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ONTOLOGY REPORT - ANNOTATIONS


Term:activation-induced cell death of T cells
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Accession:GO:0006924 term browser browse the term
Definition:A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors.
Synonyms:exact_synonym: activation-induced cell death of T lymphocytes
 broad_synonym: AICD;   activated T cell apoptosis;   antigen-driven apoptosis


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activation-induced cell death of T cells term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt1 AKT serine/threonine kinase 1 JBrowse link 6 137,218,398 137,239,970 RGD:1624291
G Dnaja3 DnaJ heat shock protein family (Hsp40) member A3 JBrowse link 10 11,059,701 11,085,186 RGD:1624291
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:1624291
G Il2ra interleukin 2 receptor subunit alpha JBrowse link 17 70,500,672 70,547,929 RGD:1624291
G Rps6 ribosomal protein S6 JBrowse link 5 105,197,821 105,200,681 RGD:1624291
G Siva1 SIVA1, apoptosis-inducing factor JBrowse link 6 137,209,999 137,214,379 RGD:1624291
negative regulation of activation-induced cell death of T cells term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:1624291
RGD:1600115
G Gpam glycerol-3-phosphate acyltransferase, mitochondrial JBrowse link 1 275,843,823 275,906,880 RGD:1624291
RGD:1600115
G Tnfrsf4 TNF receptor superfamily member 4 JBrowse link 5 173,447,784 173,450,474 RGD:1624291
G Tsc22d3 TSC22 domain family, member 3 JBrowse link X 111,884,285 111,944,693 RGD:1624291
positive regulation of activation-induced cell death of T cells term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ceacam1 CEA cell adhesion molecule 1 JBrowse link 1 82,327,955 82,344,345 RGD:1624291
G Tgfb2 transforming growth factor, beta 2 JBrowse link 13 105,039,639 105,142,010 RGD:1624291
regulation of activation-induced cell death of T cells term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ripk3 receptor-interacting serine-threonine kinase 3 JBrowse link 15 34,470,796 34,479,741 RGD:1624291
RGD:1600115

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19332
    immune system process 2640
      leukocyte homeostasis 111
        lymphocyte homeostasis 78
          T cell homeostasis 47
            activation-induced cell death of T cells 13
              negative regulation of activation-induced cell death of T cells 4
              positive regulation of activation-induced cell death of T cells 2
              regulation of activation-induced cell death of T cells + 7
Path 2
Term Annotations click to browse term
  biological_process 19332
    biological regulation 13335
      regulation of biological quality 4236
        homeostatic process 2017
          homeostasis of number of cells 319
            leukocyte homeostasis 111
              lymphocyte homeostasis 78
                T cell homeostasis 47
                  activation-induced cell death of T cells 13
                    negative regulation of activation-induced cell death of T cells 4
                    positive regulation of activation-induced cell death of T cells 2
                    regulation of activation-induced cell death of T cells + 7
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.