2 immunoglobulin heavy constant alpha 2 (A2m marker) JBrowse link 14 105,586,937 105,588,394 RGD:2290271
G IGHD immunoglobulin heavy constant delta JBrowse link 14 105,838,401 105,845,677 RGD:2290271
G IGHE immunoglobulin heavy constant epsilon JBrowse link 14 105,600,066 105,601,727 RGD:2290271
G IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) JBrowse link 14 105,741,473 105,743,070 RGD:2290271
G IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker) JBrowse link 14 105,643,203 105,644,789 RGD:2290271
G IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker) JBrowse link 14 105,765,914 105,771,405 RGD:2290271
G IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker) JBrowse link 14 105,624,476 105,626,065 RGD:2290271
G IGHM immunoglobulin heavy constant mu JBrowse link 14 105,851,966 105,856,217 RGD:2290271
G IGHV1-18 immunoglobulin heavy variable 1-18 JBrowse link 14 106,184,899 106,185,335 RGD:2290271
G IGHV1-2 immunoglobulin heavy variable 1-2 JBrowse link 14 105,986,582 105,987,019 RGD:2290271
G IGHV1-24 immunoglobulin heavy variable 1-24 JBrowse link 14 106,276,546 106,276,983 RGD:2290271
G IGHV1-3 immunoglobulin heavy variable 1-3 JBrowse link 14 106,005,095 106,005,532 RGD:2290271
G IGHV1-45 immunoglobulin heavy variable 1-45 JBrowse link 14 106,506,996 106,507,433 RGD:2290271
G IGHV1-46 immunoglobulin heavy variable 1-46 JBrowse link 14 106,511,115 106,511,552 RGD:2290271
G IGHV1-58 immunoglobulin heavy variable 1-58 JBrowse link 14 106,622,357 106,622,794 RGD:2290271
G IGHV1-69 immunoglobulin heavy variable 1-69 JBrowse link 14 106,714,682 106,715,120 RGD:2290271
G IGHV1-69-2 immunoglobulin heavy variable 1-69-2 JBrowse link 14 106,737,110 106,737,547 RGD:2290271
G IGHV1-69D immunoglobulin heavy variable 1-69D JBrowse link 14 106,762,092 106,762,530 RGD:2290271
G IGHV1-8 immunoglobulin heavy variable 1-8 RGD:2290271
G IGHV1OR15-1 immunoglobulin heavy variable 1/OR15-1 (non-functional) JBrowse link 15 22,160,289 22,160,930 RGD:2290271
G IGHV1OR15-9 immunoglobulin heavy variable 1/OR15-9 (non-functional) JBrowse link 15 19,964,656 19,965,101 RGD:2290271
G IGHV1OR21-1 immunoglobulin heavy variable 1/OR21-1 (non-functional) JBrowse link 21 10,649,390 10,649,835 RGD:2290271
G IGHV2-26 immunoglobulin heavy variable 2-26 JBrowse link 14 106,301,395 106,301,838 RGD:2290271
G IGHV2-5 immunoglobulin heavy variable 2-5 JBrowse link 14 106,037,902 106,038,345 RGD:2290271
G IGHV2-70 immunoglobulin heavy variable 2-70 JBrowse link 14 106,770,577 106,771,020 RGD:2290271
G IGHV2-70D immunoglobulin heavy variable 2-70D JBrowse link 14 106,723,574 106,724,017 RGD:2290271
G IGHV2OR16-5 immunoglobulin heavy variable 2/OR16-5 (non-functional) JBrowse link 16 32,847,713 32,848,254 RGD:2290271
G IGHV3-11 immunoglobulin heavy variable 3-11 JBrowse link 14 106,116,635 106,117,084 RGD:2290271
G IGHV3-13 immunoglobulin heavy variable 3-13 JBrowse link 14 106,129,540 106,129,992 RGD:2290271
G IGHV3-15 immunoglobulin heavy variable 3-15 JBrowse link 14 106,153,622 106,154,083 RGD:2290271
G IGHV3-16 immunoglobulin heavy variable 3-16 (non-functional) JBrowse link 14 106,165,203 106,165,656 RGD:2290271
G IGHV3-20 immunoglobulin heavy variable 3-20 JBrowse link 14 106,210,936 106,211,391 RGD:2290271
G IGHV3-21 immunoglobulin heavy variable 3-21 JBrowse link 14 106,235,062 106,235,515 RGD:2290271
G IGHV3-23 immunoglobulin heavy variable 3-23 JBrowse link 14 106,268,606 106,269,061 RGD:2290271
G IGHV3-30 immunoglobulin heavy variable 3-30 JBrowse link 14 106,335,080 106,335,533 RGD:2290271
G IGHV3-30-3 immunoglobulin heavy variable 3-30-3 RGD:2290271
G IGHV3-30-5 immunoglobulin heavy variable 3-30-5 RGD:2290271
G IGHV3-33 immunoglobulin heavy variable 3-33 JBrowse link 14 106,359,791 106,360,244 RGD:2290271
G IGHV3-35 immunoglobulin heavy variable 3-35 (non-functional) JBrowse link 14 106,389,390 106,389,843 RGD:2290271
G IGHV3-38 immunoglobulin heavy variable 3-38 (non-functional) JBrowse link 14 106,410,494 106,410,943 RGD:2290271
G IGHV3-43 immunoglobulin heavy variable 3-43 JBrowse link 14 106,470,263 106,470,720 RGD:2290271
G IGHV3-48 immunoglobulin heavy variable 3-48 JBrowse link 14 106,537,810 106,538,265 RGD:2290271
G IGHV3-49 immunoglobulin heavy variable 3-49 JBrowse link 14 106,556,936 106,557,397 RGD:2290271
G IGHV3-53 immunoglobulin heavy variable 3-53 JBrowse link 14 106,592,676 106,593,126 RGD:2290271
G IGHV3-64 immunoglobulin heavy variable 3-64 JBrowse link 14 106,657,723 106,658,178 RGD:2290271
G IGHV3-64D immunoglobulin heavy variable 3-64D JBrowse link 14 106,088,122 106,088,573 RGD:2290271
G IGHV3-66 immunoglobulin heavy variable 3-66 JBrowse link 14 106,675,015 106,675,465 RGD:2290271
G IGHV3-7 immunoglobulin heavy variable 3-7 JBrowse link 14 106,062,149 106,062,604 RGD:2290271
G IGHV3-72 immunoglobulin heavy variable 3-72 JBrowse link 14 106,790,692 106,791,153 RGD:2290271
G IGHV3-73 immunoglobulin heavy variable 3-73 JBrowse link 14 106,802,692 106,803,153 RGD:2290271
G IGHV3-74 immunoglobulin heavy variable 3-74 JBrowse link 14 106,810,440 106,810,895 RGD:2290271
G IGHV3-9 immunoglobulin heavy variable 3-9 RGD:2290271
G IGHV3OR15-7 immunoglobulin heavy variable 3/OR15-7 (pseudogene) RGD:2290271
G IGHV3OR16-10 immunoglobulin heavy variable 3/OR16-10 (non-functional) JBrowse link 16 32,995,213 32,995,503 RGD:2290271
G IGHV3OR16-12 immunoglobulin heavy variable 3/OR16-12 (non-functional) JBrowse link 16 33,802,922 33,803,215 RGD:2290271
G IGHV3OR16-13 immunoglobulin heavy variable 3/OR16-13 (non-functional) JBrowse link 16 33,827,366 33,827,659 RGD:2290271
G IGHV3OR16-17 immunoglobulin heavy variable 3/OR16-17 (non-functional) JBrowse link 16 33,844,758 33,845,274 RGD:2290271
G IGHV3OR16-8 immunoglobulin heavy variable 3/OR16-8 (non-functional) JBrowse link 16 33,009,124 33,009,646 RGD:2290271
G IGHV3OR16-9 immunoglobulin heavy variable 3/OR16-9 (non-functional) JBrowse link 16 32,066,065 32,066,358 RGD:2290271
G IGHV4-28 immunoglobulin heavy variable 4-28 JBrowse link 14 106,324,254 106,324,688 RGD:2290271
G IGHV4-30-2 immunoglobulin heavy variable 4-30-2 JBrowse link 14 106,349,283 106,349,720 RGD:2290271
G IGHV4-30-4 immunoglobulin heavy variable 4-30-4 RGD:2290271
G IGHV4-31 immunoglobulin heavy variable 4-31 JBrowse link 14 106,349,283 106,349,720 RGD:2290271
G IGHV4-34 immunoglobulin heavy variable 4-34 JBrowse link 14 106,373,661 106,374,093 RGD:2290271
G IGHV4-38-2 immunoglobulin heavy variable 4-38-2 RGD:2290271
G IGHV4-39 immunoglobulin heavy variable 4-39 JBrowse link 14 106,421,709 106,422,147 RGD:2290271
G IGHV4-4 immunoglobulin heavy variable 4-4 JBrowse link 14 106,011,922 106,012,356 RGD:2290271
G IGHV4-59 immunoglobulin heavy variable 4-59 JBrowse link 14 106,627,249 106,627,680 RGD:2290271
G IGHV4-61 immunoglobulin heavy variable 4-61 JBrowse link 14 106,639,119 106,639,556 RGD:2290271
G IGHV4OR15-8 immunoglobulin heavy variable 4/OR15-8 (non-functional) RGD:2290271
G IGHV5-10-1 immunoglobulin heavy variable 5-10-1 JBrowse link 14 106,107,972 106,108,513 RGD:2290271
G IGHV5-51 immunoglobulin heavy variable 5-51 JBrowse link 14 106,578,742 106,579,177 RGD:2290271
G IGHV6-1 immunoglobulin heavy variable 6-1 JBrowse link 14 105,939,754 105,940,201 RGD:2290271
G IGHV7-4-1 immunoglobulin heavy variable 7-4-1 JBrowse link 14 106,025,145 106,025,581 RGD:2290271
G IGHV7-81 immunoglobulin heavy variable 7-81 (non-functional) JBrowse link 14 106,874,581 106,875,017 RGD:2290271
G IGKC immunoglobulin kappa constant JBrowse link 2 88,857,361 88,857,683 RGD:2290271
G IGLC1 immunoglobulin lambda constant 1 JBrowse link 22 22,895,375 22,895,694 RGD:2290271
G IGLC2 immunoglobulin lambda constant 2 JBrowse link 22 22,900,976 22,901,295 RGD:2290271
G IGLC3 immunoglobulin lambda constant 3 (Kern-Oz+ marker) JBrowse link 22 22,906,342 22,906,661 RGD:2290271
G IGLC6 immunoglobulin lambda constant 6 JBrowse link 22 22,919,535 22,919,858 RGD:2290271
G IGLC7 immunoglobulin lambda constant 7 JBrowse link 22 22,922,594 22,922,913 RGD:2290271
G IGLL1 immunoglobulin lambda like polypeptide 1 JBrowse link 22 23,573,125 23,580,290 RGD:2290271
G IGLL5 immunoglobulin lambda like polypeptide 5 JBrowse link 22 22,887,816 22,896,111 RGD:2290271
G ITGAM integrin subunit alpha M JBrowse link 16 31,259,975 31,332,877 RGD:2290271
G ITGB2 integrin subunit beta 2 JBrowse link 21 44,885,949 44,928,815 RGD:2290271
G MARCO macrophage receptor with collagenous structure JBrowse link 2 118,942,169 118,994,664 RGD:2290271
G MFGE8 milk fat globule EGF and factor V/VIII domain containing JBrowse link 15 88,898,683 88,913,405 RGD:2290271
G MSR1 macrophage scavenger receptor 1 JBrowse link 8 16,107,878 16,192,791 RGD:2290271
G MYH9 myosin heavy chain 9 JBrowse link 22 36,281,280 36,387,967 RGD:2290271
G RAC1 Rac family small GTPase 1 JBrowse link 7 6,374,527 6,403,967 RGD:9068941
G SH3BP1 SH3 domain binding protein 1 JBrowse link 22 37,639,669 37,656,117 RGD:2290271
G SIRPA signal regulatory protein alpha JBrowse link 20 1,894,167 1,940,592 RGD:9068941
G TRBC1 T cell receptor beta constant 1 JBrowse link 7 142,791,694 142,793,141 RGD:2290271
G TRBC2 T cell receptor beta constant 2 JBrowse link 7 142,801,041 142,802,529 RGD:2290271
G TRDC T cell receptor delta constant JBrowse link 14 22,462,932 22,466,577 RGD:2290271
G TREM2 triggering receptor expressed on myeloid cells 2 JBrowse link 6 41,158,508 41,163,116 RGD:2290271
G TREML4 triggering receptor expressed on myeloid cells like 4 JBrowse link 6 41,228,287 41,239,386 RGD:9068941
G VAMP7 vesicle associated membrane protein 7 JBrowse link X
Y
155,881,318
57,067,838
155,943,769
57,130,289
RGD:2290271
engulfment of apoptotic cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADGRB1 adhesion G protein-coupled receptor B1 JBrowse link 8 142,449,649 142,545,009 RGD:2290271
G BECN1 beclin 1 JBrowse link 17 42,810,132 42,824,316 RGD:9068941
G MEGF10 multiple EGF like domains 10 JBrowse link 5 127,229,519 127,461,222 RGD:2290271
G RAC1 Rac family small GTPase 1 JBrowse link 7 6,374,527 6,403,967 RGD:2290271
G RAC2 Rac family small GTPase 2 JBrowse link 22 37,225,270 37,244,269 RGD:2290271
G RHOBTB1 Rho related BTB domain containing 1 JBrowse link 10 60,869,438 61,001,486 RGD:2290271
G RHOBTB2 Rho related BTB domain containing 2 JBrowse link 8 22,987,251 23,020,199 RGD:2290271
G RHOG ras homolog family member G JBrowse link 11 3,826,978 3,840,959 RGD:2290271
G RHOH ras homolog family member H JBrowse link 4 40,191,080 40,246,967 RGD:2290271
G THBS1 thrombospondin 1 JBrowse link 15 39,581,079 39,599,466 RGD:2290271
G XKR4 XK related 4 JBrowse link 8 55,102,028 55,542,054 RGD:2290271
G XKR5 XK related 5 JBrowse link 8 6,808,517 6,835,524 RGD:2290271
G XKR6 XK related 6 JBrowse link 8 10,893,764 11,201,833 RGD:2290271
G XKR7 XK related 7 JBrowse link 20 31,968,151 32,003,387 RGD:2290271
G XKR8 XK related 8 JBrowse link 1 27,959,557 27,968,093 RGD:2290271
G XKR9 XK related 9 JBrowse link 8 70,669,339 71,066,635 RGD:2290271
negative regulation of phagocytosis, engulfment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD300A CD300a molecule JBrowse link 17 74,466,373 74,484,798 RGD:2290271
G SIGLEC9 sialic acid binding Ig like lectin 9 JBrowse link 19 51,124,880 51,140,480 RGD:9068941
positive regulation of engulfment of apoptotic cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ABCA7 ATP binding cassette subfamily A member 7 JBrowse link 19 1,040,107 1,065,572 RGD:2290271
G TREM2 triggering receptor expressed on myeloid cells 2 JBrowse link 6 41,158,508 41,163,116 RGD:2290271
positive regulation of phagocytosis, engulfment term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AGER advanced glycosylation end-product specific receptor JBrowse link 6 32,180,968 32,184,380 RGD:9068941
G ANO6 anoctamin 6 JBrowse link 12 45,216,033 45,440,404 RGD:2290271
G APPL2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 JBrowse link 12 105,173,297 105,236,230 RGD:2290271
G C3 complement C3 JBrowse link 19 6,677,704 6,720,650 RGD:2290271
G CD36 CD36 molecule JBrowse link 7 80,602,207 80,679,277 RGD:2290271
G F2RL1 F2R like trypsin receptor 1 JBrowse link 5 76,819,030 76,835,315 RGD:2290271
G FCGR1A Fc fragment of IgG receptor Ia JBrowse link 1 149,782,694 149,800,609 RGD:9068941
G GATA2 GATA binding protein 2 JBrowse link 3 128,479,422 128,493,201 RGD:2290271
G ITGA2 integrin subunit alpha 2 JBrowse link 5 52,989,352 53,094,779 RGD:2290271
G LBP lipopolysaccharide binding protein JBrowse link 20 38,346,482 38,377,013 RGD:9068941
G NCKAP1L NCK associated protein 1 like JBrowse link 12 54,497,752 54,548,243 RGD:2290271
G PPARG peroxisome proliferator activated receptor gamma JBrowse link 3 12,287,368 12,434,344 RGD:2290271
G RAB31 RAB31, member RAS oncogene family JBrowse link 18 9,708,187 9,862,551 RGD:2290271
G STAP1 signal transducing adaptor family member 1 JBrowse link 4 67,558,727 67,607,337 RGD:2290271
G TREM2 triggering receptor expressed on myeloid cells 2 JBrowse link 6 41,158,508 41,163,116 RGD:2290271
regulation of engulfment of apoptotic cell term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ALOX15 arachidonate 15-lipoxygenase JBrowse link 17 4,630,919 4,641,678 RGD:2290271

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18536
    cellular process 17545
      vesicle-mediated transport 2290
        phagocytosis 416
          phagocytosis, engulfment 148
            cytoskeletal rearrangement involved in phagocytosis, engulfment 0
            engulfment of apoptotic cell + 19
            membrane reorganization involved in phagocytosis, engulfment 0
            negative regulation of phagocytosis, engulfment + 2
            positive regulation of phagocytosis, engulfment + 16
            regulation of phagocytosis, engulfment + 19
Path 2
Term Annotations click to browse term
  biological_process 18536
    cellular process 17545
      cellular component organization or biogenesis 7081
        cellular component organization 6890
          membrane organization 1013
            membrane invagination 166
              plasma membrane invagination 157
                phagocytosis, engulfment 148
                  cytoskeletal rearrangement involved in phagocytosis, engulfment 0
                  engulfment of apoptotic cell + 19
                  membrane reorganization involved in phagocytosis, engulfment 0
                  negative regulation of phagocytosis, engulfment + 2
                  positive regulation of phagocytosis, engulfment + 16
                  regulation of phagocytosis, engulfment + 19
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.