Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

ONTOLOGY REPORT - ANNOTATIONS


Term:ER-nucleus signaling pathway
go back to main search page
Accession:GO:0006984 term browser browse the term
Definition:Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.
Synonyms:exact_synonym: ER to nucleus signaling pathway;   ER to nucleus signalling pathway;   ER-nuclear signaling pathway;   ER-nuclear signalling pathway;   endoplasmic reticulum to nucleus signaling pathway;   endoplasmic reticulum-nuclear signaling pathway


show annotations for term's descendants           Sort by:
 
ER-nucleus signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 ISO (MGI:MGI:2684521|PMID:14561754) RGD PMID:14561754 MGI:MGI:2684521 NCBI chr12:39,553,903...39,603,326
Ensembl chr12:39,553,903...39,603,326
JBrowse link
ER overload response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atg10 autophagy related 10 ISO (PMID:17256008) RGD PMID:17256008 NCBI chr 2:19,853,546...20,152,918
Ensembl chr 2:19,853,546...20,152,884
JBrowse link
G Ccdc47 coiled-coil domain containing 47 ISO (MGI:MGI:3721716|PMID:17204322) RGD PMID:17204322 MGI:MGI:3721716 NCBI chr10:94,388,425...94,406,949
Ensembl chr10:94,388,430...94,406,949
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 IMP
IBA
IEA
ISO
PMID:21873635
GO_REF:0000107
MGI:MGI:2179046 (MGI:MGI:2158984|PMID:11854325)
Ensembl
RGD
PMID:11854325, PMID:11158311, PMID:21873635 GO_REF:0000107, MGI:MGI:2158984, RGD:70575, RGD:13792537 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISS
ISO
GO_REF:0000024
(PMID:10677345), (PMID:11907036)
UniProt
RGD
PMID:10677345, PMID:11907036 GO_REF:0000024 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Gsk3b glycogen synthase kinase 3 beta ISO
IEA
(PMID:14744935)
GO_REF:0000107
(MGI:MGI:3032464|PMID:14744935)
RGD
Ensembl
PMID:14744935 GO_REF:0000107, MGI:MGI:3032464 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 ISO (MGI:MGI:2158984|PMID:11854325) RGD PMID:11854325 MGI:MGI:2158984 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
JBrowse link
G Ins2 insulin 2 ISO MGI:MGI:1857572 (MGI:MGI:2158984|PMID:11854325) RGD PMID:11854325 MGI:MGI:2158984 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
JBrowse link
G Ppp1r15b protein phosphatase 1, regulatory subunit 15B ISO (MGI:MGI:2681361|PMID:14638860) RGD PMID:14638860 MGI:MGI:2681361 NCBI chr13:49,933,155...49,940,961
Ensembl chr13:49,933,155...49,940,961
JBrowse link
G Selenos selenoprotein S IEA
ISO
GO_REF:0000107
(PMID:16574427), (PMID:17210132)
Ensembl
RGD
PMID:16574427, PMID:17210132 GO_REF:0000107 NCBI chr 1:126,979,579...126,989,344
Ensembl chr 1:126,979,575...126,989,344
JBrowse link
G Tmco1 transmembrane and coiled-coil domains 1 ISO
ISS
(PMID:27212239)
GO_REF:0000024
RGD
UniProt
PMID:27212239 GO_REF:0000024 NCBI chr13:85,465,015...85,559,113
Ensembl chr13:85,465,792...85,559,087
JBrowse link
G Tp53 tumor protein p53 ISO (PMID:14744935) RGD PMID:14744935 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6b activating transcription factor 6 beta ISO (PMID:9837962) RGD PMID:9837962 NCBI chr20:4,414,283...4,422,283
Ensembl chr20:4,414,276...4,422,283
JBrowse link
G Wfs1 wolframin ER transmembrane glycoprotein ISO
IGI
(PMID:20160352) RGD PMID:20160352, PMID:20160352 RGD:10047363 NCBI chr14:78,640,707...78,665,224
Ensembl chr14:78,640,620...78,665,966
JBrowse link
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Nck1 NCK adaptor protein 1 ISO (PMID:14676213)
UniProtKB:O55033 (MGI:MGI:5613478|PMID:14676213)
RGD PMID:14676213 MGI:MGI:5613478 NCBI chr 8:108,787,797...108,847,779
Ensembl chr 8:108,787,798...108,847,779
JBrowse link
G Nck2 NCK adaptor protein 2 ISO UniProtKB:Q99M51 (MGI:MGI:5613478|PMID:14676213) RGD PMID:14676213 MGI:MGI:5613478 NCBI chr 9:50,246,767...50,373,307
Ensembl chr 9:50,247,692...50,373,284
JBrowse link
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 ISO (PMID:21216966)
(MGI:MGI:5619464|PMID:21216966)
RGD PMID:21216966 MGI:MGI:5619464 NCBI chr 3:164,665,462...164,711,936
Ensembl chr 3:164,665,532...164,711,848
JBrowse link
PERK-mediated unfolded protein response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf4 activating transcription factor 4 ISS
ISO
GO_REF:0000024
(MGI:MGI:3722921|PMID:14729979), (MGI:MGI:3798818|PMID:12667446)
UniProt
RGD
PMID:12667446, PMID:14729979 GO_REF:0000024, MGI:MGI:3722921, MGI:MGI:3798818 NCBI chr 7:121,480,723...121,482,781
Ensembl chr 7:121,480,723...121,482,772
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:MGI:3722921|PMID:14729979) RGD PMID:14729979 MGI:MGI:3722921 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 ISO (MGI:MGI:2677605|PMID:14517290) RGD PMID:14517290 MGI:MGI:2677605 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 ISO MGI:MGI:4456438 (MGI:MGI:5914333|PMID:28797121) RGD PMID:28797121 MGI:MGI:5914333 NCBI chr12:37,471,259...37,480,344
Ensembl chr12:37,471,260...37,480,297
JBrowse link
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atf6 activating transcription factor 6 ISO (PMID:9837962) RGD PMID:9837962 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
JBrowse link
positive regulation of autophagy in response to ER overload term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2l11 BCL2 like 11 IMP RGD PMID:25772147 RGD:13782257 NCBI chr 3:120,726,906...120,764,192
Ensembl chr 3:120,726,906...120,764,192
JBrowse link
G Bid BH3 interacting domain death agonist IMP RGD PMID:25772147 RGD:13782257 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 IMP RGD PMID:25772147 RGD:13782257 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
JBrowse link
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agr2 anterior gradient 2, protein disulphide isomerase family member ISO (PMID:23220234) RGD PMID:23220234 NCBI chr 6:55,465,782...55,487,087
Ensembl chr 6:55,465,782...55,487,714
JBrowse link
G Bok BCL2 family apoptosis regulator BOK ISO
ISS
(MGI:MGI:5648772|PMID:26015568)
GO_REF:0000024
RGD
UniProt
PMID:26015568 GO_REF:0000024, MGI:MGI:5648772 NCBI chr 9:100,829,593...100,840,498
Ensembl chr 9:100,829,552...100,840,504
JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 ISO (MGI:MGI:5619464|PMID:21216966) RGD PMID:21216966 MGI:MGI:5619464 NCBI chr18:63,415,298...63,489,240
Ensembl chr18:63,415,306...63,488,027
JBrowse link
G Tmem33 transmembrane protein 33 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:26268696)
Ensembl
UniProt
RGD
PMID:26268696 GO_REF:0000024, GO_REF:0000107 NCBI chr14:42,537,352...42,559,580
Ensembl chr14:42,535,701...42,560,174
JBrowse link
positive regulation of SREBP signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Spring1 SREBF pathway regulator in golgi 1 ISO
IEA
(PMID:32111832)
(MGI:MGI:6401656|PMID:32111832)
GO_REF:0000107
RGD
Ensembl
PMID:32111832 GO_REF:0000107, MGI:MGI:6401656 NCBI chr12:43,920,564...43,940,798
Ensembl chr12:43,920,564...43,940,798
JBrowse link
G Zbtb7b zinc finger and BTB domain containing 7B ISO (MGI:MGI:6120228|PMID:29420538) RGD PMID:29420538 MGI:MGI:6120228 NCBI chr 2:188,704,989...188,719,674
Ensembl chr 2:188,704,687...188,718,704
JBrowse link
positive regulation of sterol regulatory element binding protein cleavage term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Lpcat3 lysophosphatidylcholine acyltransferase 3 ISS
ISO
GO_REF:0000024
(MGI:MGI:5927299|PMID:28846071)
UniProt
RGD
PMID:28846071 GO_REF:0000024, MGI:MGI:5927299 NCBI chr 4:157,181,722...157,222,997
Ensembl chr 4:157,181,795...157,222,996
JBrowse link
regulation of SREBP signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Amfr autocrine motility factor receptor ISO
IEA
(MGI:MGI:6276494|PMID:22863805)
GO_REF:0000107
RGD
Ensembl
PMID:22863805 GO_REF:0000107, MGI:MGI:6276494 NCBI chr19:11,473,538...11,509,500
Ensembl chr19:11,473,541...11,508,102
JBrowse link
G Tmed2 transmembrane p24 trafficking protein 2 ISO MGI:MGI:4456438 (MGI:MGI:5914333|PMID:28797121) RGD PMID:28797121 MGI:MGI:5914333 NCBI chr12:37,471,259...37,480,344
Ensembl chr12:37,471,260...37,480,297
JBrowse link
SREBP signaling pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07060293.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 4:66,336,143...66,336,901 JBrowse link
G Arhgef10l Rho guanine nucleotide exchange factor 10 like ISO
IBA
(PMID:16112081)
PMID:21873635
RGD PMID:16112081, PMID:21873635 RGD:13792537 NCBI chr 5:159,018,373...159,089,383
Ensembl chr 5:159,018,893...159,119,171
JBrowse link
G Eif2a eukaryotic translation initiation factor 2A ISO (MGI:MGI:3815371|PMID:18852460) RGD PMID:18852460 MGI:MGI:3815371 NCBI chr 2:148,722,343...148,755,781
Ensembl chr 2:148,722,231...148,755,520
JBrowse link
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 ISO (MGI:MGI:3815371|PMID:18852460) RGD PMID:18852460 MGI:MGI:3815371 NCBI chr 4:98,648,513...98,709,695
Ensembl chr 4:98,648,545...98,709,694
JBrowse link
G Erlin1 ER lipid raft associated 1 ISO
IBA
(PMID:24217618)
PMID:21873635
RGD PMID:24217618, PMID:21873635 RGD:13792537 NCBI chr 1:263,810,439...263,845,762
Ensembl chr 1:263,810,439...263,845,762
JBrowse link
G Erlin2 ER lipid raft associated 2 ISO
IBA
(PMID:24217618)
PMID:21873635
RGD PMID:24217618, PMID:21873635 RGD:13792537 NCBI chr16:69,179,005...69,195,452
Ensembl chr16:69,179,588...69,195,097
JBrowse link
G Insig1 insulin induced gene 1 IBA
ISO
PMID:21873635
(PMID:12242332), (PMID:32322062)
RGD PMID:12242332, PMID:32322062, PMID:21873635 RGD:13792537 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Insig2 insulin induced gene 2 IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:12242332), (PMID:17428920), (PMID:32322062)
UniProt
RGD
PMID:12242332, PMID:17428920, PMID:32322062, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
JBrowse link
G Scap SREBF chaperone ISO
ISS
(PMID:11726962), (PMID:32322062)
GO_REF:0000024
RGD
UniProt
PMID:11726962, PMID:32322062 GO_REF:0000024 NCBI chr 8:118,551,869...118,628,650
Ensembl chr 8:118,570,503...118,628,651
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 ISO
ISS
(PMID:27614840), (PMID:32322062)
GO_REF:0000024
RGD
UniProt
PMID:27614840, PMID:32322062 GO_REF:0000024 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 IEA
ISS
ISO
GO_REF:0000107
GO_REF:0000024
(PMID:27614840), (PMID:32322062)
Ensembl
UniProt
RGD
PMID:27614840, PMID:32322062 GO_REF:0000024, GO_REF:0000107 NCBI chr 7:123,381,082...123,438,605
Ensembl chr 7:123,381,077...123,438,603
JBrowse link
SREBP-SCAP complex retention in endoplasmic reticulum term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AABR07060293.1 IBA PMID:21873635 GO_Central PMID:21873635 RGD:13792537 Ensembl chr 4:66,336,143...66,336,901 JBrowse link
G Insig1 insulin induced gene 1 IBA
ISO
PMID:21873635
(PMID:12202038), (PMID:32322062)
RGD PMID:12202038, PMID:32322062, PMID:21873635 RGD:13792537 NCBI chr 4:342,302...350,515
Ensembl chr 4:342,302...350,515
JBrowse link
G Insig2 insulin induced gene 2 IBA
ISS
ISO
PMID:21873635
GO_REF:0000024
(PMID:32322062)
UniProt
RGD
PMID:32322062, PMID:21873635 GO_REF:0000024, RGD:13792537 NCBI chr13:37,264,818...37,292,718
Ensembl chr13:37,266,312...37,287,458
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 20014
    signaling 7588
      signal transduction 7015
        ER-nucleus signaling pathway 41
          ATF6-mediated unfolded protein response + 3
          ER overload response + 13
          PERK-mediated unfolded protein response + 11
          SREBP signaling pathway + 16
Path 2
Term Annotations click to browse term
  biological_process 20014
    biological regulation 13759
      regulation of biological process 13071
        regulation of cellular process 12560
          signal transduction 7015
            ER-nucleus signaling pathway 41
              ATF6-mediated unfolded protein response + 3
              ER overload response + 13
              PERK-mediated unfolded protein response + 11
              SREBP signaling pathway + 16
paths to the root

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.