Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:activation of cysteine-type endopeptidase activity involved in apoptotic process
go back to main search page
Accession:GO:0006919 term browser browse the term
Definition:Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process.
Comment:This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase.
Synonyms:exact_synonym: caspase activation
 narrow_synonym: activation of caspase activity;   activation of metacaspase activity
 xref: MIPS_funcat:40.10.02.02.02


show annotations for term's descendants       view all columns           Sort by:
 
activation of cysteine-type endopeptidase activity involved in apoptotic process term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Acer2 alkaline ceramidase 2 JBrowse link 5 105,230,540 105,279,732 RGD:1624291
RGD:1600115
G Aifm1 apoptosis inducing factor, mitochondria associated 1 JBrowse link X 135,304,063 135,343,062 RGD:1624291
RGD:1600115
G Anp32b acidic nuclear phosphoprotein 32 family member B JBrowse link 5 62,070,709 62,094,633 RGD:1600115
RGD:1624291
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:1624291
G Atp2a3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 JBrowse link 10 59,528,849 59,560,440 RGD:1624291
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:1624291
RGD:1600115
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:1624291
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1600115
RGD:1624291
G Bbc3 Bcl-2 binding component 3 JBrowse link 1 78,261,491 78,267,802 RGD:1624291
RGD:13792537
G Bcl2l11 BCL2 like 11 JBrowse link 3 120,726,906 120,764,192 RGD:1624291
G Bid BH3 interacting domain death agonist JBrowse link 4 153,439,812 153,465,247 RGD:1624291
RGD:13792537
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:1624291
RGD:1600115
G Casp1 caspase 1 JBrowse link 8 2,605,743 2,614,637 RGD:13792537
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:13792537
G Casp14 caspase 14 JBrowse link 7 13,938,376 13,944,286 RGD:13792537
G Casp4 caspase 4 JBrowse link 8 2,616,391 2,651,682 RGD:632459
RGD:13792537
G Casp8 caspase 8 JBrowse link 9 65,614,142 65,662,624 RGD:1624291
RGD:13792537
G Casp8ap2 caspase 8 associated protein 2 JBrowse link 5 47,853,699 47,891,147 RGD:1624291
RGD:13792537
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:1624291
RGD:13792537
G Cck cholecystokinin JBrowse link 8 130,120,525 130,127,515 RGD:625521
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:1624291
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:13792537
G Col4a3 collagen type IV alpha 3 chain JBrowse link 9 88,357,528 88,484,735 RGD:1624291
RGD:1600115
G Cradd CASP2 and RIPK1 domain containing adaptor with death domain JBrowse link 7 36,395,665 36,408,588 RGD:1624291
RGD:13792537
G Ctsh cathepsin H JBrowse link 8 97,439,155 97,458,293 RGD:1600115
G Dap death-associated protein JBrowse link 2 84,275,884 84,328,998 RGD:1624291
G Diablo diablo, IAP-binding mitochondrial protein JBrowse link 12 38,490,230 38,503,344 RGD:1624291
G Dlc1 DLC1 Rho GTPase activating protein JBrowse link 16 58,776,489 59,247,752 RGD:1600115
RGD:1624291
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 10 11,059,701 11,085,186 RGD:1624291
G Egln3 egl-9 family hypoxia-inducible factor 3 JBrowse link 6 75,050,329 75,075,795 RGD:1600115
RGD:1624291
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1624291
G F2r coagulation factor II (thrombin) receptor JBrowse link 2 26,118,760 26,135,340 RGD:1624291
RGD:1600115
G F3 coagulation factor III, tissue factor JBrowse link 2 225,310,686 225,322,281 RGD:1624291
RGD:1600115
G Fam162a family with sequence similarity 162, member A JBrowse link 11 67,618,683 67,646,253 RGD:1624291
RGD:1600115
G Faslg Fas ligand JBrowse link 13 79,696,811 79,717,581 RGD:1624291
RGD:1600115
G Hip1 huntingtin interacting protein 1 JBrowse link 12 24,180,795 24,315,373 RGD:1624291
RGD:13792537
G Hip1r huntingtin interacting protein 1 related JBrowse link 12 38,024,517 38,053,184 RGD:1624291
RGD:13792537
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link 9 61,680,529 61,691,202 RGD:1624291
G Ift57 intraflagellar transport 57 JBrowse link 11 53,664,638 53,731,779 RGD:1624291
RGD:1600115
G Jak2 Janus kinase 2 JBrowse link 1 247,398,667 247,457,521 RGD:1624291
G Khdc1 KH domain containing 1 JBrowse link 9 27,546,069 27,547,769 RGD:13792537
G Khdc1b KH domain containing 1B JBrowse link 9 27,554,436 27,556,770 RGD:1624291
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:1624291
RGD:1600115
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:1600115
G Mtch1 mitochondrial carrier 1 JBrowse link 20 6,937,341 6,961,165 RGD:1624291
RGD:1600115
G Mul1 mitochondrial E3 ubiquitin protein ligase 1 JBrowse link 5 156,855,105 156,864,517 RGD:1624291
RGD:1600115
G Myc MYC proto-oncogene, bHLH transcription factor JBrowse link 7 102,586,313 102,591,240 RGD:1624291
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:1624291
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:1600115
RGD:1624291
G Nkx3-1 NK3 homeobox 1 JBrowse link 15 51,065,316 51,067,908 RGD:1600115
RGD:1624291
G Nlrc4 NLR family, CARD domain containing 4 JBrowse link 6 22,167,874 22,194,755 RGD:1624291
RGD:1600115
G Nlrp1a NLR family, pyrin domain containing 1A JBrowse link 10 57,692,474 57,747,608 RGD:1624291
RGD:13792537
G Nlrp3 NLR family, pyrin domain containing 3 JBrowse link 10 45,884,324 45,918,290 RGD:1624291
RGD:1600115
G Nod1 nucleotide-binding oligomerization domain containing 1 JBrowse link 4 85,123,965 85,175,206 RGD:1624291
RGD:1600115
G P2rx1 purinergic receptor P2X 1 JBrowse link 10 59,566,268 59,581,328 RGD:1624291
RGD:1600115
G Pdcd2 programmed cell death 2 JBrowse link 1 57,512,968 57,518,458 RGD:1624291
RGD:1600115
G Pdcd6 programmed cell death 6 JBrowse link 1 31,576,183 31,591,852 RGD:1624291
RGD:1600115
G Pidd1 p53-induced death domain protein 1 JBrowse link 1 214,418,751 214,423,959 RGD:1624291
G Pmaip1 phorbol-12-myristate-13-acetate-induced protein 1 JBrowse link 18 62,159,128 62,179,635 RGD:1624291
RGD:1600115
G Pml promyelocytic leukemia JBrowse link 8 63,002,515 63,034,310 RGD:1624291
RGD:1600115
G Pparg peroxisome proliferator-activated receptor gamma JBrowse link 4 147,274,055 147,399,383 RGD:1624291
RGD:1600115
G Pycard PYD and CARD domain containing JBrowse link 1 199,438,029 199,439,062 RGD:1624291
RGD:1600115
G Rack1 receptor for activated C kinase 1 JBrowse link 10 34,149,717 34,155,198 RGD:1624291
G Ret ret proto-oncogene JBrowse link 4 150,202,170 150,249,196 RGD:1624291
G Rnf7 ring finger protein 7 JBrowse link 8 104,326,719 104,336,098 RGD:1624291
G Robo1 roundabout guidance receptor 1 JBrowse link 11 9,079,291 10,146,302 RGD:1600115
RGD:1624291
G Rps27l ribosomal protein S27-like JBrowse link 8 72,741,155 72,746,090 RGD:1624291
RGD:1600115
G S100a8 S100 calcium binding protein A8 JBrowse link 2 190,073,239 190,074,333 RGD:1624291
RGD:1600115
G S100a9 S100 calcium binding protein A9 JBrowse link 2 190,097,436 190,100,209 RGD:1600115
RGD:1624291
G Senp1 SUMO specific peptidase 1 JBrowse link 7 139,626,444 139,684,587 RGD:1624291
G Slc11a2 solute carrier family 11 member 2 JBrowse link 7 142,025,812 142,062,892 RGD:1624291
G Smad3 SMAD family member 3 JBrowse link 8 68,569,530 68,678,349 RGD:1624291
RGD:1600115
G Snca synuclein alpha JBrowse link 4 90,782,412 90,883,236 RGD:1624291
RGD:1600115
G Stat1 signal transducer and activator of transcription 1 JBrowse link 9 54,287,540 54,327,958 RGD:1624291
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:1624291
G Tnfsf15 TNF superfamily member 15 JBrowse link 5 79,553,935 79,569,974 RGD:634236
RGD:13792537
RGD:1600115
RGD:1624291
G Vcp valosin-containing protein JBrowse link 5 58,426,548 58,445,953 RGD:1624291
RGD:1600115
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:1600115
RGD:1624291
activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:1624291
RGD:13792537
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:1624291
RGD:1600115
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1624291
RGD:1600115
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:1624291
RGD:1600115
G Cops5 COP9 signalosome subunit 5 JBrowse link 5 8,876,090 8,894,345 RGD:1624291
G Cycs cytochrome c, somatic JBrowse link 4 80,331,226 80,333,326 RGD:1624291
G Diablo diablo, IAP-binding mitochondrial protein JBrowse link 12 38,490,230 38,503,344 RGD:1624291
RGD:13792537
G LOC100360940 diablo-like JBrowse link 5 147,607,350 147,608,936 RGD:13792537

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18179
    cellular process 16288
      positive regulation of cellular process 5538
        positive regulation of cell death 738
          positive regulation of programmed cell death 671
            positive regulation of apoptotic process 666
              positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 131
                activation of cysteine-type endopeptidase activity involved in apoptotic process 81
                  activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c 8
Path 2
Term Annotations click to browse term
  biological_process 18179
    metabolic process 10866
      organic substance metabolic process 10300
        macromolecule metabolic process 8834
          protein metabolic process 5607
            cellular protein metabolic process 4948
              regulation of cellular protein metabolic process 2673
                positive regulation of cellular protein metabolic process 1624
                  positive regulation of proteolysis 358
                    positive regulation of peptidase activity 186
                      positive regulation of endopeptidase activity 169
                        positive regulation of cysteine-type endopeptidase activity 148
                          positive regulation of cysteine-type endopeptidase activity involved in apoptotic process 131
                            activation of cysteine-type endopeptidase activity involved in apoptotic process 81
                              activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c 8
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.