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ONTOLOGY REPORT - ANNOTATIONS


Term:ER overload response
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Accession:GO:0006983 term browser browse the term
Definition:The series of molecular signals generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB.
Synonyms:exact_synonym: EOR;   endoplasmic reticulum overload response
 narrow_synonym: EOR-mediated NF-kappaB activation;   EOR-mediated activation of NF-kappaB;   positive regulation of NF-kappaB transcription factor activity by EOR;   positive regulation of NF-kappaB transcription factor activity by ER overload response
 alt_id: GO:0006985


show annotations for term's descendants           Sort by:
 
ER overload response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg10 autophagy related 10 ISO (PMID:17256008) RGD PMID:17256008 NCBI chr 2:19,853,546...20,152,918
Ensembl chr 2:19,853,546...20,152,884
JBrowse link
G Ccdc47 coiled-coil domain containing 47 ISO (MGI:MGI:3721716|PMID:17204322) RGD PMID:17204322 MGI:MGI:3721716 NCBI chr10:94,388,425...94,406,949
Ensembl chr10:94,388,430...94,406,949
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 IMP
IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
MGI:MGI:2179046 (MGI:MGI:2158984|PMID:11854325)
Ensembl
RGD
PMID:11854325, PMID:11158311, PMID:21873635 GO_REF:0000107, MGI:MGI:2158984, RGD:70575, RGD:13792537 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISS
ISO
GO_REF:0000024
(PMID:10677345), (PMID:11907036)
UniProt
RGD
PMID:10677345, PMID:11907036 GO_REF:0000024 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO
IEA
(PMID:14744935)
GO_REF:0000107
(MGI:MGI:3032464|PMID:14744935)
RGD
Ensembl
PMID:14744935 GO_REF:0000107, MGI:MGI:3032464 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO (MGI:MGI:2158984|PMID:11854325) RGD PMID:11854325 MGI:MGI:2158984 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ins2 insulin 2 ISO MGI:MGI:1857572 (MGI:MGI:2158984|PMID:11854325) RGD PMID:11854325 MGI:MGI:2158984 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B ISO (MGI:MGI:2681361|PMID:14638860) RGD PMID:14638860 MGI:MGI:2681361 NCBI chr13:49,933,155...49,940,961
Ensembl chr13:49,933,155...49,940,961
JBrowse link
G Selenos selenoprotein S IEA
ISO
GO_REF:0000107
(PMID:16574427), (PMID:17210132)
Ensembl
RGD
PMID:16574427, PMID:17210132 GO_REF:0000107 NCBI chr 1:126,979,579...126,989,344
Ensembl chr 1:126,979,575...126,989,344
JBrowse link
G Tmco1 transmembrane and coiled-coil domains 1 ISO
ISS
(PMID:27212239)
GO_REF:0000024
RGD
UniProt
PMID:27212239 GO_REF:0000024 NCBI chr13:85,465,015...85,559,113
Ensembl chr13:85,465,792...85,559,087
JBrowse link
G Tp53 tumor protein p53 ISO (PMID:14744935) RGD PMID:14744935 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
positive regulation of autophagy in response to ER overload term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 BCL2 like 11 IMP RGD PMID:25772147 RGD:13782257 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bid BH3 interacting domain death agonist IMP RGD PMID:25772147 RGD:13782257 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 IMP RGD PMID:25772147 RGD:13782257 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20027
    response to stimulus 10583
      response to biotic stimulus 1743
        cellular response to biotic stimulus 344
          ER overload response 13
            detection of endoplasmic reticulum overloading 0
            positive regulation of autophagy in response to ER overload 3
Path 2
Term Annotations click to browse term
  biological_process 20027
    biological regulation 13773
      regulation of biological process 13075
        regulation of cellular process 12561
          signal transduction 7011
            ER-nucleus signaling pathway 42
              ER overload response 13
                detection of endoplasmic reticulum overloading 0
                positive regulation of autophagy in response to ER overload 3
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.