Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:complement activation, alternative pathway
go back to main search page
Accession:GO:0006957 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes.
Synonyms:exact_synonym: complement cascade, alternative pathway


show annotations for term's descendants           Sort by:
 
complement activation, alternative pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G C3 complement C3 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 9:9,721,137...9,747,084
Ensembl chr 9:9,721,105...9,747,167
JBrowse link
G C5 complement C5 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 3:14,049,993...14,113,931
NCBI chr 3:14,206,466...14,229,141
Ensembl chr 3:14,049,995...14,229,080
JBrowse link
G C8b complement C8 beta chain IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 5:124,298,269...124,338,055
Ensembl chr 5:124,300,477...124,338,053
JBrowse link
G C9 complement C9 IEA GO_REF:0000043 UniProt GO_REF:0000043 NCBI chr 2:55,775,562...55,823,807
Ensembl chr 2:55,775,274...55,823,826
JBrowse link
G Cfb complement factor B ISO MGI:MGI:1861129 (MGI:MGI:1096110|PMID:9238044), (MGI:MGI:6100611|PMID:27564415) RGD PMID:9238044, PMID:27564415 MGI:MGI:1096110, MGI:MGI:6100611 NCBI chr20:4,536,206...4,542,073
Ensembl chr20:4,536,203...4,561,066
Ensembl chr20:4,536,203...4,561,066
JBrowse link
G Cfd complement factor D IEA
ISO
GO_REF:0000107
(MGI:MGI:6100611|PMID:27564415)
Ensembl
RGD
PMID:27564415 GO_REF:0000107, MGI:MGI:6100611 NCBI chr 7:12,634,216...12,635,939
Ensembl chr 7:12,634,216...12,635,943
JBrowse link
G Cfh complement factor H ISO (MGI:MGI:4421084|PMID:19828624), (MGI:MGI:6100611|PMID:27564415) RGD PMID:19828624, PMID:27564415 MGI:MGI:4421084, MGI:MGI:6100611 NCBI chr13:56,979,155...57,080,540
Ensembl chr13:56,978,607...57,080,622
JBrowse link
G Cfp complement factor properdin ISO MGI:MGI:3774548 (MGI:MGI:3773929|PMID:18292556) RGD PMID:18292556 MGI:MGI:3773929 NCBI chr  X:1,311,121...1,316,683
Ensembl chr  X:1,311,121...1,316,682
JBrowse link
G Cr2 complement C3d receptor 2 ISO (MGI:MGI:4421084|PMID:19828624) RGD PMID:19828624 MGI:MGI:4421084 NCBI chr13:113,890,274...113,927,824
Ensembl chr13:113,890,272...113,927,877
JBrowse link
negative regulation of complement activation, alternative pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cd46 CD46 molecule ISO (PMID:9029106) RGD PMID:9029106 NCBI chr13:113,786,525...113,818,741
Ensembl chr13:113,787,349...113,817,995
JBrowse link
G Susd4 sushi domain containing 4 ISO
IBA
(PMID:23482636)
PMID:21873635
RGD PMID:23482636, PMID:21873635 RGD:13792537 NCBI chr13:101,181,932...101,307,912
Ensembl chr13:101,181,994...101,307,908
JBrowse link
G Vsig4 V-set and immunoglobulin domain containing 4 ISO
IBA
UniProtKB:P01024 (PMID:17051150)
PMID:21873635
RGD PMID:17051150, PMID:21873635 RGD:13792537 NCBI chr  X:65,370,851...65,400,298
Ensembl chr  X:65,370,851...65,400,298
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20028
    immune system process 2843
      immune effector process 877
        complement activation 173
          complement activation, alternative pathway 12
            negative regulation of complement activation, alternative pathway + 3
            positive regulation of complement activation, alternative pathway + 0
            regulation of complement activation, alternative pathway + 3
Path 2
Term Annotations click to browse term
  biological_process 20028
    biological regulation 13773
      regulation of biological process 13075
        positive regulation of biological process 6651
          positive regulation of immune system process 1016
            positive regulation of immune response 656
              activation of immune response 418
                complement activation 173
                  complement activation, alternative pathway 12
                    negative regulation of complement activation, alternative pathway + 3
                    positive regulation of complement activation, alternative pathway + 0
                    regulation of complement activation, alternative pathway + 3
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.