ONTOLOGY REPORT - ANNOTATIONS


Term:syncytium formation
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Accession:GO:0006949 term browser browse the term
Definition:The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division.


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syncytium formation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit JBrowse link 19 50,951,674 50,994,600 RGD:9068941
G ERVFRD-1 endogenous retrovirus group FRD member 1, envelope JBrowse link 6 11,216,488 11,225,808 RGD:9068941
G ERVH48-1 endogenous retrovirus group 48 member 1 JBrowse link 21 42,539,734 42,547,631 RGD:9068941
G ERVW-1 endogenous retrovirus group W member 1, envelope JBrowse link 7 98,062,384 98,071,924 RGD:9068941
macrophage fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD81 CD81 molecule JBrowse link 11 2,442,322 2,449,308 RGD:9068941
myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADAM12 ADAM metallopeptidase domain 12 JBrowse link 10 126,847,555 127,165,887 RGD:9068941
G ADGRB3 adhesion G protein-coupled receptor B3 JBrowse link 6 69,785,260 70,537,440 RGD:9068941
G CACNA1H calcium voltage-gated channel subunit alpha1 H JBrowse link 16 1,195,991 1,222,917 RGD:9068941
G CAPN2 calpain 2 JBrowse link 1 204,346,476 204,410,137 RGD:9068941
G CAV3 caveolin 3 JBrowse link 3 8,928,069 8,940,942 RGD:9068941
G CDON cell adhesion associated, oncogene regulated JBrowse link 11 124,685,084 124,789,649 RGD:9068941
G DYRK1B dual specificity tyrosine phosphorylation regulated kinase 1B JBrowse link 19 45,405,063 45,411,483 RGD:9068941
G FER1L5 fer-1 like family member 5 JBrowse link 2A 97,566,703 97,628,325 RGD:9068941
G KCNH1 potassium voltage-gated channel subfamily H member 1 JBrowse link 1 191,102,299 191,561,879 RGD:9068941
G MYH9 myosin heavy chain 9 JBrowse link 22 35,039,461 35,121,618 RGD:9068941
G MYMK myomaker, myoblast fusion factor JBrowse link 9 133,248,761 133,259,631 RGD:9068941
G MYMX myomixer, myoblast fusion factor JBrowse link 6 45,096,551 45,097,878 RGD:9068941
G MYOD1 myogenic differentiation 1 JBrowse link 11 17,456,124 17,458,690 RGD:9068941
G MYOF myoferlin JBrowse link 10 93,561,190 93,735,979 RGD:9068941
G NOS1 nitric oxide synthase 1 JBrowse link 12 118,163,655 118,314,005 RGD:9068941
G NPHS1 NPHS1 adhesion molecule, nephrin JBrowse link 19 41,492,126 41,518,587 RGD:9068941
G PLEKHO1 pleckstrin homology domain containing O1 JBrowse link 1 129,147,114 129,157,401 RGD:9068941
G TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 JBrowse link 2B 163,632,616 163,895,940 RGD:9068941
G WNT1 Wnt family member 1 JBrowse link 12 40,648,413 40,652,583 RGD:9068941
myoblast fusion involved in skeletal muscle regeneration term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD81 CD81 molecule JBrowse link 11 2,442,322 2,449,308 RGD:9068941
G CD9 CD9 molecule JBrowse link 12 6,245,351 6,283,385 RGD:9068941
G MYMK myomaker, myoblast fusion factor JBrowse link 9 133,248,761 133,259,631 RGD:9068941
G MYMX myomixer, myoblast fusion factor JBrowse link 6 45,096,551 45,097,878 RGD:9068941
G PTGFRN prostaglandin F2 receptor inhibitor JBrowse link 1 120,524,859 120,608,105 RGD:9068941
negative regulation of myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CFLAR CASP8 and FADD like apoptosis regulator JBrowse link 2B 206,528,943 206,585,848 RGD:9068941
G CXCL10 C-X-C motif chemokine ligand 10 JBrowse link 4 54,020,204 54,022,606 RGD:9068941
negative regulation of syncytium formation by plasma membrane fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G RAPGEF3 Rap guanine nucleotide exchange factor 3 JBrowse link 12 41,836,354 41,873,252 RGD:9068941
osteoclast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD109 CD109 molecule JBrowse link 6 74,801,384 74,937,414 RGD:9068941
G CD81 CD81 molecule JBrowse link 11 2,442,322 2,449,308 RGD:9068941
G DCSTAMP dendrocyte expressed seven transmembrane protein JBrowse link 8 103,121,332 103,138,223 RGD:9068941
G SBNO2 strawberry notch homolog 2 JBrowse link 19 1,086,385 1,161,261 RGD:9068941
G SH3PXD2A SH3 and PX domains 2A JBrowse link 10 103,655,409 103,729,572 RGD:9068941
G TCTA T cell leukemia translocation altered JBrowse link 3 50,584,614 50,588,891 RGD:9068941
positive regulation of macrophage fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADAM9 ADAM metallopeptidase domain 9 JBrowse link 8 35,473,280 35,581,192 RGD:9068941
G DCSTAMP dendrocyte expressed seven transmembrane protein JBrowse link 8 103,121,332 103,138,223 RGD:9068941
G OCSTAMP osteoclast stimulatory transmembrane protein JBrowse link 20 43,958,499 43,968,118 RGD:9068941
G TREM2 triggering receptor expressed on myeloid cells 2 JBrowse link 6 42,043,887 42,048,578 RGD:9068941
G TYROBP TYRO protein tyrosine kinase binding protein JBrowse link 19 41,570,674 41,575,226 RGD:9068941
positive regulation of myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ADGRB1 adhesion G protein-coupled receptor B1 JBrowse link 8 142,221,371 142,277,665 RGD:9068941
G CAPN2 calpain 2 JBrowse link 1 204,346,476 204,410,137 RGD:9068941
G CD53 CD53 molecule JBrowse link 1 126,799,910 126,828,671 RGD:9068941
G CXCL9 C-X-C motif chemokine ligand 9 JBrowse link 4 54,036,343 54,042,502 RGD:9068941
G EHD1 EH domain containing 1 JBrowse link 11 63,550,258 63,577,252 RGD:9068941
G EHD2 EH domain containing 2 JBrowse link 19 53,361,831 53,390,877 RGD:9068941
G FLOT1 flotillin 1 JBrowse link 6 31,342,026 31,357,505 RGD:9068941
G FLT3LG fms related tyrosine kinase 3 ligand JBrowse link 19 55,410,448 55,422,545 RGD:9068941
G GDF15 growth differentiation factor 15 JBrowse link 19 18,835,216 18,838,470 RGD:9068941
G IL4R interleukin 4 receptor JBrowse link 16 27,686,760 27,737,445 RGD:9068941
G MAPK14 mitogen-activated protein kinase 14 JBrowse link 6 36,788,233 36,871,114 RGD:9068941
G MYF5 myogenic factor 5 JBrowse link 12 81,347,640 81,350,389 RGD:9068941
G MYF6 myogenic factor 6 JBrowse link 12 81,338,339 81,340,176 RGD:9068941
G MYOD1 myogenic differentiation 1 JBrowse link 11 17,456,124 17,458,690 RGD:9068941
G MYOG myogenin JBrowse link 1 182,979,700 182,982,607 RGD:9068941
G NFATC2 nuclear factor of activated T cells 2 JBrowse link 20 48,858,238 49,034,007 RGD:9068941
G RIPOR2 RHO family interacting cell polarization regulator 2 JBrowse link 6 24,973,412 25,099,034 RGD:9068941
G SCGB3A1 secretoglobin family 3A member 1 JBrowse link 5 183,102,004 183,107,851 RGD:9068941
G TNFSF14 TNF superfamily member 14 JBrowse link 19 6,614,372 6,621,763 RGD:9068941
positive regulation of syncytium formation by plasma membrane fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CAMK1 calcium/calmodulin dependent protein kinase I JBrowse link 3 9,947,275 9,959,560 RGD:9068941
G GCM1 glial cells missing transcription factor 1 JBrowse link 6 54,319,737 54,341,582 RGD:9068941
G RAPGEF3 Rap guanine nucleotide exchange factor 3 JBrowse link 12 41,836,354 41,873,252 RGD:9068941
regulation of myoblast fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G MYOG myogenin JBrowse link 1 182,979,700 182,982,607 RGD:9068941
syncytium formation by plasma membrane fusion term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G ERVFRD-1 endogenous retrovirus group FRD member 1, envelope JBrowse link 6 11,216,488 11,225,808 RGD:9068941
G ERVW-1 endogenous retrovirus group W member 1, envelope JBrowse link 7 98,062,384 98,071,924 RGD:9068941
G VASH2 vasohibin 2 JBrowse link 1 193,371,541 193,411,540 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 15700
    cellular process 14381
      syncytium formation 58
        syncytium formation by mitosis without cytokinesis 0
        syncytium formation by plasma membrane fusion + 56
Path 2
Term Annotations click to browse term
  biological_process 15700
    developmental process 5911
      anatomical structure development 5547
        anatomical structure morphogenesis 2590
          anatomical structure formation involved in morphogenesis 1072
            syncytium formation 58
              syncytium formation by mitosis without cytokinesis 0
              syncytium formation by plasma membrane fusion + 56
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.