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ONTOLOGY REPORT - ANNOTATIONS


Term:response to unfolded protein
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Accession:GO:0006986 term browser browse the term
Definition:Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus.
Comment:Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER.
Synonyms:related_synonym: heat shock protein activity


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response to unfolded protein term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07011951.1 RGD:13792537
G AABR07033324.1 RGD:13792537
G AABR07048992.1 RGD:13792537
G Chac1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 JBrowse link 3 111,160,205 111,163,425 RGD:1600115
G Comp cartilage oligomeric matrix protein JBrowse link 16 20,798,437 20,807,070 RGD:1624291
RGD:1600115
G Crebrf CREB3 regulatory factor JBrowse link 10 16,693,846 16,753,162 RGD:1600115
G Dab2ip DAB2 interacting protein JBrowse link 3 14,889,263 15,060,286 RGD:1600115
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:1624291
RGD:1600115
G Derl1 derlin 1 JBrowse link 7 97,737,176 97,759,852 RGD:1624291
G Dnajb5 DnaJ heat shock protein family (Hsp40) member B5 JBrowse link 5 58,393,197 58,402,162 RGD:1624291
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 JBrowse link 6 64,165,913 64,170,122 RGD:1600115
G Dnajc3 DnaJ heat shock protein family (Hsp40) member C3 JBrowse link 15 104,186,918 104,226,236 RGD:1600115
G Erp44 endoplasmic reticulum protein 44 JBrowse link 5 63,937,866 64,030,827 RGD:1624291
G Faf2 Fas associated factor family member 2 JBrowse link 17 10,485,650 10,527,886 RGD:1600115
G Fbxo6 F-box protein 6 JBrowse link 5 164,956,285 164,962,075 RGD:1600115
G Ficd FIC domain protein adenylyltransferase JBrowse link 12 48,658,283 48,663,175 RGD:1600115
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 19 11,046,905 11,057,440 RGD:1624291
G Hsc70-ps1 heat shock cognate protein 70, pseudogene 1 JBrowse link 2 177,651,231 177,653,349 RGD:13792537
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 JBrowse link 9 17,817,791 17,823,163 RGD:1304537
RGD:1304538
G Hspa13 heat shock protein family A (Hsp70) member 13 JBrowse link 11 14,146,515 14,160,697 RGD:13792537
G Hspa14 heat shock protein family A (Hsp70) member 14 JBrowse link 17 78,735,630 78,756,412 RGD:13792537
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:1300068
RGD:13792537
RGD:1600115
RGD:1624291
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:1298961
RGD:13792537
RGD:1600115
RGD:1624291
G Hspa1l heat shock protein family A (Hsp70) member 1 like JBrowse link 20 4,879,998 4,965,191 RGD:13792537
G Hspa2 heat shock protein family A (Hsp70) member 2 JBrowse link 6 99,433,575 99,436,288 RGD:13792537
G Hspa4l heat shock protein family A (Hsp70) member 4 like JBrowse link 2 127,625,737 127,682,864 RGD:8554521
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:13792537
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:13792537
G Hspa9 heat shock protein family A (Hsp70) member 9 JBrowse link 18 27,731,072 27,749,235 RGD:13792537
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link 9 61,680,529 61,691,202 RGD:1624291
G Jkamp JNK1/MAPK8-associated membrane protein JBrowse link 6 94,835,845 94,849,784 RGD:1600115
G LOC100363133 heat shock cognate 71 kDa protein-like JBrowse link 5 99,030,998 99,033,110 RGD:13792537
G LOC108348108 heat shock 70 kDa protein 1A JBrowse link 20 2,699,707 2,701,856 RGD:1600115
RGD:13792537
G LOC680121 similar to heat shock protein 8 JBrowse link 11 13,499,168 13,501,271 RGD:13792537
G Manf mesencephalic astrocyte-derived neurotrophic factor JBrowse link 8 115,623,175 115,626,408 RGD:1600115
G Mfn2 mitofusin 2 JBrowse link 5 164,684,244 164,715,414 RGD:1600115
G Pigbos1 PIGB opposite strand 1 JBrowse link 8 79,715,337 79,719,706 RGD:1600115
G Prkn parkin RBR E3 ubiquitin protein ligase JBrowse link 1 48,880,015 50,069,998 RGD:628414
G RGD1562515 similar to RIKEN cDNA 4931417E11 JBrowse link 4 101,392,229 101,393,329 RGD:1600115
G Stt3b STT3 oligosaccharyltransferase complex catalytic subunit B JBrowse link 8 123,303,910 123,370,729 RGD:1624291
G Thbs4 thrombospondin 4 JBrowse link 2 22,343,727 22,385,855 RGD:1600115
G Ubxn4 UBX domain protein 4 JBrowse link 13 44,956,963 44,989,653 RGD:1600115
G Umod uromodulin JBrowse link 1 189,186,027 189,199,939 RGD:1624291
cellular response to unfolded protein term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07011951.1 RGD:13792537
G AABR07033324.1 RGD:13792537
G AABR07048992.1 RGD:13792537
G Bag3 BAG cochaperone 3 JBrowse link 1 199,941,258 199,965,191 RGD:1624291
G Daxx death-domain associated protein JBrowse link 20 5,480,103 5,485,962 RGD:1624291
RGD:1600115
G Derl1 derlin 1 JBrowse link 7 97,737,176 97,759,852 RGD:1624291
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:1624291
G Hsc70-ps1 heat shock cognate protein 70, pseudogene 1 JBrowse link 2 177,651,231 177,653,349 RGD:13792537
G Hsf1 heat shock transcription factor 1 JBrowse link 7 117,538,523 117,565,478 RGD:1624291
G Hspa13 heat shock protein family A (Hsp70) member 13 JBrowse link 11 14,146,515 14,160,697 RGD:13792537
G Hspa14 heat shock protein family A (Hsp70) member 14 JBrowse link 17 78,735,630 78,756,412 RGD:13792537
G Hspa1a heat shock protein family A (Hsp70) member 1A JBrowse link 20 4,875,834 4,881,751 RGD:1624291
RGD:13792537
G Hspa1b heat shock protein family A (Hsp70) member 1B JBrowse link 20 4,877,638 4,880,112 RGD:1624291
RGD:13792537
G Hspa1l heat shock protein family A (Hsp70) member 1 like JBrowse link 20 4,879,998 4,965,191 RGD:13792537
G Hspa2 heat shock protein family A (Hsp70) member 2 JBrowse link 6 99,433,575 99,436,288 RGD:13792537
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:13792537
G Hspa8 heat shock protein family A (Hsp70) member 8 JBrowse link 8 44,989,401 44,993,261 RGD:13792537
G Hspa9 heat shock protein family A (Hsp70) member 9 JBrowse link 18 27,731,072 27,749,235 RGD:13792537
G Hspb8 heat shock protein family B (small) member 8 JBrowse link 12 45,905,371 45,920,014 RGD:1624291
RGD:13792537
G LOC100363133 heat shock cognate 71 kDa protein-like JBrowse link 5 99,030,998 99,033,110 RGD:13792537
G LOC108348108 heat shock 70 kDa protein 1A JBrowse link 20 2,699,707 2,701,856 RGD:13792537
G LOC680121 similar to heat shock protein 8 JBrowse link 11 13,499,168 13,501,271 RGD:13792537
G Optn optineurin JBrowse link 17 77,167,700 77,218,374 RGD:1600115
RGD:1624291
G Pmp22 peripheral myelin protein 22 JBrowse link 10 49,538,588 49,568,583 RGD:1624291
G Rhbdd1 rhomboid domain containing 1 JBrowse link 9 88,110,731 88,229,462 RGD:1624291
RGD:13792537
RGD:1600115
G Tm7sf3 transmembrane 7 superfamily member 3 JBrowse link 4 180,913,703 180,951,564 RGD:1624291
RGD:1600115
G Tmbim6 transmembrane BAX inhibitor motif containing 6 JBrowse link 7 141,039,433 141,070,269 RGD:1600115
RGD:1624291
G Umod uromodulin JBrowse link 1 189,186,027 189,199,939 RGD:1624291
endoplasmic reticulum unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Amfr autocrine motility factor receptor JBrowse link 19 11,473,538 11,509,500 RGD:1624291
RGD:13792537
G Atf3 activating transcription factor 3 JBrowse link 13 109,817,892 109,849,632 RGD:1624291
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:1600115
RGD:1624291
G Atf6 activating transcription factor 6 JBrowse link 13 89,053,457 89,242,531 RGD:1600115
G Atf6b activating transcription factor 6 beta JBrowse link 20 4,414,283 4,422,283 RGD:1600115
G Bhlha15 basic helix-loop-helix family, member a15 JBrowse link 12 12,403,385 12,409,103 RGD:1624291
RGD:1600115
G Calr calreticulin JBrowse link 19 25,956,771 25,961,666 RGD:13792537
G Calr3 calreticulin 3 JBrowse link 16 19,097,391 19,124,062 RGD:13792537
G Calr4 calreticulin 4 JBrowse link 5 128,865,339 128,900,135 RGD:13792537
G Canx calnexin JBrowse link 10 35,800,942 35,833,939 RGD:13792537
G Casp12 caspase 12 JBrowse link 8 2,658,892 2,686,160 RGD:1624291
RGD:1600115
G Ccnd1 cyclin D1 JBrowse link 1 218,090,750 218,100,447 RGD:1624291
G Cdk5rap3 CDK5 regulatory subunit associated protein 3 JBrowse link 10 84,780,644 84,789,800 RGD:1600115
RGD:1624291
G Clgn calmegin JBrowse link 19 24,545,257 24,578,527 RGD:13792537
G Creb3l1 cAMP responsive element binding protein 3-like 1 JBrowse link 3 80,892,433 80,933,283 RGD:1624291
RGD:1600115
G Creb3l2 cAMP responsive element binding protein 3-like 2 JBrowse link 4 64,869,285 64,981,519 RGD:1600115
G Creb3l3 cAMP responsive element binding protein 3-like 3 JBrowse link 7 11,490,852 11,499,287 RGD:1600115
G Creb3l4 cAMP responsive element binding protein 3-like 4 JBrowse link 2 189,596,657 189,602,243 RGD:1600115
G Ddit3 DNA-damage inducible transcript 3 JBrowse link 7 70,578,564 70,585,074 RGD:1600115
RGD:1624291
G Derl1 derlin 1 JBrowse link 7 97,737,176 97,759,852 RGD:1624291
RGD:13792537
G Derl2 derlin 2 JBrowse link 10 57,641,682 57,653,554 RGD:1624291
RGD:13792537
G Derl3 derlin 3 JBrowse link 20 13,692,102 13,707,645 RGD:1624291
RGD:13792537
G Eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 JBrowse link 6 1,428,845 1,466,193 RGD:1624291
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1600115
RGD:1624291
G Eif2ak4 eukaryotic translation initiation factor 2 alpha kinase 4 JBrowse link 3 110,159,624 110,245,382 RGD:1624291
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:1624291
RGD:13792537
G Ern2 endoplasmic reticulum to nucleus signaling 2 JBrowse link 1 192,126,023 192,142,865 RGD:13792537
G Ero1a endoplasmic reticulum oxidoreductase 1 alpha JBrowse link 15 19,619,947 19,655,381 RGD:1624291
G Fgf21 fibroblast growth factor 21 JBrowse link 1 101,595,579 101,596,822 RGD:10401883
G Herpud1 homocysteine inducible ER protein with ubiquitin like domain 1 JBrowse link 19 11,046,905 11,057,440 RGD:1304324
RGD:13792537
RGD:1624291
G Herpud2 HERPUD family member 2 JBrowse link 8 26,266,571 26,311,528 RGD:13792537
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:1624291
RGD:13792537
G Ifng interferon gamma JBrowse link 7 61,337,383 61,341,419 RGD:1624291
G LOC103694875 derlin-3 RGD:13792537
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:1624291
G Parp16 poly (ADP-ribose) polymerase family, member 16 JBrowse link 8 70,712,393 70,731,212 RGD:1624291
RGD:13792537
G Ppp1r15a protein phosphatase 1, regulatory subunit 15A JBrowse link 1 101,511,899 101,515,043 RGD:1624291
RGD:9999413
RGD:9999171
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1624291
RGD:1600115
G Rnf121 ring finger protein 121 JBrowse link 1 167,095,916 167,165,257 RGD:13792537
G Selenos selenoprotein S JBrowse link 1 126,979,579 126,989,344 RGD:1600115
RGD:13792537
RGD:1624291
G Serp1 stress-associated endoplasmic reticulum protein 1 JBrowse link 2 148,718,279 148,722,263 RGD:1624291
RGD:13792537
G Serp2 stress-associated endoplasmic reticulum protein family member 2 JBrowse link 15 58,687,784 58,712,023 RGD:13792537
G Stc2 stanniocalcin 2 JBrowse link 10 16,542,909 16,552,675 RGD:1624291
G Stub1 STIP1 homology and U-box containing protein 1 JBrowse link 10 15,197,754 15,200,035 RGD:1624291
G Tbl2 transducin (beta)-like 2 JBrowse link 12 24,565,843 24,578,855 RGD:1624291
G Tmtc4 transmembrane O-mannosyltransferase targeting cadherins 4 JBrowse link 15 109,338,762 109,394,905 RGD:1624291
G Vapb VAMP associated protein B and C JBrowse link 3 171,832,558 171,871,042 RGD:1624291
RGD:1600115
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link 14 78,640,707 78,665,224 RGD:13792537
RGD:1624291
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1304536
RGD:1624291
G Yod1 YOD1 deubiquitinase JBrowse link 13 47,441,296 47,443,013 RGD:1624291
RGD:13792537
RGD:1600115
IRE1-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:13792537
RGD:1624291
G Ern2 endoplasmic reticulum to nucleus signaling 2 JBrowse link 1 192,126,023 192,142,865 RGD:13792537
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:1624291
G Parp16 poly (ADP-ribose) polymerase family, member 16 JBrowse link 8 70,712,393 70,731,212 RGD:1600115
RGD:1624291
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1624291
G Vapb VAMP associated protein B and C JBrowse link 3 171,832,558 171,871,042 RGD:1600115
RGD:1624291
mitochondrial unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G AABR07014739.1 RGD:13792537
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link 9 61,680,529 61,691,202 RGD:13792537
negative regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf6b activating transcription factor 6 beta JBrowse link 20 4,414,283 4,422,283 RGD:1624291
G Wfs1 wolframin ER transmembrane glycoprotein JBrowse link 14 78,640,707 78,665,224 RGD:1624291
RGD:10047363
negative regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Crebrf CREB3 regulatory factor JBrowse link 10 16,693,846 16,753,162 RGD:1624291
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1624291
negative regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bfar bifunctional apoptosis regulator JBrowse link 10
10
1,464,658
1,464,783
1,471,152
1,497,653
RGD:1624291
G Ddrgk1 DDRGK domain containing 1 JBrowse link 3 123,195,580 123,206,828 RGD:1624291
G Dnajb9 DnaJ heat shock protein family (Hsp40) member B9 JBrowse link 6 64,165,913 64,170,122 RGD:1600115
G Hspa5 heat shock protein family A (Hsp70) member 5 JBrowse link 3 13,838,304 13,842,763 RGD:1600115
G Pdia6 protein disulfide isomerase family A, member 6 JBrowse link 6 42,568,269 42,585,654 RGD:1624291
G Ufl1 Ufm1-specific ligase 1 JBrowse link 5 39,616,479 39,650,894 RGD:1624291
RGD:1600115
negative regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Nck1 NCK adaptor protein 1 JBrowse link 8 108,787,797 108,847,779 RGD:1624291
G Nck2 NCK adaptor protein 2 JBrowse link 9 50,246,767 50,373,307 RGD:1624291
G Ptpn1 protein tyrosine phosphatase, non-receptor type 1 JBrowse link 3 164,665,462 164,711,936 RGD:1624291
PERK-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf4 activating transcription factor 4 JBrowse link 7 121,480,723 121,482,781 RGD:1600115
RGD:1624291
G Eif2ak3 eukaryotic translation initiation factor 2 alpha kinase 3 JBrowse link 4 98,648,513 98,709,695 RGD:1624291
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:1624291
G Tmed2 transmembrane p24 trafficking protein 2 JBrowse link 12 37,471,259 37,480,344 RGD:1624291
positive regulation of ATF6-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Atf6 activating transcription factor 6 JBrowse link 13 89,053,457 89,242,531 RGD:1624291
positive regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bak1 BCL2-antagonist/killer 1 JBrowse link 20 5,609,620 5,618,899 RGD:1624291
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:1600115
RGD:1624291
G Ern1 endoplasmic reticulum to nucleus signaling 1 JBrowse link 10 94,588,555 94,682,072 RGD:1624291
G Pik3r1 phosphoinositide-3-kinase regulatory subunit 1 JBrowse link 2 31,742,326 31,826,882 RGD:1600115
RGD:1624291
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1624291
RGD:13792537
positive regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agr2 anterior gradient 2, protein disulphide isomerase family member JBrowse link 6 55,465,782 55,487,087 RGD:1624291
G Tmem33 transmembrane protein 33 JBrowse link 14 42,537,352 42,559,580 RGD:1600115
RGD:1624291
positive regulation of PERK-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Agr2 anterior gradient 2, protein disulphide isomerase family member JBrowse link 6 55,465,782 55,487,087 RGD:1624291
G Bok BCL2 family apoptosis regulator BOK JBrowse link 9 100,829,593 100,840,498 RGD:1624291
RGD:1600115
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 JBrowse link 18 63,415,298 63,489,240 RGD:1624291
G Tmem33 transmembrane protein 33 JBrowse link 14 42,537,352 42,559,580 RGD:1600115
RGD:1624291
positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:1624291
G Creb3 cAMP responsive element binding protein 3 JBrowse link 5 59,063,532 59,068,196 RGD:1624291
G Ep300 E1A binding protein p300 JBrowse link 7 122,818,194 122,889,055 RGD:1624291
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:1624291
RGD:13792537
RGD:1600115
regulation of endoplasmic reticulum unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Pigbos1 PIGB opposite strand 1 JBrowse link 8 79,715,337 79,719,706 RGD:1624291
RGD:1600115
regulation of IRE1-mediated unfolded protein response term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Cops5 COP9 signalosome subunit 5 JBrowse link 5 8,876,090 8,894,345 RGD:1624291
G Ficd FIC domain protein adenylyltransferase JBrowse link 12 48,658,283 48,663,175 RGD:1600115
RGD:1624291

Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 19858
    response to stimulus 10526
      response to stress 4032
        response to topologically incorrect protein 142
          response to unfolded protein 117
            cellular response to unfolded protein + 99
            detection of unfolded protein 0
Path 2
Term Annotations click to browse term
  biological_process 19858
    response to stimulus 10526
      response to chemical 6306
        response to organic substance 3833
          response to topologically incorrect protein 142
            response to unfolded protein 117
              cellular response to unfolded protein + 99
              detection of unfolded protein 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.