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ONTOLOGY REPORT - ANNOTATIONS


Term:complement activation, classical pathway
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Accession:GO:0006958 term browser browse the term
Definition:Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes.
Synonyms:exact_synonym: complement cascade, classical pathway


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complement activation, classical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AC135068.2 novel protein, identical to IGHV4-4 RGD:2290271
G APCS amyloid P component, serum JBrowse link 1 159,587,826 159,588,865 RGD:2290271
G C1QA complement C1q A chain JBrowse link 1 22,636,628 22,639,682 RGD:2290271
G C1QB complement C1q B chain JBrowse link 1 22,653,236 22,661,637 RGD:2290271
G C1QBP complement C1q binding protein JBrowse link 17 5,432,777 5,439,155 RGD:2290271
G C1QC complement C1q C chain JBrowse link 1 22,643,633 22,648,108 RGD:2290271
G C1R complement C1r JBrowse link 12 7,080,219 7,092,445 RGD:2290271
G C1RL complement C1r subcomponent like JBrowse link 12 7,094,554 7,109,214 RGD:2290271
G C1S complement C1s JBrowse link 12 7,060,718 7,071,032 RGD:2290271
G C2 complement C2 JBrowse link 6 31,897,783 31,945,674 RGD:2290271
G C3 complement C3 JBrowse link 19 6,677,704 6,720,650 RGD:2290271
G C4A complement C4A (Rodgers blood group) JBrowse link 6 31,982,057 32,002,681 RGD:2290271
G C4B complement C4B (Chido blood group) JBrowse link 6 32,014,795 32,035,418 RGD:2290271
G C4B_2 complement component 4B (Chido blood group), copy 2 RGD:2290271
G C4BPA complement component 4 binding protein alpha JBrowse link 1 207,104,232 207,144,972 RGD:2290271
G C4BPB complement component 4 binding protein beta JBrowse link 1 207,088,795 207,099,993 RGD:2290271
G C5 complement C5 JBrowse link 9 120,952,335 121,074,865 RGD:2290271
G C6 complement C6 JBrowse link 5 41,142,116 41,261,486 RGD:2290271
G C7 complement C7 JBrowse link 5 40,909,497 40,984,643 RGD:2290271
G C8A complement C8 alpha chain JBrowse link 1 56,854,796 56,918,223 RGD:2290271
G C8B complement C8 beta chain JBrowse link 1 56,929,207 56,974,383 RGD:2290271
G C8G complement C8 gamma chain JBrowse link 9 136,944,870 136,946,981 RGD:2290271
G C9 complement C9 JBrowse link 5 39,284,140 39,364,495 RGD:2290271
G CD46 CD46 molecule JBrowse link 1 207,752,038 207,795,516 RGD:2290271
G CD55 CD55 molecule (Cromer blood group) JBrowse link 1 207,321,674 207,360,966 RGD:2290271
G CFI complement factor I JBrowse link 4 109,730,982 109,802,040 RGD:2290271
G CLU clusterin JBrowse link 8 27,596,917 27,614,700 RGD:2290271
G CR1 complement C3b/C4b receptor 1 (Knops blood group) JBrowse link 1 207,496,157 207,641,765 RGD:2290271
G CR2 complement C3d receptor 2 JBrowse link 1 207,454,328 207,489,892 RGD:2290271
G CRP C-reactive protein JBrowse link 1 159,712,289 159,714,589 RGD:2290271
G IGHA1 immunoglobulin heavy constant alpha 1 JBrowse link 14 105,707,168 105,708,664 RGD:2290271
G IGHA2 immunoglobulin heavy constant alpha 2 (A2m marker) JBrowse link 14 105,586,937 105,588,394 RGD:2290271
G IGHD immunoglobulin heavy constant delta JBrowse link 14 105,838,401 105,845,677 RGD:2290271
G IGHE immunoglobulin heavy constant epsilon JBrowse link 14 105,600,066 105,601,727 RGD:2290271
G IGHG1 immunoglobulin heavy constant gamma 1 (G1m marker) JBrowse link 14 105,741,473 105,743,070 RGD:2290271
G IGHG2 immunoglobulin heavy constant gamma 2 (G2m marker) JBrowse link 14 105,643,203 105,644,789 RGD:2290271
G IGHG3 immunoglobulin heavy constant gamma 3 (G3m marker) JBrowse link 14 105,765,914 105,771,405 RGD:2290271
G IGHG4 immunoglobulin heavy constant gamma 4 (G4m marker) JBrowse link 14 105,624,476 105,626,065 RGD:2290271
G IGHM immunoglobulin heavy constant mu JBrowse link 14 105,851,966 105,856,217 RGD:2290271
G IGHV1-18 immunoglobulin heavy variable 1-18 JBrowse link 14 106,184,899 106,185,335 RGD:2290271
G IGHV1-2 immunoglobulin heavy variable 1-2 JBrowse link 14 105,986,582 105,987,019 RGD:2290271
G IGHV1-24 immunoglobulin heavy variable 1-24 JBrowse link 14 106,276,546 106,276,983 RGD:2290271
G IGHV1-3 immunoglobulin heavy variable 1-3 JBrowse link 14 106,005,095 106,005,532 RGD:2290271
G IGHV1-45 immunoglobulin heavy variable 1-45 JBrowse link 14 106,506,996 106,507,433 RGD:2290271
G IGHV1-46 immunoglobulin heavy variable 1-46 JBrowse link 14 106,511,115 106,511,552 RGD:2290271
G IGHV1-58 immunoglobulin heavy variable 1-58 JBrowse link 14 106,622,357 106,622,794 RGD:2290271
G IGHV1-69 immunoglobulin heavy variable 1-69 JBrowse link 14 106,714,682 106,715,120 RGD:2290271
G IGHV1-69-2 immunoglobulin heavy variable 1-69-2 JBrowse link 14 106,737,110 106,737,547 RGD:2290271
G IGHV1-69D immunoglobulin heavy variable 1-69D JBrowse link 14 106,762,092 106,762,530 RGD:2290271
G IGHV1-8 immunoglobulin heavy variable 1-8 RGD:2290271
G IGHV1OR15-1 immunoglobulin heavy variable 1/OR15-1 (non-functional) JBrowse link 15 22,160,289 22,160,930 RGD:2290271
G IGHV1OR15-9 immunoglobulin heavy variable 1/OR15-9 (non-functional) JBrowse link 15 19,964,656 19,965,101 RGD:2290271
G IGHV1OR21-1 immunoglobulin heavy variable 1/OR21-1 (non-functional) JBrowse link 21 10,649,390 10,649,835 RGD:2290271
G IGHV2-26 immunoglobulin heavy variable 2-26 JBrowse link 14 106,301,395 106,301,838 RGD:2290271
G IGHV2-5 immunoglobulin heavy variable 2-5 JBrowse link 14 106,037,902 106,038,345 RGD:2290271
G IGHV2-70 immunoglobulin heavy variable 2-70 JBrowse link 14 106,770,577 106,771,020 RGD:2290271
G IGHV2-70D immunoglobulin heavy variable 2-70D JBrowse link 14 106,723,574 106,724,017 RGD:2290271
G IGHV2OR16-5 immunoglobulin heavy variable 2/OR16-5 (non-functional) JBrowse link 16 32,847,713 32,848,254 RGD:2290271
G IGHV3-11 immunoglobulin heavy variable 3-11 JBrowse link 14 106,116,635 106,117,084 RGD:2290271
G IGHV3-13 immunoglobulin heavy variable 3-13 JBrowse link 14 106,129,540 106,129,992 RGD:2290271
G IGHV3-15 immunoglobulin heavy variable 3-15 JBrowse link 14 106,153,622 106,154,083 RGD:2290271
G IGHV3-16 immunoglobulin heavy variable 3-16 (non-functional) JBrowse link 14 106,165,203 106,165,656 RGD:2290271
G IGHV3-20 immunoglobulin heavy variable 3-20 JBrowse link 14 106,210,936 106,211,391 RGD:2290271
G IGHV3-21 immunoglobulin heavy variable 3-21 JBrowse link 14 106,235,062 106,235,515 RGD:2290271
G IGHV3-23 immunoglobulin heavy variable 3-23 JBrowse link 14 106,268,606 106,269,061 RGD:2290271
G IGHV3-30 immunoglobulin heavy variable 3-30 JBrowse link 14 106,335,080 106,335,533 RGD:2290271
G IGHV3-30-3 immunoglobulin heavy variable 3-30-3 RGD:2290271
G IGHV3-30-5 immunoglobulin heavy variable 3-30-5 RGD:2290271
G IGHV3-33 immunoglobulin heavy variable 3-33 JBrowse link 14 106,359,791 106,360,244 RGD:2290271
G IGHV3-35 immunoglobulin heavy variable 3-35 (non-functional) JBrowse link 14 106,389,390 106,389,843 RGD:2290271
G IGHV3-38 immunoglobulin heavy variable 3-38 (non-functional) JBrowse link 14 106,410,494 106,410,943 RGD:2290271
G IGHV3-43 immunoglobulin heavy variable 3-43 JBrowse link 14 106,470,263 106,470,720 RGD:2290271
G IGHV3-48 immunoglobulin heavy variable 3-48 JBrowse link 14 106,537,810 106,538,265 RGD:2290271
G IGHV3-49 immunoglobulin heavy variable 3-49 JBrowse link 14 106,556,936 106,557,397 RGD:2290271
G IGHV3-53 immunoglobulin heavy variable 3-53 JBrowse link 14 106,592,676 106,593,126 RGD:2290271
G IGHV3-64 immunoglobulin heavy variable 3-64 JBrowse link 14 106,657,723 106,658,178 RGD:2290271
G IGHV3-64D immunoglobulin heavy variable 3-64D JBrowse link 14 106,088,122 106,088,573 RGD:2290271
G IGHV3-66 immunoglobulin heavy variable 3-66 JBrowse link 14 106,675,015 106,675,465 RGD:2290271
G IGHV3-7 immunoglobulin heavy variable 3-7 JBrowse link 14 106,062,149 106,062,604 RGD:2290271
G IGHV3-72 immunoglobulin heavy variable 3-72 JBrowse link 14 106,790,692 106,791,153 RGD:2290271
G IGHV3-73 immunoglobulin heavy variable 3-73 JBrowse link 14 106,802,692 106,803,153 RGD:2290271
G IGHV3-74 immunoglobulin heavy variable 3-74 JBrowse link 14 106,810,440 106,810,895 RGD:2290271
G IGHV3-9 immunoglobulin heavy variable 3-9 RGD:2290271
G IGHV3OR15-7 immunoglobulin heavy variable 3/OR15-7 (pseudogene) RGD:2290271
G IGHV3OR16-10 immunoglobulin heavy variable 3/OR16-10 (non-functional) JBrowse link 16 32,995,213 32,995,503 RGD:2290271
G IGHV3OR16-12 immunoglobulin heavy variable 3/OR16-12 (non-functional) JBrowse link 16 33,802,922 33,803,215 RGD:2290271
G IGHV3OR16-13 immunoglobulin heavy variable 3/OR16-13 (non-functional) JBrowse link 16 33,827,366 33,827,659 RGD:2290271
G IGHV3OR16-17 immunoglobulin heavy variable 3/OR16-17 (non-functional) JBrowse link 16 33,844,758 33,845,274 RGD:2290271
G IGHV3OR16-8 immunoglobulin heavy variable 3/OR16-8 (non-functional) JBrowse link 16 33,009,124 33,009,646 RGD:2290271
G IGHV3OR16-9 immunoglobulin heavy variable 3/OR16-9 (non-functional) JBrowse link 16 32,066,065 32,066,358 RGD:2290271
G IGHV4-28 immunoglobulin heavy variable 4-28 JBrowse link 14 106,324,254 106,324,688 RGD:2290271
G IGHV4-30-2 immunoglobulin heavy variable 4-30-2 JBrowse link 14 106,349,283 106,349,720 RGD:2290271
G IGHV4-30-4 immunoglobulin heavy variable 4-30-4 RGD:2290271
G IGHV4-31 immunoglobulin heavy variable 4-31 JBrowse link 14 106,349,283 106,349,720 RGD:2290271
G IGHV4-34 immunoglobulin heavy variable 4-34 JBrowse link 14 106,373,661 106,374,093 RGD:2290271
G IGHV4-38-2 immunoglobulin heavy variable 4-38-2 RGD:2290271
G IGHV4-39 immunoglobulin heavy variable 4-39 JBrowse link 14 106,421,709 106,422,147 RGD:2290271
G IGHV4-4 immunoglobulin heavy variable 4-4 JBrowse link 14 106,011,922 106,012,356 RGD:2290271
G IGHV4-59 immunoglobulin heavy variable 4-59 JBrowse link 14 106,627,249 106,627,680 RGD:2290271
G IGHV4-61 immunoglobulin heavy variable 4-61 JBrowse link 14 106,639,119 106,639,556 RGD:2290271
G IGHV4OR15-8 immunoglobulin heavy variable 4/OR15-8 (non-functional) RGD:2290271
G IGHV5-10-1 immunoglobulin heavy variable 5-10-1 JBrowse link 14 106,107,972 106,108,513 RGD:2290271
G IGHV5-51 immunoglobulin heavy variable 5-51 JBrowse link 14 106,578,742 106,579,177 RGD:2290271
G IGHV6-1 immunoglobulin heavy variable 6-1 JBrowse link 14 105,939,754 105,940,201 RGD:2290271
G IGHV7-4-1 immunoglobulin heavy variable 7-4-1 JBrowse link 14 106,025,145 106,025,581 RGD:2290271
G IGHV7-81 immunoglobulin heavy variable 7-81 (non-functional) JBrowse link 14 106,874,581 106,875,017 RGD:2290271
G IGKC immunoglobulin kappa constant JBrowse link 2 88,857,361 88,857,683 RGD:2290271
G IGKV1-12 immunoglobulin kappa variable 1-12 JBrowse link 2 89,040,224 89,040,698 RGD:2290271
G IGKV1-16 immunoglobulin kappa variable 1-16 JBrowse link 2 89,099,859 89,100,334 RGD:2290271
G IGKV1-17 immunoglobulin kappa variable 1-17 JBrowse link 2 89,117,342 89,117,817 RGD:2290271
G IGKV1-33 immunoglobulin kappa variable 1-33 JBrowse link 2 89,268,001 89,268,475 RGD:2290271
G IGKV1-39 immunoglobulin kappa variable 1-39 JBrowse link 2 89,319,625 89,320,099 RGD:2290271
G IGKV1-5 immunoglobulin kappa variable 1-5 JBrowse link 2 88,947,301 88,947,776 RGD:2290271
G IGKV1D-12 immunoglobulin kappa variable 1D-12 JBrowse link 2 90,159,860 90,160,335 RGD:2290271
G IGKV1D-16 immunoglobulin kappa variable 1D-16 JBrowse link 2 90,100,263 90,100,738 RGD:2290271
G IGKV1D-33 immunoglobulin kappa variable 1D-33 JBrowse link 2 89,914,071 89,914,545 RGD:2290271
G IGKV1D-39 immunoglobulin kappa variable 1D-39 JBrowse link 2 89,862,505 89,862,979 RGD:2290271
G IGKV2-28 immunoglobulin kappa variable 2-28 JBrowse link 2 89,221,698 89,222,431 RGD:2290271
G IGKV2-29 immunoglobulin kappa variable 2-29 JBrowse link 2 89,234,185 89,234,911 RGD:2290271
G IGKV2-30 immunoglobulin kappa variable 2-30 JBrowse link 2 89,244,781 89,245,566 RGD:2290271
G IGKV2-40 immunoglobulin kappa variable 2-40 JBrowse link 2 89,330,116 89,330,429 RGD:2290271
G IGKV2D-28 immunoglobulin kappa variable 2D-28 JBrowse link 2 89,960,015 89,960,747 RGD:2290271
G IGKV2D-30 immunoglobulin kappa variable 2D-30 JBrowse link 2 89,936,894 89,937,679 RGD:2290271
G IGKV2D-40 immunoglobulin kappa variable 2D-40 JBrowse link 2 89,851,758 89,852,491 RGD:2290271
G IGKV3-11 immunoglobulin kappa variable 3-11 JBrowse link 2 89,027,171 89,027,684 RGD:2290271
G IGKV3-15 immunoglobulin kappa variable 3-15 JBrowse link 2 89,085,177 89,085,690 RGD:2290271
G IGKV3-20 immunoglobulin kappa variable 3-20 JBrowse link 2 89,142,574 89,143,108 RGD:2290271
G IGKV3D-11 immunoglobulin kappa variable 3D-11 JBrowse link 2 90,172,899 90,173,412 RGD:2290271
G IGKV3D-20 immunoglobulin kappa variable 3D-20 JBrowse link 2 90,038,945 90,039,479 RGD:2290271
G IGKV4-1 immunoglobulin kappa variable 4-1 JBrowse link 2 88,885,572 88,886,153 RGD:2290271
G IGKV5-2 immunoglobulin kappa variable 5-2 JBrowse link 2 88,897,295 88,897,784 RGD:2290271
G IGLC1 immunoglobulin lambda constant 1 JBrowse link 22 22,895,375 22,895,694 RGD:2290271
G IGLC2 immunoglobulin lambda constant 2 JBrowse link 22 22,900,976 22,901,295 RGD:2290271
G IGLC3 immunoglobulin lambda constant 3 (Kern-Oz+ marker) JBrowse link 22 22,906,342 22,906,661 RGD:2290271
G IGLC6 immunoglobulin lambda constant 6 JBrowse link 22 22,919,535 22,919,858 RGD:2290271
G IGLC7 immunoglobulin lambda constant 7 JBrowse link 22 22,922,594 22,922,913 RGD:2290271
G IGLL1 immunoglobulin lambda like polypeptide 1 JBrowse link 22 23,573,125 23,580,290 RGD:2290271
G IGLL5 immunoglobulin lambda like polypeptide 5 JBrowse link 22 22,887,816 22,896,111 RGD:2290271
G IGLV1-40 immunoglobulin lambda variable 1-40 JBrowse link 22 22,409,817 22,410,282 RGD:2290271
G IGLV1-44 immunoglobulin lambda variable 1-44 JBrowse link 22 22,380,880 22,381,347 RGD:2290271
G IGLV1-47 immunoglobulin lambda variable 1-47 JBrowse link 22 22,357,795 22,358,262 RGD:2290271
G IGLV1-51 immunoglobulin lambda variable 1-51 JBrowse link 22 22,322,508 22,322,969 RGD:2290271
G IGLV2-11 immunoglobulin lambda variable 2-11 JBrowse link 22 22,792,533 22,793,003 RGD:2290271
G IGLV2-14 immunoglobulin lambda variable 2-14 JBrowse link 22 22,758,741 22,759,211 RGD:2290271
G IGLV2-23 immunoglobulin lambda variable 2-23 JBrowse link 22 22,697,951 22,698,421 RGD:2290271
G IGLV2-8 immunoglobulin lambda variable 2-8 JBrowse link 22 22,822,821 22,823,289 RGD:2290271
G IGLV3-1 immunoglobulin lambda variable 3-1 JBrowse link 22 22,880,912 22,881,392 RGD:2290271
G IGLV3-19 immunoglobulin lambda variable 3-19 JBrowse link 22 22,720,663 22,721,155 RGD:2290271
G IGLV3-21 immunoglobulin lambda variable 3-21 JBrowse link 22 22,712,419 22,713,199 RGD:2290271
G IGLV3-25 immunoglobulin lambda variable 3-25 JBrowse link 22 22,686,769 22,687,281 RGD:2290271
G IGLV3-27 immunoglobulin lambda variable 3-27 JBrowse link 22 22,668,326 22,668,808 RGD:2290271
G IGLV6-57 immunoglobulin lambda variable 6-57 JBrowse link 22 22,195,799 22,196,276 RGD:2290271
G IGLV7-43 immunoglobulin lambda variable 7-43 JBrowse link 22 22,395,052 22,395,489 RGD:2290271
G MASP2 mannan binding lectin serine peptidase 2 JBrowse link 1 11,026,523 11,047,239 RGD:2290271
G MBL2 mannose binding lectin 2 JBrowse link 10 52,765,380 52,772,784 RGD:2290271
G SERPING1 serpin family G member 1 JBrowse link 11 57,597,685 57,614,848 RGD:2290271
G SUSD4 sushi domain containing 4 JBrowse link 1 223,220,826 223,365,271 RGD:2290271
G TRBC1 T cell receptor beta constant 1 JBrowse link 7 142,791,694 142,793,141 RGD:2290271
G TRBC2 T cell receptor beta constant 2 JBrowse link 7 142,801,041 142,802,529 RGD:2290271
G TRDC T cell receptor delta constant JBrowse link 14 22,462,932 22,466,577 RGD:2290271
negative regulation of complement activation, classical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G C4BPA complement component 4 binding protein alpha JBrowse link 1 207,104,232 207,144,972 RGD:2290271
G C4BPB complement component 4 binding protein beta JBrowse link 1 207,088,795 207,099,993 RGD:2290271
G CD46 CD46 molecule JBrowse link 1 207,752,038 207,795,516 RGD:9068941
G CR1 complement C3b/C4b receptor 1 (Knops blood group) JBrowse link 1 207,496,157 207,641,765 RGD:2290271
G SUSD4 sushi domain containing 4 JBrowse link 1 223,220,826 223,365,271 RGD:2290271
regulation of complement activation, classical pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G CD55 CD55 molecule (Cromer blood group) JBrowse link 1 207,321,674 207,360,966 RGD:9068941

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 18536
    immune system process 3544
      immune effector process 1405
        complement activation 199
          complement activation, classical pathway 160
            negative regulation of complement activation, classical pathway + 5
            positive regulation of complement activation, classical pathway + 0
            regulation of complement activation, classical pathway + 6
Path 2
Term Annotations click to browse term
  biological_process 18536
    biological regulation 13170
      regulation of biological process 12526
        positive regulation of biological process 6928
          positive regulation of immune system process 1217
            positive regulation of immune response 836
              activation of immune response 608
                complement activation 199
                  complement activation, classical pathway 160
                    negative regulation of complement activation, classical pathway + 5
                    positive regulation of complement activation, classical pathway + 0
                    regulation of complement activation, classical pathway + 6
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.