ONTOLOGY REPORT - ANNOTATIONS


Term:response to osmotic stress
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Accession:GO:0006970 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.
Synonyms:exact_synonym: osmotic response;   osmotic stress response


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response to osmotic stress term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Akt2 AKT serine/threonine kinase 2 JBrowse link 1 84,400,939 84,451,223 RGD:2313404
G Apobec1 apolipoprotein B mRNA editing enzyme catalytic subunit 1 JBrowse link 4 155,386,367 155,414,034 RGD:1626285
G Atf2 activating transcription factor 2 JBrowse link 3 60,721,137 60,795,951 RGD:1624291
RGD:1600115
G Cul5 cullin 5 JBrowse link 8 58,199,992 58,255,149 RGD:1299332
G Egfr epidermal growth factor receptor JBrowse link 14 99,919,485 100,104,136 RGD:2289968
G Fmo1 flavin containing monooxygenase 1 JBrowse link 13 80,712,885 80,745,095 RGD:2316303
G Kcnma1 potassium calcium-activated channel subfamily M alpha 1 JBrowse link 15 344,204 1,048,849 RGD:1600115
RGD:1624291
G LOC102550456 TSC22 domain family protein 4-like JBrowse link 12 21,748,608 21,761,500 RGD:13792537
G Lrrc8a leucine rich repeat containing 8 VRAC subunit A JBrowse link 3 8,801,544 8,829,506 RGD:1600115
RGD:13673739
RGD:1624291
G Map2k7 mitogen activated protein kinase kinase 7 JBrowse link 12 2,546,278 2,555,310 RGD:1600115
RGD:2298561
RGD:1624291
G Map3k1 mitogen-activated protein kinase kinase kinase 1 JBrowse link 2 43,329,516 43,393,203 RGD:2293490
G Map7 microtubule-associated protein 7 JBrowse link 1 15,620,665 15,748,203 RGD:1624291
G Mapk13 mitogen activated protein kinase 13 JBrowse link 20 6,018,374 6,027,467 RGD:1600115
RGD:1624291
G Mapk8 mitogen-activated protein kinase 8 JBrowse link 16 9,620,854 9,709,342 RGD:1582332
G Marveld3 MARVEL domain containing 3 JBrowse link 19 41,710,076 41,724,923 RGD:1624291
RGD:1600115
G Nfat5 nuclear factor of activated T-cells 5 JBrowse link 19 38,446,059 38,533,735 RGD:8693586
G Nolc1 nucleolar and coiled-body phosphoprotein 1 JBrowse link 1 265,829,055 265,839,819 RGD:2303816
G Pcp4 Purkinje cell protein 4 JBrowse link 11 36,851,035 36,912,272 RGD:9850274
G Plk3 polo-like kinase 3 JBrowse link 5 135,997,725 136,002,900 RGD:1624291
RGD:1600115
G Ptk2b protein tyrosine kinase 2 beta JBrowse link 15 42,827,306 42,947,796 RGD:1642640
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:730230
G Slc6a18 solute carrier family 6 member 18 JBrowse link 1 32,221,679 32,235,599 RGD:68841
G Sord sorbitol dehydrogenase JBrowse link 3 114,176,127 114,207,368 RGD:1601363
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 JBrowse link 12 47,698,915 47,737,902 RGD:1624291
G Tsc22d2 TSC22 domain family, member 2 JBrowse link 2 148,607,148 148,659,632 RGD:1624291
RGD:1600115
G Tsc22d3 TSC22 domain family, member 3 JBrowse link X 111,884,285 111,944,693 RGD:1624291
G Tsc22d4 TSC22 domain family, member 4 JBrowse link 12 22,008,956 22,021,814 RGD:1624291
RGD:13792537
cellular hyperosmotic response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aqp1 aquaporin 1 (Colton blood group) JBrowse link 4 85,551,503 85,563,683 RGD:1624291
RGD:1600115
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 JBrowse link 2 187,964,100 188,022,847 RGD:1624291
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:1624291
RGD:1600115
G Errfi1 ERBB receptor feedback inhibitor 1 JBrowse link 5 167,951,564 167,966,011 RGD:9685546
G Mapk10 mitogen activated protein kinase 10 JBrowse link 14 8,079,955 8,371,508 RGD:10412695
G Mapk9 mitogen-activated protein kinase 9 JBrowse link 10 35,333,859 35,374,364 RGD:10412695
G Rcsd1 RCSD domain containing 1 JBrowse link 13 83,854,650 83,917,040 RGD:1624291
RGD:1600115
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:12879856
G Slc6a12 solute carrier family 6 member 12 JBrowse link 4 153,921,199 153,941,333 RGD:2316970
G Ybx3 Y box binding protein 3 JBrowse link 4 165,606,819 165,630,041 RGD:1624291
RGD:1600115
cellular hyperosmotic salinity response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:2301086
G Akr1b1 aldo-keto reductase family 1 member B JBrowse link 4 61,706,866 61,720,959 RGD:1600115
RGD:1624291
G Fxyd2 FXYD domain-containing ion transport regulator 2 JBrowse link 8 49,710,334 49,717,492 RGD:1598989
G Mir100 microRNA 100 JBrowse link 8 45,746,948 45,747,027 RGD:1624291
G Mir137 microRNA 137 JBrowse link 2 221,658,106 221,658,207 RGD:1624291
G Mir204 microRNA 204 JBrowse link 1 240,403,000 240,403,109 RGD:1624291
G Mir29b1 microRNA 29b-1 JBrowse link 4 58,344,310 58,344,390 RGD:1624291
G Mir29b2 microRNA 29b-2 JBrowse link 13 113,782,057 113,782,137 RGD:1624291
G Mir30b microRNA 30b JBrowse link 7 109,282,662 109,282,747 RGD:1624291
G Mir3597-1 microRNA 3597-1 JBrowse link 2 187,582,790 187,582,897 RGD:1624291
G Mir451a microRNA 451a JBrowse link 10 65,291,204 65,291,275 RGD:1624291
G Mir7b microRNA 7b JBrowse link 9 10,812,432 10,812,541 RGD:1624291
G Mir9-3 microRNA 9-3 JBrowse link 1 141,229,353 141,229,442 RGD:1624291
G Mir99a microRNA 99a JBrowse link 11 16,052,153 16,052,233 RGD:1624291
G Slc12a1 solute carrier family 12 member 1 JBrowse link 3 117,421,531 117,498,372 RGD:1624291
G Xrcc5 X-ray repair cross complementing 5 JBrowse link 9 79,659,275 79,748,050 RGD:2317102
G Xrcc6 X-ray repair cross complementing 6 JBrowse link 7 123,259,881 123,280,613 RGD:2317102
cellular hypotonic response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aqp5 aquaporin 5 JBrowse link 7 141,249,044 141,252,576 RGD:1600115
RGD:1624291
G Mylk myosin light chain kinase JBrowse link 11 69,013,060 69,260,039 RGD:1624291
RGD:1600115
G Oxsr1 oxidative stress responsive kinase 1 JBrowse link 8 127,920,349 128,009,951 RGD:1624291
RGD:1600115
G Prkg2 protein kinase cGMP-dependent 2 JBrowse link 14 12,217,121 12,313,616 RGD:1624291
G Slc12a6 solute carrier family 12, member 6 JBrowse link 3 103,752,213 103,852,686 RGD:1624291
G Stk39 serine threonine kinase 39 JBrowse link 3 54,359,449 54,625,702 RGD:1624291
RGD:1600115
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 JBrowse link 12 47,698,915 47,737,902 RGD:1624291
RGD:13792537
G Tspo translocator protein JBrowse link 7 124,460,358 124,470,610 RGD:2317141
cellular hypotonic salinity response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Slc12a6 solute carrier family 12, member 6 JBrowse link 3 103,752,213 103,852,686 RGD:1624291
RGD:1600115
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 JBrowse link 12 47,698,915 47,737,902 RGD:1624291
RGD:1600115
cellular response to non-ionic osmotic stress term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:1624291
RGD:1600115
cellular response to osmotic stress term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ddx3x DEAD-box helicase 3, X-linked JBrowse link X 10,400,363 10,414,010 RGD:1624291
G Dysf dysferlin JBrowse link 4 115,700,942 115,901,873 RGD:1624291
RGD:1600115
G Lrrc8c leucine rich repeat containing 8 VRAC subunit C JBrowse link 14 5,283,655 5,378,738 RGD:13673739
G Lrrc8d leucine rich repeat containing 8 VRAC subunit D JBrowse link 14 5,085,606 5,194,808 RGD:1600115
RGD:1624291
RGD:13673739
G Lrrc8e leucine rich repeat containing 8 VRAC subunit E JBrowse link 12 2,557,267 2,568,416 RGD:1600115
RGD:1624291
G Pkd2 polycystin 2, transient receptor potential cation channel JBrowse link 14 6,602,004 6,645,257 RGD:1624291
RGD:1600115
G Relb RELB proto-oncogene, NF-kB subunit JBrowse link 1 80,517,081 80,545,019 RGD:7777165
G Serpinb6a serpin family B member 6A JBrowse link 17 32,154,747 32,209,598 RGD:1624291
G Slc2a4 solute carrier family 2 member 4 JBrowse link 10 56,552,921 56,558,562 RGD:1624291
RGD:1600115
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 JBrowse link 12 47,698,915 47,737,902 RGD:1624291
RGD:1600115
G Zfand1 zinc finger AN1-type containing 1 JBrowse link 2 93,656,895 93,666,745 RGD:1624291
cellular response to salt stress term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aqp1 aquaporin 1 (Colton blood group) JBrowse link 4 85,551,503 85,563,683 RGD:1624291
RGD:1600115
G Capn3 calpain 3 JBrowse link 3 112,227,486 112,278,408 RGD:1600115
RGD:1624291
G Zfp36l1 zinc finger protein 36, C3H type-like 1 JBrowse link 6 103,308,032 103,313,074 RGD:1624291
RGD:1600115
hyperosmotic response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aqp1 aquaporin 1 (Colton blood group) JBrowse link 4 85,551,503 85,563,683 RGD:2316074
RGD:13792537
G Aqp2 aquaporin 2 JBrowse link 7 141,237,802 141,242,837 RGD:2313121
G Hnmt histamine N-methyltransferase JBrowse link 3 905,111 937,038 RGD:2316838
G Nts neurotensin JBrowse link 7 44,111,594 44,120,998 RGD:9698448
G Pdpk1 3-phosphoinositide dependent protein kinase-1 JBrowse link 10 13,446,373 13,525,248 RGD:1624291
RGD:1600115
G Pkn1 protein kinase N1 JBrowse link 19 24,803,524 24,832,305 RGD:1624291
RGD:1600115
G Rac1 Rac family small GTPase 1 JBrowse link 12 13,090,316 13,111,841 RGD:1624291
G Slc12a2 solute carrier family 12 member 2 JBrowse link 18 52,917,124 52,985,281 RGD:1580437
G Slc6a18 solute carrier family 6 member 18 JBrowse link 1 32,221,679 32,235,599 RGD:68841
RGD:1580633
G Sst somatostatin JBrowse link 11 80,358,172 80,359,449 RGD:2303157
hyperosmotic salinity response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Aqp1 aquaporin 1 (Colton blood group) JBrowse link 4 85,551,503 85,563,683 RGD:2316078
G Aqp4 aquaporin 4 JBrowse link 18 6,766,009 6,782,757 RGD:2307072
G Avp arginine vasopressin JBrowse link 3 123,117,482 123,119,460 RGD:2304116
G Avpr1b arginine vasopressin receptor 1B JBrowse link 13 48,367,307 48,378,831 RGD:728880
G Cldn1 claudin 1 JBrowse link 11 77,815,216 77,830,373 RGD:11341802
G Mt-cyb mitochondrially encoded cytochrome b JBrowse link MT 14,136 15,278 RGD:634225
G Nkx2-1 NK2 homeobox 1 JBrowse link 6 77,418,096 77,423,383 RGD:2303984
G Oxt oxytocin/neurophysin I prepropeptide JBrowse link 3 123,106,694 123,107,534 RGD:2304116
G Tacr3 tachykinin receptor 3 JBrowse link 2 240,021,152 240,118,971 RGD:2305930
G Trip10 thyroid hormone receptor interactor 10 JBrowse link 9 9,689,214 9,702,353 RGD:634225
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 JBrowse link 12 47,698,915 47,737,902 RGD:1624291
RGD:1600115
hypotonic response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Itga2 integrin subunit alpha 2 JBrowse link 2 46,996,904 47,097,011 RGD:2303705
G Slc12a5 solute carrier family 12 member 5 JBrowse link 3 161,433,303 161,465,078 RGD:1600115
RGD:1624291
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 JBrowse link 12 47,698,915 47,737,902 RGD:68824
intrinsic apoptotic signaling pathway in response to osmotic stress term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:1624291
RGD:1600115
G Scn2a sodium voltage-gated channel alpha subunit 2 JBrowse link 3 51,687,910 51,822,008 RGD:1624291
RGD:1600115
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 JBrowse link 2 187,964,100 188,022,847 RGD:1624291
G Bdkrb2 bradykinin receptor B2 JBrowse link 6 129,399,468 129,429,676 RGD:1624291
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:1624291
RGD:1600115
G Ptger2 prostaglandin E receptor 2 JBrowse link 15 19,336,029 19,349,759 RGD:1624291
G Ptgs2 prostaglandin-endoperoxide synthase 2 JBrowse link 13 67,351,230 67,356,920 RGD:1624291
RGD:1600115
G Ybx3 Y box binding protein 3 JBrowse link 4 165,606,819 165,630,041 RGD:1624291
RGD:1600115
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bdkrb2 bradykinin receptor B2 JBrowse link 6 129,399,468 129,429,676 RGD:1624291
RGD:1600115
osmosensory signaling pathway term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Oxsr1 oxidative stress responsive kinase 1 JBrowse link 8 127,920,349 128,009,951 RGD:1600115
RGD:1624291
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 JBrowse link 12 47,698,915 47,737,902 RGD:1624291
RGD:13792537
positive regulation of intrinsic apoptotic signaling pathway in response to osmotic stress term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:1624291
RGD:1600115
regulation of cellular hyperosmotic salinity response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Efhd1 EF-hand domain family, member D1 JBrowse link 9 94,362,249 94,408,884 RGD:1600115
RGD:1624291
G Letm1 leucine zipper and EF-hand containing transmembrane protein 1 JBrowse link 14 82,227,790 82,267,298 RGD:1600115
RGD:1624291
G Micu1 mitochondrial calcium uptake 1 JBrowse link 20 29,284,833 29,433,617 RGD:1600115
RGD:1624291
G Slc25a23 solute carrier family 25 member 23 JBrowse link 9 9,987,988 10,003,599 RGD:1600115
RGD:1624291
regulation of response to osmotic stress term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcb1a ATP binding cassette subfamily B member 1A JBrowse link 4 22,339,829 22,517,642 RGD:1624291
G Mlc1 modulator of VRAC current 1 JBrowse link 7 129,949,984 129,970,314 RGD:1624291
RGD:1600115
G Prkca protein kinase C, alpha JBrowse link 10 96,186,509 96,585,168 RGD:1624291
G Trpv4 transient receptor potential cation channel, subfamily V, member 4 JBrowse link 12 47,698,915 47,737,902 RGD:1624291
RGD:10400856
response to salt stress term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:1624291
G Agtr1a angiotensin II receptor, type 1a JBrowse link 17 35,907,102 35,958,136 RGD:10047102
G Agtr1b angiotensin II receptor, type 1b JBrowse link 2 105,149,020 105,224,335 RGD:10047098
G Anxa7 annexin A7 JBrowse link 15 4,254,470 4,281,296 RGD:1624291
RGD:1600115
G Aqp2 aquaporin 2 JBrowse link 7 141,237,802 141,242,837 RGD:625535
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1624291
RGD:1600115
G Bdkrb2 bradykinin receptor B2 JBrowse link 6 129,399,468 129,429,676 RGD:1624291
RGD:1600115
G Ccl5 C-C motif chemokine ligand 5 JBrowse link 10 70,739,764 70,744,303 RGD:4889915
G Cdkn2a cyclin-dependent kinase inhibitor 2A JBrowse link 5 107,823,323 107,832,405 RGD:11252108
G Cdkn2a_v1 cyclin-dependent kinase inhibitor 2A, variant 1 RGD:11252108
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 JBrowse link 8 62,798,317 62,809,848 RGD:4391949
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 JBrowse link 7 116,248,759 116,255,205 RGD:2307302
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:2313666
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:4889915
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 JBrowse link 6 135,107,262 135,112,793 RGD:2316936
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:2316936
G Kmo kynurenine 3-monooxygenase JBrowse link 13 93,684,324 93,715,378 RGD:1624291
RGD:1600115
G Mknk1 MAP kinase-interacting serine/threonine kinase 1 JBrowse link 5 134,691,852 134,730,887 RGD:1624291
G Nedd4l neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase JBrowse link 18 60,392,376 60,719,720 RGD:1624291
G Pappa2 pappalysin 2 JBrowse link 13 76,389,150 76,660,248 RGD:11553579
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:5128807
G Tp53 tumor protein p53 JBrowse link 10 56,186,299 56,198,449 RGD:1624291
RGD:1600115

Term paths to the root
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Term Annotations click to browse term
  biological_process 17896
    response to stimulus 9794
      response to abiotic stimulus 1471
        response to osmotic stress 122
          cellular response to osmotic stress + 57
          detection of osmotic stimulus 0
          hyperosmotic response + 50
          hypotonic response + 10
          regulation of response to osmotic stress + 15
          regulation of translation in response to osmotic stress + 0
          response to non-ionic osmotic stress + 1
          response to salt stress + 57
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.