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ONTOLOGY REPORT - ANNOTATIONS


Term:complement activation
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Accession:GO:0006956 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway.
Synonyms:exact_synonym: complement cascade;   complement response
 related_synonym: complement activity


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complement activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C2 complement C2 JBrowse link 20 4,542,340 4,561,152 RGD:1624291
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:5129529
RGD:13792537
RGD:1624291
RGD:1600115
G C4a complement C4A JBrowse link 20 2,651,599 2,678,183 RGD:1302926
RGD:13792537
RGD:1624291
RGD:1600115
G C4b complement C4B (Chido blood group) JBrowse link 20 4,302,344 4,316,752 RGD:1624291
RGD:13792537
G C5 complement C5 JBrowse link 3
3
14,049,993
14,206,466
14,113,931
14,229,141
RGD:1600115
G C6 complement C6 JBrowse link 2 54,460,333 54,533,801 RGD:1600115
G C7 complement C7 JBrowse link 2 54,707,621 54,781,624 RGD:1600115
G C8a complement C8 alpha chain JBrowse link 5 124,348,536 124,403,117 RGD:1624291
G Cfb complement factor B JBrowse link 20 4,536,206 4,542,073 RGD:2311339
G Cfh complement factor H JBrowse link 13 56,979,155 57,080,540 RGD:1599888
RGD:1624291
G Cfi complement factor I JBrowse link 2 235,264,149 235,305,779 RGD:1624291
G Colec11 collectin sub-family member 11 JBrowse link 6 47,857,767 47,889,961 RGD:1624291
G Cr1l complement C3b/C4b receptor 1 like JBrowse link 13 113,824,886 113,872,097 RGD:1624291
G Fcna ficolin A JBrowse link 3 2,850,006 2,853,230 RGD:1624291
G LOC103689965 complement C4-like JBrowse link 20 4,495,440 4,508,232 RGD:1600115
G Masp1 mannan-binding lectin serine peptidase 1 JBrowse link 11 80,736,424 80,806,278 RGD:633273
G Masp2 mannan-binding lectin serine peptidase 2 JBrowse link 5 165,415,105 165,429,857 RGD:633276
G Rgcc regulator of cell cycle JBrowse link 15 61,551,861 61,564,695 RGD:1624291
activation of membrane attack complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cfh complement factor H JBrowse link 13 56,979,155 57,080,540 RGD:1624291
complement activation, alternative pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:1600115
G C5 complement C5 JBrowse link 3
3
14,049,993
14,206,466
14,113,931
14,229,141
RGD:1600115
G C8b complement C8 beta chain JBrowse link 5 124,298,269 124,338,055 RGD:1600115
G C9 complement C9 JBrowse link 2 55,775,562 55,823,807 RGD:1600115
G Cfb complement factor B JBrowse link 20 4,536,206 4,542,073 RGD:1624291
G Cfd complement factor D JBrowse link 7 12,634,216 12,635,939 RGD:1600115
RGD:1624291
G Cfh complement factor H JBrowse link 13 56,979,155 57,080,540 RGD:1624291
G Cfp complement factor properdin JBrowse link X 1,311,121 1,316,683 RGD:1624291
G Cr2 complement C3d receptor 2 JBrowse link 13 113,890,274 113,927,824 RGD:1624291
complement activation, classical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07034739.1 Ig lambda-2 chain C region RGD:13792537
G AABR07065640.1 RGD:13792537
G AABR07065643.1 RGD:13792537
G AABR07065645.1 RGD:13792537
G AABR07065645.2 RGD:13792537
G AABR07065651.2 RGD:13792537
G AABR07065651.3 RGD:13792537
G AABR07065651.4 RGD:13792537
G AABR07065651.5 RGD:13792537
G AABR07065651.6 RGD:13792537
G AABR07065651.7 RGD:13792537
G AABR07065651.8 RGD:13792537
G AABR07065656.1 RGD:13792537
G AABR07065656.10 RGD:13792537
G AABR07065656.2 RGD:13792537
G AABR07065656.3 RGD:13792537
G AABR07065656.4 RGD:13792537
G AABR07065656.5 RGD:13792537
G AABR07065656.6 RGD:13792537
G AABR07065656.7 RGD:13792537
G AABR07065656.9 RGD:13792537
G AABR07065673.1 RGD:13792537
G AABR07065676.1 RGD:13792537
G AABR07065680.1 RGD:13792537
G AABR07065688.1 RGD:13792537
G AABR07065693.1 RGD:13792537
G AABR07065693.2 RGD:13792537
G AABR07065693.3 RGD:13792537
G AABR07065699.2 RGD:13792537
G AABR07065699.3 RGD:13792537
G AABR07065699.4 RGD:13792537
G AABR07065699.5 RGD:13792537
G AABR07065705.4 RGD:13792537
G AABR07065705.5 RGD:13792537
G AABR07065705.6 RGD:13792537
G AABR07065714.1 RGD:13792537
G AABR07065737.1 RGD:13792537
G AABR07065740.1 RGD:13792537
G AABR07065750.1 RGD:13792537
G AABR07065750.2 RGD:13792537
G AABR07065753.1 RGD:13792537
G AABR07065768.1 RGD:13792537
G AABR07065768.2 RGD:13792537
G AABR07065768.3 RGD:13792537
G AABR07065772.1 RGD:13792537
G AABR07065772.2 RGD:13792537
G AABR07065772.4 RGD:13792537
G AABR07065773.1 RGD:13792537
G AABR07065774.1 RGD:13792537
G AABR07065776.2 RGD:13792537
G AABR07065778.1 RGD:13792537
G AABR07065778.2 RGD:13792537
G AABR07065778.3 RGD:13792537
G AABR07065782.1 RGD:13792537
G AABR07065789.1 RGD:13792537
G AABR07065789.2 RGD:13792537
G AABR07065789.3 RGD:13792537
G AABR07065790.1 RGD:13792537
G AABR07065792.1 RGD:13792537
G AABR07065792.2 RGD:13792537
G AABR07065798.1 RGD:13792537
G AABR07065802.1 RGD:13792537
G AABR07065804.1 RGD:13792537
G AABR07065808.1 RGD:13792537
G AABR07065811.1 RGD:13792537
G AABR07065812.1 RGD:13792537
G AABR07065812.2 RGD:13792537
G AABR07065813.1 RGD:13792537
G AABR07065814.1 RGD:13792537
G AABR07065814.2 RGD:13792537
G AABR07065814.3 RGD:13792537
G AABR07065814.4 RGD:13792537
G AABR07065814.5 RGD:13792537
G AABR07065814.7 RGD:13792537
G AABR07065815.1 RGD:13792537
G AABR07065815.2 RGD:13792537
G AABR07065821.1 RGD:13792537
G AABR07065823.2 RGD:13792537
G AABR07065823.3 RGD:13792537
G AABR07065827.1 RGD:13792537
G AABR07065834.1 RGD:13792537
G AABR07065837.1 RGD:13792537
G AABR07065839.1 RGD:13792537
G AABR07065844.1 RGD:13792537
G AABR07065883.1 RGD:13792537
G AABR07065886.1 RGD:13792537
G AABR07065889.1 RGD:13792537
G AC109737.1 RGD:13792537
G Apcs amyloid P component, serum JBrowse link 13 91,426,621 91,427,417 RGD:13792537
G C1qa complement C1q A chain JBrowse link 5 155,261,254 155,264,101 RGD:1624291
G C1qb complement C1q B chain JBrowse link 5 155,246,444 155,251,995 RGD:1600115
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1600115
G C1qc complement C1q C chain JBrowse link 5 155,255,013 155,258,631 RGD:1600115
G C1r complement C1r JBrowse link 4 157,126,060 157,136,825 RGD:1600115
G C1rl complement C1r subcomponent like JBrowse link 4 157,108,190 157,122,689 RGD:1600115
G C1s complement C1s JBrowse link 4 157,143,592 157,155,592 RGD:1600115
G C2 complement C2 JBrowse link 20 4,542,340 4,561,152 RGD:1600115
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:1600605
G C4a complement C4A JBrowse link 20 2,651,599 2,678,183 RGD:1600115
G C4bpa complement component 4 binding protein, alpha JBrowse link 13 47,342,090 47,377,580 RGD:1600115
G C4bpb complement component 4 binding protein, beta JBrowse link 13 47,387,173 47,398,115 RGD:1600115
G C5 complement C5 JBrowse link 3
3
14,049,993
14,206,466
14,113,931
14,229,141
RGD:1600115
G C6 complement C6 JBrowse link 2 54,460,333 54,533,801 RGD:1600115
G C8b complement C8 beta chain JBrowse link 5 124,298,269 124,338,055 RGD:1600115
G C9 complement C9 JBrowse link 2 55,775,562 55,823,807 RGD:1600115
G Cfb complement factor B JBrowse link 20 4,536,206 4,542,073 RGD:1600115
G Cfi complement factor I JBrowse link 2 235,264,149 235,305,779 RGD:1600115
G Cr1l complement C3b/C4b receptor 1 like JBrowse link 13 113,824,886 113,872,097 RGD:1600115
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:1580273
RGD:13792537
G IgG-2a gamma-2a immunoglobulin heavy chain RGD:13792537
G Igh-6 immunoglobulin heavy chain 6 RGD:13792537
G Ighe immunoglobulin heavy constant epsilon JBrowse link 6 138,066,728 138,068,606 RGD:13792537
G Ighg1 immunoglobulin heavy constant gamma 1 JBrowse link 6 139,140,572 139,784,388 RGD:1624291
RGD:13792537
G Ighm immunoglobulin heavy constant mu RGD:13792537
G Igkc immunoglobulin kappa constant RGD:13792537
G Igll1 immunoglobulin lambda-like polypeptide 1 JBrowse link 11 88,388,378 88,391,524 RGD:13792537
G LOC100361706 lambda-chain C1-region-like JBrowse link 11 86,094,822 86,096,399 RGD:13792537
G LOC100911854 mannose-binding protein C-like JBrowse link 1 248,723,370 248,730,969 RGD:1600115
G LOC362795 immunoglobulin G heavy chain JBrowse link 6 138,192,156 138,201,560 RGD:13792537
G Masp2 mannan-binding lectin serine peptidase 2 JBrowse link 5 165,415,105 165,429,857 RGD:1600115
G Mbl1 mannose-binding lectin (protein A) 1 JBrowse link 16 18,736,154 18,742,193 RGD:1600115
G Mbl2 mannose binding lectin 2 JBrowse link 1 248,435,069 248,442,669 RGD:1600115
G Mptx1 mucosal pentraxin 1 JBrowse link 13 91,772,927 91,827,231 RGD:13792537
G RGD1564318 similar to immunoglobulin light chain variable region RGD:13792537
G Serping1 serpin family G member 1 JBrowse link 3 72,161,230 72,171,109 RGD:1600115
complement activation, lectin pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07006691.1 RGD:1600115
G Cd69 Cd69 molecule JBrowse link 4 163,041,147 163,049,065 RGD:1354527
RGD:1354528
G Colec11 collectin sub-family member 11 JBrowse link 6 47,857,767 47,889,961 RGD:1624291
G Fcna ficolin A JBrowse link 3 2,850,006 2,853,230 RGD:1624291
RGD:13792537
G Fcnb ficolin B JBrowse link 3 6,617,816 6,626,193 RGD:13792537
G Krt1 keratin 1 JBrowse link 7 143,448,318 143,453,544 RGD:1600115
RGD:1624291
G Masp1 mannan-binding lectin serine peptidase 1 JBrowse link 11 80,736,424 80,806,278 RGD:1600115
RGD:13792537
RGD:1624291
G Masp2 mannan-binding lectin serine peptidase 2 JBrowse link 5 165,415,105 165,429,857 RGD:1624291
RGD:1600115
G Mbl1 mannose-binding lectin (protein A) 1 JBrowse link 16 18,736,154 18,742,193 RGD:1582134
RGD:1624291
G Mbl2 mannose binding lectin 2 JBrowse link 1 248,435,069 248,442,669 RGD:1624291
negative regulation of activation of membrane attack complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd59 CD59 molecule JBrowse link 3 94,010,481 94,028,660 RGD:1600482
RGD:13792537
RGD:1624291
negative regulation of complement activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd55 CD55 molecule (Cromer blood group) JBrowse link 13 47,125,156 47,153,557 RGD:2326180
RGD:1624291
G Cd59 CD59 molecule JBrowse link 3 94,010,481 94,028,660 RGD:1624291
G Cr1l complement C3b/C4b receptor 1 like JBrowse link 13 113,824,886 113,872,097 RGD:625470
RGD:1624291
G Masp1 mannan-binding lectin serine peptidase 1 JBrowse link 11 80,736,424 80,806,278 RGD:1624291
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd46 CD46 molecule JBrowse link 13 113,786,525 113,818,741 RGD:1624291
G Susd4 sushi domain containing 4 JBrowse link 13 101,181,932 101,307,912 RGD:1624291
RGD:13792537
G Vsig4 V-set and immunoglobulin domain containing 4 JBrowse link X 65,370,851 65,400,298 RGD:1624291
RGD:13792537
negative regulation of complement activation, classical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C4bpa complement component 4 binding protein, alpha JBrowse link 13 47,342,090 47,377,580 RGD:1624291
RGD:1600115
G C4bpb complement component 4 binding protein, beta JBrowse link 13 47,387,173 47,398,115 RGD:1624291
RGD:1600115
G Cd46 CD46 molecule JBrowse link 13 113,786,525 113,818,741 RGD:1624291
G Susd4 sushi domain containing 4 JBrowse link 13 101,181,932 101,307,912 RGD:1624291
RGD:13792537
negative regulation of complement activation, lectin pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G A2m alpha-2-macroglobulin JBrowse link 4 154,309,426 154,359,138 RGD:1624291
G Serping1 serpin family G member 1 JBrowse link 3 72,161,230 72,171,109 RGD:1624291
RGD:1600115
positive regulation of activation of membrane attack complex term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:1624291
RGD:1600115
G C6 complement C6 JBrowse link 2 54,460,333 54,533,801 RGD:1624291
positive regulation of complement activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C6 complement C6 JBrowse link 2 54,460,333 54,533,801 RGD:1624291
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:1600115
RGD:1624291
G Mbl2 mannose binding lectin 2 JBrowse link 1 248,435,069 248,442,669 RGD:4889148
G Phb prohibitin JBrowse link 10 83,476,107 83,488,878 RGD:1624291
regulation of complement activation term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C1qbp complement C1q binding protein JBrowse link 10 57,613,876 57,618,527 RGD:1624291
RGD:13792537
RGD:1600115
G Cd55 CD55 molecule (Cromer blood group) JBrowse link 13 47,125,156 47,153,557 RGD:1624291
G Cd59 CD59 molecule JBrowse link 3 94,010,481 94,028,660 RGD:727654
RGD:13792537
RGD:1624291
G Cd5l Cd5 molecule-like JBrowse link 2 186,685,104 186,696,117 RGD:1624291
G Cfh complement factor H JBrowse link 13 56,979,155 57,080,540 RGD:628500
RGD:1624291
G Cr1l complement C3b/C4b receptor 1 like JBrowse link 13 113,824,886 113,872,097 RGD:1624291
G Phb2 prohibitin 2 JBrowse link 4 157,230,769 157,235,375 RGD:1624291
G Susd4 sushi domain containing 4 JBrowse link 13 101,181,932 101,307,912 RGD:1624291
regulation of complement activation, classical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cd55 CD55 molecule (Cromer blood group) JBrowse link 13 47,125,156 47,153,557 RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19576
    immune system process 2692
      immune effector process 860
        complement activation 151
          activation of membrane attack complex + 4
          complement activation, alternative pathway + 12
          complement activation, classical pathway + 128
          complement activation, lectin pathway + 12
          negative regulation of complement activation + 11
          positive regulation of complement activation + 5
          regulation of complement activation + 20
Path 2
Term Annotations click to browse term
  biological_process 19576
    biological regulation 13536
      regulation of biological process 12839
        positive regulation of biological process 6506
          positive regulation of response to stimulus 2358
            positive regulation of immune response 647
              activation of immune response 393
                complement activation 151
                  activation of membrane attack complex + 4
                  complement activation, alternative pathway + 12
                  complement activation, classical pathway + 128
                  complement activation, lectin pathway + 12
                  negative regulation of complement activation + 11
                  positive regulation of complement activation + 5
                  regulation of complement activation + 20
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.